BE1003252A4 - Derives d'acide pyridone carboxylique et leurs sels, leur procede de fabrication et agents antibacteriens les comprenant. - Google Patents

Derives d'acide pyridone carboxylique et leurs sels, leur procede de fabrication et agents antibacteriens les comprenant. Download PDF

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Publication number
BE1003252A4
BE1003252A4 BE8900452A BE8900452A BE1003252A4 BE 1003252 A4 BE1003252 A4 BE 1003252A4 BE 8900452 A BE8900452 A BE 8900452A BE 8900452 A BE8900452 A BE 8900452A BE 1003252 A4 BE1003252 A4 BE 1003252A4
Authority
BE
Belgium
Prior art keywords
lower alkyl
protected
amino
unprotected
salts
Prior art date
Application number
BE8900452A
Other languages
English (en)
Inventor
Hirokazu Narita
Yozo Todo
Jun Nitta
Hiroyasu Takagi
Fumihiko Iino
Mikako Miyajima
Yoshikazu Fukuoka
Isamu Saikawa
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Application granted granted Critical
Publication of BE1003252A4 publication Critical patent/BE1003252A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Ce composé (I), qui est un agent antibactérien, a un groupe cyclopropyle substitué ou non en position 10 d'un noyau pyridobenzoxazine, pyridobenzothiazine ou pyridoquinoxaline : R1 = H ou groupe protecteur de carboxyle; R2 = H, Hal, alcoxy, hydroxyle protégé ou non, amino protégé ou non, alkylamino inférieur protégé ou non ou di-(alkyl inférieur) amino; R3 = moins l'un parmi H, alkyl inférieur, amino protégé ou non, alkylamino inférieur protégé ou non, di-(alkyl inférieur)amino, carboxyle protégé ou non, amino-alkyl inférieur protégé ou non, (alkyl inférieur)amino-(alkyl inférieur) protégé ou non, di-(alkyl inférieur) amino-(alkyl inférieur) et hydroxy-(alkyl inférieur) protégé ou non ; R4 = au moins l'un parm H, alkyl inférieur, halogéno-(alkyl inférieur), hydroxy-(alkyl inférieur) protégé ou non, alkylidène inférieur et un groupe formant un noyau cycloalcane avec l'atome de C auquel R4 se rattache; X= Hal; et A=O ou S, imino substitué par alkyl inférieur ou non-substitué.
BE8900452A 1988-04-23 1989-04-24 Derives d'acide pyridone carboxylique et leurs sels, leur procede de fabrication et agents antibacteriens les comprenant. BE1003252A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10062888 1988-04-23
JP1075873A JPH0228178A (ja) 1988-04-23 1989-03-28 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法

Publications (1)

Publication Number Publication Date
BE1003252A4 true BE1003252A4 (fr) 1992-02-11

Family

ID=26417038

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8900452A BE1003252A4 (fr) 1988-04-23 1989-04-24 Derives d'acide pyridone carboxylique et leurs sels, leur procede de fabrication et agents antibacteriens les comprenant.

Country Status (21)

Country Link
US (1) US4990508A (fr)
JP (1) JPH0228178A (fr)
KR (1) KR910005833B1 (fr)
AT (1) AT398422B (fr)
AU (1) AU601324B2 (fr)
BE (1) BE1003252A4 (fr)
CA (1) CA1340493C (fr)
CH (1) CH680793A5 (fr)
DE (1) DE3913245C2 (fr)
DK (1) DK175649B1 (fr)
ES (1) ES2016012A6 (fr)
FI (1) FI91529C (fr)
FR (1) FR2630441B1 (fr)
GB (1) GB2217710B (fr)
HU (2) HU205759B (fr)
IL (1) IL89931A (fr)
IT (1) IT1231760B (fr)
NL (1) NL192832C (fr)
NO (1) NO171214C (fr)
NZ (1) NZ228847A (fr)
SE (1) SE504625C2 (fr)

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EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
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EG20543A (en) * 1992-10-30 1999-07-31 Procter & Gamble Process for preparing of novel antimicrobial -5- (n-heterosubstituted amino) quinolones
TW252107B (fr) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
IT1270834B (it) * 1993-10-27 1997-05-13 Archimica Spa Disolfuro chinolico
IT1270836B (it) * 1993-10-27 1997-05-13 Archimica Spa Procedimento per la preparazione di rufloxacina e suoi sali
USH1480H (en) * 1993-12-09 1995-09-05 The Procter & Gamble Company Methods of using dyphylline for the promotion of hair growth
KR100768034B1 (ko) 1999-03-17 2007-10-17 다이이찌 세이야꾸 가부시기가이샤 의약 조성물
KR20040105772A (ko) 2002-03-21 2004-12-16 바스프 악티엔게젤샤프트 살진균성 트리아졸로피리미딘, 이의 제조방법 및 유해진균 방제를 위한 이의 용도 및 상기 성분을 함유하는조성물
CN1332962C (zh) * 2005-07-12 2007-08-22 武汉人福药业有限责任公司 一种合成甲磺酸帕珠沙星中间体的方法
PL2383271T3 (pl) * 2006-03-13 2013-12-31 Kyorin Seiyaku Kk Aminochinolony jako inhibitory GSK-3
EP2203458B1 (fr) * 2007-09-11 2011-11-02 Kyorin Pharmaceutical Co., Ltd. Cyanoaminoquinolones en tant qu'inhibiteurs de gsk-3
CA2699152C (fr) 2007-09-12 2015-11-24 Activx Biosciences, Inc. Aminoquinolones spirocycliques utilisees en tant qu'inhibiteurs de gsk-3
JP5502889B2 (ja) * 2009-03-11 2014-05-28 杏林製薬株式会社 ｇｓｋ−３阻害剤としての７−シクロアルキルアミノキノロン
CN101928290B (zh) * 2009-11-27 2011-11-09 浙江司太立制药股份有限公司 一种甲磺酸帕珠沙星的纯化方法
CN102295652A (zh) * 2011-06-27 2011-12-28 辽宁海神联盛制药有限公司 一种甲磺酸帕珠沙星合成工艺的改进方法
CN102850375A (zh) * 2012-03-06 2013-01-02 江西师范大学 一类多取代吡啶并[4, 3-d]噁嗪化合物及制备方法
CN103772412B (zh) * 2012-10-23 2016-03-16 浙江海森药业有限公司 一种帕珠沙星中间体的制备方法
CN105622632B (zh) * 2014-10-29 2018-06-29 浙江海森药业股份有限公司 一种喹诺酮类化合物及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0206101A1 (fr) * 1985-06-22 1986-12-30 Bayer Ag Procédé pour la préparation d'acides quinolone-4 carboxyliques-3 pontés entre les positions 1,8
JPH0193573A (ja) * 1987-10-05 1989-04-12 Toyama Chem Co Ltd 新規なキノリン誘導体およびその塩

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US4623650A (en) * 1984-12-06 1986-11-18 Pfizer Inc. Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
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DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
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Publication number Priority date Publication date Assignee Title
EP0206101A1 (fr) * 1985-06-22 1986-12-30 Bayer Ag Procédé pour la préparation d'acides quinolone-4 carboxyliques-3 pontés entre les positions 1,8
JPH0193573A (ja) * 1987-10-05 1989-04-12 Toyama Chem Co Ltd 新規なキノリン誘導体およびその塩

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Title
CHEMICAL ABSTRACTS, vol. 111, no. 19, 6 novembre 1989, page 714, résumé no. 174003d, Columbus, Ohio, US; & JP-A-01 93 573 (TOYAMA CHEMICAL CO.) 12-04-1989 *

Also Published As

Publication number Publication date
US4990508A (en) 1991-02-05
CH680793A5 (fr) 1992-11-13
FI91529B (fi) 1994-03-31
AU3266189A (en) 1989-10-26
FR2630441B1 (fr) 1994-10-14
CA1340493C (fr) 1999-04-13
FI891910A (fi) 1989-10-24
SE8901464L (sv) 1989-10-24
FR2630441A1 (fr) 1989-10-27
DE3913245C2 (de) 1999-07-15
GB2217710B (en) 1991-12-04
DK192589A (da) 1989-10-24
GB8908096D0 (en) 1989-05-24
GB2217710A (en) 1989-11-01
JPH0228178A (ja) 1990-01-30
NL192832C (nl) 1998-03-04
FI891910A0 (fi) 1989-04-21
AT398422B (de) 1994-12-27
HU205759B (en) 1992-06-29
NL8901007A (nl) 1989-11-16
ES2016012A6 (es) 1990-10-01
SE8901464D0 (sv) 1989-04-21
IL89931A (en) 1993-06-10
HUT51621A (en) 1990-05-28
NZ228847A (en) 1990-04-26
DK192589D0 (da) 1989-04-20
HU211568A9 (en) 1995-12-28
FI91529C (fi) 1994-07-11
DE3913245A1 (de) 1989-11-02
KR910005833B1 (ko) 1991-08-05
AU601324B2 (en) 1990-09-06
KR900016222A (ko) 1990-11-12
DK175649B1 (da) 2005-01-03
NO891650L (no) 1989-10-24
ATA95989A (de) 1994-04-15
IT8947875A0 (it) 1989-04-21
NL192832B (nl) 1997-11-03
IT1231760B (it) 1991-12-21
IL89931A0 (en) 1989-12-15
NO171214B (no) 1992-11-02
SE504625C2 (sv) 1997-03-17
JPH0588714B2 (fr) 1993-12-24
NO171214C (no) 1993-02-10
NO891650D0 (no) 1989-04-21

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Legal Events

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RE20 Patent expired

Owner name: *TOYAMA CHEMICAL CO. LTD

Effective date: 20090424