BG106454A - Антибиотик, антибиотичен състав със забавено освобождаване на активното вещество - Google Patents

Антибиотик, антибиотичен състав със забавено освобождаване на активното вещество

Info

Publication number
BG106454A
BG106454A BG106454A BG10645402A BG106454A BG 106454 A BG106454 A BG 106454A BG 106454 A BG106454 A BG 106454A BG 10645402 A BG10645402 A BG 10645402A BG 106454 A BG106454 A BG 106454A
Authority
BG
Bulgaria
Prior art keywords
cycloalkyl
alkylaryl
antibiotic
sulphonates
component
Prior art date
Application number
BG106454A
Other languages
English (en)
Other versions
BG65467B1 (bg
Inventor
Sebastian Vogt
Matthias Schnabelrauch
Klaus-Dieter Kuehn
Original Assignee
Heraeus Kulzer Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heraeus Kulzer Gmbh & Co.Kg filed Critical Heraeus Kulzer Gmbh & Co.Kg
Publication of BG106454A publication Critical patent/BG106454A/bg
Publication of BG65467B1 publication Critical patent/BG65467B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Изобретението се отнася до антибиотичен препарат за резорбируеми и нерезорбируеми импланти за хуманната и ветеринарната медицина. Той има удължено освобождаване на активния ингредиент. Препаратът представлява смес, съдържаща поне един амфифилен компонент от представители на алкилсулфати, арилсулфати, алкиларил сулфати, циклоалкил сулфати, алкилциклоалкил сулфати, алкилсулфамати, циклоалкил сулфамати, алкилциклоалкил сулфамати, арилсулфамати, алкиларил сулфамати, алкилсулфонати, мастно-кисели 2-сулфонати, арилсулфонати, алкиларил сулфонати, циклоалкил сулфонати, алкилциклоалкил сулфонати, алкилдисулфати, циклоалкил дисулфати, алкилдисулфонати, циклоалкил дисулфонати, арилдисулфонати, алкиларил дисулфонати, арилтрисулфонати и алкиларил трисулфонати, както и поне един антибиотичен компонент от групата на аминогликозидните, линкозамидните, 4-хинолиновите и тетрациклиновите антибиотици, и, ако е необходимо, поне един безводен органичен помощен компонент, поне един неорганичен помощен компонент и най-малко един биологично активен компонент.
BG106454A 2001-03-22 2002-02-27 Антибиотичен препарат със забавено освобождаване на активния инградиент BG65467B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10114244A DE10114244A1 (de) 2001-03-22 2001-03-22 Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung

Publications (2)

Publication Number Publication Date
BG106454A true BG106454A (bg) 2002-10-31
BG65467B1 BG65467B1 (bg) 2008-09-30

Family

ID=7678691

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106454A BG65467B1 (bg) 2001-03-22 2002-02-27 Антибиотичен препарат със забавено освобождаване на активния инградиент

Country Status (32)

Country Link
US (1) US6913764B2 (bg)
EP (1) EP1243257B1 (bg)
JP (1) JP4181331B2 (bg)
CN (1) CN100486589C (bg)
AT (1) ATE258431T1 (bg)
AU (1) AU768962B2 (bg)
BG (1) BG65467B1 (bg)
BR (1) BR0200876A (bg)
CA (1) CA2378490C (bg)
CZ (1) CZ302690B6 (bg)
DE (2) DE10114244A1 (bg)
DK (1) DK1243257T3 (bg)
EE (1) EE200200153A (bg)
ES (1) ES2213717T3 (bg)
GE (1) GEP20053447B (bg)
HR (1) HRP20020240B1 (bg)
HU (1) HUP0201045A2 (bg)
IL (1) IL148703A (bg)
IS (2) IS6270A (bg)
MD (1) MD2550C2 (bg)
MX (1) MXPA02003007A (bg)
NO (1) NO331876B1 (bg)
NZ (1) NZ517922A (bg)
PL (1) PL204986B1 (bg)
PT (1) PT1243257E (bg)
RU (1) RU2264230C2 (bg)
SA (1) SA02230037B1 (bg)
SK (1) SK286493B6 (bg)
TR (1) TR200400244T4 (bg)
UA (1) UA71030C2 (bg)
YU (1) YU11802A (bg)
ZA (1) ZA200202254B (bg)

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DE10114245A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung
DE10114244A1 (de) * 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotikum-/Antibiotika-Zubereitung mit retardierender Wirkstofffreisetzung
DE10318991A1 (de) * 2003-04-25 2004-11-18 Heraeus Kulzer Gmbh & Co. Kg Poröser Körper mit antibiotischer Beschichtung, Verfahren zur Herstellung sowie Verwendung
ZA200604869B (en) * 2003-12-04 2007-11-28 Univ Utah Res Found Modified macromolecules and methods of making and using thereof
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
DE102004060666B3 (de) 2004-12-15 2006-03-30 Heraeus Kulzer Gmbh Antibiotikum/Antibiotika enthaltendes Knochenersatzmaterial mit retardierender Wirkstofffreisetzung
DE102005002703C5 (de) * 2005-01-19 2013-07-04 Heraeus Kulzer Gmbh Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung
ES2507552T3 (es) * 2005-10-27 2014-10-15 Nexilis Ag Implante que contiene amino-bisfosfonatos y procedimiento para su producción
ES2379485T3 (es) * 2005-10-27 2012-04-26 Thommen Medical Ag Implante dental y procedimiento para su fabricación
WO2007056667A2 (en) * 2005-11-04 2007-05-18 Rush University Medical Center Plastic implant impregnated with an antibiotic
DE102006007245A1 (de) 2006-02-15 2007-08-23 Heraeus Kulzer Gmbh Implantatmaterial
DE102006037362B3 (de) * 2006-08-09 2007-09-20 Heraeus Kulzer Gmbh Knochenersatzmaterial
WO2009015197A1 (en) * 2007-07-24 2009-01-29 University Of Memphis Research Foundation Local delivery method and composition
DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
CN101758337B (zh) * 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US20210361696A1 (en) * 2017-06-16 2021-11-25 Boris Farber Biologically active combinatorial polysaccharide derivatives
MX2020000265A (es) 2017-07-07 2020-07-22 Epicentrx Inc Composiciones para la administración parenteral de agentes terapéuticos.
IL256312A (en) 2017-12-14 2018-01-31 Omrix Biopharmaceuticals Ltd Antibacterial preparations containing minocycline and oxidized cellulose

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Also Published As

Publication number Publication date
EE200200153A (et) 2002-12-16
SK3892002A3 (en) 2002-10-08
TR200400244T4 (tr) 2004-04-21
SA02230037B1 (ar) 2007-04-15
US20020182251A1 (en) 2002-12-05
PL204986B1 (pl) 2010-02-26
IS6269A (is) 2002-09-22
BR0200876A (pt) 2003-03-11
EP1243257B1 (de) 2004-01-28
MD20020075A (en) 2002-11-30
CA2378490C (en) 2008-05-13
CN100486589C (zh) 2009-05-13
ES2213717T3 (es) 2004-09-01
ZA200202254B (en) 2002-10-10
BG65467B1 (bg) 2008-09-30
GEP20053447B (en) 2005-02-25
HRP20020240A2 (en) 2002-12-31
CZ302690B6 (cs) 2011-09-07
EP1243257A1 (de) 2002-09-25
AU768962B2 (en) 2004-01-08
CA2378490A1 (en) 2002-09-22
DK1243257T3 (da) 2004-05-10
AU2755402A (en) 2002-09-26
JP4181331B2 (ja) 2008-11-12
RU2264230C2 (ru) 2005-11-20
CN1376469A (zh) 2002-10-30
HUP0201045A2 (hu) 2003-02-28
NO20021390D0 (no) 2002-03-20
MXPA02003007A (es) 2003-08-20
DE50200223D1 (de) 2004-03-04
SK286493B6 (sk) 2008-11-06
UA71030C2 (uk) 2004-11-15
ATE258431T1 (de) 2004-02-15
IS2501B (is) 2009-03-15
DE10114244A1 (de) 2002-10-02
NZ517922A (en) 2003-08-29
HRP20020240B1 (en) 2005-04-30
MD2550C2 (ro) 2005-04-30
JP2002322097A (ja) 2002-11-08
PT1243257E (pt) 2004-06-30
CZ2002871A3 (cs) 2002-11-13
IL148703A0 (en) 2002-11-10
HU0201045D0 (bg) 2002-05-29
IS6270A (is) 2002-09-22
NO331876B1 (no) 2012-04-23
YU11802A (sh) 2004-12-31
MD2550B2 (en) 2004-09-30
PL352920A1 (en) 2002-09-23
IL148703A (en) 2006-07-05
US6913764B2 (en) 2005-07-05
NO20021390L (no) 2002-09-23

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