FR2560598B1 - Derives de la 2,4,7-triamino-6-phenyl-pteridine ayant une action diuretique, antikaliuretique, antagoniste du calcium et cardioprotectrice, leur procede et preparation et intermediaires de synthese - Google Patents
Derives de la 2,4,7-triamino-6-phenyl-pteridine ayant une action diuretique, antikaliuretique, antagoniste du calcium et cardioprotectrice, leur procede et preparation et intermediaires de syntheseInfo
- Publication number
- FR2560598B1 FR2560598B1 FR8501624A FR8501624A FR2560598B1 FR 2560598 B1 FR2560598 B1 FR 2560598B1 FR 8501624 A FR8501624 A FR 8501624A FR 8501624 A FR8501624 A FR 8501624A FR 2560598 B1 FR2560598 B1 FR 2560598B1
- Authority
- FR
- France
- Prior art keywords
- antikaliuretic
- cardioprotector
- triamino
- diuretic
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940127291 Calcium channel antagonist Drugs 0.000 title 1
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical class NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 title 1
- 230000003337 anti-kaliuretic effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000480 calcium channel blocker Substances 0.000 title 1
- 239000002934 diuretic Substances 0.000 title 1
- 230000001882 diuretic effect Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843407695 DE3407695A1 (de) | 1984-03-02 | 1984-03-02 | Pteridinverbindungen mit pharmazeutischer wirksamkeit |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2560598A1 FR2560598A1 (fr) | 1985-09-06 |
| FR2560598B1 true FR2560598B1 (fr) | 1988-03-18 |
Family
ID=6229385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8501624A Expired FR2560598B1 (fr) | 1984-03-02 | 1985-02-06 | Derives de la 2,4,7-triamino-6-phenyl-pteridine ayant une action diuretique, antikaliuretique, antagoniste du calcium et cardioprotectrice, leur procede et preparation et intermediaires de synthese |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4910203A (fr) |
| JP (1) | JPS60202885A (fr) |
| AT (1) | AT392642B (fr) |
| BE (1) | BE901850A (fr) |
| CA (1) | CA1242441A (fr) |
| CH (1) | CH667269A5 (fr) |
| DD (1) | DD235871A5 (fr) |
| DE (1) | DE3407695A1 (fr) |
| ES (1) | ES540684A0 (fr) |
| FR (1) | FR2560598B1 (fr) |
| GB (2) | GB2155923B (fr) |
| HU (1) | HU198301B (fr) |
| IT (1) | IT1183766B (fr) |
| NL (1) | NL8500564A (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3913142A1 (de) * | 1989-04-21 | 1990-10-31 | Roehm Gmbh | Pharmazeutisch wirksame pteridinderivate |
| HU214331B (hu) * | 1992-06-17 | 1998-03-02 | Gyógyszerkutató Intézet Kft. | Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| CN106967069A (zh) * | 2017-03-22 | 2017-07-21 | 盐城市麦迪科化学品制造有限公司 | 一种氨苯蝶啶的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3081230A (en) * | 1960-09-08 | 1963-03-12 | Smith Kline French Lab | Diuretic and antihypertensive triaminoarylpteridines |
| DE1593762A1 (de) * | 1967-02-06 | 1972-06-08 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen substituierten 1-Phenoxy-2-hydroxy-3-alkylaminopropanen |
| CA945172A (en) * | 1969-02-21 | 1974-04-09 | Imperial Chemical Industries Limited | Alkanolamine derivatives |
| GB1521471A (en) * | 1974-06-05 | 1978-08-16 | Randall & Son Ltd J | Token-deposit locks |
| DE2503222A1 (de) * | 1975-01-27 | 1976-07-29 | Boehringer Sohn Ingelheim | Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten |
| US4252809A (en) * | 1977-01-03 | 1981-02-24 | Rohm Pharma Gmbh | Substituted pteridine compounds and pharmaceutical compositions containing the same |
| FR2486082A2 (fr) * | 1977-01-03 | 1982-01-08 | Roehm Pharma Gmbh | Composes de la pteridine et leur application en tant que matieres therapeutiquement actives dans des preparations pharmaceutiques |
| DE2700073A1 (de) * | 1977-01-03 | 1978-07-13 | Roehm Pharma Gmbh | Pteridinverbindungen mit pharmazeutischer wirksamkeit |
| FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
| FR2456738A2 (fr) * | 1978-04-10 | 1980-12-12 | Delalande Sa | Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique |
| US4285947A (en) * | 1980-01-18 | 1981-08-25 | Interx Research Corporation | Aldehyde adducts of triamterene |
| AT370722B (de) * | 1981-07-24 | 1983-04-25 | Gerot Pharmazeutika | Verfahren zur herstellung von 1-phenoxy-3-amino- 2-propanolen |
-
1984
- 1984-03-02 DE DE19843407695 patent/DE3407695A1/de not_active Withdrawn
-
1985
- 1985-01-30 AT AT254/85A patent/AT392642B/de not_active IP Right Cessation
- 1985-02-06 FR FR8501624A patent/FR2560598B1/fr not_active Expired
- 1985-02-21 CH CH809/85A patent/CH667269A5/de not_active IP Right Cessation
- 1985-02-25 ES ES540684A patent/ES540684A0/es active Granted
- 1985-02-28 NL NL8500564A patent/NL8500564A/nl not_active Application Discontinuation
- 1985-02-28 DD DD85273645A patent/DD235871A5/de not_active IP Right Cessation
- 1985-02-28 BE BE0/214588A patent/BE901850A/fr not_active IP Right Cessation
- 1985-03-01 JP JP60038974A patent/JPS60202885A/ja active Pending
- 1985-03-01 CA CA000475633A patent/CA1242441A/fr not_active Expired
- 1985-03-01 IT IT67216/85A patent/IT1183766B/it active
- 1985-03-01 HU HU85767A patent/HU198301B/hu not_active IP Right Cessation
- 1985-03-01 GB GB08505277A patent/GB2155923B/en not_active Expired
-
1987
- 1987-05-20 GB GB08711877A patent/GB2190084A/en not_active Withdrawn
-
1988
- 1988-04-20 US US07/185,319 patent/US4910203A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IT1183766B (it) | 1987-10-22 |
| ES8601695A1 (es) | 1985-12-01 |
| CH667269A5 (de) | 1988-09-30 |
| US4910203A (en) | 1990-03-20 |
| GB2155923A (en) | 1985-10-02 |
| GB2190084A (en) | 1987-11-11 |
| AT392642B (de) | 1991-05-10 |
| IT8567216A0 (it) | 1985-03-01 |
| GB2155923B (en) | 1988-12-14 |
| HUT37430A (en) | 1985-12-28 |
| CA1242441A (fr) | 1988-09-27 |
| ES540684A0 (es) | 1985-12-01 |
| NL8500564A (nl) | 1985-10-01 |
| DE3407695A1 (de) | 1985-09-12 |
| ATA25485A (de) | 1990-10-15 |
| GB8505277D0 (en) | 1985-04-03 |
| HU198301B (en) | 1989-09-28 |
| GB8711877D0 (en) | 1987-06-24 |
| BE901850A (fr) | 1985-06-17 |
| IT8567216A1 (it) | 1986-09-01 |
| DD235871A5 (de) | 1986-05-21 |
| JPS60202885A (ja) | 1985-10-14 |
| FR2560598A1 (fr) | 1985-09-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |