NZ580379A - Crystalline anti-human il-12 antibodies - Google Patents
Crystalline anti-human il-12 antibodiesInfo
- Publication number
- NZ580379A NZ580379A NZ580379A NZ58037908A NZ580379A NZ 580379 A NZ580379 A NZ 580379A NZ 580379 A NZ580379 A NZ 580379A NZ 58037908 A NZ58037908 A NZ 58037908A NZ 580379 A NZ580379 A NZ 580379A
- Authority
- NZ
- New Zealand
- Prior art keywords
- antibody
- human
- crystallization
- disclosed
- aqueous
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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Abstract
Disclosed is a batch crystallization method for crystallizing an anti-human IL-12 antibody, the method comprising the steps of: (a) providing an aqueous crystallization mixture having an aqueous solution of the antibody in admixture with at least one polyalkylene glycol having an average molecular weight in the range of about 400 to about 10,000 as a crystallization agent wherein the antibody concentration is in the range of about 0.5 to about 280 mg/ml; and (b) incubating the aqueous crystallization mixture at a pH of about pH 4 to about 6.5 and at a temperature of about 4o C to about 37o C until crystals of the antibody having a length of about 2-500 ìm are formed. Also disclosed is a crystal of an anti-human IL-12 antibody obtained by a batch crystallization method. Further disclosed is the use of the anti-human IL-12 antibody crystal in the manufacture of a medicament for the treatment of an IL-12 related disorder
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ598881A NZ598881A (en) | 2007-03-29 | 2008-03-27 | Crystalline anti-human il-12 antibodies |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92060807P | 2007-03-29 | 2007-03-29 | |
PCT/US2008/004006 WO2008121301A1 (en) | 2007-03-29 | 2008-03-27 | Crystalline anti-human il-12 antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ580379A true NZ580379A (en) | 2012-10-26 |
Family
ID=39808589
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ598881A NZ598881A (en) | 2007-03-29 | 2008-03-27 | Crystalline anti-human il-12 antibodies |
NZ580379A NZ580379A (en) | 2007-03-29 | 2008-03-27 | Crystalline anti-human il-12 antibodies |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ598881A NZ598881A (en) | 2007-03-29 | 2008-03-27 | Crystalline anti-human il-12 antibodies |
Country Status (15)
Country | Link |
---|---|
US (3) | US8168760B2 (en) |
EP (2) | EP2527364A1 (en) |
JP (2) | JP2010522752A (en) |
KR (1) | KR20100014674A (en) |
CN (1) | CN101679507A (en) |
AU (1) | AU2008233173B2 (en) |
BR (1) | BRPI0809209A2 (en) |
CA (1) | CA2681752A1 (en) |
IL (1) | IL201184A0 (en) |
MX (1) | MX2009010361A (en) |
NZ (2) | NZ598881A (en) |
RU (2) | RU2476442C2 (en) |
TW (2) | TW201350504A (en) |
WO (1) | WO2008121301A1 (en) |
ZA (2) | ZA200906432B (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2243459C (en) | 1996-02-09 | 2002-09-17 | Basf Aktiengesellschaft | Human antibodies that bind human tnf.alpha. |
IL156618A0 (en) * | 2000-12-28 | 2004-01-04 | Altus Biologics Inc | Crystals of whole antibodies and fragments thereof, methods for the preparation thereof and diagnostic kits utilizing the same |
CA2903138A1 (en) | 2005-05-16 | 2006-11-23 | Abbvie Biotechnology Ltd. | Use of tnfa inhibitor for treatment of erosive polyarthritis |
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TWI429657B (en) | 2014-03-11 |
EP2142565A4 (en) | 2010-03-31 |
RU2476442C2 (en) | 2013-02-27 |
US20080292642A1 (en) | 2008-11-27 |
CN101679507A (en) | 2010-03-24 |
RU2009139922A (en) | 2011-05-10 |
AU2008233173B2 (en) | 2013-09-19 |
BRPI0809209A2 (en) | 2014-09-02 |
JP2010522752A (en) | 2010-07-08 |
IL201184A0 (en) | 2010-05-17 |
MX2009010361A (en) | 2009-10-16 |
WO2008121301A1 (en) | 2008-10-09 |
CA2681752A1 (en) | 2008-10-09 |
AU2008233173A1 (en) | 2008-10-09 |
ZA200906432B (en) | 2015-08-26 |
ZA201203820B (en) | 2013-04-24 |
TW200906854A (en) | 2009-02-16 |
US20120177704A1 (en) | 2012-07-12 |
US8168760B2 (en) | 2012-05-01 |
US20140017256A1 (en) | 2014-01-16 |
RU2012150809A (en) | 2014-06-10 |
KR20100014674A (en) | 2010-02-10 |
JP2014012674A (en) | 2014-01-23 |
EP2527364A1 (en) | 2012-11-28 |
EP2142565A1 (en) | 2010-01-13 |
NZ598881A (en) | 2013-11-29 |
US8940873B2 (en) | 2015-01-27 |
TW201350504A (en) | 2013-12-16 |
US8404819B2 (en) | 2013-03-26 |
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