BE880815A - Acetals et thioacetals de mercaptoacyl prolines, leur preparation et leur utilisation - Google Patents
Acetals et thioacetals de mercaptoacyl prolines, leur preparation et leur utilisationInfo
- Publication number
- BE880815A BE880815A BE0/198709A BE198709A BE880815A BE 880815 A BE880815 A BE 880815A BE 0/198709 A BE0/198709 A BE 0/198709A BE 198709 A BE198709 A BE 198709A BE 880815 A BE880815 A BE 880815A
- Authority
- BE
- Belgium
- Prior art keywords
- mercaptoacyl
- prolin
- thioacetals
- acetals
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97231478A | 1978-12-22 | 1978-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE880815A true BE880815A (fr) | 1980-06-23 |
Family
ID=25519507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/198709A BE880815A (fr) | 1978-12-22 | 1979-12-21 | Acetals et thioacetals de mercaptoacyl prolines, leur preparation et leur utilisation |
Country Status (31)
| Country | Link |
|---|---|
| JP (1) | JPS5594357A (it) |
| AT (1) | AT374174B (it) |
| AU (1) | AU533149B2 (it) |
| BE (1) | BE880815A (it) |
| CA (1) | CA1132985A (it) |
| CH (1) | CH642065A5 (it) |
| CS (1) | CS215036B2 (it) |
| DD (1) | DD148338A5 (it) |
| DE (1) | DE2951200A1 (it) |
| DK (1) | DK159115C (it) |
| ES (2) | ES8102094A1 (it) |
| FI (1) | FI70886C (it) |
| FR (1) | FR2444669A1 (it) |
| GB (1) | GB2039478B (it) |
| GR (1) | GR78384B (it) |
| HK (1) | HK15684A (it) |
| HU (1) | HU179644B (it) |
| IE (1) | IE49321B1 (it) |
| IL (1) | IL58930A (it) |
| IT (1) | IT1126841B (it) |
| LU (1) | LU82023A1 (it) |
| NL (1) | NL7909246A (it) |
| NO (1) | NO153569C (it) |
| NZ (1) | NZ192449A (it) |
| PH (1) | PH19213A (it) |
| PL (1) | PL133414B1 (it) |
| PT (1) | PT70620A (it) |
| SE (1) | SE451839B (it) |
| SU (1) | SU1115668A3 (it) |
| YU (1) | YU314879A (it) |
| ZA (1) | ZA796720B (it) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2455585A1 (fr) * | 1979-05-04 | 1980-11-28 | Ono Pharmaceutical Co | Derives d'oxoaminoacides, procede de fabrication et composition pharmaceutique |
| US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
| US4291040A (en) * | 1979-10-22 | 1981-09-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
| US4356182A (en) * | 1979-10-22 | 1982-10-26 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines |
| HU184082B (en) * | 1979-12-29 | 1984-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
| US4284624A (en) | 1980-05-02 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Mixed disulfides |
| US4316905A (en) * | 1980-07-01 | 1982-02-23 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of various 4-substituted prolines |
| US4311705A (en) * | 1980-10-06 | 1982-01-19 | E. R. Squibb & Sons, Inc. | Carboxyalkanoyl and hydroxycarbamoylalkanoyl derivatives of substituted prolines |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| US4374131A (en) | 1981-04-27 | 1983-02-15 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinyl-alkanoyl compounds |
| US4416831A (en) | 1981-04-27 | 1983-11-22 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinylalkanoyl compounds |
| US4381297A (en) | 1981-05-04 | 1983-04-26 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
| US4416833A (en) | 1981-05-04 | 1983-11-22 | E. R. Squibb & Sons, Inc. | Substituted carbonyl phosphinyl-alkanoyl compounds |
| US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
| US4560680A (en) * | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| US4452791A (en) * | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
| CA1258853A (en) * | 1982-04-30 | 1989-08-29 | Rudiger D. Haugwitz | Substituted 4-phenoxy prolines |
| US4452790A (en) * | 1982-06-23 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
| US4616005A (en) * | 1982-06-23 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensives |
| US4703043A (en) * | 1982-06-23 | 1987-10-27 | E. R. Squibb & Sons, Inc. | Phosphonyl hydroxyacyl amino acid derivatives as antihypertensive |
| US4567166A (en) * | 1982-07-14 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension |
| US4709046A (en) * | 1983-05-09 | 1987-11-24 | E. R. Squibb & Sons, Inc. | Acylmercaptoalkanoyl and mercaptoalkanoyl spiro compounds |
| CA2021409A1 (en) * | 1989-08-21 | 1991-02-22 | Donald S. Karanewsky | Phosphonate substituted amino or imino acids useful as antihypertensives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046889A (en) * | 1976-02-13 | 1977-09-06 | E. R. Squibb & Sons, Inc. | Azetidine-2-carboxylic acid derivatives |
| US4091024A (en) * | 1976-12-03 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
| IT7851510A0 (it) * | 1977-10-28 | 1978-10-16 | Sandoz Ag | Ammidi di amminoacidi ciclici loro preparazione e loro applicazione quali medicamenti |
| PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
| CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
-
1979
- 1979-12-07 CA CA341,486A patent/CA1132985A/en not_active Expired
- 1979-12-11 ZA ZA00796720A patent/ZA796720B/xx unknown
- 1979-12-11 AU AU53714/79A patent/AU533149B2/en not_active Ceased
- 1979-12-12 IL IL58930A patent/IL58930A/xx unknown
- 1979-12-13 GB GB7942991A patent/GB2039478B/en not_active Expired
- 1979-12-13 GR GR60746A patent/GR78384B/el unknown
- 1979-12-17 CS CS798891A patent/CS215036B2/cs unknown
- 1979-12-18 NZ NZ192449A patent/NZ192449A/en unknown
- 1979-12-19 IE IE2468/79A patent/IE49321B1/en unknown
- 1979-12-19 DE DE19792951200 patent/DE2951200A1/de not_active Ceased
- 1979-12-19 PH PH23434A patent/PH19213A/en unknown
- 1979-12-19 NO NO794181A patent/NO153569C/no unknown
- 1979-12-19 FR FR7931132A patent/FR2444669A1/fr active Granted
- 1979-12-20 AT AT0805479A patent/AT374174B/de active
- 1979-12-20 CH CH1133979A patent/CH642065A5/de not_active IP Right Cessation
- 1979-12-20 SE SE7910550A patent/SE451839B/sv not_active IP Right Cessation
- 1979-12-21 LU LU82023A patent/LU82023A1/de unknown
- 1979-12-21 IT IT51167/79A patent/IT1126841B/it active
- 1979-12-21 YU YU03148/79A patent/YU314879A/xx unknown
- 1979-12-21 ES ES487180A patent/ES8102094A1/es not_active Expired
- 1979-12-21 DD DD79218061A patent/DD148338A5/de not_active IP Right Cessation
- 1979-12-21 HU HU79SU1047A patent/HU179644B/hu not_active IP Right Cessation
- 1979-12-21 PL PL1979220609A patent/PL133414B1/pl unknown
- 1979-12-21 BE BE0/198709A patent/BE880815A/fr not_active IP Right Cessation
- 1979-12-21 FI FI794027A patent/FI70886C/fi not_active IP Right Cessation
- 1979-12-21 SU SU792860149A patent/SU1115668A3/ru active
- 1979-12-21 PT PT70620A patent/PT70620A/pt unknown
- 1979-12-21 NL NL7909246A patent/NL7909246A/nl not_active Application Discontinuation
- 1979-12-21 DK DK550079A patent/DK159115C/da not_active IP Right Cessation
- 1979-12-22 JP JP16747179A patent/JPS5594357A/ja active Pending
-
1980
- 1980-02-20 ES ES488752A patent/ES8103039A1/es not_active Expired
-
1984
- 1984-02-23 HK HK156/84A patent/HK15684A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: E.R. SQUIBB & SONS INC. Effective date: 19911231 |