BG103687A - Атропизомери на 3-хетероарил-4(3н)-хиназолинони за лечение на нервнодегенеративни процеси и състояния, свързани с травми на цнс - Google Patents

Атропизомери на 3-хетероарил-4(3н)-хиназолинони за лечение на нервнодегенеративни процеси и състояния, свързани с травми на цнс

Info

Publication number
BG103687A
BG103687A BG103687A BG10368799A BG103687A BG 103687 A BG103687 A BG 103687A BG 103687 A BG103687 A BG 103687A BG 10368799 A BG10368799 A BG 10368799A BG 103687 A BG103687 A BG 103687A
Authority
BG
Bulgaria
Prior art keywords
quinazolinones
atropisomers
heteroaryl
treatment
nervous system
Prior art date
Application number
BG103687A
Other languages
English (en)
Inventor
Bertrand Chenard
Keith DEVRIES
Jr. Willard WELCH
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG103687A publication Critical patent/BG103687A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

Изобретението се отнася до нови атропизомери на 3-хетероарил-4(3Н)-хиназолинони с формула@@в която радикалите имат значенията, посочени в описанието,до техните фармацевтично приемливи соли и до фармацевтични състави и методи за лечение на невродегенеративни процеси и състояния, свързани с травми на централната нервна система.
BG103687A 1997-02-28 1999-08-24 Атропизомери на 3-хетероарил-4(3н)-хиназолинони за лечение на нервнодегенеративни процеси и състояния, свързани с травми на цнс BG103687A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3854097P 1997-02-28 1997-02-28
PCT/IB1998/000151 WO1998038187A1 (en) 1997-02-28 1998-02-06 Atropisomers of 3-heteroaryl-4(3h)-quinazolinones for the treatment of neurodegenerative and cns-trauma related conditions

Publications (1)

Publication Number Publication Date
BG103687A true BG103687A (bg) 2000-06-30

Family

ID=21900535

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103687A BG103687A (bg) 1997-02-28 1999-08-24 Атропизомери на 3-хетероарил-4(3н)-хиназолинони за лечение на нервнодегенеративни процеси и състояния, свързани с травми на цнс

Country Status (40)

Country Link
US (1) US6380204B1 (bg)
EP (1) EP0964860B1 (bg)
JP (1) JP3299990B2 (bg)
KR (1) KR20000075812A (bg)
CN (1) CN1248254A (bg)
AP (1) AP9801202A0 (bg)
AR (1) AR011886A1 (bg)
AT (1) ATE264854T1 (bg)
AU (1) AU732448B2 (bg)
BG (1) BG103687A (bg)
BR (1) BR9807807A (bg)
CA (1) CA2282279C (bg)
CO (1) CO4950615A1 (bg)
DE (1) DE69823339T2 (bg)
DK (1) DK0964860T3 (bg)
DZ (1) DZ2438A1 (bg)
EA (1) EA001961B1 (bg)
ES (1) ES2218801T3 (bg)
GT (1) GT199800039A (bg)
HN (1) HN1998000028A (bg)
HR (1) HRP980108B1 (bg)
HU (1) HUP0000935A3 (bg)
ID (1) ID23435A (bg)
IL (1) IL130897A0 (bg)
IS (1) IS5141A (bg)
MA (1) MA24485A1 (bg)
NO (1) NO994178L (bg)
NZ (1) NZ336627A (bg)
OA (1) OA11088A (bg)
PA (1) PA8446901A1 (bg)
PE (1) PE57999A1 (bg)
PL (1) PL335307A1 (bg)
PT (1) PT964860E (bg)
SK (1) SK113199A3 (bg)
TN (1) TNSN98034A1 (bg)
TR (1) TR199902094T2 (bg)
TW (1) TW530055B (bg)
UA (1) UA58536C2 (bg)
WO (1) WO1998038187A1 (bg)
ZA (1) ZA981665B (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―４―オン誘導体の製造方法
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
US7410974B2 (en) * 2003-08-08 2008-08-12 Ulysses Pharmaceutical Products, Inc. Halogenated Quinazolinyl nitrofurans as antibacterial agents
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
TWI409070B (zh) 2005-11-04 2013-09-21 Hydra Biosciences Inc 用於調節ｔｒｐｖ３功能之化合物
AU2007303846B2 (en) * 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
JP2012521994A (ja) * 2009-03-24 2012-09-20 ギリアード カリストガ エルエルシー ２−プリニル−３−トリル−キナゾリノン誘導体のアトロプ異性体および使用方法
JP5718323B2 (ja) * 2009-05-29 2015-05-13 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 放射標識されたｐｄｅ１０阻害剤
US9216177B2 (en) 2011-02-28 2015-12-22 Drexel University Small molecular inhibitors of RAD51 recombinase and methods thereof
AU2021212754A1 (en) 2020-01-29 2022-08-04 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3748325A (en) 1970-04-06 1973-07-24 Karamchand Premchand Private Process for the preparation of quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
WO1992013535A1 (en) * 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
CZ295565B6 (cs) 1996-05-15 2005-08-17 Pfizer Inc. 2,3-Disubstituované 4(3H)-chinazolinony, jejich použití a farmaceutické kompozice na jejich bázi
PT807633E (pt) * 1996-05-15 2003-02-28 Pfizer Novas pirimidin-4-onas substituidas em 2,3, e fundidas com heteroarilo em (5,6)

Also Published As

Publication number Publication date
PL335307A1 (en) 2000-04-10
PE57999A1 (es) 1999-06-21
NO994178D0 (no) 1999-08-27
AU732448B2 (en) 2001-04-26
OA11088A (en) 2002-03-15
EP0964860B1 (en) 2004-04-21
PT964860E (pt) 2004-07-30
NO994178L (no) 1999-08-27
HUP0000935A2 (hu) 2001-04-28
DE69823339T2 (de) 2005-05-12
CN1248254A (zh) 2000-03-22
BR9807807A (pt) 2000-02-22
ES2218801T3 (es) 2004-11-16
TR199902094T2 (xx) 1999-12-21
DZ2438A1 (fr) 2003-01-11
EP0964860A1 (en) 1999-12-22
HUP0000935A3 (en) 2002-04-29
EA001961B1 (ru) 2001-10-22
ATE264854T1 (de) 2004-05-15
AP9801202A0 (en) 1999-08-26
JP3299990B2 (ja) 2002-07-08
KR20000075812A (ko) 2000-12-26
TNSN98034A1 (fr) 2005-03-15
HN1998000028A (es) 1999-02-09
MA24485A1 (fr) 1998-10-01
ID23435A (id) 2000-04-20
CO4950615A1 (es) 2000-09-01
SK113199A3 (en) 2001-10-08
GT199800039A (es) 1999-08-13
NZ336627A (en) 2000-12-22
HRP980108B1 (en) 2004-10-31
EA199900689A1 (ru) 2000-02-28
DE69823339D1 (de) 2004-05-27
CA2282279A1 (en) 1998-09-03
DK0964860T3 (da) 2004-07-26
IL130897A0 (en) 2001-01-28
AU5775998A (en) 1998-09-18
AR011886A1 (es) 2000-09-13
CA2282279C (en) 2004-11-02
UA58536C2 (uk) 2003-08-15
HRP980108A2 (en) 1998-12-31
ZA981665B (en) 1999-08-17
WO1998038187A1 (en) 1998-09-03
US6380204B1 (en) 2002-04-30
PA8446901A1 (es) 2000-05-24
JP2000509732A (ja) 2000-08-02
TW530055B (en) 2003-05-01
IS5141A (is) 1999-07-30

Similar Documents

Publication Publication Date Title
IL267381A (en) A pharmaceutical preparation containing dextromethorphan and quinidine for the treatment of nervous disorders
MX9707980A (es) Derivados de 4-aminoquinazolina, composiciones que los contienen, y uso de los mismos.
UA66825C2 (uk) Азаполіциклічні сполуки, конденсовані з арилом, фармацевтична композиція, спосіб лікування та спосіб зниження нікотинової залежності
AP9701041A0 (en) Pyridylpyrrole compounds.
SI0725779T1 (bg)
AP9701019A0 (en) Phenylamino-substituted tricycle derivatives.
AU4331400A (en) Neurotrophic substituted pyrimidines
BG103687A (bg) Атропизомери на 3-хетероарил-4(3н)-хиназолинони за лечение на нервнодегенеративни процеси и състояния, свързани с травми на цнс
UA48946C2 (uk) Арилалкілдіазинони, спосіб їх одержання (варіанти), фармацевтичний склад, спосіб його одержання та спосіб лікування
ATE381533T1 (de) Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung
BG105962A (bg) Използване на саредутант и неговите фармацевтичноприемливи соли за лечение или предотвратяване на всички разстройства на настроението, разстройства на адаптацията или смесени разстройства безпокойство-депресия
IL115589A0 (en) Use of cck-b antagonists in pharmaceutical compositions
MX9707642A (es) Uso de 2-oxoindol-1-carboxamidas 3-sustituidas y sus sales de base farmaceuticamente aceptables para preparar composiciones para el tratamiento y prevencion de la enfermedad de alzheimer en mamiferos, incluyendo a humanos.
UA42731C2 (uk) Арилалкілтіадіазинони, спосіб їх отримання, фармацевтична композиція, спосіб її отримання, спосіб лікування
MY110149A (en) Compounds for the treatment of neurodegenerative disorders
HUP0100611A2 (hu) Triazin vegyületek, és ilyeneket tartalmazó gyógyszerkészítmények a központi idegrendszer elváltozásainak kezelésére
HU9502848D0 (en) Imidazoloquinoxalinone derivatives as eaa antagonists
IL143382A0 (en) Human adult astrocytes, their preparation and uses thereof
BG105549A (bg) Използване на n-заместени азабициклоалканови производни за лечение на заболявания на централната нервна система
HU9701325D0 (en) New 2,3-benzodiazepine derivatives
WO2004091522A3 (en) Method for treating neurodegenerative disorders
MX9705390A (es) Uso de los 3,4-difenil-cromanos para la fabricacion de una composicion farmaceutica para el tratamiento o profilaxis de desordenes degenerativos cerebrales.
MX9703610A (es) Nuevas (5,6)-heteroaril condensado-pirimidin-4-onas 2,3 disustituidas.
AU2427300A (en) Use of extracts from ginkgo biloba leaves for treating sleep disorders
UA33498A (uk) Спосіб лікування терапевтично резистентних форм шизофренії