BE904254A - Derives d'ergoline et leurs sels d'addition d'acide. - Google Patents
Derives d'ergoline et leurs sels d'addition d'acide.Info
- Publication number
- BE904254A BE904254A BE0/216288A BE216288A BE904254A BE 904254 A BE904254 A BE 904254A BE 0/216288 A BE0/216288 A BE 0/216288A BE 216288 A BE216288 A BE 216288A BE 904254 A BE904254 A BE 904254A
- Authority
- BE
- Belgium
- Prior art keywords
- acid added
- added salts
- ergolin
- derivatives
- ergolin derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un dérivé d'ergoline répondant à la formule (I) dans laquelle R représente un groupe hétérocyclique pentagonal qui contient au moins un atome d'azote comme hétéro-atome et qui est un groupe monovalent sur son atome d'azote; l'invention concerne également les sels d'addition d'acide pharmaceutiquement acceptables de ce dérivé, présentant des activités anti-hypertensives, vasodilatatrices, anti-ulcère et autres.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3343085 | 1985-02-21 | ||
JP29920385A JPH0699429B2 (ja) | 1985-02-21 | 1985-12-28 | エルゴリン誘導体およびその酸付加塩 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE904254A true BE904254A (fr) | 1986-06-16 |
Family
ID=26372109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/216288A BE904254A (fr) | 1985-02-21 | 1986-02-20 | Derives d'ergoline et leurs sels d'addition d'acide. |
Country Status (13)
Country | Link |
---|---|
US (1) | US4713457A (fr) |
AU (1) | AU591094B2 (fr) |
BE (1) | BE904254A (fr) |
CA (1) | CA1292736C (fr) |
CH (1) | CH666270A5 (fr) |
DE (1) | DE3605676C2 (fr) |
ES (1) | ES8704502A1 (fr) |
FR (1) | FR2577553B1 (fr) |
GB (1) | GB2173189B (fr) |
HU (1) | HU195655B (fr) |
IT (1) | IT1203744B (fr) |
NL (1) | NL8600430A (fr) |
SE (1) | SE466016B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8714767D0 (en) * | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
GB8617907D0 (en) * | 1986-07-22 | 1986-08-28 | Erba Farmitalia | Tetracyclic indole derivatives |
GB8702364D0 (en) * | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
GB9006772D0 (en) * | 1990-03-27 | 1990-05-23 | Erba Carlo Spa | 4-piperidinyl-ergoline derivatives |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH551975A (de) * | 1971-05-19 | 1974-07-31 | Sandoz Ag | Verfahren zur herstellung neuer 6-methyl-8(beta)-(ureidomethyl) ergolen-derivate. |
CH551976A (de) * | 1971-05-19 | 1974-07-31 | Sandoz Ag | Verfahren zur herstellung neuer 6-methyl-8(beta)-(ureidomethyl) ergolen-derivate. |
US4199579A (en) * | 1975-03-14 | 1980-04-22 | Siphar S. A. | Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof |
HU172649B (hu) * | 1975-04-24 | 1978-11-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh biologicheski aktivnykh lizergamidov |
YU39278B (en) * | 1976-12-22 | 1984-10-31 | Lek Tovarna Farmacevtskih | Process for preparing 5-bromo nicotinic acid esters |
DE2802023A1 (de) * | 1977-01-28 | 1978-08-03 | Sandoz Ag | Neue ergotderivate, ihre herstellung und verwendung |
CH628049A5 (en) * | 1977-03-25 | 1982-02-15 | Sandoz Ag | Process for the preparation of ergolene derivatives |
YU216177A (en) * | 1977-09-09 | 1984-02-29 | Rudolf Rucman | Process for preparing 2-bromo ergosine |
US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
FR2421176A1 (fr) * | 1978-03-29 | 1979-10-26 | Sandoz Sa | Nouveaux derives de l'ergot de seigle, leur preparation et leur application comme medicaments |
YU40046B (en) * | 1978-09-04 | 1985-06-30 | Lek Tovarna Farmacevtskih | Process for preparing 2-bromo-9,10-dihydroergosine |
YU40533B (en) * | 1978-09-04 | 1986-02-28 | Lek Tovarna Farmacevtskih | Process for preparing 2-bromoergosinine |
AU526764B2 (en) * | 1978-09-08 | 1983-01-27 | Farmitalia Carlo Erba S.P.A. | Ergoline derivatives |
HU180467B (en) * | 1979-07-12 | 1983-03-28 | Gyogyszerkutato Intezet | Process for producing new ergol-8-ene- and ergoline-sceleted compounds |
GB2056437A (en) * | 1979-08-07 | 1981-03-18 | Erba Farmitalia | Secoergoline derivatives |
NL189462C (nl) * | 1980-04-03 | 1993-04-16 | Erba Carlo Spa | Ergolinederivaten met antiprolactinische en/of antihypertensieve eigenschappen en farmaceutische preparaat daarvan. |
ZA812103B (en) * | 1980-04-03 | 1982-04-28 | Erba Farmitalia | Ergoline derivatives |
DE3101535A1 (de) * | 1981-01-14 | 1982-08-12 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
CH645894A5 (en) * | 1981-02-24 | 1984-10-31 | Sandoz Ag | Ergoline derivatives, their preparation and use |
GB2112382B (en) * | 1981-11-06 | 1985-03-06 | Erba Farmitalia | Ergoline derivatives |
GB2120242A (en) * | 1982-04-30 | 1983-11-30 | Erba Farmitalia | Ergoline derivatives |
HU190105B (en) * | 1983-06-03 | 1986-08-28 | Gyogyszerkutato Intezet | Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts |
DE3309493A1 (de) * | 1983-03-14 | 1984-09-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel |
GB8311679D0 (en) * | 1983-04-28 | 1983-06-02 | Erba Farmitalia | Ergoline derivatives |
PH21123A (en) * | 1983-04-28 | 1987-07-27 | Erba Farmitalia | Ergoline derivatives |
-
1986
- 1986-02-12 GB GB08603442A patent/GB2173189B/en not_active Expired
- 1986-02-13 AU AU53465/86A patent/AU591094B2/en not_active Ceased
- 1986-02-19 CA CA000502188A patent/CA1292736C/fr not_active Expired - Lifetime
- 1986-02-20 SE SE8600786A patent/SE466016B/sv not_active IP Right Cessation
- 1986-02-20 IT IT47672/86A patent/IT1203744B/it active
- 1986-02-20 HU HU86711A patent/HU195655B/hu not_active IP Right Cessation
- 1986-02-20 CH CH682/86A patent/CH666270A5/de not_active IP Right Cessation
- 1986-02-20 NL NL8600430A patent/NL8600430A/nl not_active Application Discontinuation
- 1986-02-20 BE BE0/216288A patent/BE904254A/fr not_active IP Right Cessation
- 1986-02-21 US US06/831,676 patent/US4713457A/en not_active Expired - Fee Related
- 1986-02-21 ES ES552258A patent/ES8704502A1/es not_active Expired
- 1986-02-21 DE DE3605676A patent/DE3605676C2/de not_active Expired - Fee Related
- 1986-02-21 FR FR868602440A patent/FR2577553B1/fr not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IT8647672A0 (it) | 1986-02-20 |
FR2577553B1 (fr) | 1991-06-21 |
CA1292736C (fr) | 1991-12-03 |
ES8704502A1 (es) | 1987-04-16 |
AU591094B2 (en) | 1989-11-30 |
CH666270A5 (de) | 1988-07-15 |
AU5346586A (en) | 1986-08-28 |
SE466016B (sv) | 1991-12-02 |
ES552258A0 (es) | 1987-04-16 |
NL8600430A (nl) | 1986-09-16 |
GB2173189B (en) | 1988-04-27 |
HUT40121A (en) | 1986-11-28 |
IT1203744B (it) | 1989-02-23 |
FR2577553A1 (fr) | 1986-08-22 |
SE8600786L (sv) | 1986-08-22 |
HU195655B (en) | 1988-06-28 |
SE8600786D0 (sv) | 1986-02-20 |
GB2173189A (en) | 1986-10-08 |
US4713457A (en) | 1987-12-15 |
DE3605676C2 (de) | 1998-04-09 |
DE3605676A1 (de) | 1986-09-18 |
GB8603442D0 (en) | 1986-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: MARUKO SEIYAKU CO. LTD Effective date: 19990228 |