HUP0700061A2 - Pyridopyrimidine and pyrimidinopyrimidine derivatives, process for their preparation and pharmaceutical compositions therof as antibacterials having dhfr inhibitor activity - Google Patents

Pyridopyrimidine and pyrimidinopyrimidine derivatives, process for their preparation and pharmaceutical compositions therof as antibacterials having dhfr inhibitor activity

Info

Publication number
HUP0700061A2
HUP0700061A2 HU0700061A HUP0700061A HUP0700061A2 HU P0700061 A2 HUP0700061 A2 HU P0700061A2 HU 0700061 A HU0700061 A HU 0700061A HU P0700061 A HUP0700061 A HU P0700061A HU P0700061 A2 HUP0700061 A2 HU P0700061A2
Authority
HU
Hungary
Prior art keywords
pyrimidinopyrimidine
pyridopyrimidine
antibacterials
derivatives
preparation
Prior art date
Application number
HU0700061A
Other languages
English (en)
Inventor
Scott T Moe
Jacob J Clement
Carlos FAERMAN
Emanuela Perola
Manuel A Navia
Paul J Ala
Andrew S Magee
Paul M Will
Salvatore A Marchese
John V Gazzaniga
Original Assignee
Pliva D D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D D filed Critical Pliva D D
Publication of HUP0700061A2 publication Critical patent/HUP0700061A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HU0700061A 2001-06-28 2002-06-28 Pyridopyrimidine and pyrimidinopyrimidine derivatives, process for their preparation and pharmaceutical compositions therof as antibacterials having dhfr inhibitor activity HUP0700061A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30168501P 2001-06-28 2001-06-28
PCT/US2002/020479 WO2003002064A2 (en) 2001-06-28 2002-06-28 Fused pyrimidine dhfr inhibitors as antibacterials

Publications (1)

Publication Number Publication Date
HUP0700061A2 true HUP0700061A2 (en) 2007-05-02

Family

ID=23164426

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0700040A HUP0700040A2 (en) 2001-06-28 2002-06-28 Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors, and process for producing them
HU0700061A HUP0700061A2 (en) 2001-06-28 2002-06-28 Pyridopyrimidine and pyrimidinopyrimidine derivatives, process for their preparation and pharmaceutical compositions therof as antibacterials having dhfr inhibitor activity

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0700040A HUP0700040A2 (en) 2001-06-28 2002-06-28 Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors, and process for producing them

Country Status (16)

Country Link
US (3) US7345048B2 (hu)
EP (2) EP1411949A4 (hu)
CN (2) CN1543465A (hu)
BG (1) BG108548A (hu)
BR (1) BR0211310A (hu)
CA (2) CA2451840A1 (hu)
CZ (2) CZ200443A3 (hu)
EA (1) EA200400094A1 (hu)
EE (2) EE200400042A (hu)
HU (2) HUP0700040A2 (hu)
IL (2) IL159540A0 (hu)
MX (1) MXPA04000159A (hu)
PL (2) PL374589A1 (hu)
SK (1) SK302004A3 (hu)
WO (2) WO2003001887A2 (hu)
YU (2) YU102503A (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217703D0 (en) * 2002-07-31 2002-09-11 Univ Liverpool Pharmaceutical composition
WO2006050843A1 (en) * 2004-11-09 2006-05-18 F. Hoffmann-La Roche Ag Aminoquinazolines compounds
WO2007009911A1 (en) * 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
GB0608822D0 (en) * 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of DHFR
SI22338A (sl) * 2006-08-18 2008-02-29 Univerza V Ljubljani, Fakulteta Za Farmacijo Diazendikarboksamidi kot inhibitorji d-alanil-d-alanin ligaze
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
ES2475206T3 (es) * 2008-02-01 2014-07-10 Takeda Pharmaceutical Company Limited Derivados de oxima como inhibidores de HSP90
GB2480791B (en) * 2009-03-20 2014-11-05 Univ Texas Method for imparting antimicrobial activity to a medical device
EP2473511A1 (en) * 2009-08-31 2012-07-11 Dow AgroSciences LLC Pteridines and their use as agrochemicals
MD20170081A2 (ro) 2015-03-04 2018-03-31 Gilead Sciences, Inc. Compuşi 4,6-diamino-pirido[3,2-D]pirimidină modulatori ai receptorilor de tip Toll
CN106316966A (zh) * 2015-06-15 2017-01-11 董运勤 医药中间体n-(2-吡嗪甲基)苄胺磷酸盐化合物制备方法
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
CA3035346A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. Toll like receptor modulator compounds
CA3051865C (en) 2017-02-01 2023-01-17 Yale University Treatment of diuretic resistance
US20190241650A1 (en) 2018-01-05 2019-08-08 Corvidia Therapeutics, Inc. Methods for treating il-6 mediated inflammation without immunosuppression
JP2022519247A (ja) * 2019-02-01 2022-03-22 エフ エム シー コーポレーション 除草剤としてのジアミノ置換ピリジンおよびピリミジン
TWI751516B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949466A (en) * 1958-03-04 1960-08-16 Parke Davis & Co Pyrimidine compounds and means of producing the same
US3134778A (en) * 1963-08-20 1964-05-26 Smith Kline French Lab 2,5,7-triamino-4-phenyl (or thienyl)-pyrimido[4,5-d]pyrimidines
RO56210A2 (hu) 1970-12-28 1974-08-01
US4079056A (en) * 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3445298A1 (de) 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
WO1992017478A1 (en) 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5547954A (en) * 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
DK0728758T3 (da) * 1995-02-27 2004-02-23 Hoffmann La Roche Dioxopyrrolo-pyrrolderivater
WO1999050264A1 (fr) * 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Derives de quinazoline
JP2000239277A (ja) * 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd イミダゾキナゾリン誘導体
GB0219893D0 (en) 2002-08-27 2002-10-02 Melacure Therapeutics Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
US20030181470A1 (en) 2003-09-25
EP1411949A2 (en) 2004-04-28
SK302004A3 (sk) 2005-07-01
PL374259A1 (en) 2005-10-03
US20030176436A1 (en) 2003-09-18
EP1432713A4 (en) 2005-05-11
CN1547472A (zh) 2004-11-17
WO2003002064A3 (en) 2003-10-23
EE200400042A (et) 2004-10-15
CA2451840A1 (en) 2003-01-09
WO2003002064A2 (en) 2003-01-09
CN1543465A (zh) 2004-11-03
MXPA04000159A (es) 2005-01-07
HUP0700040A2 (en) 2007-05-29
CA2451800A1 (en) 2003-01-09
CZ200442A3 (cs) 2004-10-13
EP1432713A2 (en) 2004-06-30
YU102303A (sh) 2006-08-17
WO2003001887A2 (en) 2003-01-09
IL159540A0 (en) 2004-06-01
YU102503A (sh) 2006-08-17
US20080090847A1 (en) 2008-04-17
US7345048B2 (en) 2008-03-18
BR0211310A (pt) 2006-10-31
IL159538A0 (en) 2004-06-01
WO2003001887A3 (en) 2003-08-21
EE200400043A (et) 2004-10-15
BG108548A (bg) 2005-05-31
PL374589A1 (en) 2005-10-31
EA200400094A1 (ru) 2005-08-25
CZ200443A3 (cs) 2004-08-18
EP1411949A4 (en) 2004-11-24

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees