BG103957A - Паратиреоиден хормон - Google Patents
Паратиреоиден хормон Download PDFInfo
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- BG103957A BG103957A BG103957A BG10395799A BG103957A BG 103957 A BG103957 A BG 103957A BG 103957 A BG103957 A BG 103957A BG 10395799 A BG10395799 A BG 10395799A BG 103957 A BG103957 A BG 103957A
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- CWMFRHBXRUITQE-UHFFFAOYSA-N trimethylsilylacetylene Chemical compound C[Si](C)(C)C#C CWMFRHBXRUITQE-UHFFFAOYSA-N 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4647297P | 1997-05-14 | 1997-05-14 | |
PCT/US1998/009843 WO1998051324A1 (en) | 1997-05-14 | 1998-05-13 | Peptide parathyroid hormone analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BG103957A true BG103957A (bg) | 2000-04-28 |
Family
ID=21943653
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG103957A BG103957A (bg) | 1997-05-14 | 1999-12-06 | Паратиреоиден хормон |
Country Status (20)
Country | Link |
---|---|
US (2) | US6472505B1 (hu) |
EP (1) | EP0986395A4 (hu) |
JP (1) | JP2001517957A (hu) |
KR (1) | KR100351213B1 (hu) |
CN (1) | CN1261281A (hu) |
AP (1) | AP9901686A0 (hu) |
AU (1) | AU746461B2 (hu) |
BG (1) | BG103957A (hu) |
BR (1) | BR9808786A (hu) |
CA (1) | CA2290443A1 (hu) |
EA (1) | EA002819B1 (hu) |
HU (1) | HUP0003349A3 (hu) |
IL (1) | IL132901A0 (hu) |
NO (1) | NO995568L (hu) |
OA (1) | OA11216A (hu) |
PL (1) | PL336803A1 (hu) |
SK (1) | SK151599A3 (hu) |
UA (1) | UA62967C2 (hu) |
WO (1) | WO1998051324A1 (hu) |
ZA (1) | ZA984077B (hu) |
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IL138338A0 (en) | 1998-04-15 | 2001-10-31 | Aventis Pharm Prod Inc | Process for the preparation of resin-bound cyclic peptides |
US6316410B1 (en) * | 1999-09-22 | 2001-11-13 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
WO2003097690A2 (en) * | 2002-05-16 | 2003-11-27 | Theratechnologies Inc. | Pth derivatives resistant to skin proteases |
WO2004073587A2 (en) * | 2003-02-19 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 1 (pthr1) |
CN1822853A (zh) * | 2003-07-15 | 2006-08-23 | 加拿大国家研究委员会 | 用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物 |
US7439226B2 (en) * | 2003-09-30 | 2008-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | Serine protease inhibitors |
US20060052306A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | GRAS composition for enhanced mucosal delivery of parathyroid hormone |
CN101151048A (zh) * | 2004-05-10 | 2008-03-26 | 纳斯泰克制药公司 | 增强甲状旁腺激素粘膜递送的组合物和方法 |
US20060052305A1 (en) * | 2004-05-10 | 2006-03-09 | Nastech Pharmaceutical Company Inc. | Method of treating osteoporosis using intranasal parathyroid hormone |
US20060127320A1 (en) * | 2004-05-10 | 2006-06-15 | Nastech Pharmaceutical Company Inc. | Method of delivering parathyroid hormone to a human |
JP5086254B2 (ja) | 2005-07-07 | 2012-11-28 | フルクルム エスピー リミテッド | Sp1ポリペプチド、変性sp1ポリペプチドおよびそれらの使用 |
US20070173447A1 (en) * | 2005-10-25 | 2007-07-26 | Nastech Pharmaceutical Company Inc. | Method for treating osteoporosis by intranasal delivery of teriparatide with an anti-resorptive agent |
CA2628945A1 (en) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
US20080051332A1 (en) * | 2005-11-18 | 2008-02-28 | Nastech Pharmaceutical Company Inc. | Method of modulating hematopoietic stem cells and treating hematologic diseases using intranasal parathyroid hormone |
PL2084183T3 (pl) * | 2006-10-13 | 2010-10-29 | Lilly Co Eli | Pegylowane pth jako modulatory receptora pth i ich zastosowania |
WO2010086867A2 (en) | 2009-02-02 | 2010-08-05 | Ramot At Tel Aviv University Ltd. | Peptides, pharmaceutical compositions comprising same and uses thereof |
EP2344179A1 (en) | 2009-04-01 | 2011-07-20 | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center | A method of regulating proliferation and differentiation of keratinocyes |
WO2010116375A1 (en) | 2009-04-08 | 2010-10-14 | Yeda Research And Development Co. Ltd. | Isolated peptides for regulating apoptosis |
US20120070449A1 (en) | 2009-05-28 | 2012-03-22 | Yeda Research And Development Co. Ltd. | Methods of treating inflammation |
SG10201406921SA (en) * | 2009-07-29 | 2014-11-27 | Kai Pharmaceuticals Inc | Therapeutic agents for reducing parathyroid hormone levels |
CA2782640A1 (en) | 2009-12-07 | 2011-06-16 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
WO2011138785A2 (en) | 2010-05-05 | 2011-11-10 | Rappaport Family Institute For Research In The Medical Sciences | Use of ccl1 in therapy |
CN103002906B (zh) * | 2010-05-13 | 2017-12-29 | 总医院有限公司 | 甲状旁腺激素类似物及其应用 |
US8901074B2 (en) | 2010-08-04 | 2014-12-02 | Ramot At Tel-Aviv University | Methods of treating autoimmune diseases of the central nervous system (CNS) and neurodegenerative diseases |
WO2012131680A2 (en) | 2011-03-28 | 2012-10-04 | Yeda Research And Development Co. Ltd. | Compositions and methods for treating inflammation |
EP2721686B1 (en) * | 2011-06-17 | 2018-11-28 | NantEnergy, Inc. | Ionic liquid containing sulfonate ions |
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WO2016135716A1 (en) | 2015-02-26 | 2016-09-01 | Jacob Schneiderman | Methods and compositions relating to leptin antagonists |
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WO2019016819A1 (en) | 2017-07-20 | 2019-01-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | NANOPARTICLE COMPOSITIONS |
IL253642A0 (en) | 2017-07-24 | 2017-09-28 | Seger Rony | Combined treatment for cancer |
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US4086196A (en) * | 1975-03-28 | 1978-04-25 | Armour Pharmaceutical Company | Parathyroid hormone |
US4423037A (en) | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
US4427827A (en) | 1982-10-20 | 1984-01-24 | Usv Pharmaceutical Corporation | Synthesis of hormone fragments |
FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
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NZ257212A (en) | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
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DE19508672A1 (de) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Neue cyclische Parathormonfragmente, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
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JP4122061B2 (ja) * | 1996-08-02 | 2008-07-23 | ナショナル リサーチ カウンシル オブ カナダ | 骨粗鬆症の治寮のための副甲状腺ホルモン類似体 |
-
1998
- 1998-05-13 CA CA002290443A patent/CA2290443A1/en not_active Abandoned
- 1998-05-13 EP EP98921200A patent/EP0986395A4/en not_active Withdrawn
- 1998-05-13 AP APAP/P/1999/001686A patent/AP9901686A0/en unknown
- 1998-05-13 AU AU73867/98A patent/AU746461B2/en not_active Ceased
- 1998-05-13 SK SK1515-99A patent/SK151599A3/sk unknown
- 1998-05-13 CN CN98806651A patent/CN1261281A/zh active Pending
- 1998-05-13 HU HU0003349A patent/HUP0003349A3/hu unknown
- 1998-05-13 WO PCT/US1998/009843 patent/WO1998051324A1/en not_active Application Discontinuation
- 1998-05-13 PL PL98336803A patent/PL336803A1/xx unknown
- 1998-05-13 JP JP54953698A patent/JP2001517957A/ja not_active Ceased
- 1998-05-13 BR BR9808786-0A patent/BR9808786A/pt not_active Application Discontinuation
- 1998-05-13 KR KR1019997010523A patent/KR100351213B1/ko not_active IP Right Cessation
- 1998-05-13 IL IL13290198A patent/IL132901A0/xx unknown
- 1998-05-13 EA EA199901025A patent/EA002819B1/ru not_active IP Right Cessation
- 1998-05-13 UA UA99126574A patent/UA62967C2/uk unknown
- 1998-05-14 ZA ZA984077A patent/ZA984077B/xx unknown
-
1999
- 1999-01-12 US US09/228,990 patent/US6472505B1/en not_active Expired - Fee Related
- 1999-11-12 NO NO995568A patent/NO995568L/no not_active Application Discontinuation
- 1999-11-12 OA OA9900247A patent/OA11216A/en unknown
- 1999-12-06 BG BG103957A patent/BG103957A/bg unknown
-
2002
- 2002-03-13 US US10/097,079 patent/US20020132973A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20010012568A (ko) | 2001-02-15 |
PL336803A1 (en) | 2000-07-17 |
JP2001517957A (ja) | 2001-10-09 |
SK151599A3 (en) | 2000-09-12 |
US6472505B1 (en) | 2002-10-29 |
AU7386798A (en) | 1998-12-08 |
AU746461B2 (en) | 2002-05-02 |
WO1998051324A1 (en) | 1998-11-19 |
EP0986395A1 (en) | 2000-03-22 |
EP0986395A4 (en) | 2004-12-01 |
EA002819B1 (ru) | 2002-10-31 |
IL132901A0 (en) | 2001-03-19 |
KR100351213B1 (ko) | 2002-09-05 |
AP9901686A0 (en) | 1999-12-31 |
HUP0003349A3 (en) | 2001-12-28 |
CA2290443A1 (en) | 1998-11-19 |
BR9808786A (pt) | 2000-07-11 |
NO995568L (no) | 1999-12-29 |
OA11216A (en) | 2003-07-10 |
CN1261281A (zh) | 2000-07-26 |
ZA984077B (en) | 1998-11-24 |
NO995568D0 (no) | 1999-11-12 |
UA62967C2 (en) | 2004-01-15 |
US20020132973A1 (en) | 2002-09-19 |
HUP0003349A2 (hu) | 2001-01-29 |
EA199901025A1 (ru) | 2000-06-26 |
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