NZ580379A - Crystalline anti-human il-12 antibodies - Google Patents

Crystalline anti-human il-12 antibodies

Info

Publication number
NZ580379A
NZ580379A NZ580379A NZ58037908A NZ580379A NZ 580379 A NZ580379 A NZ 580379A NZ 580379 A NZ580379 A NZ 580379A NZ 58037908 A NZ58037908 A NZ 58037908A NZ 580379 A NZ580379 A NZ 580379A
Authority
NZ
New Zealand
Prior art keywords
antibody
human
crystallization
disclosed
aqueous
Prior art date
Application number
NZ580379A
Inventor
David W Borhani
Wolfgang Fraunhofer
Hans-Juergen Krause
Anette Koenigsdorfer
Gerhard Winter
Stefan Gottschalk
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to NZ598881A priority Critical patent/NZ598881A/en
Publication of NZ580379A publication Critical patent/NZ580379A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
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Abstract

Disclosed is a batch crystallization method for crystallizing an anti-human IL-12 antibody, the method comprising the steps of: (a) providing an aqueous crystallization mixture having an aqueous solution of the antibody in admixture with at least one polyalkylene glycol having an average molecular weight in the range of about 400 to about 10,000 as a crystallization agent wherein the antibody concentration is in the range of about 0.5 to about 280 mg/ml; and (b) incubating the aqueous crystallization mixture at a pH of about pH 4 to about 6.5 and at a temperature of about 4o C to about 37o C until crystals of the antibody having a length of about 2-500 ìm are formed. Also disclosed is a crystal of an anti-human IL-12 antibody obtained by a batch crystallization method. Further disclosed is the use of the anti-human IL-12 antibody crystal in the manufacture of a medicament for the treatment of an IL-12 related disorder
NZ580379A 2007-03-29 2008-03-27 Crystalline anti-human il-12 antibodies NZ580379A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ598881A NZ598881A (en) 2007-03-29 2008-03-27 Crystalline anti-human il-12 antibodies

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92060807P 2007-03-29 2007-03-29
PCT/US2008/004006 WO2008121301A1 (en) 2007-03-29 2008-03-27 Crystalline anti-human il-12 antibodies

Publications (1)

Publication Number Publication Date
NZ580379A true NZ580379A (en) 2012-10-26

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Application Number Title Priority Date Filing Date
NZ598881A NZ598881A (en) 2007-03-29 2008-03-27 Crystalline anti-human il-12 antibodies
NZ580379A NZ580379A (en) 2007-03-29 2008-03-27 Crystalline anti-human il-12 antibodies

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Application Number Title Priority Date Filing Date
NZ598881A NZ598881A (en) 2007-03-29 2008-03-27 Crystalline anti-human il-12 antibodies

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US (3) US8168760B2 (en)
EP (2) EP2527364A1 (en)
JP (2) JP2010522752A (en)
KR (1) KR20100014674A (en)
CN (1) CN101679507A (en)
AU (1) AU2008233173B2 (en)
BR (1) BRPI0809209A2 (en)
CA (1) CA2681752A1 (en)
IL (1) IL201184A0 (en)
MX (1) MX2009010361A (en)
NZ (2) NZ598881A (en)
RU (2) RU2476442C2 (en)
TW (2) TW201350504A (en)
WO (1) WO2008121301A1 (en)
ZA (2) ZA200906432B (en)

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Publication number Priority date Publication date Assignee Title
CA2243459C (en) 1996-02-09 2002-09-17 Basf Aktiengesellschaft Human antibodies that bind human tnf.alpha.
IL156618A0 (en) * 2000-12-28 2004-01-04 Altus Biologics Inc Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
CA2903138A1 (en) 2005-05-16 2006-11-23 Abbvie Biotechnology Ltd. Use of tnfa inhibitor for treatment of erosive polyarthritis
US9605064B2 (en) * 2006-04-10 2017-03-28 Abbvie Biotechnology Ltd Methods and compositions for treatment of skin disorders
WO2008057240A2 (en) 2006-10-27 2008-05-15 Abbott Biotechnology Ltd. Crystalline anti-htnfalpha antibodies
CA2675233A1 (en) * 2007-01-16 2008-07-24 Abbott Laboratories Methods for treating psoriasis
EP2527364A1 (en) 2007-03-29 2012-11-28 Abbott Laboratories Crystalline anti-human IL-12 antibodies
RU2010107994A (en) 2007-08-08 2011-09-20 Эбботт Лэборетриз (Us) COMPOSITIONS AND METHODS OF CRYSTALLIZING ANTIBODIES
CA2713342A1 (en) * 2008-01-30 2009-08-13 Abbott Laboratories Compositions and methods for crystallizing antibody fragments
CN102037011A (en) 2008-03-18 2011-04-27 雅培制药有限公司 Methods for treating psoriasis
RU2011126338A (en) * 2008-11-28 2013-01-10 Эбботт Лэборетриз STABLE COMPOSITIONS OF ANTIBODIES AND METHODS FOR THEIR STABILIZATION
KR20140048229A (en) * 2009-09-14 2014-04-23 애브비 인코포레이티드 Methods for treating psoriasis
EP2596123B1 (en) * 2010-07-22 2015-11-25 Shire Human Genetic Therapies, Inc. Crystal structure of human alpha-n-acetylglucosaminidase
SG10201701634PA (en) 2011-03-25 2017-04-27 Amgen Inc Anti - sclerostin antibody crystals and formulations thereof
WO2012149197A2 (en) 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
WO2014004436A2 (en) 2012-06-27 2014-01-03 Merck Sharp & Dohme Corp. Crystalline anti-human il-23 antibodies
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9206390B2 (en) 2012-09-02 2015-12-08 Abbvie, Inc. Methods to control protein heterogeneity
US8962888B2 (en) * 2012-12-03 2015-02-24 Physical Sciences, Inc. Forming spherical crystal habit
WO2014143205A1 (en) 2013-03-12 2014-09-18 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US8921526B2 (en) 2013-03-14 2014-12-30 Abbvie, Inc. Mutated anti-TNFα antibodies and methods of their use
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
AR103726A1 (en) 2015-02-27 2017-05-31 Merck Sharp & Dohme HUMAN ANTI-PD-1 MONOCLONAL ANTIBODY CRYSTALS
JOP20190260A1 (en) 2017-05-02 2019-10-31 Merck Sharp & Dohme Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
RU2019138507A (en) 2017-05-02 2021-06-02 Мерк Шарп И Доум Корп. ANTIBODY AGAINST LAG3 AND JOINT ANTIBODY AGAINST LAG3 AND ANTIBODY AGAINST PD-1

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4597966A (en) * 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
DE3631229A1 (en) * 1986-09-13 1988-03-24 Basf Ag MONOCLONAL ANTIBODIES AGAINST HUMAN TUMORNESCROSE FACTOR (TNF) AND THEIR USE
US4877608A (en) * 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
US4897465A (en) * 1988-10-12 1990-01-30 Abbott Laboratories Enrichment and concentration of proteins by ultrafiltration
US5811523A (en) * 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JPH0791318B2 (en) 1989-09-21 1995-10-04 三井東圧化学株式会社 Aqueous protein solution, method for increasing concentration of aqueous protein solution, and protein preparation
DE69032483T2 (en) * 1989-10-05 1998-11-26 Optein, Inc., Seattle, Wash. CELL-FREE SYNTHESIS AND ISOLATION OF GENES AND POLYPEPTIDES
US6683046B1 (en) * 1989-12-22 2004-01-27 Hoffmann-La Roche Inc. Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto
US6713610B1 (en) * 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US5945098A (en) * 1990-02-01 1999-08-31 Baxter International Inc. Stable intravenously-administrable immune globulin preparation
AU665190B2 (en) 1990-07-10 1995-12-21 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5618710A (en) 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
ES2113940T3 (en) 1990-12-03 1998-05-16 Genentech Inc ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES.
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
GB9122820D0 (en) * 1991-10-28 1991-12-11 Wellcome Found Stabilised antibodies
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
CA2125763C (en) * 1993-07-02 2007-08-28 Maurice Kent Gately P40 homodimer of interleukin-12
EP0638644A1 (en) 1993-07-19 1995-02-15 F. Hoffmann-La Roche Ag Receptors of interleukin-12 and antibodies
FR2708467B1 (en) 1993-07-30 1995-10-20 Pasteur Merieux Serums Vacc Stabilized immunoglobulin preparations and process for their preparation.
EP0659766A1 (en) 1993-11-23 1995-06-28 Schering-Plough Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
DE4344824C1 (en) * 1993-12-28 1995-08-31 Immuno Ag Highly concentrated immunoglobulin preparation and process for its preparation
ZA95960B (en) 1994-03-14 1995-10-10 Genetics Inst Use of interleukin-12 antagonists in the treatment of autoimmune diseases
US5910486A (en) * 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
EP1978033A3 (en) 1995-04-27 2008-12-24 Amgen Fremont Inc. Human antibodies derived from immunized xenomice
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
CN102416176A (en) 1995-07-27 2012-04-18 基因技术股份有限公司 Stabile isotonic lyophilized protein formulation
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5853697A (en) 1995-10-25 1998-12-29 The United States Of America, As Represented By The Department Of Health & Human Services Methods of treating established colitis using antibodies against IL-12
US6297395B1 (en) * 1995-11-10 2001-10-02 The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Calixarenes and their use for sequestration of metals
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
GB9610992D0 (en) 1996-05-24 1996-07-31 Glaxo Group Ltd Concentrated antibody preparation
WO1998016248A1 (en) 1996-10-11 1998-04-23 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Methods for enhancing oral tolerance and treating autoimmune disease using inhibitors of interleukin-12
AU4959997A (en) 1996-11-15 1998-06-10 Kennedy Institute Of Rheumatology, The Suppression of tnf alpha and il-12 in therapy
EP1500329B1 (en) * 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
CA2282845A1 (en) 1997-03-18 1998-09-24 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
GB9705810D0 (en) 1997-03-20 1997-05-07 Common Services Agency Intravenous immune globulin
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
WO1998044948A2 (en) 1997-04-07 1998-10-15 Cangene Corporation Intravenous immune globulin formulation containing a non-ionic surface active agent with improved pharmacokinetic properties
EA002149B1 (en) * 1997-04-28 2001-12-24 Эли Лилли Энд Компани Improved methods for processing activated protein c
EP0999853B1 (en) 1997-06-13 2003-01-02 Genentech, Inc. Stabilized antibody formulation
US6171586B1 (en) * 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
EP1015480A2 (en) 1997-08-18 2000-07-05 Innogenetics N.V. Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
CN1149100C (en) * 1997-10-23 2004-05-12 三菱制药株式会社 Room temperature storable immunoglobulin preparation for intravenous injection
WO1999022766A2 (en) 1997-10-31 1999-05-14 Terry Strom Use of anti-il-12 antibodies in transplantation rejection
ATE553129T1 (en) 1998-01-23 2012-04-15 Hoffmann La Roche ANTIBODIES TO HUMAN IL-12
US20020161199A1 (en) * 1998-04-08 2002-10-31 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US6284282B1 (en) * 1998-04-29 2001-09-04 Genentech, Inc. Method of spray freeze drying proteins for pharmaceutical administration
EP0953639A1 (en) 1998-04-30 1999-11-03 Boehringer Ingelheim International GmbH FAPalpha-specific antibody with improved producibility
ES2251248T3 (en) * 1998-12-09 2006-04-16 Protein Design Labs, Inc. USE OF ANTIBODIES AGAINST IL-12 TO TREAT PSORIASIS.
US6914128B1 (en) * 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
US7883704B2 (en) * 1999-03-25 2011-02-08 Abbott Gmbh & Co. Kg Methods for inhibiting the activity of the P40 subunit of human IL-12
CZ303725B6 (en) 1999-03-25 2013-04-03 Abbott Gmbh & Co. Kg Human antibodies binding to human IL-12, and processes for preparing thereof
US20030148955A1 (en) * 1999-04-19 2003-08-07 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
AUPQ026799A0 (en) 1999-05-10 1999-06-03 Csl Limited Method of increasing protein stability by removing immunoglobulin aggregates
DE10022092A1 (en) * 2000-05-08 2001-11-15 Aventis Behring Gmbh Stabilized protein preparation and process for its preparation
EP1336410A4 (en) * 2000-08-04 2005-10-12 Chugai Pharmaceutical Co Ltd Protein injection preparations
US6902734B2 (en) 2000-08-07 2005-06-07 Centocor, Inc. Anti-IL-12 antibodies and compositions thereof
EP1309312A2 (en) 2000-08-07 2003-05-14 Inhale Therapeutic Systems, Inc. Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
AU2001277781A1 (en) 2000-08-11 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
ES2332402T5 (en) 2000-10-12 2018-05-14 Genentech, Inc. Concentrated protein formulations of reduced viscosity
AU3664102A (en) 2000-12-01 2002-06-11 Battelle Memorial Institute Method for stabilizing biomolecules in liquid formulations
US6693173B2 (en) * 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
IL156618A0 (en) * 2000-12-28 2004-01-04 Altus Biologics Inc Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same
JP5052736B2 (en) * 2001-05-30 2012-10-17 中外製薬株式会社 Protein preparation
GB0113179D0 (en) * 2001-05-31 2001-07-25 Novartis Ag Organic compounds
US6818613B2 (en) 2001-11-07 2004-11-16 Ortho-Mcneil Pharmaceutical, Inc. Aqueous sustained-release formulations of proteins
EP1585477A4 (en) * 2001-11-30 2007-06-27 Centocor Inc Anti-tnf antibodies, compositions, methods and uses
EP2311489A3 (en) * 2002-02-14 2013-08-21 Chugai Seiyaku Kabushiki Kaisha Formulation of antibody-containing solutions comprising a sugar as a stabilizer
US20040105889A1 (en) * 2002-12-03 2004-06-03 Elan Pharma International Limited Low viscosity liquid dosage forms
US7101576B2 (en) 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
EP1551875A4 (en) 2002-06-21 2006-06-28 Biogen Idec Inc Buffered formulations for concentrating antibodies and methods of use thereof
EP1539212A4 (en) * 2002-07-12 2007-05-02 Medarex Inc Methods and compositions for preventing oxidative degradation of proteins
NZ598346A (en) 2002-07-19 2013-10-25 Abbvie Biotechnology Ltd Treatment of tnf alpha related disorders
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
HUE027134T2 (en) * 2002-09-11 2016-10-28 Chugai Pharmaceutical Co Ltd Method of purifying protein
JP4500683B2 (en) * 2002-11-01 2010-07-14 バイエル・ヘルスケア・エルエルシー Macromolecule concentration method
US20040086532A1 (en) * 2002-11-05 2004-05-06 Allergan, Inc., Botulinum toxin formulations for oral administration
AU2003293543A1 (en) 2002-12-13 2004-07-09 Abgenix, Inc. System and method for stabilizing antibodies with histidine
WO2004058156A2 (en) 2002-12-17 2004-07-15 Medimmune Vaccines, Inc. High pressure spray-dry of bioactive materials
WO2004060343A1 (en) 2002-12-31 2004-07-22 Nektar Therapeutics Antibody-containing particles and compositions
US7608260B2 (en) * 2003-01-06 2009-10-27 Medimmune, Llc Stabilized immunoglobulins
AU2004207003A1 (en) 2003-01-30 2004-08-12 Medimmune, Llc Anti-integrin alphanubeta3 antibody formulations and uses thereof
CN1798575A (en) * 2003-04-04 2006-07-05 健泰科生物技术公司 High concentration antibody and protein formulations
WO2004094020A2 (en) * 2003-04-17 2004-11-04 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
WO2004102184A1 (en) 2003-05-09 2004-11-25 Arizeke Pharmaceuticals, Inc. Compositions and methods for concentrating polypeptides and proteins
AU2004220325B2 (en) * 2003-06-30 2011-05-12 Domantis Limited Polypeptides
EP3006463A1 (en) * 2003-10-01 2016-04-13 Kyowa Hakko Kirin Co., Ltd. Method for stabilizing antibody and stabilized solution-type antibody preparation
ATE518888T1 (en) * 2003-10-09 2011-08-15 Chugai Pharmaceutical Co Ltd STABILIZED SOLUTION WITH HIGH IGM CONCENTRATION
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
EP1532983A1 (en) * 2003-11-18 2005-05-25 ZLB Bioplasma AG Immunoglobulin preparations having increased stability
EP1694317A4 (en) * 2003-12-19 2010-05-12 Protemix Corp Ltd Copper antagonist compounds
CN1953768B (en) * 2004-02-12 2010-10-13 默克专利有限公司 Highly concentrated liquid formulations of anti-EGFR antibodies
KR100486028B1 (en) 2004-04-20 2005-05-03 주식회사 펩트론 Protein-containing lipid implant for sustained delivery and its preparation method
US7727962B2 (en) * 2004-05-10 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder comprising new compositions of oligosaccharides and methods for their preparation
AR049390A1 (en) * 2004-06-09 2006-07-26 Wyeth Corp ANTIBODIES AGAINST HUMAN INTERLEUQUINE-13 AND USES OF THE SAME
WO2006012500A2 (en) 2004-07-23 2006-02-02 Genentech, Inc. Crystallization of antibodies or fragments thereof
TW200621282A (en) * 2004-08-13 2006-07-01 Wyeth Corp Stabilizing formulations
US20060051347A1 (en) * 2004-09-09 2006-03-09 Winter Charles M Process for concentration of antibodies and therapeutic products thereof
WO2007011390A2 (en) * 2004-10-09 2007-01-25 Government Of The United States As Represented By The Secretary Of The Army Large-scale production of human serum butyrylcholinesterase as a bioscavenger
JO3000B1 (en) * 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
EA016022B1 (en) * 2004-12-21 2012-01-30 Сентокор, Инк. Isolated mammalian anti-il-12 antibody and method for altering the activity thereof
TW200638943A (en) * 2005-01-28 2006-11-16 Wyeth Corp Stabilized liquid polypeptide formulations
US8349991B2 (en) * 2005-04-19 2013-01-08 Massachusetts Institute Of Technology Amphiphilic polymers and methods of use thereof
US20080311078A1 (en) 2005-06-14 2008-12-18 Gokarn Yatin R Self-Buffering Protein Formulations
AU2006265002B2 (en) * 2005-06-30 2012-09-20 Centocor, Inc. Anti-IL-23 antibodies, compositions, methods and uses
KR20130080058A (en) 2005-06-30 2013-07-11 아보트 러보러터리즈 Il-12/p40 binding proteins
EP2264162A1 (en) 2005-07-02 2010-12-22 Arecor Limited Stable aqueous systems comprising proteins
EP2468768A3 (en) * 2005-07-21 2012-10-31 Abbott Laboratories Multiple gene expression including sorf contructs and methods with polyproteins, pro-proteins, and proteolysis
AU2006330858A1 (en) * 2005-12-21 2007-07-05 Wyeth Protein formulations with reduced viscosity and uses thereof
EP1977763A4 (en) 2005-12-28 2010-06-02 Chugai Pharmaceutical Co Ltd Antibody-containing stabilizing preparation
AU2007212147A1 (en) * 2006-02-03 2007-08-16 Medimmune, Llc Protein formulations
US20070202051A1 (en) * 2006-02-10 2007-08-30 Pari Gmbh Aerosols for sinunasal drug delivery
CA2642270A1 (en) 2006-02-15 2007-08-23 Imclone Systems Incorporated Antibody formulation
DE102006030164A1 (en) * 2006-06-29 2008-01-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalative powders
TWI527603B (en) * 2006-06-30 2016-04-01 艾伯維生物技術有限責任公司 Automatic injection device
GB0615312D0 (en) 2006-08-02 2006-09-13 Univ Dundee Protein Solubilisation
SG175622A1 (en) 2006-10-13 2011-11-28 Centocor Ortho Biotech Inc Enhancement of hybridoma fusion efficiencies through cell synchronization
WO2008057240A2 (en) * 2006-10-27 2008-05-15 Abbott Biotechnology Ltd. Crystalline anti-htnfalpha antibodies
BRPI0720125A2 (en) * 2006-12-06 2014-01-28 Wyeth Corp Method for storing a liquid formulation; Method for the preparation of a liquid formulation; COMPOSITION; AND METHOD FOR INHIBITING MANNITOL-INDUCED AGGREGATION OF A PROTEIN IN A NET FORMULATION.
CA2675233A1 (en) * 2007-01-16 2008-07-24 Abbott Laboratories Methods for treating psoriasis
CN101605532A (en) * 2007-02-16 2009-12-16 惠氏公司 The protein formulations that contains Sorbitol
EP2527364A1 (en) 2007-03-29 2012-11-28 Abbott Laboratories Crystalline anti-human IL-12 antibodies
CA2685372A1 (en) * 2007-05-02 2008-11-13 F. Hoffmann-La Roche Ag Method for stabilizing a protein
RU2010107994A (en) * 2007-08-08 2011-09-20 Эбботт Лэборетриз (Us) COMPOSITIONS AND METHODS OF CRYSTALLIZING ANTIBODIES
TWI661833B (en) * 2007-11-30 2019-06-11 百慕達商艾伯維生物技術有限責任公司 Protein formulations and methods of making same
AU2009204863B2 (en) * 2008-01-15 2015-07-16 AbbVie Deutschland GmbH & Co. KG Powdered protein compositions and methods of making same
CA2713342A1 (en) * 2008-01-30 2009-08-13 Abbott Laboratories Compositions and methods for crystallizing antibody fragments
CN102037011A (en) * 2008-03-18 2011-04-27 雅培制药有限公司 Methods for treating psoriasis
RU2011126338A (en) * 2008-11-28 2013-01-10 Эбботт Лэборетриз STABLE COMPOSITIONS OF ANTIBODIES AND METHODS FOR THEIR STABILIZATION
US8470308B2 (en) 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
KR101721906B1 (en) * 2009-04-29 2017-03-31 애브비 바이오테크놀로지 리미티드 Automatic injection device
JP2012526121A (en) * 2009-05-04 2012-10-25 アボツト・バイオテクノロジー・リミテツド Stable high protein concentration formulation of human anti-TNF alpha antibody

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