BG50609A3 - Method for the preparation of oxophthalazinylacetic acids and their analogues - Google Patents

Method for the preparation of oxophthalazinylacetic acids and their analogues

Info

Publication number
BG50609A3
BG50609A3 BG091982A BG9198290A BG50609A3 BG 50609 A3 BG50609 A3 BG 50609A3 BG 091982 A BG091982 A BG 091982A BG 9198290 A BG9198290 A BG 9198290A BG 50609 A3 BG50609 A3 BG 50609A3
Authority
BG
Bulgaria
Prior art keywords
acids
oxophthalazinylacetic
oxopyridopyridazinonacetic
oxophthalazinyl
indazole
Prior art date
Application number
BG091982A
Other languages
Bulgarian (bg)
English (en)
Inventor
Banavara MYLARI
William Zembrowski
Original Assignee
Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware filed Critical Pfizer Inc., a corporation organized аnd existing under the laws of the State of Delaware
Publication of BG50609A3 publication Critical patent/BG50609A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG091982A 1989-05-11 1990-05-10 Method for the preparation of oxophthalazinylacetic acids and their analogues BG50609A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/350,997 US4954629A (en) 1989-05-11 1989-05-11 Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

Publications (1)

Publication Number Publication Date
BG50609A3 true BG50609A3 (en) 1992-09-15

Family

ID=23379152

Family Applications (1)

Application Number Title Priority Date Filing Date
BG091982A BG50609A3 (en) 1989-05-11 1990-05-10 Method for the preparation of oxophthalazinylacetic acids and their analogues

Country Status (30)

Country Link
US (1) US4954629A (OSRAM)
EP (1) EP0397350B1 (OSRAM)
JP (1) JPH035479A (OSRAM)
KR (1) KR920006419B1 (OSRAM)
CN (1) CN1025855C (OSRAM)
AR (1) AR246968A1 (OSRAM)
AT (1) ATE103913T1 (OSRAM)
AU (2) AU618898B2 (OSRAM)
BG (1) BG50609A3 (OSRAM)
CA (1) CA2016504C (OSRAM)
CZ (1) CZ281213B6 (OSRAM)
DD (1) DD294257A5 (OSRAM)
DE (1) DE69007846T2 (OSRAM)
DK (1) DK0397350T3 (OSRAM)
EG (1) EG19082A (OSRAM)
ES (1) ES2063265T3 (OSRAM)
FI (1) FI93959C (OSRAM)
HU (1) HU212304B (OSRAM)
IE (1) IE62591B1 (OSRAM)
IL (3) IL114271A (OSRAM)
MX (2) MX167455B (OSRAM)
NO (1) NO177708C (OSRAM)
NZ (1) NZ233597A (OSRAM)
PH (1) PH26567A (OSRAM)
PL (1) PL164427B1 (OSRAM)
PT (1) PT93985B (OSRAM)
RO (1) RO107256B1 (OSRAM)
RU (1) RU2014333C1 (OSRAM)
YU (1) YU91290A (OSRAM)
ZA (1) ZA903565B (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
IL124236A (en) * 1997-05-05 2003-01-12 Pfizer Pharmaceutical composition for treating or reversing diabetic cardiomyopathy comprising aldose reductase inhibitor
EP0982306A3 (en) * 1998-08-21 2000-07-05 Pfizer Products Inc. Polymorph of zopolrestat monohydrate
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
DK3192796T3 (da) * 2010-07-16 2019-12-09 Univ Columbia Aldosereduktaseinhibitorer og anvendelser deraf
CN102558184B (zh) * 2011-12-30 2014-07-16 西南大学 酞嗪类衍生物的合成方法
CN102702108A (zh) * 2012-06-27 2012-10-03 上海大学 1,2-二氢酞嗪类化合物及其合成方法
CN102863393A (zh) * 2012-09-26 2013-01-09 上海大学 1,2-二氢酞嗪类化合物及其合成方法
SI3352754T1 (sl) 2016-06-21 2021-03-31 The Trustees Of Columbia University In The City Of New York Zaviralci aldozne reduktaze in postopki njihove uporabe
IL272246B1 (en) 2017-07-28 2025-09-01 Applied Therapeutics Inc Derivatives of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as aldose reductase inhibitors in treating galactosemia or preventing complications associated with galactosemia
KR20220003529A (ko) 2019-04-01 2022-01-10 어플라이드 테라퓨틱스 인크. 알도스 리덕타제의 억제제
CN113966396A (zh) 2019-05-07 2022-01-21 迈阿密大学 遗传性神经病和相关障碍的治疗和检测

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
DE3337859A1 (de) * 1983-01-21 1984-07-26 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von benzthiazolen
CA1299178C (en) * 1985-11-07 1992-04-21 Banavara Lakshmana Mylari Heterocyclic oxophtalazinyl acetic acids
ES2032749T3 (es) * 1985-11-07 1993-03-01 Pfizer Inc. Acidos oxoftalazinil-aceticos heterociclicos.
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
EP0322153A3 (en) * 1987-12-21 1990-08-16 Pfizer Inc. Heterocyclic oxophtalazinyl acetic acids
WO1989006651A1 (en) * 1988-01-19 1989-07-27 Pfizer Inc. 1h-indazole-3-acetic acids as aldose reductase inhibitors
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Also Published As

Publication number Publication date
CA2016504A1 (en) 1990-11-11
KR900018114A (ko) 1990-12-20
ATE103913T1 (de) 1994-04-15
IL114271A (en) 1998-04-05
MX167455B (es) 1993-03-23
DK0397350T3 (da) 1994-05-09
EP0397350B1 (en) 1994-04-06
FI93959B (fi) 1995-03-15
NO177708C (no) 1995-11-08
RU2014333C1 (ru) 1994-06-15
CN1025855C (zh) 1994-09-07
IL114271A0 (en) 1995-10-31
AU618898B2 (en) 1992-01-09
IE901626L (en) 1990-11-11
HU212304B (en) 1996-05-28
US4954629A (en) 1990-09-04
CA2016504C (en) 1999-07-27
ZA903565B (en) 1991-12-24
NZ233597A (en) 1992-02-25
PL285113A1 (en) 1991-07-15
CN1047499A (zh) 1990-12-05
YU91290A (sh) 1992-09-07
NO902071L (no) 1990-11-12
IL94301A (en) 1996-01-19
AR246968A1 (es) 1994-10-31
MX9207687A (es) 1994-06-30
PT93985A (pt) 1991-01-08
NO177708B (no) 1995-07-31
HU902995D0 (en) 1990-09-28
NO902071D0 (no) 1990-05-10
FI902333A0 (fi) 1990-05-10
CZ281213B6 (cs) 1996-07-17
ES2063265T3 (es) 1995-01-01
PH26567A (en) 1992-08-19
DE69007846D1 (de) 1994-05-11
AU5490690A (en) 1990-11-15
CZ227890A3 (en) 1996-04-17
AU8680691A (en) 1992-01-02
FI93959C (fi) 1995-06-26
AU626225B2 (en) 1992-07-23
IE62591B1 (en) 1995-02-08
JPH0573753B2 (OSRAM) 1993-10-15
DE69007846T2 (de) 1994-07-28
EG19082A (en) 1994-07-30
RO107256B1 (ro) 1993-10-30
PL164427B1 (pl) 1994-07-29
IL94301A0 (en) 1991-03-10
PT93985B (pt) 1996-11-29
HUT54690A (en) 1991-03-28
DD294257A5 (de) 1991-09-26
JPH035479A (ja) 1991-01-11
KR920006419B1 (ko) 1992-08-06
EP0397350A1 (en) 1990-11-14

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