FR2622888B1 - Procede perfectionne de synthese de la vinblastine et de la vincristine - Google Patents

Procede perfectionne de synthese de la vinblastine et de la vincristine

Info

Publication number
FR2622888B1
FR2622888B1 FR888810637A FR8810637A FR2622888B1 FR 2622888 B1 FR2622888 B1 FR 2622888B1 FR 888810637 A FR888810637 A FR 888810637A FR 8810637 A FR8810637 A FR 8810637A FR 2622888 B1 FR2622888 B1 FR 2622888B1
Authority
FR
France
Prior art keywords
vinblastine
vincristine
synthesis
improved process
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR888810637A
Other languages
English (en)
Other versions
FR2622888A1 (fr
Inventor
James P Kutney
Lewis S L Choi
Jun Nakano
Hiroki Tsukamoto
Camille A Boulet
Michael Mchugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA000527897A external-priority patent/CA1341261C/fr
Priority claimed from CA000543832A external-priority patent/CA1341262C/fr
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of FR2622888A1 publication Critical patent/FR2622888A1/fr
Application granted granted Critical
Publication of FR2622888B1 publication Critical patent/FR2622888B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR888810637A 1987-01-22 1988-08-05 Procede perfectionne de synthese de la vinblastine et de la vincristine Expired - Fee Related FR2622888B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA000527897A CA1341261C (fr) 1987-01-22 1987-01-22 Procede pour la synthese de 3',4'-anhydrovinblastine, de la vinblastine et de la vincristine
CA000543832A CA1341262C (fr) 1987-08-06 1987-08-06 Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine

Publications (2)

Publication Number Publication Date
FR2622888A1 FR2622888A1 (fr) 1989-05-12
FR2622888B1 true FR2622888B1 (fr) 1994-07-29

Family

ID=25671207

Family Applications (1)

Application Number Title Priority Date Filing Date
FR888810637A Expired - Fee Related FR2622888B1 (fr) 1987-01-22 1988-08-05 Procede perfectionne de synthese de la vinblastine et de la vincristine

Country Status (2)

Country Link
US (1) US5047528A (fr)
FR (1) FR2622888B1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2266607A3 (fr) 1999-10-01 2011-04-20 Immunogen, Inc. Des immunoconjugués pour le traitement des cancers.
JP2003513756A (ja) * 1999-11-12 2003-04-15 アンジオテック ファーマシューティカルズ，インコーポレイテッド 放射性治療と細胞周期インヒビターとの組合せの組成物
JP3808735B2 (ja) * 2001-08-24 2006-08-16 独立行政法人科学技術振興機構 ビンブラスチン合成用中間体類、それらの製法、およびビンブラスチン類の合成方法
CA2511521C (fr) 2002-12-30 2012-02-07 Angiotech International Ag Liberation de medicaments a partir d'une composition polymere a gelification rapide
NZ547370A (en) * 2003-12-04 2010-09-30 Amr Technology Inc Vinca derivatives
WO2005055943A2 (fr) * 2003-12-04 2005-06-23 Amr Technology, Inc. Derives de la vinorelbine
CA2642717C (fr) 2006-02-17 2015-08-18 Novacea, Inc. Traitement de maladies hyperproliferatives avec un n-oxyde d'alcaloide de la pervenche et des analogues correspondants
WO2008033935A2 (fr) * 2006-09-12 2008-03-20 Amr Technology, Inc. Dérivés de la vinorelbine
US8039453B2 (en) * 2006-09-12 2011-10-18 Albany Molecular Research, Inc. Vinca derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (fr) * 1974-12-30 1978-07-21 Anvar
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
HU180924B (en) * 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
FR2443470A1 (fr) * 1978-12-08 1980-07-04 Anvar Nouveau procede de synthese de la vinblastine et de la leurosidine
US4841045A (en) * 1985-03-12 1989-06-20 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4778885A (en) * 1986-09-18 1988-10-18 Allelix Inc. Production of alkaloid dimers using ferric ion
CA1341261C (fr) * 1987-01-22 2001-06-26 James P. Kutney Procede pour la synthese de 3',4'-anhydrovinblastine, de la vinblastine et de la vincristine
CA1341262C (fr) * 1987-08-06 2001-06-26 Camille A. Boulet Nouveau procede de synthese de 3',4'-anhydrovinblastine de la vinblastine et de la vincristine

Also Published As

Publication number Publication date
US5047528A (en) 1991-09-10
FR2622888A1 (fr) 1989-05-12

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Legal Events

Date Code Title Description
ST Notification of lapse