BE2016C045I2 - - Google Patents

Info

Publication number
BE2016C045I2
BE2016C045I2 BE2016C045C BE2016C045C BE2016C045I2 BE 2016C045 I2 BE2016C045 I2 BE 2016C045I2 BE 2016C045 C BE2016C045 C BE 2016C045C BE 2016C045 C BE2016C045 C BE 2016C045C BE 2016C045 I2 BE2016C045 I2 BE 2016C045I2
Authority
BE
Belgium
Application number
BE2016C045C
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BE2016C045I2 publication Critical patent/BE2016C045I2/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
BE2016C045C 2005-12-13 2016-08-31 BE2016C045I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74995305P 2005-12-13 2005-12-13
US80194806P 2006-05-19 2006-05-19

Publications (1)

Publication Number Publication Date
BE2016C045I2 true BE2016C045I2 (fr) 2026-02-02

Family

ID=38008638

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2016C045C BE2016C045I2 (fr) 2005-12-13 2016-08-31

Country Status (24)

Country Link
US (2) US7838638B2 (fr)
EP (4) EP2481753B1 (fr)
JP (1) JP5063612B2 (fr)
KR (1) KR101158959B1 (fr)
CN (1) CN101326195B9 (fr)
AU (1) AU2006325860B2 (fr)
BE (1) BE2016C045I2 (fr)
BR (1) BRPI0619792B1 (fr)
CA (1) CA2631938C (fr)
CY (3) CY1113097T1 (fr)
DK (2) DK1963368T6 (fr)
EA (1) EA014298B1 (fr)
ES (2) ES2672221T3 (fr)
HR (2) HRP20120606T4 (fr)
HU (2) HUE039353T2 (fr)
IL (1) IL191217A (fr)
LT (2) LT2481753T (fr)
LU (1) LU93189I2 (fr)
NO (2) NO340827B1 (fr)
PL (2) PL2481753T3 (fr)
PT (2) PT2481753T (fr)
RS (2) RS57255B1 (fr)
SI (2) SI1963368T1 (fr)
WO (1) WO2007070750A1 (fr)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070269428A1 (en) 2003-11-21 2007-11-22 Celltech R&D Limited Method for the Treatment of Multiple Sclerosis by Inhibiting Il-17 Activity
CN101326195B9 (zh) * 2005-12-13 2022-11-11 伊莱利利公司 抗il-17抗体
US7790163B2 (en) 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
US20070218065A1 (en) 2006-03-10 2007-09-20 Jaspers Stephen R Antibodies that bind both il-17a and il-17f and methods of using the same
TW200815469A (en) 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) * 2006-06-29 2006-08-09 Ucb Sa Biological products
CA2660463C (fr) 2006-08-11 2013-07-16 Schering Corporation Anticorps diriges contre l'il-17a
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
IN2009DN05758A (fr) 2007-03-12 2015-07-24 Esbatech Ag
KR101530723B1 (ko) 2007-06-25 2015-06-22 에스바테크 - 어 노바티스 컴파니 엘엘씨 단일 쇄 항체의 서열에 기초한 공학처리 및 최적화
US20090074780A1 (en) * 2007-06-25 2009-03-19 David Urech Methods of modifying antibodies, and modified antibodies with improved functional properties
US20110300154A1 (en) * 2007-08-21 2011-12-08 Children's Medical Center Corporation Treatment of airway hyperreactivity
WO2009082624A2 (fr) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonistes de il-17a, il-17f et il-23 et procédés d'utilisation de ceux-ci
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
SG10201608871XA (en) 2008-05-05 2016-12-29 Novimmune Sa Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof
JP5581323B2 (ja) * 2008-09-29 2014-08-27 ロシュ グリクアート アクチェンゲゼルシャフト ヒトil17に対する抗体およびその使用
AU2009314111A1 (en) * 2008-11-12 2010-05-20 Merck Sharp & Dohme Corp. BetaGI-IgG intron for enhanced anti-IGF1 R expression
WO2010062857A1 (fr) 2008-11-26 2010-06-03 Allergan, Inc. Inhibiteur à base d'anticorps de klk-13 pour traiter une kératoconjonctivite sèche
WO2010062858A1 (fr) * 2008-11-26 2010-06-03 Allergan, Inc. Anticorps inhibiteur d’il-17 pour traiter la sécheresse oculaire
EP2403531A4 (fr) 2009-03-05 2013-02-27 Abbott Lab Protéines de liaison à il-17
CA2759848C (fr) 2009-05-05 2018-12-04 Novimmune S.A. Anticorps anti-il-17f et leurs methodes d'utilisation
WO2011053763A2 (fr) 2009-10-30 2011-05-05 Centocor Ortho Biotech Inc. Antagonistes de l'il-17a
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
EP2552967A4 (fr) * 2010-04-02 2014-10-08 Amunix Operating Inc Protéines de fusion liantes, conjugués protéines de fusion liantes-médicaments, conjugués xten-médicaments et procédés pour les préparer et les utiliser
EP2569335B1 (fr) * 2010-05-14 2018-08-22 Orega Biotech Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17
BR112013002831A2 (pt) * 2010-08-05 2016-11-01 Anaptysbio Inc anticorpos direcionados contra a il-17
TW201302793A (zh) * 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
PH12013500660B1 (en) * 2010-10-08 2017-10-27 Novartis Ag Methods of treating psoriasis using il-17 antagonists
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
SG10201510762YA (en) 2011-01-14 2016-01-28 Ucb Pharma Sa Antibody molecules which bind il-17a and il-17f
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
US9943594B2 (en) 2011-10-11 2018-04-17 Sanofi Biotechnology Methods for the treatment of rheumatoid arthritis
CA2856252A1 (fr) 2011-11-21 2013-05-30 Novartis Ag Procedes de traitement du rhumatisme psoriasique (psa) utilisant des antagonistes d'il-17 et des alleles repondeurs ou non repondeurs a psa
US9284283B2 (en) 2012-02-02 2016-03-15 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating IL-17
AU2013230490B2 (en) 2012-03-07 2017-04-13 Eli Lilly And Company IL-17 antibody formulation
EP2838560A2 (fr) 2012-04-20 2015-02-25 Novartis AG Procédés de traitement de la spondylarthrite ankylosante en utilisant des antagonistes de il-17
AR090626A1 (es) 2012-04-20 2014-11-26 Lilly Co Eli Anticuerpos anti-baff-anti-il-17 biespecificos
US8945553B2 (en) * 2012-05-22 2015-02-03 Bristol-Myers Squibb Company Bispecific antibodies to IL-23 and IL-17A/F
US9676847B2 (en) 2012-06-25 2017-06-13 Orega Biotech IL-17 antagonist antibodies
WO2014066726A2 (fr) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Composés pour la modulation d'il-17
HK1215174A1 (zh) * 2012-11-29 2016-08-19 Bayer Healthcare Llc 針對活化蛋白c的人源化單克隆抗體及其用途
LT2953969T (lt) * 2013-02-08 2019-12-10 Novartis Ag Anti-il-17a antikūnai ir jų panaudojimas autoimuninių ir uždegiminių ligų gydymui
TW201444867A (zh) 2013-03-08 2014-12-01 Lilly Co Eli 抗tnf-抗il-17雙特異性抗體
WO2014155278A2 (fr) 2013-03-26 2014-10-02 Novartis Ag Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'il -17
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US20150004133A1 (en) * 2013-06-07 2015-01-01 The Regents Of The University Of California Compositions And Methods For Treating Steatohepatitis, Liver Fibrosis, and Hepatocellular Carcinoma (HCC)
US9603882B2 (en) 2013-08-13 2017-03-28 Industrial Technology Research Institute Method for modulating Th17 cells and method for treating a disease related to modulation of Th17 cells
EP4223312A1 (fr) 2013-08-15 2023-08-09 Novartis AG Procédés de traitement du psoriasis en plaques à l'aide d'antagonistes de l'il-17
CA2929662C (fr) 2013-11-18 2023-05-02 Shanghai Hengrui Pharmaceutical Co., Ltd. Conjugue de il-17a et utilisations associees
WO2015099167A1 (fr) * 2013-12-27 2015-07-02 国立大学法人大阪大学 Vaccin ciblant l'il-17a
BR112016015140A2 (pt) 2013-12-30 2018-01-23 Epimab Biotherapeutics Inc. imunoglobulina com fabs in-tandem e usos das mesmas
JP2017507939A (ja) 2014-02-21 2017-03-23 ジェネンテック, インコーポレイテッド 抗il−13/il−17二重特異性抗体及びその使用
RU2577228C2 (ru) * 2014-03-14 2016-03-10 Закрытое Акционерное Общество "Биокад" Анти-il-17-антитела, способ их получения и способ применения
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
MX2017003216A (es) 2014-09-10 2017-05-23 Novartis Ag Uso de antagonistas de il-17 para inhibir la progresion del daño estructural en pacientes con artritis psoriasica.
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
TWI716362B (zh) 2014-10-14 2021-01-21 瑞士商諾華公司 針對pd-l1之抗體分子及其用途
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
CN108064235A (zh) 2015-01-12 2018-05-22 阿菲博迪公司 Il-17a结合多肽
WO2016123329A2 (fr) 2015-01-28 2016-08-04 Genentech, Inc. Marqueurs d'expression génique et traitement de la sclérose en plaques
CN106336459B (zh) * 2015-07-13 2020-12-08 三生国健药业(上海)股份有限公司 抗人白细胞介素-17a单克隆抗体、其制备方法和应用
BR112017025264A2 (pt) 2015-07-16 2018-08-07 Lilly Co Eli tratamento de prurido
EP3878465A1 (fr) 2015-07-29 2021-09-15 Novartis AG Polythérapies comprenant des molécules d'anticorps tim-3
US20180222982A1 (en) 2015-07-29 2018-08-09 Novartis Ag Combination therapies comprising antibody molecules to pd-1
DK3317301T3 (da) 2015-07-29 2021-06-28 Immutep Sas Kombinationsterapier omfattende antistofmolekyler mod lag-3
US11077187B2 (en) 2015-11-17 2021-08-03 Oklahoma Medical Research Foundation Epitope of optimized humanized monoclonal antibodies against activated protein C and uses thereof
WO2017106656A1 (fr) 2015-12-17 2017-06-22 Novartis Ag Molécules d'anticorps anti-pd-1 et leurs utilisations
RU2767329C2 (ru) 2016-02-06 2022-03-17 Эпимаб Биотерапьютикс, Инк. Иммуноглобулин с тандемными fab-фрагментами и варианты его применения
CN107488227A (zh) * 2016-06-12 2017-12-19 三生国健药业(上海)股份有限公司 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用
WO2017221174A1 (fr) 2016-06-22 2017-12-28 Novartis Ag Méthodes de traitement du vitiligo à l'aide d'anticorps de l'interleukine-17 (il -17)
WO2018015880A1 (fr) 2016-07-19 2018-01-25 Novartis Ag Procédés de traitement du psoriasis de type en plaques d'apparition récente au moyen d'antagonistes de l'il-17
KR102329490B1 (ko) * 2016-09-14 2021-11-23 베이징 한미 파마슈티컬 컴퍼니 리미티드 Il-17a에 특이적으로 결합하는 항체 및 그의 기능성 단편
JP2019505516A (ja) 2016-11-28 2019-02-28 ノバルティス アーゲー インターロイキン−17(il−17)アンタゴニストを使用してざ瘡を治療する方法
PE20191548A1 (es) 2017-02-10 2019-10-24 Genentech Inc Anticuerpos contra triptasa, composiciones de estos y usos de estos
WO2018158741A1 (fr) 2017-03-03 2018-09-07 Novartis Ag Modification de la maladie du psoriasis suite à un traitement à long terme avec un antagoniste de l'il-17
CN110582512B (zh) 2017-03-10 2022-08-30 苏州鑫康合生物医药科技有限公司 针对il-17a和il-17f二者的单克隆抗体及其用途
US10941178B2 (en) * 2017-03-17 2021-03-09 Gilead Sciences, Inc. Method of purifying an antibody
US10676522B2 (en) 2017-05-05 2020-06-09 Novartis Ag Methods of selectively treating asthma using IL-17 antagonists
CA3065553A1 (fr) 2017-06-18 2018-12-27 Kindred Biosciences, Inc. Anticorps et antagonistes d'il17a a usage veterinaire
WO2019027828A1 (fr) 2017-08-04 2019-02-07 Eli Lilly And Company Schéma posologique d'anticorps anti-il-17
EP3672988A1 (fr) 2017-08-23 2020-07-01 Eli Lilly and Company Traitement du psoriasis génital
WO2019087133A1 (fr) 2017-11-02 2019-05-09 Novartis Ag Procédé de traitement d'une tendinopathie à l'aide de l'interleukine-17 (il-17)
WO2019091449A1 (fr) * 2017-11-10 2019-05-16 江苏恒瑞医药股份有限公司 Anticorps cd96, fragment de liaison à l'antigène de celui-ci et utilisation pharmaceutique associée
KR102048475B1 (ko) * 2017-11-10 2019-11-26 주식회사 와이바이오로직스 IL-17A (Interleukin-17A)에 특이적으로 결합하는 항체 및 이의 용도
US20200277369A1 (en) 2017-11-20 2020-09-03 Novartis Ag Method of treating hidradentitis suppurativa with il-17 antagonists
BR112020010579A2 (pt) 2017-11-30 2020-11-10 Novartis Ag receptor de antígeno quimérico de alvejamento de bcma e usos do mesmo
US11619832B2 (en) 2018-03-08 2023-04-04 Coopervision International Limited Identification of contact lens wearers predisposed to contact lens discomfort
MX2020011588A (es) 2018-05-03 2020-12-07 Shanghai Epimab Biotherapeutics Co Ltd Anticuerpos de alta afinidad a pd-1 y lag-3 y proteinas de union bispecificas preparadas a partir de las mismas.
US12110323B2 (en) 2018-05-17 2024-10-08 Jiangsu Qyuns Therapeutics Co., Ltd. Anti-human interleukin 17A monoclonal antibody and application thereof
UY38251A (es) 2018-06-01 2019-12-31 Novartis Ag Moléculas de unión contra bcma y usos de las mismas
GB201810327D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to IL-17
AU2019329958B2 (en) 2018-08-29 2025-05-29 Regeneron Pharmaceuticals, Inc. Methods and compositions for treating subjects having rheumatoid arthritis
US12473357B2 (en) 2018-09-25 2025-11-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of antagonists of Th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma
CN111018974B (zh) * 2018-10-10 2022-04-01 东莞市朋志生物科技有限公司 一种抗人心肌肌钙蛋白i的重组抗体
GB201820316D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for IL-17
CN109369806B (zh) * 2019-01-14 2019-04-19 迈威(上海)生物科技有限公司 苏金单抗制品中半胱氨酸化变异体的去除方法
JP7525499B2 (ja) 2019-01-31 2024-07-30 ヌマブ セラピューティクス アクチェンゲゼルシャフト TNFα及びIL-17Aに対する特異性を有する多重特異性抗体、IL-17Aを標的とする抗体、及びそれらの使用方法
EP3689907A1 (fr) 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
BR112021014377A2 (pt) 2019-01-31 2021-12-28 Regeneron Pharma Composições e métodos para o tratamento de artrite idiopática juvenil
KR102735988B1 (ko) 2019-02-18 2024-12-03 일라이 릴리 앤드 캄파니 치료 항체 제제
AU2020261431A1 (en) 2019-04-24 2021-12-09 Regeneron Pharmaceuticals, Inc. Methods of diagnosis and treatment of rheumatoid arthritis
KR102400401B1 (ko) * 2019-05-22 2022-05-24 (주)셀인바이오 항염증 펩타이드 및 항염증 조성물
EP3980459A1 (fr) 2019-06-04 2022-04-13 Sanofi Biotechnology Compositions et procédés de traitement de la douleur chez des sujets atteints de polyarthrite rhumatoïde
MY205369A (en) 2019-07-26 2024-10-17 Sinocelltech Ltd Humanized anti-il17a antibody and use thereof
EP4006053A4 (fr) 2019-07-30 2022-10-26 Jiangsu Hengrui Medicine Co., Ltd. Méthode de traitement d'une maladie auto-immune par un antagoniste de l'il-17
US12497449B2 (en) 2019-09-20 2025-12-16 Novartis Ag Methods of treating autoimmune diseases using interleukin-17 (IL-17) antagonists
EP4045641A1 (fr) 2019-10-15 2022-08-24 Eli Lilly and Company Lignées cellulaires mammifères déficientes en lipase/estérase modifiées par recombinaison
AU2020386669A1 (en) 2019-11-19 2022-06-02 Novartis Ag Methods of treating Lupus Nephritis using interleukin-17 (IL-17) antagonists
EP4069737A2 (fr) 2019-12-06 2022-10-12 Novartis AG Procédés de traitement de lichen plan à l'aide d'antagonistes de l'interleukine 17 (il-17)
GB201918558D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
WO2021123767A1 (fr) 2019-12-16 2021-06-24 Bicycletx Limited Ligands peptidiques bicycliques spécifiques de l'il-17
GB201918559D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201918557D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201919062D0 (en) * 2019-12-20 2020-02-05 Ucb Biopharma Sprl Antibody
MX2022014925A (es) 2020-05-27 2023-01-04 Sanofi Sa Moduladores de il-17a.
US20230286943A1 (en) 2020-05-27 2023-09-14 Sanofi Il-17a modulators
BR112022026273A2 (pt) 2020-06-23 2023-01-17 Novartis Ag Métodos de tratamento da doença ocular da tireoide e orbitopatia de graves usando antagonistas de interleucina-17 (il-17)
US20240025993A1 (en) 2020-11-06 2024-01-25 Novartis Ag Cd19 binding molecules and uses thereof
CN115746132B (zh) * 2021-09-03 2023-09-08 三优生物医药(上海)有限公司 抗il-17a抗体及其用途
IT202100023816A1 (it) * 2021-09-16 2023-03-16 Takis S R L Anticorpo contro SARS-CoV-2 e suoi usi in campo medico.
CN113896793B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
CA3253618A1 (fr) 2022-05-16 2023-11-23 Novartis Ag Méthodes de traitement de l'artérite à cellules géantes à l'aide d'antagonistes de l'interleukine-17 (il-17)
EP4525914A1 (fr) 2022-05-18 2025-03-26 Novartis AG Procédés de traitement sélectif de la tendinopathie à l'aide d'antagonistes de l'interleukine-17 (il-17)
KR20250117693A (ko) 2022-12-09 2025-08-05 사노피 치료용 화합물
WO2025083549A1 (fr) 2023-10-16 2025-04-24 Sun Pharma Advanced Research Company Limited Méthodes et combinaisons d'inhibiteurs de la voie il-23 et de modulateurs de la voie de signalisation s1p pour le traitement de maladies auto-immunes
WO2025104230A1 (fr) 2023-11-17 2025-05-22 Sanofi Benzoxazoles utilisés en tant que modulateurs de l'il-17a
WO2025248073A1 (fr) 2024-05-30 2025-12-04 Sanofi Composés thérapeutiques
KR20250179689A (ko) 2024-06-20 2025-12-30 (주)셀트리온 안정한 약제학적 제제
CN120249218B (zh) * 2024-10-15 2026-03-20 武汉纺织大学 一种分泌抗微纳塑料广谱性单克隆抗体的杂交瘤细胞株及其应用

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225A (en) 1847-08-07 Latch
US539A (en) 1837-12-26 Standard measurer for taking measure for coats
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
ATE352612T1 (de) 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
WO1994004679A1 (fr) 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
WO1993004169A1 (fr) 1991-08-20 1993-03-04 Genpharm International, Inc. Ciblage de genes dans des cellules animales au moyen de produits de synthese d'adn isogeniques
ATE244763T1 (de) 1992-02-11 2003-07-15 Cell Genesys Inc Erzielen von homozygotem durch zielgerichtete genetische ereignisse
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
US6274711B1 (en) * 1993-06-14 2001-08-14 Inserm, Institut National De La Sante Et De La Recherche Medicale Purified mammalian CTLA-8 antigens and related reagents
US5625825A (en) 1993-10-21 1997-04-29 Lsi Logic Corporation Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
US5698762A (en) 1994-12-09 1997-12-16 Dauerman; Leonard Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons
WO1997007671A1 (fr) 1995-08-29 1997-03-06 Kirin Beer Kabushiki Kaisha Animal chimerique et procede de constitution
GB0312481D0 (en) * 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
EP1644416A4 (fr) 2003-06-30 2007-08-29 Centocor Inc Proteines derivees de l'immunoglobuline anti-cible et genetiquement modifiees, compositions, procedes et utilisations
US20070269428A1 (en) 2003-11-21 2007-11-22 Celltech R&D Limited Method for the Treatment of Multiple Sclerosis by Inhibiting Il-17 Activity
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) * 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
CN101326195B9 (zh) * 2005-12-13 2022-11-11 伊莱利利公司 抗il-17抗体

Also Published As

Publication number Publication date
ES2672221T3 (es) 2018-06-13
ES2389780T3 (es) 2012-10-31
RS57255B1 (sr) 2018-08-31
EP3366702B1 (fr) 2023-08-09
HK1120275A1 (en) 2009-03-27
RS52509B (sr) 2013-04-30
HUS1600037I1 (hu) 2016-10-28
EP2481753B1 (fr) 2018-04-18
DK1963368T6 (da) 2020-06-29
NO340827B1 (no) 2017-06-26
JP2009519348A (ja) 2009-05-14
HUE039353T2 (hu) 2018-12-28
PT2481753T (pt) 2018-07-13
CY1120365T1 (el) 2019-07-10
SI1963368T1 (sl) 2012-11-30
EP3366702A1 (fr) 2018-08-29
CY1113097T1 (el) 2016-04-13
JP5063612B2 (ja) 2012-10-31
EP3808769A1 (fr) 2021-04-21
LU93189I2 (fr) 2016-10-31
EA200870050A1 (ru) 2009-12-30
EP1963368A1 (fr) 2008-09-03
HRP20120606T1 (en) 2012-10-31
BRPI0619792A2 (pt) 2011-10-18
EA014298B1 (ru) 2010-10-29
SI2481753T1 (en) 2018-06-29
AU2006325860A1 (en) 2007-06-21
LTPA2016026I1 (lt) 2016-09-26
CA2631938C (fr) 2014-05-20
ES2389780T7 (es) 2021-01-14
EP2481753A1 (fr) 2012-08-01
EP1963368B1 (fr) 2012-07-18
NO2017044I1 (no) 2017-08-18
PT1963368E (pt) 2012-09-14
WO2007070750A1 (fr) 2007-06-21
US20110027290A1 (en) 2011-02-03
RS52509B2 (sr) 2020-09-30
AU2006325860B2 (en) 2011-09-22
NO2017044I2 (no) 2017-08-18
CN101326195B9 (zh) 2022-11-11
DK1963368T3 (da) 2012-08-06
LT2481753T (lt) 2018-05-25
CY2016030I2 (el) 2016-12-14
PL1963368T3 (pl) 2012-11-30
LTC1963368I2 (lt) 2018-01-10
CY2016030I1 (el) 2016-12-14
CN101326195B (zh) 2012-01-11
PL1963368T6 (pl) 2021-02-08
DK2481753T3 (en) 2018-06-18
CN101326195A (zh) 2008-12-17
US20080269467A1 (en) 2008-10-30
PL2481753T3 (pl) 2018-09-28
CA2631938A1 (fr) 2007-06-21
KR101158959B1 (ko) 2012-07-09
IL191217A (en) 2015-10-29
HRP20120606T4 (hr) 2020-08-07
BRPI0619792B1 (pt) 2021-09-28
US8110191B2 (en) 2012-02-07
NO20082905L (no) 2008-09-03
US7838638B2 (en) 2010-11-23
EP1963368B3 (fr) 2020-06-10
KR20080068122A (ko) 2008-07-22
HRP20180941T1 (hr) 2018-08-10

Similar Documents

Publication Publication Date Title
BE2024C510I2 (fr)
BE2023C529I2 (fr)
BE2020C004I2 (fr)
BE2019C521I2 (fr)
BE2019C503I2 (fr)
BE2018C037I2 (fr)
BE2018C035I2 (fr)
BE2018C019I2 (fr)
BE2018C016I2 (fr)
BE2017C028I2 (fr)
BE2019C533I2 (fr)
BE2017C007I2 (fr)
BE2018C028I2 (fr)
BE2016C045I2 (fr)
BE2016C022I2 (fr)
BE2015C074I2 (fr)
BE2014C012I2 (fr)
BE2014C057I2 (fr)
BE2013C073I2 (fr)
BE2013C014I2 (fr)
BE2012C042I2 (fr)
BE2012C028I2 (fr)
BRPI0601358B8 (pt) Aplicador de clipe cirúrgico
BRPI0601402B8 (pt) Aplicador de grampos cirúrgicos
BE2019C013I2 (fr)