PA8446901A1 - Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas - Google Patents

Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas

Info

Publication number
PA8446901A1
PA8446901A1 PA19988446901A PA8446901A PA8446901A1 PA 8446901 A1 PA8446901 A1 PA 8446901A1 PA 19988446901 A PA19988446901 A PA 19988446901A PA 8446901 A PA8446901 A PA 8446901A PA 8446901 A1 PA8446901 A1 PA 8446901A1
Authority
PA
Panama
Prior art keywords
heteroaril
quinazolinones
atropisomers
procedures
formula
Prior art date
Application number
PA19988446901A
Other languages
English (en)
Inventor
Bertrand Leo Chenard
Keith Michael Devries
Welch Jr Willard Mckowan
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8446901A1 publication Critical patent/PA8446901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A ATROPISOMEROS DE 3-HETEROARIL -4(3H)-QUINAZOLINONAS DE LA FORMULA IA; A SUS SALES FARMACEUTICAMENTE ACEPTABLES Y A COMPOSICIONES FARMACEUTICAS Y PROCEDIMIENTOS PARA EL TRATAMIENTO DE AFECCIONES NEURODEGENERATIVAS Y RELACIONADAS CON TRAUMAS DEL SNC.
PA19988446901A 1997-02-28 1998-02-17 Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas PA8446901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3854097P 1997-02-28 1997-02-28

Publications (1)

Publication Number Publication Date
PA8446901A1 true PA8446901A1 (es) 2000-05-24

Family

ID=21900535

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988446901A PA8446901A1 (es) 1997-02-28 1998-02-17 Atropisomeros de 3-heteroaril-4(3h)-quinazolinonas

Country Status (40)

Country Link
US (1) US6380204B1 (es)
EP (1) EP0964860B1 (es)
JP (1) JP3299990B2 (es)
KR (1) KR20000075812A (es)
CN (1) CN1248254A (es)
AP (1) AP9801202A0 (es)
AR (1) AR011886A1 (es)
AT (1) ATE264854T1 (es)
AU (1) AU732448B2 (es)
BG (1) BG103687A (es)
BR (1) BR9807807A (es)
CA (1) CA2282279C (es)
CO (1) CO4950615A1 (es)
DE (1) DE69823339T2 (es)
DK (1) DK0964860T3 (es)
DZ (1) DZ2438A1 (es)
EA (1) EA001961B1 (es)
ES (1) ES2218801T3 (es)
GT (1) GT199800039A (es)
HN (1) HN1998000028A (es)
HR (1) HRP980108B1 (es)
HU (1) HUP0000935A3 (es)
ID (1) ID23435A (es)
IL (1) IL130897A0 (es)
IS (1) IS5141A (es)
MA (1) MA24485A1 (es)
NO (1) NO994178L (es)
NZ (1) NZ336627A (es)
OA (1) OA11088A (es)
PA (1) PA8446901A1 (es)
PE (1) PE57999A1 (es)
PL (1) PL335307A1 (es)
PT (1) PT964860E (es)
SK (1) SK113199A3 (es)
TN (1) TNSN98034A1 (es)
TR (1) TR199902094T2 (es)
TW (1) TW530055B (es)
UA (1) UA58536C2 (es)
WO (1) WO1998038187A1 (es)
ZA (1) ZA981665B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323208B1 (en) * 1997-09-05 2001-11-27 Pfizer Inc Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones
JPH11279158A (ja) * 1998-02-09 1999-10-12 Pfizer Prod Inc キナゾリン―４―オン誘導体の製造方法
US6890930B1 (en) * 1999-09-28 2005-05-10 3-Dimensional Pharmaceuticals, Inc. Quinazolinones
CA2534405A1 (en) * 2003-08-08 2005-02-17 Ulysses Pharmaceutical Products Inc. Halogenated quinazolinyl nitrofurans as antibacterial agents
US20080146562A1 (en) * 2003-08-08 2008-06-19 Ulysses Pharmaceutical Products Inc., Halogenated quinazolinyl nitrofurans as antibacterial agents
GB0416730D0 (en) 2004-07-27 2004-09-01 Novartis Ag Organic compounds
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
TWI409070B (zh) * 2005-11-04 2013-09-21 Hydra Biosciences Inc 用於調節ｔｒｐｖ３功能之化合物
MX2009003673A (es) * 2006-10-04 2009-04-22 Pfizer Prod Inc Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio.
WO2008140750A1 (en) * 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2010111432A1 (en) * 2009-03-24 2010-09-30 Calistoga Pharmaceuticals Inc. Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use
JP5718323B2 (ja) * 2009-05-29 2015-05-13 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 放射標識されたｐｄｅ１０阻害剤
US9216177B2 (en) 2011-02-28 2015-12-22 Drexel University Small molecular inhibitors of RAD51 recombinase and methods thereof
AU2021212754A1 (en) 2020-01-29 2022-08-04 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298603A (en) * 1970-04-06 1972-12-06 Karamchand Premchand Private Quinazolinone derivatives
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
WO1992013535A1 (en) 1991-02-06 1992-08-20 Research Corporation Technologies, Inc. Anticonvulsant substituted quinazolones
ES2184960T3 (es) 1996-05-15 2003-04-16 Pfizer Nuevas pirimidin-4-onas-(5,6)-heteroaril condensadas 2,3 disustituidas.
KR100375155B1 (ko) 1996-05-15 2003-08-19 화이자 인코포레이티드 신규한2,3-이치환된-4(3에이치)-퀴나졸리논

Also Published As

Publication number Publication date
HRP980108B1 (en) 2004-10-31
HN1998000028A (es) 1999-02-09
EA199900689A1 (ru) 2000-02-28
SK113199A3 (en) 2001-10-08
JP2000509732A (ja) 2000-08-02
AP9801202A0 (en) 1999-08-26
AR011886A1 (es) 2000-09-13
AU732448B2 (en) 2001-04-26
PT964860E (pt) 2004-07-30
UA58536C2 (uk) 2003-08-15
EA001961B1 (ru) 2001-10-22
HUP0000935A2 (hu) 2001-04-28
HUP0000935A3 (en) 2002-04-29
NO994178D0 (no) 1999-08-27
IL130897A0 (en) 2001-01-28
DE69823339D1 (de) 2004-05-27
HRP980108A2 (en) 1998-12-31
IS5141A (is) 1999-07-30
ID23435A (id) 2000-04-20
DE69823339T2 (de) 2005-05-12
CA2282279A1 (en) 1998-09-03
EP0964860A1 (en) 1999-12-22
US6380204B1 (en) 2002-04-30
BG103687A (en) 2000-06-30
AU5775998A (en) 1998-09-18
PE57999A1 (es) 1999-06-21
ES2218801T3 (es) 2004-11-16
DZ2438A1 (fr) 2003-01-11
ZA981665B (en) 1999-08-17
BR9807807A (pt) 2000-02-22
EP0964860B1 (en) 2004-04-21
CA2282279C (en) 2004-11-02
CO4950615A1 (es) 2000-09-01
OA11088A (en) 2002-03-15
WO1998038187A1 (en) 1998-09-03
MA24485A1 (fr) 1998-10-01
PL335307A1 (en) 2000-04-10
GT199800039A (es) 1999-08-13
DK0964860T3 (da) 2004-07-26
CN1248254A (zh) 2000-03-22
ATE264854T1 (de) 2004-05-15
KR20000075812A (ko) 2000-12-26
TR199902094T2 (xx) 1999-12-21
NZ336627A (en) 2000-12-22
JP3299990B2 (ja) 2002-07-08
NO994178L (no) 1999-08-27
TW530055B (en) 2003-05-01
TNSN98034A1 (fr) 2005-03-15

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