BG107121A - Нови lhrh-антагонисти, тяхното получаване и използване като лекарственo средствo - Google Patents

Нови lhrh-антагонисти, тяхното получаване и използване като лекарственo средствo Download PDF

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Publication number
BG107121A
BG107121A BG107121A BG10712102A BG107121A BG 107121 A BG107121 A BG 107121A BG 107121 A BG107121 A BG 107121A BG 10712102 A BG10712102 A BG 10712102A BG 107121 A BG107121 A BG 107121A
Authority
BG
Bulgaria
Prior art keywords
xxx
liz
hfa
nle
nal
Prior art date
Application number
BG107121A
Other languages
Bulgarian (bg)
English (en)
Inventor
Michael Bernd
Bernhard Kutscher
Eckhard Gunther
Peter Romeis
Thomas Reissmann
Thomas Beckers
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/525,007 external-priority patent/US6627609B1/en
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BG107121A publication Critical patent/BG107121A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG107121A 2000-03-14 2002-09-18 Нови lhrh-антагонисти, тяхното получаване и използване като лекарственo средствo BG107121A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/525,007 US6627609B1 (en) 1999-03-17 2000-03-14 LHRH antagonists having improved solubility properties
PCT/EP2001/002719 WO2001068676A2 (de) 2000-03-14 2001-03-12 Lh-rh-antagonisten, deren herstellung und verwendung als arzeimittel

Publications (1)

Publication Number Publication Date
BG107121A true BG107121A (bg) 2003-05-30

Family

ID=24091545

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107121A BG107121A (bg) 2000-03-14 2002-09-18 Нови lhrh-антагонисти, тяхното получаване и използване като лекарственo средствo

Country Status (25)

Country Link
EP (1) EP1268522B1 (zh)
JP (1) JP3805679B2 (zh)
KR (1) KR100607396B1 (zh)
CN (2) CN1443195A (zh)
AT (1) ATE408619T1 (zh)
AU (2) AU2001260110B2 (zh)
BG (1) BG107121A (zh)
BR (1) BR0109279A (zh)
CA (1) CA2402193C (zh)
DE (1) DE50114335D1 (zh)
DK (1) DK1268522T3 (zh)
ES (1) ES2312435T3 (zh)
HR (1) HRP20020810A2 (zh)
HU (1) HUP0300222A3 (zh)
IL (1) IL151647A0 (zh)
MX (1) MXPA02008870A (zh)
NO (1) NO20024363L (zh)
NZ (1) NZ521273A (zh)
PL (1) PL357999A1 (zh)
PT (1) PT1268522E (zh)
RU (1) RU2248982C9 (zh)
SK (1) SK14332002A3 (zh)
UA (1) UA79070C2 (zh)
WO (1) WO2001068676A2 (zh)
ZA (1) ZA200207248B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100340572C (zh) * 2004-12-01 2007-10-03 中国人民解放军军事医学科学院毒物药物研究所 新的lhrh拮抗剂
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
CA2713126C (en) 2008-01-24 2017-08-15 Esperance Pharmaceuticals Lytic domain fusion constructs and methods of making and using same
CN101597321B (zh) * 2008-06-03 2013-04-24 中国人民解放军军事医学科学院毒物药物研究所 长效低组胺释放副作用的lhrh拮抗剂
WO2010142060A1 (zh) * 2009-06-11 2010-12-16 中国人民解放军军事医学科学院毒物药物研究所 长效低组胺释放副作用的lhrh拮抗剂
KR20210090298A (ko) 2012-10-30 2021-07-19 에스퍼란스 파마슈티컬스, 인코포레이티드 항체/약물 컨쥬게이트 및 이의 사용 방법
CN104418936B (zh) * 2013-08-20 2018-06-05 中国人民解放军军事医学科学院毒物药物研究所 Lhrh拮抗剂衍生物及其药物用途
FR3024612B1 (fr) * 2014-08-04 2018-03-09 Alstom Transp Tech Module d'alimentation electrique d'un bloc moteur, systeme de traction et vehicule electrique associe
RU2585367C1 (ru) * 2014-11-05 2016-05-27 Наталья Владимировна Спиридонова Способ лечения бесплодия у женщин с миомой матки

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300492A (en) 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs
US5110904A (en) 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs
US5140009A (en) 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
IL101074A (en) 1991-03-14 1997-09-30 Salk Inst For Biological Studi GnRH ANALOGS AND THEIR PREPARATION
EP0593491B1 (en) 1991-04-25 1996-10-23 DEGHENGHI, Romano Luteinizing hormone releasing hormone antagonist peptides
EP0673254A4 (en) 1992-12-04 1998-11-18 Abbott Lab HORMONE ANTAGONISTS RELEASING LUTEINIZING HORMONE (LHRH) OF MODIFIED DECAPEPTIDES IN POSITION 6.
JP3568952B2 (ja) 1992-12-18 2004-09-22 アボット・ラボラトリーズ ５位及び６位に修飾アミノアシル残基を有するｌｈｒｈ拮抗薬
IL108509A0 (en) 1993-02-22 1994-05-30 Salk Inst For Biological Studi GnRH antagonist peptides
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
DE19544212A1 (de) * 1995-11-28 1997-06-05 Asta Medica Ag Neue LH-RH-Antagonisten mit verbesserter Wirkung
DE19911771B4 (de) 1999-03-17 2006-03-30 Zentaris Gmbh LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung

Also Published As

Publication number Publication date
HUP0300222A2 (hu) 2003-07-28
DE50114335D1 (de) 2008-10-30
MXPA02008870A (es) 2003-06-24
CA2402193C (en) 2010-05-18
AU6011001A (en) 2001-09-24
CN1876677A (zh) 2006-12-13
EP1268522B1 (de) 2008-09-17
HUP0300222A3 (en) 2004-08-30
NO20024363D0 (no) 2002-09-12
PT1268522E (pt) 2008-12-22
DK1268522T3 (da) 2009-01-12
RU2248982C9 (ru) 2005-06-10
SK14332002A3 (sk) 2003-09-11
CA2402193A1 (en) 2002-09-09
PL357999A1 (en) 2004-08-09
CN100500692C (zh) 2009-06-17
JP2003535044A (ja) 2003-11-25
ZA200207248B (en) 2003-02-21
CN1443195A (zh) 2003-09-17
HRP20020810A2 (en) 2004-12-31
EP1268522A2 (de) 2003-01-02
RU2248982C2 (ru) 2005-03-27
ES2312435T3 (es) 2009-03-01
NZ521273A (en) 2005-01-28
KR20020083179A (ko) 2002-11-01
BR0109279A (pt) 2002-12-17
NO20024363L (no) 2002-11-13
WO2001068676A3 (de) 2002-10-24
KR100607396B1 (ko) 2006-08-02
IL151647A0 (en) 2003-04-10
JP3805679B2 (ja) 2006-08-02
WO2001068676A2 (de) 2001-09-20
ATE408619T1 (de) 2008-10-15
AU2001260110B2 (en) 2005-05-05
UA79070C2 (en) 2007-05-25

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