YU102303A - Kondenzovani pirimidini kao inhibitori d-alanil-d-alanin ligaze - Google Patents

Kondenzovani pirimidini kao inhibitori d-alanil-d-alanin ligaze

Info

Publication number
YU102303A
YU102303A YU102303A YUP102303A YU102303A YU 102303 A YU102303 A YU 102303A YU 102303 A YU102303 A YU 102303A YU P102303 A YUP102303 A YU P102303A YU 102303 A YU102303 A YU 102303A
Authority
YU
Yugoslavia
Prior art keywords
ala
alanyl
enzyme
ligase inhibitors
alanine ligase
Prior art date
Application number
YU102303A
Other languages
English (en)
Inventor
Scott T. Moe
Paul J. Ala
Emanuele Perola
Carlos H. Faerman
Jacob J. Clement
Janid A. Ali
Paul M. Will
Salvatore A. Marchese
Andrew S. Magee
John V. Gazzaniga
Christopher Farady
Manuel A. Navia
Patrick R. Connelly
Original Assignee
Pliva D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva D.D. filed Critical Pliva D.D.
Publication of YU102303A publication Critical patent/YU102303A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak se zasniva na otkriću nove klase heterocikličnih jedinjenja koja imaju, na primer, antibakterijske osobine. Enzim D-Ala-D-Ala ligaza je ključan enzim u putu sisnteze ćelijskog zida bakterija. Jedinjenja mogu da se vezuju za, i da inhibiraju enzim D-Ala-D-Ala ligazu. Aktivnost novih jedinjenja, u kombinaciji sa njihovom sposobnošću da prođu kroz membrane bakterijskih ćelija, čini ih pogodnim za upotrebu kao antibakterijskih lekova ili drugih antibakterijskih sredstava.[The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.
YU102303A 2001-06-28 2002-06-28 Kondenzovani pirimidini kao inhibitori d-alanil-d-alanin ligaze YU102303A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30168501P 2001-06-28 2001-06-28

Publications (1)

Publication Number Publication Date
YU102303A true YU102303A (sh) 2006-08-17

Family

ID=23164426

Family Applications (2)

Application Number Title Priority Date Filing Date
YU102303A YU102303A (sh) 2001-06-28 2002-06-28 Kondenzovani pirimidini kao inhibitori d-alanil-d-alanin ligaze
YU102503A YU102503A (sh) 2001-06-28 2002-06-28 Kondenzovani pirimidinski dhfr inhibitori kao antibakterijska sredstva

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU102503A YU102503A (sh) 2001-06-28 2002-06-28 Kondenzovani pirimidinski dhfr inhibitori kao antibakterijska sredstva

Country Status (16)

Country Link
US (3) US7345048B2 (sh)
EP (2) EP1411949A4 (sh)
CN (2) CN1543465A (sh)
BG (1) BG108548A (sh)
BR (1) BR0211310A (sh)
CA (2) CA2451800A1 (sh)
CZ (2) CZ200442A3 (sh)
EA (1) EA200400094A1 (sh)
EE (2) EE200400042A (sh)
HU (2) HUP0700040A2 (sh)
IL (2) IL159538A0 (sh)
MX (1) MXPA04000159A (sh)
PL (2) PL374589A1 (sh)
SK (1) SK302004A3 (sh)
WO (2) WO2003001887A2 (sh)
YU (2) YU102303A (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0217703D0 (en) * 2002-07-31 2002-09-11 Univ Liverpool Pharmaceutical composition
AU2005304040B2 (en) * 2004-11-09 2009-04-23 F. Hoffmann-La Roche Ag Aminoquinazolines compounds
AU2006271809B2 (en) * 2005-07-21 2010-03-18 F. Hoffmann-La Roche Ag Pyrido [2 , 3-D] pyrimidine-2 , 4-diamine compounds as PTP1B inhibitors
GB0608822D0 (en) * 2006-05-04 2006-06-14 Chroma Therapeutics Ltd Inhibitors of DHFR
SI22338A (sl) * 2006-08-18 2008-02-29 Univerza V Ljubljani, Fakulteta Za Farmacijo Diazendikarboksamidi kot inhibitorji d-alanil-d-alanin ligaze
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
CN101084901B (zh) * 2007-06-22 2011-12-21 复旦大学 一种葡萄球菌抑制剂
MX2010008269A (es) * 2008-02-01 2011-02-21 Takeda Pharmaceutical Inhibidores de hsp90.
DE112010001212T5 (de) * 2009-03-20 2012-07-05 The Board Of Regents Of The University Of Texas System Verfahren, urn einem medizinischen Gerät antimikrobielle Aktivität zu verleihen
AU2009351623B2 (en) * 2009-08-31 2014-12-11 Dow Agrosciences Llc Pteridines and their use as agrochemicals
EP3722297A1 (en) 2015-03-04 2020-10-14 Gilead Sciences, Inc. Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds
CN106316966A (zh) * 2015-06-15 2017-01-11 董运勤 医药中间体n-(2-吡嗪甲基)苄胺磷酸盐化合物制备方法
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
AU2017318601B2 (en) 2016-09-02 2020-09-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
EP3576790A4 (en) 2017-02-01 2020-12-23 Yale University TREATMENT OF DIURETIC RESISTANCE
PE20211196A1 (es) 2018-01-05 2021-07-01 Novo Nordisk As Metodos para tratar inflamacion mediada por il-6 sin inmunosupresion
WO2020160202A1 (en) * 2019-02-01 2020-08-06 Fmc Corporation Diamino-substituted pyridines and pyrimidines as herbicides
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949466A (en) * 1958-03-04 1960-08-16 Parke Davis & Co Pyrimidine compounds and means of producing the same
US3134778A (en) * 1963-08-20 1964-05-26 Smith Kline French Lab 2,5,7-triamino-4-phenyl (or thienyl)-pyrimido[4,5-d]pyrimidines
RO56210A2 (sh) 1970-12-28 1974-08-01
US4079056A (en) * 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3445298A1 (de) * 1984-12-12 1986-06-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue pteridine, verfahren zu ihrer herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
WO1992017478A1 (en) 1991-04-08 1992-10-15 Duquesne University Of The Holy Ghost 5-ALKYL-6-[[AMINO]METHYL]PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AND METHODS OF PREPARING AND USING THESE DERIVATIVES
US5547954A (en) 1994-05-26 1996-08-20 Fmc Corporation 2,4-Diamino-5,6-disubstituted-and 5,6,7-trisubstituted-5-deazapteridines as insecticides
ES2207657T3 (es) * 1995-02-27 2004-06-01 F. Hoffmann-La Roche Ag Pirrolderivados de dioxopirrolo.
WO1999050264A1 (fr) * 1998-03-30 1999-10-07 Kyowa Hakko Kogyo Co., Ltd. Derives de quinazoline
JP2000239277A (ja) 1999-02-19 2000-09-05 Kyowa Hakko Kogyo Co Ltd イミダゾキナゾリン誘導体
GB0219893D0 (en) 2002-08-27 2002-10-02 Melacure Therapeutics Ab Pharmaceutically active compounds

Also Published As

Publication number Publication date
SK302004A3 (sk) 2005-07-01
CA2451800A1 (en) 2003-01-09
WO2003001887A3 (en) 2003-08-21
US20030181470A1 (en) 2003-09-25
CN1547472A (zh) 2004-11-17
MXPA04000159A (es) 2005-01-07
PL374589A1 (en) 2005-10-31
WO2003001887A2 (en) 2003-01-09
EP1432713A2 (en) 2004-06-30
BG108548A (bg) 2005-05-31
EP1411949A2 (en) 2004-04-28
EE200400042A (et) 2004-10-15
EP1432713A4 (en) 2005-05-11
HUP0700061A2 (en) 2007-05-02
WO2003002064A2 (en) 2003-01-09
BR0211310A (pt) 2006-10-31
CA2451840A1 (en) 2003-01-09
CZ200443A3 (cs) 2004-08-18
EE200400043A (et) 2004-10-15
HUP0700040A2 (en) 2007-05-29
US20080090847A1 (en) 2008-04-17
US7345048B2 (en) 2008-03-18
CZ200442A3 (cs) 2004-10-13
US20030176436A1 (en) 2003-09-18
PL374259A1 (en) 2005-10-03
EA200400094A1 (ru) 2005-08-25
IL159540A0 (en) 2004-06-01
YU102503A (sh) 2006-08-17
IL159538A0 (en) 2004-06-01
EP1411949A4 (en) 2004-11-24
WO2003002064A3 (en) 2003-10-23
CN1543465A (zh) 2004-11-03

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