BG108548A - Хетероциклични съединения и използването им като d-аланил-d-аланин лигазни инхибитори - Google Patents

Хетероциклични съединения и използването им като d-аланил-d-аланин лигазни инхибитори Download PDF

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Publication number
BG108548A
BG108548A BG108548A BG10854804A BG108548A BG 108548 A BG108548 A BG 108548A BG 108548 A BG108548 A BG 108548A BG 10854804 A BG10854804 A BG 10854804A BG 108548 A BG108548 A BG 108548A
Authority
BG
Bulgaria
Prior art keywords
alkyl
hydrogen
compound
aryl
nitrogen
Prior art date
Application number
BG108548A
Other languages
Bulgarian (bg)
English (en)
Inventor
Scott Moe
Paul Ala
Emanuele Perola
Carlos FAERMAN
Jacob Clement
Janid Ali
Paul Will
Salvatore Marchese
Andrew MAGEE
John GAZZANIGA
Christopher Farady
Manuel Navia
Patrick Connelly
Original Assignee
Pliva D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D.D. filed Critical Pliva D.D.
Publication of BG108548A publication Critical patent/BG108548A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BG108548A 2001-06-28 2004-01-28 Хетероциклични съединения и използването им като d-аланил-d-аланин лигазни инхибитори BG108548A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30168501P 2001-06-28 2001-06-28

Publications (1)

Publication Number Publication Date
BG108548A true BG108548A (bg) 2005-05-31

Family

ID=23164426

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108548A BG108548A (bg) 2001-06-28 2004-01-28 Хетероциклични съединения и използването им като d-аланил-d-аланин лигазни инхибитори

Country Status (16)

Country Link
US (3) US7345048B2 (de)
EP (2) EP1411949A4 (de)
CN (2) CN1543465A (de)
BG (1) BG108548A (de)
BR (1) BR0211310A (de)
CA (2) CA2451840A1 (de)
CZ (2) CZ200442A3 (de)
EA (1) EA200400094A1 (de)
EE (2) EE200400042A (de)
HU (2) HUP0700061A2 (de)
IL (2) IL159540A0 (de)
MX (1) MXPA04000159A (de)
PL (2) PL374259A1 (de)
SK (1) SK302004A3 (de)
WO (2) WO2003002064A2 (de)
YU (2) YU102303A (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217703D0 (en) * 2002-07-31 2002-09-11 Univ Liverpool Pharmaceutical composition
WO2006050843A1 (en) * 2004-11-09 2006-05-18 F. Hoffmann-La Roche Ag Aminoquinazolines compounds
KR100962723B1 (ko) * 2005-07-21 2010-06-09 에프. 호프만-라 로슈 아게 단백질 티로신 포스파타제1ｂ 억제제로서의피리도[2,3-ｄ]피리미딘-2,4-다이아민 화합물
GB0608822D0 (en) * 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of DHFR
SI22338A (sl) * 2006-08-18 2008-02-29 Univerza V Ljubljani, Fakulteta Za Farmacijo Diazendikarboksamidi kot inhibitorji d-alanil-d-alanin ligaze
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
MX2010008269A (es) * 2008-02-01 2011-02-21 Takeda Pharmaceutical Inhibidores de hsp90.
JP2012520745A (ja) 2009-03-20 2012-09-10 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 医療装置に抗菌活性を付与するための方法
WO2011025505A1 (en) * 2009-08-31 2011-03-03 Dow Agrosciences Llc Pteridines and their use as agrochemicals
EA035093B1 (ru) 2015-03-04 2020-04-27 Джилид Сайэнс, Инк. 4,6-диаминопиридо[3,2-d]пиримидиновые соединения, модулирующие toll-подобные рецепторы
CN106316966A (zh) * 2015-06-15 2017-01-11 董运勤 医药中间体n-(2-吡嗪甲基)苄胺磷酸盐化合物制备方法
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
ES2906581T3 (es) 2016-09-02 2022-04-19 Gilead Sciences Inc Compuestos moduladores de los receptores tipo Toll
SG10201912128SA (en) 2017-02-01 2020-02-27 Univ Yale Treatment of diuretic resistance
WO2019136312A1 (en) 2018-01-05 2019-07-11 Corvidia Therapeutics, Inc. Methods for treating il-6 mediated inflammation without immunosuppression
CN113646300A (zh) * 2019-02-01 2021-11-12 Fmc公司 作为除草剂的二氨基取代的吡啶和嘧啶
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法
GB2626567A (en) * 2023-01-26 2024-07-31 De Montfort Univ Quinazoline derivatives for use as a medicament

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949466A (en) * 1958-03-04 1960-08-16 Parke Davis & Co Pyrimidine compounds and means of producing the same
US3134778A (en) * 1963-08-20 1964-05-26 Smith Kline French Lab 2,5,7-triamino-4-phenyl (or thienyl)-pyrimido[4,5-d]pyrimidines
RO56210A2 (de) 1970-12-28 1974-08-01
US4079056A (en) * 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3445298A1 (de) 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
WO1992017478A1 (en) 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5547954A (en) * 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
ES2207657T3 (es) * 1995-02-27 2004-06-01 F. Hoffmann-La Roche Ag Pirrolderivados de dioxopirrolo.
WO1999050264A1 (fr) * 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Derives de quinazoline
JP2000239277A (ja) * 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd イミダゾキナゾリン誘導体
GB0219893D0 (en) 2002-08-27 2002-10-02 Melacure Therapeutics Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
PL374589A1 (en) 2005-10-31
US20030176436A1 (en) 2003-09-18
US20080090847A1 (en) 2008-04-17
US7345048B2 (en) 2008-03-18
IL159540A0 (en) 2004-06-01
SK302004A3 (sk) 2005-07-01
CN1547472A (zh) 2004-11-17
BR0211310A (pt) 2006-10-31
EA200400094A1 (ru) 2005-08-25
WO2003001887A2 (en) 2003-01-09
EP1411949A2 (de) 2004-04-28
EE200400043A (et) 2004-10-15
YU102503A (sh) 2006-08-17
CZ200443A3 (cs) 2004-08-18
MXPA04000159A (es) 2005-01-07
US20030181470A1 (en) 2003-09-25
EP1432713A2 (de) 2004-06-30
EP1432713A4 (de) 2005-05-11
HUP0700061A2 (en) 2007-05-02
IL159538A0 (en) 2004-06-01
HUP0700040A2 (en) 2007-05-29
CA2451800A1 (en) 2003-01-09
EE200400042A (et) 2004-10-15
PL374259A1 (en) 2005-10-03
CN1543465A (zh) 2004-11-03
EP1411949A4 (de) 2004-11-24
WO2003001887A3 (en) 2003-08-21
CZ200442A3 (cs) 2004-10-13
WO2003002064A2 (en) 2003-01-09
CA2451840A1 (en) 2003-01-09
YU102303A (sh) 2006-08-17
WO2003002064A3 (en) 2003-10-23

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