BG34336A3 - Method for obtaining derivates of phtalazine-4-yl-acetic acid - Google Patents

Method for obtaining derivates of phtalazine-4-yl-acetic acid

Info

Publication number
BG34336A3
BG34336A3 BG7841857A BG4185778A BG34336A3 BG 34336 A3 BG34336 A3 BG 34336A3 BG 7841857 A BG7841857 A BG 7841857A BG 4185778 A BG4185778 A BG 4185778A BG 34336 A3 BG34336 A3 BG 34336A3
Authority
BG
Bulgaria
Prior art keywords
phtalazine
derivates
obtaining
acetic acid
acetic
Prior art date
Application number
BG7841857A
Other languages
Bulgarian (bg)
English (en)
Inventor
Brittain
Wood
Original Assignee
Imperial Chemical Industries Ltd,Gb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd,Gb filed Critical Imperial Chemical Industries Ltd,Gb
Publication of BG34336A3 publication Critical patent/BG34336A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG7841857A 1977-12-29 1978-12-26 Method for obtaining derivates of phtalazine-4-yl-acetic acid BG34336A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5414277 1977-12-29

Publications (1)

Publication Number Publication Date
BG34336A3 true BG34336A3 (en) 1983-08-15

Family

ID=10470067

Family Applications (1)

Application Number Title Priority Date Filing Date
BG7841857A BG34336A3 (en) 1977-12-29 1978-12-26 Method for obtaining derivates of phtalazine-4-yl-acetic acid

Country Status (31)

Country Link
US (2) US4251528A (fr)
EP (1) EP0002895B1 (fr)
JP (2) JPS5495582A (fr)
AT (1) AT365581B (fr)
AU (1) AU516264B2 (fr)
BG (1) BG34336A3 (fr)
CA (1) CA1107732A (fr)
CS (1) CS241015B2 (fr)
CY (1) CY1219A (fr)
DD (1) DD141021A5 (fr)
DE (1) DE2861170D1 (fr)
DK (1) DK151253C (fr)
ES (1) ES476496A1 (fr)
FI (1) FI64357C (fr)
GR (1) GR65303B (fr)
HK (1) HK22484A (fr)
HU (1) HU182585B (fr)
IE (1) IE47592B1 (fr)
IL (1) IL56099A0 (fr)
IN (1) IN150196B (fr)
IT (1) IT1110885B (fr)
MY (1) MY8500359A (fr)
NO (1) NO154346C (fr)
NZ (1) NZ189034A (fr)
PH (1) PH15435A (fr)
PL (1) PL118443B1 (fr)
PT (1) PT68956A (fr)
SG (1) SG68683G (fr)
SU (3) SU1087075A3 (fr)
YU (3) YU41607B (fr)
ZW (1) ZW24978A1 (fr)

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IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
CA1143733A (fr) * 1979-07-31 1983-03-29 Masao Yoshida Obtention de 7-alcoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phtalazone, et de produits intermediaires
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
EP0222576B1 (fr) * 1985-11-07 1992-03-18 Pfizer Inc. Acides hétérocyclyl-oxophtalazinyl acétiques
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
WO1993013092A1 (fr) * 1986-11-24 1993-07-08 Reinhard Sarges Derives d'imidazolidinedione
GB8704569D0 (en) * 1987-02-26 1987-04-01 Ici America Inc Therapeutic agent
US4868301A (en) * 1987-06-09 1989-09-19 Pfizer Inc. Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
IL88150A0 (en) * 1987-11-02 1989-06-30 Merck & Co Inc Pharmaceutical tablet compositions containing phthalizine acetic acid compounds
DK607188A (da) * 1987-11-02 1989-06-22 Merck & Co Inc Tablet indeholdende en phthalazineddikesyreforbindelse
US4880928A (en) * 1987-12-21 1989-11-14 Merck & Co., Inc. Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl)-3,4-dihydro-4-oxo-1-phthalazine-acetic acid
US4940791A (en) * 1988-02-29 1990-07-10 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel hydrazine containing intermediate
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
EP0397930A1 (fr) * 1989-05-18 1990-11-22 Merck & Co. Inc. Procédé de préparation de l'acide 3-[(4-bromo-2-fluorophényl)méthyl]-3,4-dihydro-4-oxo-1-phtalazine acétique
FR2647676A1 (fr) * 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
WO1991009019A1 (fr) * 1989-12-15 1991-06-27 Pfizer Inc. Acides acetiques d'oxophtalazinyle substitues et analogues de ceux-ci
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
FR2682108B1 (fr) * 1991-10-07 1994-01-07 Lipha Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
JP2789134B2 (ja) * 1992-09-28 1998-08-20 ファイザー・インク． 糖尿病の合併症を制御する置換ピリミジン類
EP0666851A4 (en) * 1992-11-02 1995-08-30 Merck & Co. Inc. Substituted phthalazinones as nerotensin antagonists.
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
WO1995003053A1 (fr) * 1993-07-26 1995-02-02 Fujisawa Pharmaceutical Co., Ltd. Oxophtalazine de traitement de la cachexie
WO1998042324A2 (fr) * 1997-03-21 1998-10-01 The Regents Of The University Of California Utilisation d'inhibiteurs d'aldose reductase pour moduler l'activite associee aux facteurs neurotrophiques
US6696407B1 (en) 1997-03-21 2004-02-24 The Regents Of The University Of California Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
HUP0000838A3 (en) * 1997-04-15 2001-04-28 Csir Extract containing steroid-glucosid, process for its isolation and synthesis, pharmaceutical composition containing it having appetite suppressant activity
CN1205207C (zh) 1998-03-31 2005-06-08 药品发现学会公司 取代的吲哚链烷酸
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
GB2355657B (en) * 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
MXPA03004871A (es) * 2000-11-30 2003-08-19 Pfizer Prod Inc Combinacion de agonistas de gaba e inhibidores de aldosa-reductasa.
ATE297902T1 (de) 2001-02-28 2005-07-15 Pfizer Prod Inc Sulfonyl-pyridazinon-derivate zur verwendung als aldose-reduktase-inhibitoren
YU71403A (sh) 2001-03-30 2006-05-25 Pfizer Products Inc. Piridazinoni kao inhibitori aldoza reduktaze
JP2004528344A (ja) * 2001-04-30 2004-09-16 ファイザー・プロダクツ・インク アルドースレダクターゼ阻害薬とシクロオキシゲナーゼ−２阻害薬の併用
AU761191B2 (en) 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
WO2003092696A1 (fr) * 2002-04-30 2003-11-13 Novartis Ag Procede de diminution de la permeabilite de capillaires dans la retine
US20060100255A1 (en) * 2002-07-26 2006-05-11 Van Zandt Michael C Substituted indolealkanoic acids derivative and formulations containing same for use in the treatment of diabetic complications
US7572910B2 (en) * 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
JP4838582B2 (ja) * 2004-12-27 2011-12-14 岐阜プラスチック工業株式会社 台車用本体
ES2371393T3 (es) 2007-03-12 2011-12-30 Zadec Aps Extracto antidiabético de rooibos.
EP2139330B1 (fr) 2007-03-23 2014-09-24 The Board of Regents of The University of Texas System Procédés engageant des inhibiteurs d'aldose réductase
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
EP2654749B1 (fr) 2010-12-23 2017-05-10 The Board of Regents of The University of Texas System Méthodes de traitement de copd
JP6357292B2 (ja) * 2012-12-14 2018-07-11 フューシス セラピューティクス、インク． Ｃｎｋｓｒ１を阻害するための方法及び組成物
US10227356B2 (en) 2015-04-20 2019-03-12 Phusis Therapeutics, Inc. Compounds, compositions and methods for inhibiting CNKSR1
CN112789149B (zh) * 2018-10-04 2023-06-06 日东电工株式会社 耐热脱模片和热压接方法
JP6751974B1 (ja) * 2019-10-16 2020-09-09 株式会社コバヤシ 離型フィルム及び離型フィルムの製造方法

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JPS5116430B2 (fr) * 1971-08-05 1976-05-24
GB1398549A (en) * 1972-11-06 1975-06-25 Boots Co Ltd Phthalazine derivatives and their use in pharmaceutical compo sitions
AR205004A1 (es) * 1973-10-30 1976-03-31 Ishikawa M Procedimiento para preparar derivados de 6,8-dialquil-7-alcoxi-carbonil-4-hidroximetil-1-ftalazona y la 7,8-lactona
DE2451117A1 (de) * 1973-10-31 1975-05-22 Boots Co Ltd Therapeutisch wirksame verbindungen
IE43079B1 (en) * 1975-03-20 1980-12-17 Ici Ltd Quinolone derivatives
GB1502312A (en) 1975-03-20 1978-03-01 Ici Ltd Quinolone derivatives
JPS5214788A (en) * 1975-07-21 1977-02-03 Fuji Photo Film Co Ltd Process for preparing phthalazinone and its derivatives
NL7702763A (nl) * 1976-03-18 1977-09-20 Takio Shimamoto En Masayuki Is Werkwijze voor de bereiding van thromboxaan- -antagonisten en van preparaten die deze stof- fen bevatten.
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4293553A (en) * 1978-08-11 1981-10-06 Masayuki Ishikawa 1-Phthalazone derivatives, and use thereof

Also Published As

Publication number Publication date
PT68956A (en) 1979-01-01
IN150196B (fr) 1982-08-14
JPS6326110B2 (fr) 1988-05-27
AU4204078A (en) 1979-07-05
FI783844A (fi) 1979-06-30
US4393062A (en) 1983-07-12
ZW24978A1 (en) 1980-10-22
SU1087075A3 (ru) 1984-04-15
IE47592B1 (en) 1984-05-02
EP0002895A1 (fr) 1979-07-11
HK22484A (en) 1984-03-23
JPH0262532B2 (fr) 1990-12-26
NO784397L (no) 1979-07-02
PH15435A (en) 1983-01-18
YU312778A (en) 1983-01-21
SU1072803A3 (ru) 1984-02-07
IL56099A0 (en) 1979-01-31
CA1107732A (fr) 1981-08-25
DK151253C (da) 1988-05-16
FI64357C (fi) 1983-11-10
HU182585B (en) 1984-02-28
YU42054B (en) 1988-04-30
YU232182A (en) 1983-01-21
MY8500359A (en) 1985-12-31
DE2861170D1 (en) 1981-12-24
CS241015B2 (en) 1986-03-13
NO154346B (no) 1986-05-26
CY1219A (en) 1984-04-06
DK541878A (da) 1979-06-30
IT7852480A0 (it) 1978-12-28
ATA937678A (de) 1981-06-15
SU1272984A3 (ru) 1986-11-23
EP0002895B1 (fr) 1981-10-14
YU41607B (en) 1987-12-31
AU516264B2 (en) 1981-05-28
JPS5495582A (en) 1979-07-28
NO154346C (no) 1986-09-03
SG68683G (en) 1984-08-03
JPS63119469A (ja) 1988-05-24
DK151253B (da) 1987-11-16
IT1110885B (it) 1986-01-06
IE782337L (en) 1979-06-29
YU42807B (en) 1988-12-31
ES476496A1 (es) 1979-04-16
US4251528A (en) 1981-02-17
PL118443B1 (en) 1981-10-31
FI64357B (fi) 1983-07-29
NZ189034A (en) 1981-11-19
AT365581B (de) 1982-01-25
GR65303B (en) 1980-08-01
YU232082A (en) 1983-01-21
DD141021A5 (de) 1980-04-09

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