EP1516630A3 - Use of anti-il-12 antibodies in transplantation rejection - Google Patents

Use of anti-il-12 antibodies in transplantation rejection Download PDF

Info

Publication number
EP1516630A3
EP1516630A3 EP04020503A EP04020503A EP1516630A3 EP 1516630 A3 EP1516630 A3 EP 1516630A3 EP 04020503 A EP04020503 A EP 04020503A EP 04020503 A EP04020503 A EP 04020503A EP 1516630 A3 EP1516630 A3 EP 1516630A3
Authority
EP
European Patent Office
Prior art keywords
antibodies
transplantation rejection
antibody
administration
alone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04020503A
Other languages
German (de)
French (fr)
Other versions
EP1516630A2 (en
Inventor
Terry Strom
Xiang Chang Li
Martin S. Zand
Xin Xiao Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Beth Israel Deaconess Medical Center Inc
Original Assignee
Wyeth LLC
Beth Israel Deaconess Medical Center Inc
Beth Israel Hospital Association
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth LLC, Beth Israel Deaconess Medical Center Inc, Beth Israel Hospital Association filed Critical Wyeth LLC
Priority claimed from EP98956450A external-priority patent/EP0969867B1/en
Publication of EP1516630A2 publication Critical patent/EP1516630A2/en
Publication of EP1516630A3 publication Critical patent/EP1516630A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

Methods are disclosed for reducing or ameliorating chronic rejection of a transplanted tissue by administration of an anti-IL-12 antibody, alone or in combination with other beneficial therapeutic agents.
EP04020503A 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection Withdrawn EP1516630A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6385397P 1997-10-31 1997-10-31
US63853P 1997-10-31
EP98956450A EP0969867B1 (en) 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP98956450A Division EP0969867B1 (en) 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection

Publications (2)

Publication Number Publication Date
EP1516630A2 EP1516630A2 (en) 2005-03-23
EP1516630A3 true EP1516630A3 (en) 2006-05-03

Family

ID=34196208

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04020503A Withdrawn EP1516630A3 (en) 1997-10-31 1998-10-30 Use of anti-il-12 antibodies in transplantation rejection

Country Status (1)

Country Link
EP (1) EP1516630A3 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019786A1 (en) * 1994-01-21 1995-07-27 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease
WO1998041232A2 (en) * 1997-03-18 1998-09-24 Basf Aktiengesellschaft Compositions for modulating responsiveness to corticosteroids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019786A1 (en) * 1994-01-21 1995-07-27 Genetics Institute, Inc. Use of interleukin-12 to prevent graft versus host disease
WO1998041232A2 (en) * 1997-03-18 1998-09-24 Basf Aktiengesellschaft Compositions for modulating responsiveness to corticosteroids

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
B. WASOWSKA ET AL.: "Rapamycin and cyclosporine A treatment: A novel regimen to prevent chronic allograft rejection in sensitized hosts.", TRANSPLANTATION PROCEEDINGS, vol. 29, no. 1-2, February 1997 (1997-02-01), New York, NY, USA, pages 333, XP002099943 *
DE MATTOS A M ET AL: "Interleukin-12 p40 m-RNA expression in human kidney allograft biopsies.", TRANSPLANT IMMUNOLOGY. SEP 1997, vol. 5, no. 3, September 1997 (1997-09-01), pages 199 - 203, XP002367748, ISSN: 0966-3274 *
K. SAITO ET AL.: "Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-versus-host disease.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 26, no. 12, December 1996 (1996-12-01), Weinheim, Germany, pages 3098 - 3106, XP002099939 *
M. BERTAGNOLLI ET AL.: "Evidence that rapamycin inhibits interleukin-12-induced proliferation of activated T lymphocytes.", TRANSPLANTATION, vol. 58, no. 10, 27 November 1994 (1994-11-27), Baltimore, MD, USA, pages 1091 - 1096, XP002099940 *
P. NICKERSON ET AL.: "Manipulation of cytokine networks in transplantation.", TRANSPLANTATION, vol. 63, no. 4, 27 February 1997 (1997-02-27), Baltimore, MD, USA, pages 489 - 494, XP002099942 *
R. CARTER ET AL.: "Production and characterization of monoclonal antibodies to human interleukin-12.", HYBRIDOMA, vol. 16, no. 4, August 1997 (1997-08-01), New York, NY, USA, pages 363 - 369, XP002099941 *
RABINOVITCH ALEX ET AL: "Interleukin 12 mRNA expression in islets correlates with beta-cell destruction in NOD mice", JOURNAL OF AUTOIMMUNITY, vol. 9, no. 5, 1996, pages 645 - 651, XP008060106, ISSN: 0896-8411 *
X. LI ET AL.: "On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses.", THE JOURNAL OF IMMUNOLOGY, vol. 161, no. 5, 1 September 1998 (1998-09-01), Baltimore, MD, USA, pages 2241 - 2247, XP002099985 *
Y. WADA ET AL.: "Treatment with anti-interleukin-12 monoclonal antibody alleviates acute rejection of mouse islet allografts.", GASTROENTEROLOGY, vol. 114, no. 4 part 2 suppl., 15 April 1998 (1998-04-15), Baltimore, MD, USA, pages A1433, XP002099944 *

Also Published As

Publication number Publication date
EP1516630A2 (en) 2005-03-23

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