BG103711A - Съединения, полезни при лечение на възпалителни заболявания - Google Patents
Съединения, полезни при лечение на възпалителни заболявания Download PDFInfo
- Publication number
- BG103711A BG103711A BG103711A BG10371199A BG103711A BG 103711 A BG103711 A BG 103711A BG 103711 A BG103711 A BG 103711A BG 10371199 A BG10371199 A BG 10371199A BG 103711 A BG103711 A BG 103711A
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- carbon atoms
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- alkyl
- hydrogen atom
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- 239000011593 sulfur Substances 0.000 description 1
- 229940032330 sulfuric acid Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- SYUVAXDZVWPKSI-UHFFFAOYSA-N tributyl(phenyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)C1=CC=CC=C1 SYUVAXDZVWPKSI-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- XREXPQGDOPQPAH-QKUPJAQQSA-K trisodium;[(z)-18-[1,3-bis[[(z)-12-sulfonatooxyoctadec-9-enoyl]oxy]propan-2-yloxy]-18-oxooctadec-9-en-7-yl] sulfate Chemical compound [Na+].[Na+].[Na+].CCCCCCC(OS([O-])(=O)=O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O)COC(=O)CCCCCCC\C=C/CC(CCCCCC)OS([O-])(=O)=O XREXPQGDOPQPAH-QKUPJAQQSA-K 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 230000005951 type IV hypersensitivity Effects 0.000 description 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
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Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- C07D207/36—Oxygen or sulfur atoms
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- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
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- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/78—Radicals substituted by oxygen atoms
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
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- C07D263/44—Two oxygen atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US4001197P | 1997-03-03 | 1997-03-03 | |
PCT/US1998/004254 WO1998039303A1 (en) | 1997-03-03 | 1998-03-03 | Small molecules useful in the treatment of inflammatory disease |
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BG103711A true BG103711A (bg) | 2001-09-28 |
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Family Applications (1)
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---|---|---|---|
BG103711A Pending BG103711A (bg) | 1997-03-03 | 1999-09-02 | Съединения, полезни при лечение на възпалителни заболявания |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0966447B1 (sk) |
JP (1) | JP2001513821A (sk) |
KR (1) | KR20000075893A (sk) |
CN (1) | CN1249748A (sk) |
AT (1) | ATE233738T1 (sk) |
AU (1) | AU6541898A (sk) |
BG (1) | BG103711A (sk) |
BR (1) | BR9811260A (sk) |
CA (1) | CA2278547A1 (sk) |
DE (1) | DE69811867T2 (sk) |
DK (1) | DK0966447T3 (sk) |
EA (1) | EA199900758A1 (sk) |
EE (1) | EE9900481A (sk) |
ES (1) | ES2191286T3 (sk) |
HU (1) | HUP0002347A2 (sk) |
IL (1) | IL130931A0 (sk) |
NO (1) | NO994256L (sk) |
PL (1) | PL336580A1 (sk) |
PT (1) | PT966447E (sk) |
SK (1) | SK117499A3 (sk) |
TR (1) | TR199902124T2 (sk) |
WO (1) | WO1998039303A1 (sk) |
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TW200303200A (en) | 2002-02-07 | 2003-09-01 | Tanabe Seiyaku Co | Inhibitors of α L β 2 integrin mediated cell adhesion |
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FR2850652B1 (fr) * | 2003-01-31 | 2008-05-30 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
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US7491743B2 (en) | 2003-08-29 | 2009-02-17 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis |
US7199125B2 (en) | 2003-10-02 | 2007-04-03 | Bristol-Myers Squibb Company | Spiro-cyclic compounds useful as anti-inflammatory agents |
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US7482370B2 (en) * | 2004-07-16 | 2009-01-27 | Schering Corporation | Compounds for the treatment of inflammatory disorders |
RU2007106927A (ru) * | 2004-07-27 | 2008-09-10 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Синтез амидов 6,7,-дигидро-5н-имидазо [1.2-а] имидазол-3-сульфоновой кислоты |
EP1621535A1 (en) * | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
US7375237B2 (en) | 2004-08-18 | 2008-05-20 | Bristol-Myers Squibb Company | Pyrrolizine compounds useful as anti-inflammatory agents |
TW200616634A (en) | 2004-10-01 | 2006-06-01 | Bristol Myers Squibb Co | Crystalline forms and process for preparing spiro-hydantoin compounds |
WO2006051937A1 (ja) * | 2004-11-15 | 2006-05-18 | Shionogi & Co., Ltd. | ヘテロ5員環誘導体 |
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AU2006303955A1 (en) * | 2005-10-11 | 2007-04-26 | Intermune, Inc. | Inhibitors of viral replication |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
PL2225238T3 (pl) | 2007-11-29 | 2015-03-31 | Boehringer Ingelheim Int | Pochodne amidów kwasu 6,7-dihydro-5H-imidazo[1,2-a]imidazolo-3-karboksylowego |
GB2463514C (en) | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
CA2772760A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
ITBO20090078A1 (it) * | 2009-02-13 | 2010-08-14 | Consiglio Nazionale Ricerche | Composti per il trattamento del tumore alla prostata e procedimenti per la loro sintesi |
EA019990B1 (ru) | 2009-06-02 | 2014-07-30 | Бёрингер Ингельхайм Интернациональ Гмбх | ПРОИЗВОДНЫЕ АМИДОВ 6,7-ДИГИДРО-5H-ИМИДАЗО[1,2-a]ИМИДАЗОЛ-3-КАРБОНОВОЙ КИСЛОТЫ |
WO2010141330A1 (en) | 2009-06-02 | 2010-12-09 | Boehringer Ingelheim International Gmbh | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES |
CN102731525A (zh) * | 2011-04-08 | 2012-10-17 | 上海艾力斯医药科技有限公司 | 苯并吗啉衍生物 |
WO2014145022A1 (en) | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
SG11201609664RA (en) * | 2014-06-12 | 2016-12-29 | Allocyte Pharmaceuticals Ag | Small molecule lfa-1 inhibitors |
AU2015360291A1 (en) | 2014-12-11 | 2017-07-13 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
AR102942A1 (es) | 2014-12-11 | 2017-04-05 | Bayer Cropscience Ag | Derivados de arilsulfuro y arilsulfóxido de cinco miembros c-n-conectados, como plaguicidas |
CN113024513A (zh) * | 2021-03-22 | 2021-06-25 | 中国药科大学 | 新型雄激素受体降解剂、制备方法和医药用途 |
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FR2015493A1 (sk) * | 1968-08-12 | 1970-04-30 | Sumitomo Chemical Co | |
DK123717B (da) * | 1968-11-25 | 1972-07-24 | Sumitomo Chemical Co | 3-(3',5'-Dihalogenphenyl)-imidazolidin-2,4-dionderivater med mirobicid virkning. |
DE3382406D1 (de) * | 1982-04-08 | 1991-10-17 | Shell Int Research | Neue hydantoine, ihre herstellung und verwendung. |
IE62214B1 (en) * | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
EP0545478A1 (en) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
TW521073B (en) * | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
-
1998
- 1998-03-03 AT AT98911475T patent/ATE233738T1/de not_active IP Right Cessation
- 1998-03-03 TR TR1999/02124T patent/TR199902124T2/xx unknown
- 1998-03-03 EP EP98911475A patent/EP0966447B1/en not_active Expired - Lifetime
- 1998-03-03 EE EEP199900481A patent/EE9900481A/xx unknown
- 1998-03-03 KR KR1019997007972A patent/KR20000075893A/ko not_active Application Discontinuation
- 1998-03-03 CA CA002278547A patent/CA2278547A1/en not_active Abandoned
- 1998-03-03 IL IL13093198A patent/IL130931A0/xx unknown
- 1998-03-03 ES ES98911475T patent/ES2191286T3/es not_active Expired - Lifetime
- 1998-03-03 JP JP53877298A patent/JP2001513821A/ja not_active Ceased
- 1998-03-03 HU HU0002347A patent/HUP0002347A2/hu unknown
- 1998-03-03 PT PT98911475T patent/PT966447E/pt unknown
- 1998-03-03 DK DK98911475T patent/DK0966447T3/da active
- 1998-03-03 BR BR9811260-0A patent/BR9811260A/pt not_active Application Discontinuation
- 1998-03-03 WO PCT/US1998/004254 patent/WO1998039303A1/en active IP Right Grant
- 1998-03-03 CN CN98803012A patent/CN1249748A/zh active Pending
- 1998-03-03 EA EA199900758A patent/EA199900758A1/ru unknown
- 1998-03-03 SK SK1174-99A patent/SK117499A3/sk unknown
- 1998-03-03 DE DE69811867T patent/DE69811867T2/de not_active Expired - Fee Related
- 1998-03-03 PL PL98336580A patent/PL336580A1/xx unknown
- 1998-03-03 AU AU65418/98A patent/AU6541898A/en not_active Abandoned
-
1999
- 1999-09-02 NO NO994256A patent/NO994256L/no unknown
- 1999-09-02 BG BG103711A patent/BG103711A/bg active Pending
Also Published As
Publication number | Publication date |
---|---|
IL130931A0 (en) | 2001-01-28 |
WO1998039303A1 (en) | 1998-09-11 |
JP2001513821A (ja) | 2001-09-04 |
EP0966447A1 (en) | 1999-12-29 |
NO994256D0 (no) | 1999-09-02 |
ES2191286T3 (es) | 2003-09-01 |
HUP0002347A2 (hu) | 2000-10-28 |
DE69811867D1 (de) | 2003-04-10 |
TR199902124T2 (xx) | 2000-06-21 |
AU6541898A (en) | 1998-09-22 |
NO994256L (no) | 1999-11-02 |
CN1249748A (zh) | 2000-04-05 |
KR20000075893A (ko) | 2000-12-26 |
ATE233738T1 (de) | 2003-03-15 |
BR9811260A (pt) | 2000-08-08 |
PT966447E (pt) | 2003-07-31 |
EA199900758A1 (ru) | 2000-04-24 |
PL336580A1 (en) | 2000-07-03 |
DE69811867T2 (de) | 2003-11-20 |
SK117499A3 (en) | 2000-05-16 |
EE9900481A (et) | 2000-06-15 |
CA2278547A1 (en) | 1998-09-11 |
DK0966447T3 (da) | 2003-06-23 |
EP0966447B1 (en) | 2003-03-05 |
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