ES2126750T3 - Analgesicos a base de 4-arilisoindol. - Google Patents

Analgesicos a base de 4-arilisoindol.

Info

Publication number
ES2126750T3
ES2126750T3 ES94912324T ES94912324T ES2126750T3 ES 2126750 T3 ES2126750 T3 ES 2126750T3 ES 94912324 T ES94912324 T ES 94912324T ES 94912324 T ES94912324 T ES 94912324T ES 2126750 T3 ES2126750 T3 ES 2126750T3
Authority
ES
Spain
Prior art keywords
beta
alpha
image
position carbons
double bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94912324T
Other languages
English (en)
Inventor
Richard J Carmosin
John R Carson
Dennis C Liotta
Philip Pitis
Robert B Raffa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Application granted granted Critical
Publication of ES2126750T3 publication Critical patent/ES2126750T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

LOS 4-ARISILISOINDOL DE FORMULA (I) SON ANALGESICOS EFICACES QUE INCLUYEN ESTEROISOMEROS Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, DONDE (II) ES (III), (IV) O (V) ; CON LA CONDICION DE QUE HAYA 0 O 1 UNIONES INSATURADAS EN EL ANILLO DE ISOINDOL, Y CON LA CONDICION DE QUE DONDE EL ESTEROISOMERO ES: A) LOS DIASTEROMEROS 3A{BE},4{BE},7A{BE}, ENTONCES LA DOBLE UNION SE UNE A CARBONOS DE POSICION 5 Y 6 O CARBONOS DE POSICION 6 Y 7; B) LOS DIASTEREOMEROS 3A{BE},4{AL},7A{AL} O 3A{BE},4{AL},7A{BE}, ENTONCES LA DOBLE UNION SE UNE A LOS CARBONOS DE POSICION 5 Y 6; Y C) LOS DIASTEREOMEROS 3A{BE},4{BE},7A{BE}, ENTONCES LA DOBLE UNION SE UNE A LOS CARBONOS DE POSICION 6 Y 7.
ES94912324T 1993-03-26 1994-03-28 Analgesicos a base de 4-arilisoindol. Expired - Lifetime ES2126750T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3857193A 1993-03-26 1993-03-26
US9996593A 1993-07-29 1993-07-29
US08/173,586 US5508424A (en) 1993-03-26 1993-12-23 4-arylisoindole analgesics

Publications (1)

Publication Number Publication Date
ES2126750T3 true ES2126750T3 (es) 1999-04-01

Family

ID=27365417

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94912324T Expired - Lifetime ES2126750T3 (es) 1993-03-26 1994-03-28 Analgesicos a base de 4-arilisoindol.

Country Status (19)

Country Link
US (1) US5508424A (es)
EP (1) EP0690842B1 (es)
JP (1) JP3326180B2 (es)
CN (1) CN1123546A (es)
AT (1) ATE174588T1 (es)
AU (1) AU674746B2 (es)
BG (1) BG100017A (es)
CA (1) CA2159071C (es)
CZ (1) CZ248195A3 (es)
DE (1) DE69415307T2 (es)
DK (1) DK0690842T3 (es)
ES (1) ES2126750T3 (es)
FI (1) FI954537A (es)
GR (1) GR3029534T3 (es)
HU (1) HUT74087A (es)
NO (1) NO953785D0 (es)
PL (1) PL310829A1 (es)
SK (1) SK118295A3 (es)
WO (1) WO1994022823A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543530A (en) * 1993-12-23 1996-08-06 Ortho Pharmaceutical Corporation 4-arylisoindole analgesics
US5541217A (en) * 1995-05-17 1996-07-30 Ortho Pharmaceutical Corporation 4-arylcyclopenta[c]pyrrole analgesics
US5602167A (en) * 1995-05-17 1997-02-11 Ortho Pharmaceutical Corporation 4-arylcyclohepta[c] pyrrole analgesics
CA2413970A1 (en) * 2000-06-22 2001-12-27 James D. Burrington Acylating agents and dispersants for lubricating oil and fuels
WO2004016604A2 (en) * 2002-08-14 2004-02-26 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
US7135484B2 (en) 2002-08-14 2006-11-14 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
CA2589483C (en) 2004-12-03 2013-10-29 Schering Corporation Substituted piperazines as cb1 antagonists
CA2637565A1 (en) * 2006-01-18 2007-07-26 Schering Corporation Cannibinoid receptor modulators
US20100197564A1 (en) * 2007-04-19 2010-08-05 Schering Corporation Diaryl morpholines as cb1 modulators
WO2009005671A2 (en) * 2007-06-28 2009-01-08 Schering Corporation Substituted piperazines as cb1 antagonists
RU2010102478A (ru) * 2007-06-28 2011-08-10 Интэрвэт Интэрнэшнл Б.Ф. (NL) Замещенные пиперазины как антагонисты св1
CN104513172B (zh) * 2013-09-30 2018-02-02 天士力医药集团股份有限公司 含有三氟甲基的酰胺生物碱、制备方法及其药物用途
MA45656A (fr) 2016-07-14 2021-03-24 Pfizer Nouveaux pyrimidine carboxamides utilisées comme inhibiteurs de l'enzyme vanin-1
JP7390401B2 (ja) * 2019-05-30 2023-12-01 シャンハイ インスティテュート オブ マテリア メディカ、チャイニーズ アカデミー オブ サイエンシーズ 縮合環化合物、その製造方法及び用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042707A (en) * 1976-02-19 1977-08-16 E. I. Du Pont De Nemours And Company 3α-Arylhydroisoindoles
US4689329A (en) * 1986-02-04 1987-08-25 Mcneilab, Inc. 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
FR2676442B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2676443B1 (fr) * 1991-05-17 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux derives de perhydroisoindole et leur preparation.
US5216018A (en) * 1992-02-14 1993-06-01 Du Pont Merck Pharmaceutical Company Hydroisoindolines and hydroisoquinolines as psychotropic
DE4230804A1 (de) * 1992-09-15 1994-03-17 Bayer Ag 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate

Also Published As

Publication number Publication date
NO953785L (no) 1995-09-25
CZ248195A3 (en) 1996-02-14
FI954537A0 (fi) 1995-09-25
CA2159071A1 (en) 1994-10-13
DE69415307D1 (de) 1999-01-28
SK118295A3 (en) 1996-06-05
GR3029534T3 (en) 1999-06-30
ATE174588T1 (de) 1999-01-15
HU9502793D0 (en) 1995-11-28
JP3326180B2 (ja) 2002-09-17
EP0690842A1 (en) 1996-01-10
DK0690842T3 (da) 1999-08-23
EP0690842B1 (en) 1998-12-16
WO1994022823A1 (en) 1994-10-13
US5508424A (en) 1996-04-16
NO953785D0 (no) 1995-09-25
FI954537A (fi) 1995-10-27
HUT74087A (en) 1996-11-28
AU674746B2 (en) 1997-01-09
CN1123546A (zh) 1996-05-29
AU6493394A (en) 1994-10-24
CA2159071C (en) 2005-06-28
JPH08509212A (ja) 1996-10-01
BG100017A (bg) 1996-04-30
DE69415307T2 (de) 1999-06-17
PL310829A1 (en) 1996-01-08

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