CA1268770C - Preparation of imidazole derivatives - Google Patents

Preparation of imidazole derivatives

Info

Publication number
CA1268770C
CA1268770C CA 495608 CA495608A CA1268770C CA 1268770 C CA1268770 C CA 1268770C CA 495608 CA495608 CA 495608 CA 495608 A CA495608 A CA 495608A CA 1268770 C CA1268770 C CA 1268770C
Authority
CA
Canada
Prior art keywords
preparation
och3
hal
compounds
imidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 495608
Other languages
English (en)
French (fr)
Other versions
CA1266669A1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to CA000607789A priority Critical patent/CA1268770A/en
Publication of CA1266669A1 publication Critical patent/CA1266669A1/en
Application granted granted Critical
Publication of CA1268770C publication Critical patent/CA1268770C/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
CA 495608 1984-11-23 1985-11-18 Preparation of imidazole derivatives Expired - Lifetime CA1268770C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA000607789A CA1268770A (en) 1984-11-23 1989-08-08 Preparation of imidazole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08429578A GB2167408B (en) 1984-11-23 1984-11-23 Substituted imidazole derivatives and their preparation and use
GB8429578 1984-11-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA000607789A Division CA1268770A (en) 1984-11-23 1989-08-08 Preparation of imidazole derivatives

Publications (2)

Publication Number Publication Date
CA1266669A1 CA1266669A1 (en) 1990-03-13
CA1268770C true CA1268770C (en) 1990-05-08

Family

ID=10570140

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 495608 Expired - Lifetime CA1268770C (en) 1984-11-23 1985-11-18 Preparation of imidazole derivatives

Country Status (26)

Country Link
US (1) US4689339A (ja)
EP (2) EP0310745B1 (ja)
JP (1) JPH064597B2 (ja)
KR (1) KR930004673B1 (ja)
AT (2) ATE85050T1 (ja)
AU (2) AU586839B2 (ja)
BG (1) BG60762B2 (ja)
CA (1) CA1268770C (ja)
DD (1) DD258230A1 (ja)
DE (2) DE3587045T2 (ja)
DK (2) DK164903C (ja)
ES (2) ES8704462A1 (ja)
FI (1) FI80264C (ja)
GB (1) GB2167408B (ja)
GR (1) GR852817B (ja)
HK (1) HK3592A (ja)
HU (1) HU195189B (ja)
IE (1) IE58165B1 (ja)
IL (1) IL77111A (ja)
NO (1) NO166585C (ja)
NZ (1) NZ214258A (ja)
PH (1) PH22016A (ja)
PT (1) PT81542B (ja)
SG (1) SG106891G (ja)
SU (1) SU1424736A3 (ja)
ZA (1) ZA858942B (ja)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0252162A4 (en) * 1986-01-28 1988-07-29 Mitsui Petrochemical Ind METHOD FOR PRODUCING 2-UNSUBSTITUTED IMIDAZOLES.
FI862039A0 (fi) * 1986-05-15 1986-05-15 Farmos Oy Nytt foerfarande foer framstaellning av 4(5)-substituerade imidazolderivat.
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2576493B2 (ja) * 1987-03-20 1997-01-29 アイシン精機株式会社 原稿読取り装置に用いられる原稿トレ−
FR2621327B1 (fr) * 1987-10-06 1990-01-05 Commissariat Energie Atomique Procede de production et d'extraction de polysaccharides a partir d'une culture de porphyridium cruentum et dispositif pour la mise en oeuvre du procede
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB8903437D0 (en) * 1989-02-15 1989-04-05 Erba Carlo Spa Imidazolyl derivatives of 3,4-dihydro-2h-1-benzothiopyran
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
DK344489D0 (da) * 1989-07-12 1989-07-12 Novo Nordisk As Substituerede 2-imidazoliner og fremstilling og anvendelse deraf
GB2244431A (en) * 1990-05-31 1991-12-04 Farmos Oy Treatment of age related memory impairment and other cognitive disorders
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5541211A (en) * 1991-06-18 1996-07-30 Orion-Yhtyma Oy Administration of atipamezole to elicit a yohimbine-like alpha-adrenoreceptor antagonistic noradrenergic transmission
JP2667294B2 (ja) * 1991-11-05 1997-10-27 スミスクライン・ビーチャム・コーポレイション エンドセリン受容体拮抗剤
GB9127050D0 (en) * 1991-12-20 1992-02-19 Orion Yhtymae Oy Substituted imidazole derivatives and their preparation and use
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives
GB9312669D0 (en) 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
GB9425211D0 (en) * 1994-12-14 1995-02-15 Ucb Sa Substituted 1H-imidazoles
FR2733983B1 (fr) * 1995-05-10 1997-08-01 Pf Medicament Procede de preparation d'un derive d'acide benzofurane carboxylque optiquement pur et son utilisation pour preparer l'efaroxan
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
JP2002510300A (ja) 1997-06-05 2002-04-02 ヴィーナンティアス・リミテッド インダン化合物及びそれらの医薬学的使用
AU3378399A (en) * 1998-04-02 1999-10-25 Ortho-Mcneil Pharmaceutical, Inc. 4-thionaphthyl-1h-imidazoles with alpha-2-adrenergic activity
FR2784989B1 (fr) * 1998-09-10 2002-09-27 Fabre Pierre Sante Derive d'ester d'acide 2-ethyl-2,3-dihydrobenzofurane- carboxylique, procede de preparation et utilisation pour la preparation de derives de l'efaroxan
EP1147092A1 (en) * 1999-01-18 2001-10-24 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US6593324B2 (en) 2000-03-01 2003-07-15 Orion Corporation Dervatives of quinoline as alpha-2 antagonists
AU5846901A (en) 2000-05-08 2001-11-20 Orion Corp New polycyclic indanylimidazoles with alpha2 adrenergic activity
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US6543389B2 (en) 2001-06-26 2003-04-08 Pfizer Inc. Insecticidal pet collar
NZ535950A (en) 2002-04-03 2007-11-30 Orion Corp Polycyclic compounds as potent alpha2-adrenoceptor antagonists
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
FI116292B (fi) 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
ATE411799T1 (de) * 2003-11-04 2008-11-15 Intervet Int Bv Ectoparasitische formulierungen von spinosyns und azol-pestiziden
FI20050657A0 (fi) * 2005-06-17 2005-06-17 Orion Corp Atipametsolin kiteytysmenetelmä
AU2006299833B2 (en) 2005-10-12 2012-04-12 Besins Healthcare Luxembourg Sarl Improved testosterone gel and method of use
US7592461B2 (en) * 2005-12-21 2009-09-22 Bristol-Myers Squibb Company Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
JP2010500315A (ja) * 2006-08-08 2010-01-07 インターベツト・インターナシヨナル・ベー・ベー 増強された抗寄生虫活性組成物
TWI457122B (zh) 2007-07-20 2014-10-21 Orion Corp 作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
CL2008003553A1 (es) * 2007-12-05 2009-11-27 Grindeks Jsc Proceso para preparar atipamezol o clorhidrato de 5-(2-etil-2,3-dihidro-1h-inden-2-il)-1h-imidazol: y loa compuestos intermediarios considerados en el proceso
EP3065741B1 (en) 2013-11-05 2021-09-22 3M Innovative Properties Company Sesame oil based injection formulations
TWI704145B (zh) 2015-06-05 2020-09-11 芬蘭商奧利安公司 新醫藥化合物
US20200383953A1 (en) * 2015-11-05 2020-12-10 University Of Louisville Research Foundation, Inc. Local and regional anesthesia and analgesia
EP3478676A1 (en) 2016-06-29 2019-05-08 Orion Corporation Benzodioxane derivatives and their pharmaceutical use
AU2019411230A1 (en) 2018-12-21 2021-06-10 Société des Produits Nestlé S.A. Nutritional composition for inducing a feeling of satiety, a better sleep and/or limiting nocturnal awaking in infants or young children
CN111978254A (zh) * 2019-05-22 2020-11-24 南京康德祥医药科技有限公司 一种阿替美唑盐酸盐的制备工艺
CN111925330A (zh) * 2020-09-07 2020-11-13 上海阿达玛斯试剂有限公司 一种阿替美唑的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2933962A1 (de) * 1979-08-22 1981-03-26 Hoechst Ag, 65929 Frankfurt Verfahren zur herstellung von 4,5-dichlor-imidazolen.
US4342775A (en) * 1980-03-04 1982-08-03 Farmitalia Carlo Erba S.P.A. 3-(1-Imidazolyl)-derivatives of 2,3-dihydro-4H-1-benzopyran
US4302469A (en) * 1980-09-10 1981-11-24 Syntex (U.S.A.) Inc. 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES523609A0 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
FR2539415B1 (fr) * 1983-01-14 1985-09-13 Adir Derives de la d-2 imidazoline, leur preparation et leur application en therapeutique
FR2542738A1 (fr) * 1983-03-18 1984-09-21 Synthelabo Indanyl-2 d2-imidazoline, procede pour la preparer, et compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
DK164903C (da) 1993-01-25
EP0310745A3 (en) 1989-10-11
GB8429578D0 (en) 1985-01-03
GR852817B (ja) 1986-03-21
GB2167408B (en) 1988-05-25
CA1266669A1 (en) 1990-03-13
ES8801248A1 (es) 1987-12-16
ES557268A0 (es) 1987-12-16
NO166585B (no) 1991-05-06
IE58165B1 (en) 1993-07-28
ES549178A0 (es) 1987-04-01
FI854335A (fi) 1986-05-24
DE3574252D1 (en) 1989-12-21
KR860004028A (ko) 1986-06-16
IE852929L (en) 1986-05-23
AU3332989A (en) 1989-08-10
DD258230A1 (de) 1988-07-13
DK58292D0 (da) 1992-05-04
EP0310745B1 (en) 1993-01-27
KR930004673B1 (ko) 1993-06-03
DK540485D0 (da) 1985-11-22
ATE85050T1 (de) 1993-02-15
HUT38913A (en) 1986-07-28
FI854335A0 (fi) 1985-11-05
SG106891G (en) 1992-02-14
FI80264B (fi) 1990-01-31
NO166585C (no) 1991-08-21
DK164903B (da) 1992-09-07
US4689339A (en) 1987-08-25
GB2167408A (en) 1986-05-29
ATE47997T1 (de) 1989-12-15
EP0183492A1 (en) 1986-06-04
AU5008385A (en) 1986-05-29
JPH064597B2 (ja) 1994-01-19
DE3587045D1 (de) 1993-03-11
PT81542B (pt) 1988-03-03
IL77111A0 (en) 1986-04-29
DE3587045T2 (de) 1993-06-03
ES8704462A1 (es) 1987-04-01
DK540485A (da) 1986-05-24
PT81542A (en) 1985-12-01
EP0183492B1 (en) 1989-11-15
EP0310745A2 (en) 1989-04-12
NO854671L (no) 1986-05-26
PH22016A (en) 1988-05-13
IL77111A (en) 1989-09-28
NZ214258A (en) 1989-02-24
HK3592A (en) 1992-01-17
AU586839B2 (en) 1989-07-27
BG60762B2 (bg) 1996-02-29
HU195189B (en) 1988-04-28
FI80264C (fi) 1990-05-10
ZA858942B (en) 1986-08-27
DK58292A (da) 1992-05-04
JPS61143366A (ja) 1986-07-01
SU1424736A3 (ru) 1988-09-15

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Legal Events

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