US4206122A
(en)
*
|
1978-04-14 |
1980-06-03 |
E. R. Squibb & Sons, Inc. |
Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor
|
US4105776A
(en)
*
|
1976-06-21 |
1978-08-08 |
E. R. Squibb & Sons, Inc. |
Proline derivatives and related compounds
|
US4199512A
(en)
*
|
1976-05-10 |
1980-04-22 |
E. R. Squibb & Sons, Inc. |
Compounds for alleviating hypertension
|
US4339600A
(en)
*
|
1976-05-10 |
1982-07-13 |
E. R. Squibb & Sons, Inc. |
Compounds for alleviating angiotensin related hypertension
|
US4091024A
(en)
*
|
1976-12-03 |
1978-05-23 |
E. R. Squibb & Sons, Inc. |
Pyrrolidine and piperidine-2-carboxylic acid derivatives
|
US4192878A
(en)
*
|
1976-12-03 |
1980-03-11 |
E. R. Squibb & Sons, Inc. |
Derivatives of thiazolidinecarboxylic acids and related acids
|
US4237129A
(en)
*
|
1976-12-03 |
1980-12-02 |
E. R. Squibb & Sons, Inc. |
Derivatives of thiazolidinecarboxylic acids and related acids
|
US4116962A
(en)
*
|
1976-12-03 |
1978-09-26 |
E. R. Squibb & Sons, Inc. |
Pyrrolidine and piperidine-2-carboxylic acid derivatives
|
US4198517A
(en)
*
|
1976-12-03 |
1980-04-15 |
E. R. Squibb & Sons, Inc. |
Histidine derivatives
|
US4178291A
(en)
*
|
1976-12-03 |
1979-12-11 |
E. R. Squibb & Sons, Inc. |
Substituted acyl derivatives of amino acids
|
US4175199A
(en)
*
|
1976-12-03 |
1979-11-20 |
E. R. Squibb & Sons, Inc. |
Substituted acyl derivatives of amino acids
|
US4228077A
(en)
*
|
1976-12-03 |
1980-10-14 |
E. R. Squibb & Sons, Inc. |
N-[2-(mercaptoalkyl)-3-mercaptoalkanoyl]-l-tryptophanes
|
US4176235A
(en)
*
|
1976-12-03 |
1979-11-27 |
E. R. Squibb & Sons, Inc. |
Substituted acyl derivatives of amino acids
|
US4206121A
(en)
*
|
1976-12-03 |
1980-06-03 |
E. R. Squibb & Sons, Inc. |
Substituted acyl derivatives of amino acids
|
US4237134A
(en)
*
|
1976-12-03 |
1980-12-02 |
E. R. Squibb & Sons, Inc. |
Derivatives of thiazolidinecarboxylic acids and related acids
|
US4129566A
(en)
*
|
1978-02-15 |
1978-12-12 |
E. R. Squibb & Sons, Inc. |
Derivatives of dehydrocyclicimino acids
|
US4284780A
(en)
*
|
1977-01-17 |
1981-08-18 |
E. R. Squibb & Sons, Inc. |
Amino acid derivatives
|
US4113715A
(en)
*
|
1977-01-17 |
1978-09-12 |
E. R. Squibb & Sons, Inc. |
Amino acid derivatives
|
US4284779A
(en)
*
|
1977-01-17 |
1981-08-18 |
E. R. Squibb & Sons, Inc. |
Amino acid derivatives
|
US4154937A
(en)
*
|
1977-02-11 |
1979-05-15 |
E. R. Squibb & Sons, Inc. |
Hydroxycarbamoylalkylacylpipecolic acid compounds
|
US4151172A
(en)
*
|
1977-08-11 |
1979-04-24 |
E. R. Squibb & Sons, Inc. |
Phosphonoacyl prolines and related compounds
|
IT7851510A0
(it)
*
|
1977-10-28 |
1978-10-16 |
Sandoz Ag |
Ammidi di amminoacidi ciclici loro preparazione e loro applicazione quali medicamenti
|
US4217347A
(en)
*
|
1977-12-27 |
1980-08-12 |
E. R. Squibb & Sons, Inc. |
Method of treating hypertension and medicaments therefor
|
US4154935A
(en)
*
|
1978-02-21 |
1979-05-15 |
E. R. Squibb & Sons, Inc. |
Halogen substituted mercaptoacylamino acids
|
US4241076A
(en)
*
|
1978-02-21 |
1980-12-23 |
E. R. Squibb & Sons, Inc. |
Halogenated substituted mercaptoacylamino acids
|
US4206137A
(en)
*
|
1978-03-27 |
1980-06-03 |
E. R. Squibb & Sons, Inc. |
Thioalkanoylalkanoic acid compounds
|
US4282235A
(en)
*
|
1978-05-22 |
1981-08-04 |
E. R. Squibb & Sons, Inc. |
Derivatives of thiazolidinecarboxylic acids and related acids
|
JPS559058A
(en)
*
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1978-07-06 |
1980-01-22 |
Dainippon Pharmaceut Co Ltd |
1-(3-mercapto-2-methylpropanoyl)prolyl amino acid derivative
|
US4179568A
(en)
*
|
1978-07-31 |
1979-12-18 |
E. R. Squibb & Sons, Inc. |
(N-lower alkyl-3,5-dioxo-3-pyrrolidinyl)thioalkanoylpyrrolidine-and piperidine-carboxylic acid compounds
|
US4316906A
(en)
*
|
1978-08-11 |
1982-02-23 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of substituted prolines
|
US4154934A
(en)
*
|
1978-08-11 |
1979-05-15 |
E. R. Squibb & Sons, Inc. |
Mercaptoacylamino derivatives of heterocyclic carboxylic acids
|
JPS5531022A
(en)
*
|
1978-08-24 |
1980-03-05 |
Yoshitomi Pharmaceut Ind Ltd |
Hydroxamic acid derivative and its preparation
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US4226775A
(en)
*
|
1979-06-01 |
1980-10-07 |
American Cyanamid Company |
Substituted thio-substituted benzyl-propionyl-L-prolines
|
US4695577A
(en)
*
|
1979-08-14 |
1987-09-22 |
University Of Miami |
Anti-hypertensive agents
|
US4698356A
(en)
*
|
1979-08-14 |
1987-10-06 |
University Of Miami |
Anti-hypertensive agents
|
US4690937A
(en)
*
|
1979-08-14 |
1987-09-01 |
University Of Miami |
Anti-hypertensive agents
|
ZA794723B
(en)
*
|
1978-09-11 |
1980-08-27 |
Univ Miami |
Anti-hypertensive agents
|
US4698355A
(en)
*
|
1979-08-14 |
1987-10-06 |
University Of Miami |
Anti-hypertensive agents
|
US4690939A
(en)
*
|
1979-08-14 |
1987-09-01 |
University Of Miami |
Anti-hypertensive agents
|
US4690938A
(en)
*
|
1979-08-14 |
1987-09-01 |
University Of Miami |
Anti-hypertensive agents
|
US4690940A
(en)
*
|
1979-08-14 |
1987-09-01 |
University Of Miami |
Anti-hypertensive agents
|
JPS5829950B2
(ja)
*
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1978-10-05 |
1983-06-25 |
ウェルファイド株式会社 |
環状イミノカルボン酸誘導体およびその塩類
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US4168267A
(en)
*
|
1978-10-23 |
1979-09-18 |
E. R. Squibb & Sons, Inc. |
Phosphinylalkanoyl prolines
|
US4198509A
(en)
*
|
1978-10-30 |
1980-04-15 |
E. R. Squibb & Sons, Inc. |
Mercaptoacylpiperazine carboxylic acid compounds
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US4483861A
(en)
*
|
1978-10-31 |
1984-11-20 |
Santen Pharmaceutical Co., Ltd. |
Antihypertensive sulfur-containing compounds
|
JPS5572169A
(en)
*
|
1978-11-27 |
1980-05-30 |
Tanabe Seiyaku Co Ltd |
Isoquinoline derivative and its preparation
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US4225495A
(en)
*
|
1978-12-07 |
1980-09-30 |
E. R. Squibb & Sons, Inc. |
Pyrrolo or pyrido [2,1-c][1,4] thiazines or thiazepines
|
US4198515A
(en)
*
|
1978-12-08 |
1980-04-15 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of 4,5-dihydro-1H-pyrrole-2-carboxylic acids and 1,4,5,6-tetrahydropyridine-2-carboxylic acids
|
CA1132985A
(fr)
*
|
1978-12-22 |
1982-10-05 |
John Krapcho |
Derives cetal et thiocetal de la mercaptoacyl proline
|
US4311697A
(en)
*
|
1978-12-22 |
1982-01-19 |
E. R. Squibb & Sons, Inc. |
Derivatives of mercaptoacyl prolines and pipecolic acids
|
US4410542A
(en)
*
|
1978-12-30 |
1983-10-18 |
Santen Pharmaceutical Co., Ltd. |
Disulfide compounds
|
CA1138452A
(fr)
*
|
1979-01-15 |
1982-12-28 |
John Krapcho |
Derives carbamate de mercaptoacyl hydroxyprolines
|
US4217359A
(en)
*
|
1979-01-15 |
1980-08-12 |
E. R. Squibb & Sons, Inc. |
Carbamate derivatives of mercaptoacyl hydroxy prolines
|
US4252943A
(en)
*
|
1979-01-15 |
1981-02-24 |
E. R. Squibb & Sons, Inc. |
Carbamate derivatives of mercaptoacyl hydroxy prolines
|
US4181663A
(en)
*
|
1979-01-29 |
1980-01-01 |
E. R. Squibb & Sons, Inc. |
Selenium containing derivatives of proline and pipecolic acid
|
US4186268A
(en)
*
|
1979-01-29 |
1980-01-29 |
E. R. Squibb & Sons, Inc. |
Mercaptoacylpyrrolidine phosphonic acids and related compounds
|
US4297282A
(en)
*
|
1979-03-02 |
1981-10-27 |
Sumitomo Chemical Company, Limited |
Resolution of mercaptopropionic acids
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US4211786A
(en)
*
|
1979-03-08 |
1980-07-08 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyldihydropyrazole carboxylic acid derivatives
|
EP0017390A3
(fr)
*
|
1979-03-23 |
1981-06-24 |
American Home Products Corporation |
Oxo-thiolactones bicycliques, compositions pharmaceutiques les contenant, leurs procédés de préparation et composés utilisables comme produits intermédiaires dans leur préparation
|
FR2455585A1
(fr)
*
|
1979-05-04 |
1980-11-28 |
Ono Pharmaceutical Co |
Derives d'oxoaminoacides, procede de fabrication et composition pharmaceutique
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US4303583A
(en)
*
|
1979-08-13 |
1981-12-01 |
American Home Products Corporation |
1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
|
US4291040A
(en)
*
|
1979-10-22 |
1981-09-22 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines
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US4284561A
(en)
*
|
1979-12-03 |
1981-08-18 |
E. R. Squibb & Sons, Inc. |
Hydroxamic acid derivatives of mercaptoacyl amino acids
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US4308392A
(en)
*
|
1979-12-03 |
1981-12-29 |
E. R. Squibb & Sons, Inc. |
Hydroxamic acid derivatives of mercaptoacyl amino acids
|
US4508729A
(en)
*
|
1979-12-07 |
1985-04-02 |
Adir |
Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
|
US4616031A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
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US4644008A
(en)
*
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1979-12-07 |
1987-02-17 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
US4616029A
(en)
*
|
1979-12-07 |
1986-10-07 |
Adir |
Perhydromdole-2-carboxylic acids as antihypertensives
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US4616030A
(en)
*
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1979-12-07 |
1986-10-07 |
Adir |
Perhydroindole-2-carboxylic acids as antihypertensives
|
GB2065643B
(en)
*
|
1979-12-13 |
1983-08-24 |
Kanegafuchi Chemical Ind |
Optically active n-mercaptoalkanoylamino acids
|
US4599357A
(en)
*
|
1979-12-17 |
1986-07-08 |
Ciba-Geigy Corporation |
1-mercaptoalkanoylindoline-2-carboxylic acids
|
US4296113A
(en)
*
|
1980-01-14 |
1981-10-20 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of keto substituted proline and pipecolic acid
|
US4330548A
(en)
*
|
1980-01-14 |
1982-05-18 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of keto substituted pipecolic acid
|
US4294775A
(en)
*
|
1980-03-03 |
1981-10-13 |
Ethyl Corporation |
Resolution of acylated D,L-alkyl substituted alkanoic acids
|
PT70158A1
(en)
*
|
1980-03-03 |
1982-03-01 |
Univ Miami |
Process for preparing anti-hypertensive agents
|
US4690936A
(en)
*
|
1980-03-05 |
1987-09-01 |
University Of Miami |
Anti-hypertensive agents
|
US4734420A
(en)
*
|
1980-03-05 |
1988-03-29 |
University Of Miami |
Anti-hypertensive agents
|
JPS56139455A
(en)
|
1980-04-02 |
1981-10-30 |
Santen Pharmaceut Co Ltd |
Sulfur-containing acylaminoacid
|
US4350704A
(en)
*
|
1980-10-06 |
1982-09-21 |
Warner-Lambert Company |
Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
|
US4482725A
(en)
*
|
1980-04-03 |
1984-11-13 |
E. R. Squibb & Sons, Inc. |
S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
|
EP0042639B1
(fr)
*
|
1980-06-23 |
1984-08-22 |
E.R. Squibb & Sons, Inc. |
Dérivés azido, imide, amide et amino de mercaptoacylprolines et d'acides pipécoliques doués d' activité hypotensive
|
US4316905A
(en)
*
|
1980-07-01 |
1982-02-23 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of various 4-substituted prolines
|
US4385180A
(en)
*
|
1980-07-01 |
1983-05-24 |
American Home Products Corporation |
10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones
|
US4396773A
(en)
*
|
1980-07-01 |
1983-08-02 |
American Home Products Corporation |
1,1'-[Dithiobis(2-alkyl-1-oxo-3,1-propanediyl)]-bis[2,3-dihydro-1H-indole-2-carboxylic acids and derivatives
|
US4350633A
(en)
*
|
1980-07-01 |
1982-09-21 |
American Home Products Corporation |
N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
|
US4352753A
(en)
*
|
1980-08-11 |
1982-10-05 |
American Home Products Corporation |
3-[[(2,3-Dihydro-1H-indol-2-yl)carbonyl]thio]propanoic (and acetic) acids as intermediates
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US4307110A
(en)
*
|
1980-09-12 |
1981-12-22 |
E. R. Squibb & Sons, Inc. |
Mercaptoacyl derivatives of 3-substituted proline derivatives
|
US4344949A
(en)
*
|
1980-10-03 |
1982-08-17 |
Warner-Lambert Company |
Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
US4559178A
(en)
*
|
1980-10-06 |
1985-12-17 |
American Home Products Corporation |
Resolution of 3-benzoylthio-2-methyl-propanoic acid with (+)-dehydroabietylamine
|
US4374847A
(en)
*
|
1980-10-27 |
1983-02-22 |
Ciba-Geigy Corporation |
1-Carboxyalkanoylindoline-2-carboxylic acids
|
US4479963A
(en)
*
|
1981-02-17 |
1984-10-30 |
Ciba-Geigy Corporation |
1-Carboxyalkanoylindoline-2-carboxylic acids
|
US4532342A
(en)
*
|
1981-02-20 |
1985-07-30 |
Warner-Lambert Company |
N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
|
JPS57142962A
(en)
*
|
1981-02-28 |
1982-09-03 |
Santen Pharmaceut Co Ltd |
Cyclodextrin clathrate compound of sulfur-containing compound
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US4329495A
(en)
*
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1981-05-18 |
1982-05-11 |
Pfizer Inc. |
Enkephalinase enzyme inhibiting compounds
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US4454291A
(en)
*
|
1981-07-20 |
1984-06-12 |
American Home Products Corporation |
N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
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US4454292A
(en)
*
|
1981-07-20 |
1984-06-12 |
American Home Products Corporation |
N-[2-Substituted-1-oxoalkyl]-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
|
US4503043A
(en)
*
|
1981-12-07 |
1985-03-05 |
Warner-Lambert Company |
Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
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US4395556A
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*
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1982-02-04 |
1983-07-26 |
E. R. Squibb & Sons, Inc. |
Nitrobenzofurazan derivatives
|
JPS5910570A
(ja)
*
|
1982-07-08 |
1984-01-20 |
Wakamoto Pharmaceut Co Ltd |
新規イソカルボスチリル誘導体及びその製法
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US4661515A
(en)
*
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1982-07-21 |
1987-04-28 |
Usv Pharmaceutical Corporation |
Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity
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US4508901A
(en)
*
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1982-08-19 |
1985-04-02 |
Eli Lilly And Company |
Quiuolizine and indolizine enzyme inhibitors
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US4404281A
(en)
*
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1982-08-19 |
1983-09-13 |
Eli Lilly And Company |
Process for enzyme inhibitors
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US4404282A
(en)
*
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1982-08-19 |
1983-09-13 |
Eli Lilly And Company |
Process for enzyme inhibitor
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US4826812A
(en)
*
|
1982-12-27 |
1989-05-02 |
Schering Corporation |
Antiglaucoma agent
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EP0114333B1
(fr)
*
|
1982-12-27 |
1990-08-29 |
Schering Corporation |
Composition pharmaceutique
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US4552889A
(en)
*
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1983-06-09 |
1985-11-12 |
Eli Lilly And Company |
3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
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US4594431A
(en)
*
|
1983-08-01 |
1986-06-10 |
Eli Lilly Company |
Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors
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US4675408A
(en)
*
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1983-08-01 |
1987-06-23 |
Eli Lilly And Company |
Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors
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US4602028A
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*
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1983-12-14 |
1986-07-22 |
Hoechst-Roussel Pharmaceuticals, Inc. |
Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids
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KR870001570B1
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1984-12-19 |
1987-09-04 |
보령제약 주식회사 |
피롤리딘 유도체의 제조방법
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KR870001569B1
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1985-02-11 |
1987-09-04 |
보령제약 주식회사 |
피롤리딘 유도체의 제조방법
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1985-03-22 |
1988-08-09 |
Syntex (U.S.A.) Inc. |
N',N"-dialkylguanidino dipeptides
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1985-10-09 |
1987-04-07 |
Merck & Co., Inc. |
Ace inhibitors in macular degeneration
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US4738850A
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1986-05-27 |
1988-04-19 |
E. R. Squibb & Sons, Inc. |
Controlled release formulation and method
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FR2607004B1
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*
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1986-11-20 |
1990-06-01 |
Synthelabo |
Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine
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JPH0657707B2
(ja)
*
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1987-05-25 |
1994-08-03 |
吉富製薬株式会社 |
ピペリジン化合物
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1987-10-07 |
1989-10-03 |
Marion Laboratories, Inc. |
Captopril and diltiazem composition and the like
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US4931430A
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1987-12-14 |
1990-06-05 |
E. R. Squibb & Sons, Inc. |
Method for preventing or treating anxiety employing an ACE inhibitor
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*
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1988-06-15 |
1994-10-18 |
Brigham And Women's Hospital |
S-nitroso derivatives of ace inhibitors and the use thereof
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US5025001A
(en)
*
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1988-06-15 |
1991-06-18 |
Brigham And Women's Hospital |
S-nitroso derivatives of ACE inhibitors and the use thereof
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US5187183A
(en)
*
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1988-06-15 |
1993-02-16 |
Brigham & Women's Hospital |
S-nitroso derivatives of ACE inhibitors and the use thereof
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US5002964A
(en)
*
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1988-06-15 |
1991-03-26 |
Brigham & Women's Hospital |
S-nitrosocaptopril compounds and the use thereof
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*
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1988-09-13 |
1992-11-24 |
Sepracor, Inc. |
Methods for preparing captopril and its analogues
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IL91581A
(en)
*
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1988-09-13 |
1993-07-08 |
Sepracor Inc |
Methods for preparing optically active captopril and its analogues
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US5093129A
(en)
*
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1989-01-30 |
1992-03-03 |
E. R. Squibb & Sons, Inc. |
Method for treating addiction to a drug of abuse employing an ace inhibitor
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