BG96041A - Антивирусни тетрахидроимидазо /1,4/ бензодиазепини - Google Patents
Антивирусни тетрахидроимидазо /1,4/ бензодиазепиниInfo
- Publication number
- BG96041A BG96041A BG096041A BG9604192A BG96041A BG 96041 A BG96041 A BG 96041A BG 096041 A BG096041 A BG 096041A BG 9604192 A BG9604192 A BG 9604192A BG 96041 A BG96041 A BG 96041A
- Authority
- BG
- Bulgaria
- Prior art keywords
- 6alkyl
- compounds
- aryl
- amino
- hydrogen
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- XOMOXQVMQKLWHB-UHFFFAOYSA-N 1,2,3,3a-tetrahydroimidazo[4,5-i][1,4]benzodiazepine Chemical class C1=CC2=CN=CC=NC2=C2C1NCN2 XOMOXQVMQKLWHB-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000798 anti-retroviral effect Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Изобретението се отнася до тетрахидроимидазо[1,4] бензодиазепинови съединения с формула в която r1 е с1-6алкил, по желание заместен с арил, с3-6алкинил, с3-6циклоалкил или радикал с формула r2, r3 и r7 означават водород или с1-6алкил, r4 и r5 са водород, с1-6алкил, хало, циано, нитро, трифлуорометил, хидрокси, с1-6алкилокси, амино, моноили ди(с1-6алкил)амино, (с1-6алкил или арил)-карбониламино, r6 е с1-6алкил и х е он, sн или nr16r17. Изобретението се отнася също до техните присъединителни с киселина соли и стереохимичните им изомерни форми, до фармацевтични състави, които ги включват като активни компоненти и до методите за получаването на съединенията и съставите. Съединенията имат антиретровирусна активност. 14 претенции
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40662589A | 1989-09-13 | 1989-09-13 | |
| PCT/EP1990/001546 WO1991004255A1 (en) | 1989-09-13 | 1990-09-06 | Antiviral tetrahydroimidazo[1,4]benzodiazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG96041A true BG96041A (bg) | 1993-12-24 |
| BG60681B1 BG60681B1 (bg) | 1995-12-29 |
Family
ID=23608794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG96041A BG60681B1 (bg) | 1989-09-13 | 1992-03-12 | Антивирусни тетрахидроимидазо [1,4] бензодиазепини |
Country Status (30)
| Country | Link |
|---|---|
| EP (2) | EP0417840B1 (bg) |
| JP (1) | JPH05500053A (bg) |
| KR (1) | KR927003596A (bg) |
| CN (1) | CN1029971C (bg) |
| AP (1) | AP174A (bg) |
| AT (1) | ATE115144T1 (bg) |
| AU (1) | AU635328B2 (bg) |
| BG (1) | BG60681B1 (bg) |
| CA (1) | CA2064782A1 (bg) |
| DE (1) | DE69014784T2 (bg) |
| DK (1) | DK0417840T3 (bg) |
| ES (1) | ES2067652T3 (bg) |
| FI (1) | FI98816C (bg) |
| GR (1) | GR3015270T3 (bg) |
| HU (1) | HUT62297A (bg) |
| IE (1) | IE65357B1 (bg) |
| IL (3) | IL108074A (bg) |
| MA (1) | MA21948A1 (bg) |
| MY (1) | MY106961A (bg) |
| NO (1) | NO300328B1 (bg) |
| NZ (1) | NZ235137A (bg) |
| OA (1) | OA09565A (bg) |
| PT (1) | PT95303B (bg) |
| RO (1) | RO109199B1 (bg) |
| RU (1) | RU2099341C1 (bg) |
| TN (1) | TNSN90121A1 (bg) |
| TW (1) | TW199160B (bg) |
| WO (1) | WO1991004255A1 (bg) |
| YU (1) | YU169090A (bg) |
| ZA (1) | ZA907278B (bg) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ238664A (en) * | 1990-07-06 | 1992-12-23 | Janssen Pharmaceutica Nv | Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions |
| GB9018601D0 (en) * | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
| EP0475231A1 (en) * | 1990-09-10 | 1992-03-18 | F. Hoffmann-La Roche Ag | Benzodiazepines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075206A (en) * | 1977-02-25 | 1978-02-21 | Eli Lilly And Company | Substituted pyrroloquinoxalinones and diones |
| GB8806449D0 (en) * | 1988-03-18 | 1988-04-20 | Janssen Pharmaceutica Nv | Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones |
| IL93136A (en) * | 1989-02-23 | 1995-01-24 | Janssen Pharmaceutica Nv | History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them |
-
1990
- 1990-08-31 NZ NZ235137A patent/NZ235137A/en unknown
- 1990-09-05 YU YU169090A patent/YU169090A/sh unknown
- 1990-09-06 HU HU92816A patent/HUT62297A/hu unknown
- 1990-09-06 ES ES90202369T patent/ES2067652T3/es not_active Expired - Lifetime
- 1990-09-06 KR KR1019920700394A patent/KR927003596A/ko not_active Application Discontinuation
- 1990-09-06 AT AT90202369T patent/ATE115144T1/de not_active IP Right Cessation
- 1990-09-06 RU SU925011526A patent/RU2099341C1/ru active
- 1990-09-06 CA CA002064782A patent/CA2064782A1/en not_active Abandoned
- 1990-09-06 RO RO92-200221A patent/RO109199B1/ro unknown
- 1990-09-06 AU AU62934/90A patent/AU635328B2/en not_active Ceased
- 1990-09-06 DE DE69014784T patent/DE69014784T2/de not_active Expired - Lifetime
- 1990-09-06 EP EP90202369A patent/EP0417840B1/en not_active Expired - Lifetime
- 1990-09-06 WO PCT/EP1990/001546 patent/WO1991004255A1/en active IP Right Grant
- 1990-09-06 JP JP2512169A patent/JPH05500053A/ja active Pending
- 1990-09-06 DK DK90202369.6T patent/DK0417840T3/da active
- 1990-09-06 EP EP90913194A patent/EP0491751A1/en active Pending
- 1990-09-10 MA MA22220A patent/MA21948A1/fr unknown
- 1990-09-11 AP APAP/P/1990/000205A patent/AP174A/en active
- 1990-09-11 MY MYPI90001567A patent/MY106961A/en unknown
- 1990-09-11 IL IL10807490A patent/IL108074A/en not_active IP Right Cessation
- 1990-09-11 IL IL9563890A patent/IL95638A/en not_active IP Right Cessation
- 1990-09-12 IE IE331390A patent/IE65357B1/en not_active IP Right Cessation
- 1990-09-12 ZA ZA907278A patent/ZA907278B/xx unknown
- 1990-09-13 CN CN90107656A patent/CN1029971C/zh not_active Expired - Fee Related
- 1990-09-13 PT PT95303A patent/PT95303B/pt not_active IP Right Cessation
- 1990-09-13 TN TNTNSN90121A patent/TNSN90121A1/fr unknown
- 1990-10-08 TW TW079108420A patent/TW199160B/zh active
-
1992
- 1992-02-07 NO NO920505A patent/NO300328B1/no unknown
- 1992-03-12 FI FI921070A patent/FI98816C/fi not_active IP Right Cessation
- 1992-03-12 BG BG96041A patent/BG60681B1/bg unknown
- 1992-03-13 OA OA60163A patent/OA09565A/fr unknown
-
1993
- 1993-12-17 IL IL10807493A patent/IL108074A0/xx unknown
-
1995
- 1995-03-03 GR GR940403886T patent/GR3015270T3/el unknown
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