CA3065553A1 - Anticorps et antagonistes d'il17a a usage veterinaire - Google Patents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Abstract
L'invention concerne divers modes de réalisation relatifs à des anticorps anti-IL17A et des polypeptides d'IL17Ra ECD qui se lient à l'IL17A. Dans divers modes de réalisation, de tels anticorps anti-IL17A ou polypeptides d'IL17Ra ECD peuvent être utilisés dans des méthodes pour traiter des états induits par l'IL17 chez des sujets, tels que des êtres humains ou des animaux de compagnie, notamment des canidés, des félins et des équins. L'invention concerne également divers modes de réalisation relatifs à des polypeptides variants d'IgG Fc ayant une ou plusieurs substitutions d'acides aminés pour réduire la liaison à C1q et/ou CD16. Dans certains modes de réalisation, les variants d'IgG Fc et/ou les polypeptides comprenant les variants d'IgG Fc (par exemple, des polypeptides de fusion comprenant les variants d'IgG Fc et les anticorps anti-IL17A et/ou les polypeptides d'IL17Ra ECD décrits ici) peuvent avoir des réponses immunitaires à médiation par le complément réduites et/ou une cytotoxicité à médiation cellulaire dépendante des anticorps.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762521514P | 2017-06-18 | 2017-06-18 | |
| US62/521,514 | 2017-06-18 | ||
| PCT/US2018/038033 WO2018236728A1 (fr) | 2017-06-18 | 2018-06-18 | Anticorps et antagonistes d'il17a à usage vétérinaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3065553A1 true CA3065553A1 (fr) | 2018-12-27 |
Family
ID=64737382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3065553A Pending CA3065553A1 (fr) | 2017-06-18 | 2018-06-18 | Anticorps et antagonistes d'il17a a usage veterinaire |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11299540B2 (fr) |
| EP (1) | EP3641813A4 (fr) |
| CA (1) | CA3065553A1 (fr) |
| WO (1) | WO2018236728A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2020322569A1 (en) * | 2019-07-26 | 2022-02-17 | Sinocelltech Ltd | Humanized anti-IL17A antibody and use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007070750A1 (fr) | 2005-12-13 | 2007-06-21 | Eli Lilly And Company | Anticorps anti-il-17 |
| WO2012130831A1 (fr) | 2011-03-29 | 2012-10-04 | Roche Glycart Ag | Variants de fc d'anticorps |
| US9416168B2 (en) | 2011-07-19 | 2016-08-16 | The National Institute for Biotechnology in the Negev, Ltd | IL-17R-ECD mutants and methods of using same |
| WO2015120790A1 (fr) | 2014-02-11 | 2015-08-20 | Beijing Advaccine Biotechnology Co. Ltd | Vaccins ayant pour adjuvant l'interleukine-17 |
| JP2017534577A (ja) * | 2014-09-15 | 2017-11-24 | ジェネンテック， インコーポレイテッド | Ｐｄ−１軸結合拮抗薬及びｉｌ−１７結合拮抗薬を使用したがんの治療方法 |
| KR20230164243A (ko) * | 2015-03-23 | 2023-12-01 | 조운스 테라퓨틱스, 인크. | Icos에 대한 항체 |
| JP6858766B2 (ja) | 2015-10-19 | 2021-04-14 | ノバルティス アーゲー | インターロイキン１７（ｉｌ−１７）アンタゴニストを用いてｘ線陰性体軸性脊椎関節炎を治療する方法 |
-
2018
- 2018-06-18 US US16/621,012 patent/US11299540B2/en active Active
- 2018-06-18 EP EP18820447.3A patent/EP3641813A4/fr active Pending
- 2018-06-18 WO PCT/US2018/038033 patent/WO2018236728A1/fr unknown
- 2018-06-18 CA CA3065553A patent/CA3065553A1/fr active Pending
-
2022
- 2022-03-04 US US17/687,083 patent/US20220185879A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20200199216A1 (en) | 2020-06-25 |
| EP3641813A1 (fr) | 2020-04-29 |
| WO2018236728A1 (fr) | 2018-12-27 |
| US11299540B2 (en) | 2022-04-12 |
| EP3641813A4 (fr) | 2021-04-21 |
| US20220185879A1 (en) | 2022-06-16 |
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