BG102525A - Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine - Google Patents

Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine

Info

Publication number
BG102525A
BG102525A BG102525A BG10252598A BG102525A BG 102525 A BG102525 A BG 102525A BG 102525 A BG102525 A BG 102525A BG 10252598 A BG10252598 A BG 10252598A BG 102525 A BG102525 A BG 102525A
Authority
BG
Bulgaria
Prior art keywords
alkyl
compound
formulawhere
trifluoromethyl
alkoxy
Prior art date
Application number
BG102525A
Other languages
Bulgarian (bg)
English (en)
Inventor
Keith DEVRIES
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of BG102525A publication Critical patent/BG102525A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG102525A 1995-12-15 1998-06-09 Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine BG102525A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US875395P 1995-12-15 1995-12-15
PCT/IB1996/001076 WO1997022584A1 (en) 1995-12-15 1996-10-11 Processes and intermediates for preparing 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine

Publications (1)

Publication Number Publication Date
BG102525A true BG102525A (en) 1999-05-31

Family

ID=21733469

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102525A BG102525A (en) 1995-12-15 1998-06-09 Method and intermediate compounds for the preparation of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)-methylpiperidine

Country Status (33)

Country Link
EP (1) EP0883607A1 (pl)
JP (1) JP3066083B2 (pl)
KR (1) KR20000064387A (pl)
AP (1) AP708A (pl)
AR (1) AR004368A1 (pl)
AU (1) AU716462B2 (pl)
BG (1) BG102525A (pl)
BR (1) BR9612018A (pl)
CA (1) CA2237647A1 (pl)
CO (1) CO4750831A1 (pl)
CZ (1) CZ180898A3 (pl)
DZ (1) DZ2141A1 (pl)
GT (1) GT199600092A (pl)
HN (1) HN1996000065A (pl)
HR (1) HRP960592A2 (pl)
HU (1) HUP9904275A3 (pl)
IL (3) IL136420A0 (pl)
IS (1) IS4752A (pl)
MA (1) MA24032A1 (pl)
NO (1) NO982712L (pl)
NZ (1) NZ318843A (pl)
OA (1) OA10694A (pl)
PE (1) PE25698A1 (pl)
PL (1) PL197306B1 (pl)
RO (1) RO121382B1 (pl)
RU (1) RU2160731C2 (pl)
SK (1) SK75498A3 (pl)
TN (1) TNSN96153A1 (pl)
TW (1) TW414787B (pl)
UY (1) UY24401A1 (pl)
WO (1) WO1997022584A1 (pl)
YU (1) YU49486B (pl)
ZA (1) ZA9610533B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252081B1 (en) 1998-01-16 2001-06-26 Eisai Co., Ltd. Process for production of donepezil derivative
IL125809A (en) * 1998-08-17 2005-08-31 Finetech Lab Ltd Process and intermediates for production of donepezil and related compounds
US7148354B2 (en) * 2002-07-24 2006-12-12 Dr. Reddy's Laboratories Limited Process for preparation of donepezil
IL150982A (en) 2002-07-30 2007-02-11 Ori Lerman Process for making Donafzil
IL151253A0 (en) * 2002-08-14 2003-04-10 Finetech Lab Ltd Process for production of highly pure donepezil hydrochloride
US6649765B1 (en) 2003-02-12 2003-11-18 Usv Limited, Bsd Marg. Process for the preparation of 1-benzyl-4(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCL)
US6953856B2 (en) 2003-02-12 2005-10-11 Usv, Limited Process for the preparation of 1-benzyl-4-(5,6-dimethoxy-1-indanon)-2-yl) methyl piperidine hydrochloride (Donepezil HCI)
US20070129549A1 (en) * 2003-03-21 2007-06-07 Yatendra Kumar Stable lamotrigine pharmaceutical compositions and processes for their preparation
WO2004099142A1 (en) * 2003-05-05 2004-11-18 Ranbaxy Laboratories Limited Hydrobromide salt of benzyl-piperidylmethyl-indanone and its polymorphs
WO2005003092A1 (en) 2003-07-01 2005-01-13 Hetero Drugs Limited Preparation of intermediates for acetyl cholinesterase inhibitors
CN1280273C (zh) * 2003-11-05 2006-10-18 天津和美生物技术有限公司 合成多奈哌齐及其衍生物的方法
KR20070083679A (ko) 2004-09-29 2007-08-24 케마지스 리미티드 약학적으로 순수한 비정질 도네페닐 염산염의 제조를 위한정제된 도네페질 말레산염의 용도
CN100436416C (zh) * 2005-07-29 2008-11-26 西南合成制药股份有限公司 盐酸多奈哌齐合成工艺
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
AR057910A1 (es) 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar donepezilo
KR20080085195A (ko) * 2006-01-04 2008-09-23 씨아이피엘에이 엘티디. 도네페질의 제조방법 및 중간체
US8247563B2 (en) 2006-12-11 2012-08-21 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
WO2013078608A1 (en) 2011-11-29 2013-06-06 Ziqiang Gu Donepezil pamoate and methods of making and using the same
ES2888074T3 (es) 2013-08-16 2021-12-30 Univ Maastricht Tratamiento del deterioro cognitivo con inhibidor de PDE4

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2642069B1 (fr) * 1989-01-20 1991-04-12 Rhone Poulenc Sante Nouveaux derives du benzopyranne, leur preparation et les compositions pharmaceutiques qui les contiennent
DE4439822A1 (de) * 1994-11-08 1996-08-29 Bayer Ag Verfahren zur Herstellung von Benzyl-piperidylmethyl-indanonen

Also Published As

Publication number Publication date
AP708A (en) 1998-12-04
IL136421A0 (en) 2001-06-14
CO4750831A1 (es) 1999-03-31
IS4752A (is) 1998-05-22
NO982712D0 (no) 1998-06-12
NO982712L (no) 1998-06-12
AP9600892A0 (en) 1997-01-31
HUP9904275A3 (en) 2001-05-28
HRP960592A2 (en) 1998-06-30
CZ180898A3 (cs) 1999-05-12
YU66096A (en) 1999-11-22
UY24401A1 (es) 1997-06-09
YU49486B (sh) 2006-08-17
NZ318843A (en) 2000-01-28
CA2237647A1 (en) 1997-06-26
HUP9904275A2 (hu) 2000-05-28
EP0883607A1 (en) 1998-12-16
DZ2141A1 (fr) 2002-07-23
TW414787B (en) 2000-12-11
KR20000064387A (ko) 2000-11-06
AU7092596A (en) 1997-07-14
SK75498A3 (en) 1999-08-06
GT199600092A (es) 1998-05-12
AU716462B2 (en) 2000-02-24
OA10694A (en) 2001-05-04
ZA9610533B (en) 1998-06-15
AR004368A1 (es) 1998-11-04
JP3066083B2 (ja) 2000-07-17
PE25698A1 (es) 1998-05-21
RO121382B1 (ro) 2007-04-30
MX9804820A (es) 1998-10-31
PL327512A1 (en) 1998-12-21
RU2160731C2 (ru) 2000-12-20
MA24032A1 (fr) 1997-07-01
BR9612018A (pt) 1999-02-17
PL197306B1 (pl) 2008-03-31
TNSN96153A1 (fr) 2005-03-15
JPH11500756A (ja) 1999-01-19
WO1997022584A1 (en) 1997-06-26
HN1996000065A (es) 1997-06-26
IL136420A0 (en) 2001-06-14
IL124452A0 (en) 1998-12-06

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