BG100017A - 4-арилизоиндолови аналгетици - Google Patents
4-арилизоиндолови аналгетици Download PDFInfo
- Publication number
- BG100017A BG100017A BG100017A BG10001795A BG100017A BG 100017 A BG100017 A BG 100017A BG 100017 A BG100017 A BG 100017A BG 10001795 A BG10001795 A BG 10001795A BG 100017 A BG100017 A BG 100017A
- Authority
- BG
- Bulgaria
- Prior art keywords
- compound
- vacuo
- mixture
- mol
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3857193A | 1993-03-26 | 1993-03-26 | |
US9996593A | 1993-07-29 | 1993-07-29 | |
US08/173,586 US5508424A (en) | 1993-03-26 | 1993-12-23 | 4-arylisoindole analgesics |
PCT/US1994/003329 WO1994022823A1 (en) | 1993-03-26 | 1994-03-28 | 4-arylisoindole analgesics |
Publications (1)
Publication Number | Publication Date |
---|---|
BG100017A true BG100017A (bg) | 1996-04-30 |
Family
ID=27365417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG100017A BG100017A (bg) | 1993-03-26 | 1995-09-20 | 4-арилизоиндолови аналгетици |
Country Status (19)
Country | Link |
---|---|
US (1) | US5508424A (cs) |
EP (1) | EP0690842B1 (cs) |
JP (1) | JP3326180B2 (cs) |
CN (1) | CN1123546A (cs) |
AT (1) | ATE174588T1 (cs) |
AU (1) | AU674746B2 (cs) |
BG (1) | BG100017A (cs) |
CA (1) | CA2159071C (cs) |
CZ (1) | CZ248195A3 (cs) |
DE (1) | DE69415307T2 (cs) |
DK (1) | DK0690842T3 (cs) |
ES (1) | ES2126750T3 (cs) |
FI (1) | FI954537A (cs) |
GR (1) | GR3029534T3 (cs) |
HU (1) | HUT74087A (cs) |
NO (1) | NO953785L (cs) |
PL (1) | PL310829A1 (cs) |
SK (1) | SK118295A3 (cs) |
WO (1) | WO1994022823A1 (cs) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5543530A (en) * | 1993-12-23 | 1996-08-06 | Ortho Pharmaceutical Corporation | 4-arylisoindole analgesics |
US5541217A (en) * | 1995-05-17 | 1996-07-30 | Ortho Pharmaceutical Corporation | 4-arylcyclopenta[c]pyrrole analgesics |
US5602167A (en) * | 1995-05-17 | 1997-02-11 | Ortho Pharmaceutical Corporation | 4-arylcyclohepta[c] pyrrole analgesics |
CA2413970A1 (en) * | 2000-06-22 | 2001-12-27 | James D. Burrington | Acylating agents and dispersants for lubricating oil and fuels |
US7135484B2 (en) | 2002-08-14 | 2006-11-14 | Abbott Laboratories | Azabicyclic compounds are central nervous system active agents |
MXPA05001726A (es) * | 2002-08-14 | 2005-05-27 | Abbott Lab | Compuestos azabiciclicos son agentes activos del sistema nervioso central. |
ES2435790T3 (es) | 2004-12-03 | 2013-12-23 | Intervet International B.V. | Piperazinas sustituidas como antagonistas de CB1 |
MX2008009354A (es) * | 2006-01-18 | 2008-09-30 | Schering Corp | Moduladores de receptores cannabinoides. |
WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
NZ582249A (en) * | 2007-06-28 | 2012-06-29 | Intervet Int Bv | Substituted piperazines as cb1 antagonists |
US20100286160A1 (en) * | 2007-06-28 | 2010-11-11 | Intervet Inc. | Substituted piperazines as cb1 antagonists |
CN104513172B (zh) * | 2013-09-30 | 2018-02-02 | 天士力医药集团股份有限公司 | 含有三氟甲基的酰胺生物碱、制备方法及其药物用途 |
RU2019100559A (ru) | 2016-07-14 | 2020-07-14 | Пфайзер Инк. | Новые пиримидиновые карбоксамиды в качестве ингибиторов фермента ванин-1 |
CN112010859B (zh) * | 2019-05-30 | 2022-07-19 | 中国科学院上海药物研究所 | 一种并环化合物、其制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4042707A (en) * | 1976-02-19 | 1977-08-16 | E. I. Du Pont De Nemours And Company | 3α-Arylhydroisoindoles |
US4689329A (en) * | 1986-02-04 | 1987-08-25 | Mcneilab, Inc. | 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates |
FR2676443B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveaux derives de perhydroisoindole et leur preparation. |
FR2676442B1 (fr) * | 1991-05-17 | 1993-08-06 | Rhone Poulenc Rorer Sa | Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent. |
US5216018A (en) * | 1992-02-14 | 1993-06-01 | Du Pont Merck Pharmaceutical Company | Hydroisoindolines and hydroisoquinolines as psychotropic |
DE4230804A1 (de) * | 1992-09-15 | 1994-03-17 | Bayer Ag | 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate |
-
1993
- 1993-12-23 US US08/173,586 patent/US5508424A/en not_active Expired - Lifetime
-
1994
- 1994-03-28 PL PL94310829A patent/PL310829A1/xx unknown
- 1994-03-28 DE DE69415307T patent/DE69415307T2/de not_active Expired - Lifetime
- 1994-03-28 CN CN94192113A patent/CN1123546A/zh active Pending
- 1994-03-28 AT AT94912324T patent/ATE174588T1/de active
- 1994-03-28 JP JP52224794A patent/JP3326180B2/ja not_active Expired - Lifetime
- 1994-03-28 AU AU64933/94A patent/AU674746B2/en not_active Expired
- 1994-03-28 ES ES94912324T patent/ES2126750T3/es not_active Expired - Lifetime
- 1994-03-28 CA CA002159071A patent/CA2159071C/en not_active Expired - Lifetime
- 1994-03-28 HU HU9502793A patent/HUT74087A/hu unknown
- 1994-03-28 WO PCT/US1994/003329 patent/WO1994022823A1/en active IP Right Grant
- 1994-03-28 EP EP94912324A patent/EP0690842B1/en not_active Expired - Lifetime
- 1994-03-28 DK DK94912324T patent/DK0690842T3/da active
- 1994-03-28 SK SK1182-95A patent/SK118295A3/sk unknown
- 1994-03-28 CZ CZ952481A patent/CZ248195A3/cs unknown
-
1995
- 1995-09-20 BG BG100017A patent/BG100017A/bg unknown
- 1995-09-25 NO NO953785A patent/NO953785L/no unknown
- 1995-09-25 FI FI954537A patent/FI954537A/fi not_active Application Discontinuation
-
1999
- 1999-03-01 GR GR990400629T patent/GR3029534T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1994022823A1 (en) | 1994-10-13 |
FI954537A0 (fi) | 1995-09-25 |
HUT74087A (en) | 1996-11-28 |
HU9502793D0 (en) | 1995-11-28 |
AU674746B2 (en) | 1997-01-09 |
CN1123546A (zh) | 1996-05-29 |
AU6493394A (en) | 1994-10-24 |
JPH08509212A (ja) | 1996-10-01 |
JP3326180B2 (ja) | 2002-09-17 |
EP0690842A1 (en) | 1996-01-10 |
PL310829A1 (en) | 1996-01-08 |
FI954537A (fi) | 1995-10-27 |
SK118295A3 (en) | 1996-06-05 |
DE69415307D1 (de) | 1999-01-28 |
CA2159071C (en) | 2005-06-28 |
ATE174588T1 (de) | 1999-01-15 |
DE69415307T2 (de) | 1999-06-17 |
US5508424A (en) | 1996-04-16 |
DK0690842T3 (da) | 1999-08-23 |
CA2159071A1 (en) | 1994-10-13 |
NO953785D0 (no) | 1995-09-25 |
NO953785L (no) | 1995-09-25 |
ES2126750T3 (es) | 1999-04-01 |
CZ248195A3 (en) | 1996-02-14 |
EP0690842B1 (en) | 1998-12-16 |
GR3029534T3 (en) | 1999-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1192165B1 (en) | Substituted heterocycle fused gamma-carbolines | |
BG100017A (bg) | 4-арилизоиндолови аналгетици | |
US5834493A (en) | Indole derivatives as 5-HT1A and/or 5-HT2 ligands | |
CA2068527A1 (en) | Muscarinic receptor antagonists | |
US5409929A (en) | Hydroisoindolines and hydroisoquinolines as psychotropic drugs | |
EP0777650A1 (en) | Biphenylamide derivatives as 5ht 1d? antagonists | |
AU700505B2 (en) | 4-arylisoindole analgesics | |
US4925867A (en) | Hydrocarbon substituted pyrrolidinones, intermediates therefor, and anti-convulsant use thereof | |
US5948807A (en) | Spiroindanamines and Spiroindanimides | |
JP2008523045A (ja) | ニューロンニコチン性アセチルコリン特異的受容体部位に結合し、コリン作動性機能の調節および習慣性障害の治療に有用である1,2,3,3a,8,8a−ヘキサヒドロ−2,7a−ジアダ−シクロペンタ[a]インデン−7−オン誘導体 | |
KR20210104833A (ko) | 치환된 헤테로사이클 융합 감마-카르볼린 합성 | |
US5541217A (en) | 4-arylcyclopenta[c]pyrrole analgesics | |
TW200418838A (en) | Compounds for the treatment of premature ejaculation | |
US5523412A (en) | Intermediates for 4-arylcyclohepta[c]pyrrole analgesics | |
JPS61161279A (ja) | 1,3‐ジ置換テトラヒドロピリジン類 | |
JPS62190156A (ja) | ベンゼン融合β−ジケトシクロアルキレンの対称性O−置換ジオキシム、それらの調製方法およびそれらの薬物への適用 | |
Sup Lee et al. | Asymmetric synthesis of furo-pyrrolo-isoquinoline and furo-indolizino-indole derivatives via a diastereoselective N-acyliminium ion cyclization | |
JPS62270581A (ja) | 3−ジフエニル置換オクタヒドロインドリジン鎮痛性化合物 | |
홍석창 | A novel synthetic method for chiral α, α-dialkylmalonate via phase-transfer catalytic alkylation and its application to total synthesis of (–)-horsfiline | |
JP2822274B2 (ja) | P物質拮抗剤としてのヘテロ原子置換アルキルベンジルアミノキヌクリジン類 | |
Qu | New cyclization reactions of indoles | |
CA2238162A1 (en) | Tricyclic spiro compounds as 5ht1d receptor antagonists | |
Cheesman | The synthesis of 3, 5-disubstituted indolizidines | |
Banini | Palladium-catalyzed syntheses of indoles, pyrroloindoles, quinolines; a base-mediated formation of N-alkoxyindoles, and progress toward the first total synthesis of Echinosulfone A | |
PL198153B1 (pl) | Sposób wytwarzania pochodnych 2-fenylo-3-aminopirydyny |