BG103808A - Методи и състави за модулиране реакцията спрямо кортикостероиди - Google Patents

Методи и състави за модулиране реакцията спрямо кортикостероиди

Info

Publication number
BG103808A
BG103808A BG103808A BG10380899A BG103808A BG 103808 A BG103808 A BG 103808A BG 103808 A BG103808 A BG 103808A BG 10380899 A BG10380899 A BG 10380899A BG 103808 A BG103808 A BG 103808A
Authority
BG
Bulgaria
Prior art keywords
corticosteroid
antagonist
patient
antibody
another
Prior art date
Application number
BG103808A
Other languages
English (en)
Inventor
Les Sekut
Adam Carter
Tariq Ghayur
Subhashis Banerjee
Daniel TRACEY
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/820,692 external-priority patent/US6054487A/en
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of BG103808A publication Critical patent/BG103808A/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Методите намират приложение при лечението на различни възпалителни и имунологични заболявания и смущения. Те модулират реакцията на пациента спрямо кортикостероиди. Прилага се средство, което антагонизира цел, която регулира продукцията на IFN-гамазаедно с кортикостероид, така че реакцията на пациента към кортикостероида се модулира в сравнение със самостоятелното прилагане на кортикостероид. Съгласно един вариант на изпълнение средството е IL-18 антагонист. При друго изпълнение средството е интерлевкин-12 (IL-12) антагонист. Средството можесъщо да е NK клетъчен антагонист. Според друго предпочитано изпълнение средството е инхибитор на каспазната родова протеаза, за предпочитане ICE инхибитор. При друго изпълнение средството е анти- IL-12 моноклонално антитяло. Средството може да е анти-азиало-GM1 антитяло или NН1,1 антитяло. Други предпочитани средства са фосфодиестеразни IV инхибитори и бета-2 агонисти. Разработени са и фармацевтични състави, включващи средство, което антагонизира цел, която регулира продукцията на IFN-гама организма на пациента, заедно с кортикостероид и фармацевтично приемлив носител. Предпочитаният състав включва ICE инхибитор, кортикостероид и фармацевтично приемлив носител.
BG103808A 1997-03-18 1999-10-13 Методи и състави за модулиране реакцията спрямо кортикостероиди BG103808A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/820,692 US6054487A (en) 1997-03-18 1997-03-18 Methods and compositions for modulating responsiveness to corticosteroids
US1634698A 1998-01-30 1998-01-30
PCT/US1998/004916 WO1998041232A2 (en) 1997-03-18 1998-03-12 Compositions for modulating responsiveness to corticosteroids

Publications (1)

Publication Number Publication Date
BG103808A true BG103808A (bg) 2000-07-31

Family

ID=26688484

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103808A BG103808A (bg) 1997-03-18 1999-10-13 Методи и състави за модулиране реакцията спрямо кортикостероиди

Country Status (20)

Country Link
EP (1) EP0998300A1 (bg)
JP (1) JP2002504091A (bg)
KR (1) KR20000076420A (bg)
CN (1) CN1269722A (bg)
AU (1) AU734756B2 (bg)
BG (1) BG103808A (bg)
BR (1) BR9810409A (bg)
CA (1) CA2282845A1 (bg)
DE (1) DE998300T1 (bg)
ES (1) ES2146192T1 (bg)
HU (1) HUP0104439A3 (bg)
ID (1) ID22975A (bg)
IL (1) IL131815A0 (bg)
NO (1) NO994506L (bg)
NZ (1) NZ337769A (bg)
PL (1) PL336464A1 (bg)
SI (1) SI20110A (bg)
SK (1) SK122199A3 (bg)
TR (1) TR199902615T2 (bg)
WO (1) WO1998041232A2 (bg)

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Also Published As

Publication number Publication date
EP0998300A1 (en) 2000-05-10
CA2282845A1 (en) 1998-09-24
TR199902615T2 (xx) 2000-03-21
NZ337769A (en) 2002-09-27
HUP0104439A3 (en) 2002-08-28
AU734756B2 (en) 2001-06-21
NO994506D0 (no) 1999-09-17
DE998300T1 (de) 2001-03-01
JP2002504091A (ja) 2002-02-05
ES2146192T1 (es) 2000-08-01
SK122199A3 (en) 2000-12-11
WO1998041232A2 (en) 1998-09-24
KR20000076420A (ko) 2000-12-26
HUP0104439A2 (hu) 2002-04-29
BR9810409A (pt) 2000-08-22
ID22975A (id) 1999-12-23
NO994506L (no) 1999-11-17
AU6760498A (en) 1998-10-12
SI20110A (sl) 2000-06-30
PL336464A1 (en) 2000-06-19
IL131815A0 (en) 2001-03-19
CN1269722A (zh) 2000-10-11
WO1998041232A3 (en) 2000-10-05

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