BG103807A - Антиконвулсантни изохинолил-бензамидни производни - Google Patents

Антиконвулсантни изохинолил-бензамидни производни Download PDF

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Publication number
BG103807A
BG103807A BG103807A BG10380799A BG103807A BG 103807 A BG103807 A BG 103807A BG 103807 A BG103807 A BG 103807A BG 10380799 A BG10380799 A BG 10380799A BG 103807 A BG103807 A BG 103807A
Authority
BG
Bulgaria
Prior art keywords
alkyl
hydrogen
cycloalkyl
disorders
phenyl
Prior art date
Application number
BG103807A
Other languages
Bulgarian (bg)
English (en)
Inventor
Dr. John HARLING
Dr. Barry ORLEK
Dr. Mervyn THOMPSON
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9705620.4A external-priority patent/GB9705620D0/en
Priority claimed from GBGB9726660.5A external-priority patent/GB9726660D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of BG103807A publication Critical patent/BG103807A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
BG103807A 1997-03-18 1999-10-13 Антиконвулсантни изохинолил-бензамидни производни BG103807A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9705620.4A GB9705620D0 (en) 1997-03-18 1997-03-18 Novel compounds
GBGB9726660.5A GB9726660D0 (en) 1997-12-17 1997-12-17 Novel compounds
PCT/GB1998/000781 WO1998041507A1 (en) 1997-03-18 1998-03-16 Anti-convulsant isoquinolyl-benzamide derivatives

Publications (1)

Publication Number Publication Date
BG103807A true BG103807A (bg) 2001-05-31

Family

ID=26311216

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103807A BG103807A (bg) 1997-03-18 1999-10-13 Антиконвулсантни изохинолил-бензамидни производни

Country Status (26)

Country Link
US (1) US6277861B1 (ja)
EP (1) EP0971897A1 (ja)
JP (1) JP2001516357A (ja)
KR (1) KR20000076343A (ja)
CN (1) CN1255917A (ja)
AP (1) AP9901635A0 (ja)
AR (1) AR012078A1 (ja)
AU (1) AU732162B2 (ja)
BG (1) BG103807A (ja)
BR (1) BR9809048A (ja)
CA (1) CA2283682A1 (ja)
CO (1) CO4950554A1 (ja)
DZ (1) DZ2446A1 (ja)
EA (1) EA199900836A1 (ja)
ID (1) ID22730A (ja)
IL (1) IL131958A0 (ja)
MA (1) MA24499A1 (ja)
NO (1) NO313753B1 (ja)
NZ (1) NZ337579A (ja)
OA (1) OA11390A (ja)
PE (1) PE62199A1 (ja)
PL (1) PL335675A1 (ja)
SK (1) SK126799A3 (ja)
TR (1) TR199902282T2 (ja)
TW (1) TW509679B (ja)
WO (1) WO1998041507A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9512298A (en) * 1997-09-30 1999-04-23 Molecular Design International, Inc. Beta3-adrenoreceptor agonists, agonist compositions and methods of using
GB9817424D0 (en) 1998-08-11 1998-10-07 Smithkline Beecham Plc Novel compounds
GB9915589D0 (en) * 1999-07-02 1999-09-01 Smithkline Beecham Plc Novel compounds
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
CN109608325A (zh) * 2018-12-27 2019-04-12 先尼科化工（上海）有限公司 一种卤代苯甲酸衍生物的工业化合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022900A (en) * 1970-09-09 1977-05-10 Marion Laboratories, Inc. Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents
EP0266949B1 (en) * 1986-10-28 1990-11-28 Smith Kline & French Laboratories Limited Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof
US4883593A (en) * 1988-10-27 1989-11-28 Bend Research, Inc. Ultrathin-skinned asymmetric membranes by immiscible solvents treatment
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
HUP9902166A3 (en) * 1996-06-17 2001-01-29 Smithkline Beecham Plc Substituted benzamide derivatives having anticonvulsant activity, preparation and use thereof, pharmaceutical compositions containing these compounds

Also Published As

Publication number Publication date
WO1998041507A1 (en) 1998-09-24
US6277861B1 (en) 2001-08-21
PL335675A1 (en) 2000-05-08
AU732162B2 (en) 2001-04-12
CN1255917A (zh) 2000-06-07
NO994504L (no) 1999-09-17
AR012078A1 (es) 2000-09-27
NZ337579A (en) 2001-04-27
SK126799A3 (en) 2000-05-16
CO4950554A1 (es) 2000-09-01
AP9901635A0 (en) 1999-09-30
KR20000076343A (ko) 2000-12-26
EA199900836A1 (ru) 2000-04-24
NO313753B1 (no) 2002-11-25
PE62199A1 (es) 1999-09-10
AU6412798A (en) 1998-10-12
BR9809048A (pt) 2000-08-01
EP0971897A1 (en) 2000-01-19
MA24499A1 (fr) 1998-10-01
NO994504D0 (no) 1999-09-17
OA11390A (en) 2004-04-14
IL131958A0 (en) 2001-03-19
TR199902282T2 (en) 2000-07-21
CA2283682A1 (en) 1998-09-24
TW509679B (en) 2002-11-11
JP2001516357A (ja) 2001-09-25
ID22730A (id) 1999-12-09
DZ2446A1 (fr) 2003-01-11

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