YU42807B - Process for preparing phthalazine-4-yl-acetic acid derivatives - Google Patents

Process for preparing phthalazine-4-yl-acetic acid derivatives

Info

Publication number
YU42807B
YU42807B YU2321/82A YU232182A YU42807B YU 42807 B YU42807 B YU 42807B YU 2321/82 A YU2321/82 A YU 2321/82A YU 232182 A YU232182 A YU 232182A YU 42807 B YU42807 B YU 42807B
Authority
YU
Yugoslavia
Prior art keywords
phthalazine
preparing
acetic acid
acid derivatives
derivatives
Prior art date
Application number
YU2321/82A
Other languages
English (en)
Other versions
YU232182A (en
Inventor
D R Brittain
R Wood
Original Assignee
Ici Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ici Ltd filed Critical Ici Ltd
Publication of YU232182A publication Critical patent/YU232182A/xx
Publication of YU42807B publication Critical patent/YU42807B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
YU2321/82A 1977-12-29 1982-10-14 Process for preparing phthalazine-4-yl-acetic acid derivatives YU42807B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5414277 1977-12-29

Publications (2)

Publication Number Publication Date
YU232182A YU232182A (en) 1983-01-21
YU42807B true YU42807B (en) 1988-12-31

Family

ID=10470067

Family Applications (3)

Application Number Title Priority Date Filing Date
YU3127/78A YU41607B (en) 1977-12-29 1978-12-29 Process for preparing phthalazine-4-yl-acetic acid derivatives
YU2321/82A YU42807B (en) 1977-12-29 1982-10-14 Process for preparing phthalazine-4-yl-acetic acid derivatives
YU2320/82A YU42054B (en) 1977-12-29 1982-10-14 Process for preparing phthalizine -4-yl-acetic acid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU3127/78A YU41607B (en) 1977-12-29 1978-12-29 Process for preparing phthalazine-4-yl-acetic acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU2320/82A YU42054B (en) 1977-12-29 1982-10-14 Process for preparing phthalizine -4-yl-acetic acid

Country Status (31)

Country Link
US (2) US4251528A (xx)
EP (1) EP0002895B1 (xx)
JP (2) JPS5495582A (xx)
AT (1) AT365581B (xx)
AU (1) AU516264B2 (xx)
BG (1) BG34336A3 (xx)
CA (1) CA1107732A (xx)
CS (1) CS241015B2 (xx)
CY (1) CY1219A (xx)
DD (1) DD141021A5 (xx)
DE (1) DE2861170D1 (xx)
DK (1) DK151253C (xx)
ES (1) ES476496A1 (xx)
FI (1) FI64357C (xx)
GR (1) GR65303B (xx)
HK (1) HK22484A (xx)
HU (1) HU182585B (xx)
IE (1) IE47592B1 (xx)
IL (1) IL56099A0 (xx)
IN (1) IN150196B (xx)
IT (1) IT1110885B (xx)
MY (1) MY8500359A (xx)
NO (1) NO154346C (xx)
NZ (1) NZ189034A (xx)
PH (1) PH15435A (xx)
PL (1) PL118443B1 (xx)
PT (1) PT68956A (xx)
SG (1) SG68683G (xx)
SU (3) SU1087075A3 (xx)
YU (3) YU41607B (xx)
ZW (1) ZW24978A1 (xx)

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CA1143733A (en) * 1979-07-31 1983-03-29 Masao Yoshida Producing 7-alkoxycarbonyl-6,8-dimethyl-4- hydroxymethyl-1-phthalazone and intermediates
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
DE3684410D1 (de) * 1985-11-07 1992-04-23 Pfizer Heterocyclische oxophthalazinylessigsaeure.
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
US5011840A (en) * 1986-11-24 1991-04-30 Pfizer Inc. Imidazolidinedione derivatives in diabetes treatment
GB8704569D0 (en) * 1987-02-26 1987-04-01 Ici America Inc Therapeutic agent
JPH0676391B2 (ja) * 1987-06-09 1994-09-28 フアイザー・インコーポレイテツド ベンゾチアゾール等の複素環側鎖を有するオキソフタラジニル酢酸類の製造方法
US4868301A (en) * 1987-06-09 1989-09-19 Pfizer Inc. Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains
EP0315249A1 (en) * 1987-11-02 1989-05-10 Merck & Co. Inc. Phthalazineacetic acid composition and tablet
DK607188A (da) * 1987-11-02 1989-06-22 Merck & Co Inc Tablet indeholdende en phthalazineddikesyreforbindelse
US4880928A (en) * 1987-12-21 1989-11-14 Merck & Co., Inc. Process for the preparation of 3-((4-bromo-2-fluorophenyl)methyl)-3,4-dihydro-4-oxo-1-phthalazine-acetic acid
US4904782A (en) * 1988-02-29 1990-02-27 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
US4940791A (en) * 1988-02-29 1990-07-10 Pfizer Inc. Process for the production of phthalazineacetic acid ester derivatives and a novel hydrazine containing intermediate
US4954629A (en) * 1989-05-11 1990-09-04 Pfizer Inc. Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US4996204A (en) * 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
EP0397930A1 (en) * 1989-05-18 1990-11-22 Merck & Co. Inc. Process for the preparation of 3-[(4-bromo-2-fluorophenyl) methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
FR2647676A1 (fr) * 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
US5304557A (en) * 1989-12-15 1994-04-19 Pfizer Inc. Substituted oxoophthalazinyl acetic acids and analogs thereof
US5037831A (en) * 1990-05-21 1991-08-06 American Home Products Corporation Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
FR2682108B1 (fr) * 1991-10-07 1994-01-07 Lipha Acide 3,4-dihydro-4-oxo-3(prop-2-enyl)-1-phtalazineacetiques et derives, leurs preparations et medicaments les contenant.
CA2145640C (en) * 1992-09-28 2001-01-30 Banavara L. Mylari Substituted pyrimidines for control of diabetic complications
AU5455194A (en) * 1992-11-02 1994-05-24 Merck & Co., Inc. Substituted phthalazinones as nerotensin antagonists
CH683965A5 (it) * 1993-02-19 1994-06-30 Limad Marketing Exp & Imp Composti della classe dei ftalidrazidici come sostanza attiva in agenti antinfiammatori ed antitossici.
AU7195594A (en) * 1993-07-26 1995-02-20 Fujisawa Pharmaceutical Co., Ltd. Oxophthalazines for treating cachexia
US6696407B1 (en) 1997-03-21 2004-02-24 The Regents Of The University Of California Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF
AU6473898A (en) * 1997-03-21 1998-10-20 Regents Of The University Of California, The Methods for modulating neurotrophic factor-associated activity using aldose reductase inhibitors
DE69840552D1 (de) * 1997-04-15 2009-03-26 Csir Verbindungen und Pharmazeutische Zusammensetzungen mit appetitunterdrückender Aktivität
ATE269861T1 (de) 1998-03-31 2004-07-15 Inst For Pharm Discovery Inc Substituierte indolalkansäure
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
DE19963607B4 (de) * 1999-12-23 2005-12-15 Schering Ag Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
GB2363985B (en) 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
KR20030059287A (ko) * 2000-11-30 2003-07-07 화이자 프로덕츠 인코포레이티드 Ｇａｂａ 작용제 및 알도스 리덕타제 억제제의 혼합물
ATE297902T1 (de) 2001-02-28 2005-07-15 Pfizer Prod Inc Sulfonyl-pyridazinon-derivate zur verwendung als aldose-reduktase-inhibitoren
EP1491540B1 (en) * 2001-03-30 2006-12-13 Pfizer Products Inc. Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors
EP1392310A1 (en) * 2001-04-30 2004-03-03 Pfizer Products Inc. Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors
AU761191B2 (en) 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
AU2003233198A1 (en) * 2002-04-30 2003-11-17 Novartis Ag Method for decreasing capillary permeability in the retina
JP2006500336A (ja) * 2002-07-26 2006-01-05 ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー 糖尿病合併症の処置に使用するための置換インドールアルカン酸誘導体及びそれを含む製剤。
US7572910B2 (en) * 2003-02-20 2009-08-11 Pfizer, Inc. Pyridazinone aldose reductase inhibitors
US20110092566A1 (en) * 2004-11-19 2011-04-21 Srivastava Satish K Treatment of cancer with aldose reductase inhibitors
JP4838582B2 (ja) * 2004-12-27 2011-12-14 岐阜プラスチック工業株式会社 台車用本体
CN101765433A (zh) 2007-03-12 2010-06-30 Zadec私人有限责任公司 一种抗糖尿病的红灌木提取物
CA2685202C (en) * 2007-03-23 2017-11-28 The Board Of Regents Of The University Of Texas System Methods for treating allergic asthma
US20090270490A1 (en) * 2008-04-24 2009-10-29 The Board Of Regents Of The University Of Texas System Methods involving aldose reductase inhibition
WO2012088525A2 (en) 2010-12-23 2012-06-28 The Board Of Regents Of The University Of Texas System Methods for treating copd
JP6357292B2 (ja) * 2012-12-14 2018-07-11 フューシス セラピューティクス、インク． Ｃｎｋｓｒ１を阻害するための方法及び組成物
WO2016172191A1 (en) 2015-04-20 2016-10-27 Phusis Therapeutics, Inc. Compounds, compositions and methods for inhibiting cnksr1
KR20210068495A (ko) * 2018-10-04 2021-06-09 닛토덴코 가부시키가이샤 내열 이형 시트 및 열 압착 방법
JP6751974B1 (ja) * 2019-10-16 2020-09-09 株式会社コバヤシ 離型フィルム及び離型フィルムの製造方法

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GB1398549A (en) * 1972-11-06 1975-06-25 Boots Co Ltd Phthalazine derivatives and their use in pharmaceutical compo sitions
AR205004A1 (es) * 1973-10-30 1976-03-31 Ishikawa M Procedimiento para preparar derivados de 6,8-dialquil-7-alcoxi-carbonil-4-hidroximetil-1-ftalazona y la 7,8-lactona
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NL7702763A (nl) * 1976-03-18 1977-09-20 Takio Shimamoto En Masayuki Is Werkwijze voor de bereiding van thromboxaan- -antagonisten en van preparaten die deze stof- fen bevatten.
IE47592B1 (en) * 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
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Also Published As

Publication number Publication date
YU41607B (en) 1987-12-31
PH15435A (en) 1983-01-18
AT365581B (de) 1982-01-25
SU1072803A3 (ru) 1984-02-07
YU232082A (en) 1983-01-21
SG68683G (en) 1984-08-03
FI64357B (fi) 1983-07-29
IL56099A0 (en) 1979-01-31
ES476496A1 (es) 1979-04-16
IE47592B1 (en) 1984-05-02
YU232182A (en) 1983-01-21
AU4204078A (en) 1979-07-05
EP0002895A1 (en) 1979-07-11
PT68956A (en) 1979-01-01
US4393062A (en) 1983-07-12
JPS6326110B2 (xx) 1988-05-27
CA1107732A (en) 1981-08-25
JPH0262532B2 (xx) 1990-12-26
EP0002895B1 (en) 1981-10-14
HU182585B (en) 1984-02-28
NO154346C (no) 1986-09-03
SU1272984A3 (ru) 1986-11-23
FI64357C (fi) 1983-11-10
FI783844A (fi) 1979-06-30
IT7852480A0 (it) 1978-12-28
DK151253C (da) 1988-05-16
IN150196B (xx) 1982-08-14
YU42054B (en) 1988-04-30
NO154346B (no) 1986-05-26
PL118443B1 (en) 1981-10-31
MY8500359A (en) 1985-12-31
DK541878A (da) 1979-06-30
ZW24978A1 (en) 1980-10-22
DK151253B (da) 1987-11-16
SU1087075A3 (ru) 1984-04-15
DE2861170D1 (en) 1981-12-24
IT1110885B (it) 1986-01-06
ATA937678A (de) 1981-06-15
GR65303B (en) 1980-08-01
NO784397L (no) 1979-07-02
BG34336A3 (en) 1983-08-15
DD141021A5 (de) 1980-04-09
IE782337L (en) 1979-06-29
JPS63119469A (ja) 1988-05-24
AU516264B2 (en) 1981-05-28
JPS5495582A (en) 1979-07-28
US4251528A (en) 1981-02-17
CS241015B2 (en) 1986-03-13
NZ189034A (en) 1981-11-19
HK22484A (en) 1984-03-23
YU312778A (en) 1983-01-21
CY1219A (en) 1984-04-06

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