BE901850A - Composes de pteridine, leur procede de preparation et leur utilisation. - Google Patents

Composes de pteridine, leur procede de preparation et leur utilisation.

Info

Publication number
BE901850A
BE901850A BE0/214588A BE214588A BE901850A BE 901850 A BE901850 A BE 901850A BE 0/214588 A BE0/214588 A BE 0/214588A BE 214588 A BE214588 A BE 214588A BE 901850 A BE901850 A BE 901850A
Authority
BE
Belgium
Prior art keywords
compounds
preparation process
radical
pteridine
pteridine compounds
Prior art date
Application number
BE0/214588A
Other languages
English (en)
Original Assignee
Roehm Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Pharma Gmbh filed Critical Roehm Pharma Gmbh
Publication of BE901850A publication Critical patent/BE901850A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composés de ptéridine de la formule I ou R1 et R2 représentent H, un radical alkyle en C1-C6 éventuellement ramifié ou un radical benzyle, R1 et R2 pouvant former conjoitement avec N, et éventuellement avec un ou deux autres hétéroatomes, un hétérocycle pentagonal ou hexagonal et R1 et R2 pouvant aussi former conjoitement avec N un radical -NH-C(NH2)= NH, et les sels d'addition physiologiquement tolérables, dérivés de ces composés. Les dérivés, qui sont solubles dans l'eau, ont une action diurétique, antikaliurétique, antihypertensive et cardioprotectrice.
BE0/214588A 1984-03-02 1985-02-28 Composes de pteridine, leur procede de preparation et leur utilisation. BE901850A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843407695 DE3407695A1 (de) 1984-03-02 1984-03-02 Pteridinverbindungen mit pharmazeutischer wirksamkeit

Publications (1)

Publication Number Publication Date
BE901850A true BE901850A (fr) 1985-06-17

Family

ID=6229385

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214588A BE901850A (fr) 1984-03-02 1985-02-28 Composes de pteridine, leur procede de preparation et leur utilisation.

Country Status (14)

Country Link
US (1) US4910203A (fr)
JP (1) JPS60202885A (fr)
AT (1) AT392642B (fr)
BE (1) BE901850A (fr)
CA (1) CA1242441A (fr)
CH (1) CH667269A5 (fr)
DD (1) DD235871A5 (fr)
DE (1) DE3407695A1 (fr)
ES (1) ES540684A0 (fr)
FR (1) FR2560598B1 (fr)
GB (2) GB2155923B (fr)
HU (1) HU198301B (fr)
IT (1) IT1183766B (fr)
NL (1) NL8500564A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0574906A3 (fr) * 1992-06-17 1994-04-13 Nisshin Flour Milling Co

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3913142A1 (de) * 1989-04-21 1990-10-31 Roehm Gmbh Pharmazeutisch wirksame pteridinderivate
CN106967069A (zh) * 2017-03-22 2017-07-21 盐城市麦迪科化学品制造有限公司 一种氨苯蝶啶的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3081230A (en) * 1960-09-08 1963-03-12 Smith Kline French Lab Diuretic and antihypertensive triaminoarylpteridines
DE1593762A1 (de) * 1967-02-06 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung von neuen substituierten 1-Phenoxy-2-hydroxy-3-alkylaminopropanen
CA945172A (en) * 1969-02-21 1974-04-09 Imperial Chemical Industries Limited Alkanolamine derivatives
GB1521471A (en) * 1974-06-05 1978-08-16 Randall & Son Ltd J Token-deposit locks
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
US4252809A (en) * 1977-01-03 1981-02-24 Rohm Pharma Gmbh Substituted pteridine compounds and pharmaceutical compositions containing the same
FR2486082A2 (fr) * 1977-01-03 1982-01-08 Roehm Pharma Gmbh Composes de la pteridine et leur application en tant que matieres therapeutiquement actives dans des preparations pharmaceutiques
DE2700073A1 (de) * 1977-01-03 1978-07-13 Roehm Pharma Gmbh Pteridinverbindungen mit pharmazeutischer wirksamkeit
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
FR2456738A2 (fr) * 1978-04-10 1980-12-12 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique
US4285947A (en) * 1980-01-18 1981-08-25 Interx Research Corporation Aldehyde adducts of triamterene
AT370722B (de) * 1981-07-24 1983-04-25 Gerot Pharmazeutika Verfahren zur herstellung von 1-phenoxy-3-amino- 2-propanolen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0574906A3 (fr) * 1992-06-17 1994-04-13 Nisshin Flour Milling Co
US5380724A (en) * 1992-06-17 1995-01-10 Gyogyszerkutato Intezet Kft Piperazine and homopiperazine derivatives, pharmaceutical compositions containing them and process for preparing same

Also Published As

Publication number Publication date
IT1183766B (it) 1987-10-22
ES8601695A1 (es) 1985-12-01
CH667269A5 (de) 1988-09-30
US4910203A (en) 1990-03-20
GB2155923A (en) 1985-10-02
GB2190084A (en) 1987-11-11
AT392642B (de) 1991-05-10
IT8567216A0 (it) 1985-03-01
GB2155923B (en) 1988-12-14
HUT37430A (en) 1985-12-28
FR2560598B1 (fr) 1988-03-18
CA1242441A (fr) 1988-09-27
ES540684A0 (es) 1985-12-01
NL8500564A (nl) 1985-10-01
DE3407695A1 (de) 1985-09-12
ATA25485A (de) 1990-10-15
GB8505277D0 (en) 1985-04-03
HU198301B (en) 1989-09-28
GB8711877D0 (en) 1987-06-24
IT8567216A1 (it) 1986-09-01
DD235871A5 (de) 1986-05-21
JPS60202885A (ja) 1985-10-14
FR2560598A1 (fr) 1985-09-06

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ROHM PHARMA .M.B.H.

Effective date: 19930228