IT1270836B - Procedimento per la preparazione di rufloxacina e suoi sali - Google Patents
Procedimento per la preparazione di rufloxacina e suoi saliInfo
- Publication number
- IT1270836B IT1270836B ITMI932286A ITMI932286A IT1270836B IT 1270836 B IT1270836 B IT 1270836B IT MI932286 A ITMI932286 A IT MI932286A IT MI932286 A ITMI932286 A IT MI932286A IT 1270836 B IT1270836 B IT 1270836B
- Authority
- IT
- Italy
- Prior art keywords
- rufloxacin
- salts
- pct
- preparation
- formula
- Prior art date
Links
- 229960004062 rufloxacin Drugs 0.000 title abstract 3
- NJCJBUHJQLFDSW-UHFFFAOYSA-N Rufloxacin Chemical compound C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 NJCJBUHJQLFDSW-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- IDOOHFNLEQZVKF-UHFFFAOYSA-N 2-quinolin-2-ylethanethiol Chemical compound C1=CC=CC2=NC(CCS)=CC=C21 IDOOHFNLEQZVKF-UHFFFAOYSA-N 0.000 abstract 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- -1 rufloxacin ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI932286A IT1270836B (it) | 1993-10-27 | 1993-10-27 | Procedimento per la preparazione di rufloxacina e suoi sali |
| JP7512408A JPH09504283A (ja) | 1993-10-27 | 1994-10-26 | ルフロキサシンおよびその塩の調製方法 |
| ES94931550T ES2105780T3 (es) | 1993-10-27 | 1994-10-26 | Procedimiento para la preparacion de rufloxacina y sus sales. |
| AT94931550T ATE155788T1 (de) | 1993-10-27 | 1994-10-26 | Verfahren zur herstellung von rufloxacin und salze davon |
| EP94931550A EP0725785B1 (en) | 1993-10-27 | 1994-10-26 | Process for the preparation of rufloxacin and salts thereof |
| DK94931550.1T DK0725785T3 (da) | 1993-10-27 | 1994-10-26 | Fremgangsmåde til fremstilling af rufloxacin af deraf |
| PCT/EP1994/003512 WO1995011907A1 (en) | 1993-10-27 | 1994-10-26 | Process for the preparation of rufloxacin and salts thereof |
| US08/632,426 US5731433A (en) | 1993-10-27 | 1994-10-26 | Process for the preparation of rufloxacin and salts thereof |
| DE69404476T DE69404476T2 (de) | 1993-10-27 | 1994-10-26 | Verfahren zur herstellung von rufloxacin und salze davon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI932286A IT1270836B (it) | 1993-10-27 | 1993-10-27 | Procedimento per la preparazione di rufloxacina e suoi sali |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI932286A0 ITMI932286A0 (it) | 1993-10-27 |
| ITMI932286A1 ITMI932286A1 (it) | 1995-04-27 |
| IT1270836B true IT1270836B (it) | 1997-05-13 |
Family
ID=11367102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI932286A IT1270836B (it) | 1993-10-27 | 1993-10-27 | Procedimento per la preparazione di rufloxacina e suoi sali |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5731433A (it) |
| EP (1) | EP0725785B1 (it) |
| JP (1) | JPH09504283A (it) |
| AT (1) | ATE155788T1 (it) |
| DE (1) | DE69404476T2 (it) |
| DK (1) | DK0725785T3 (it) |
| ES (1) | ES2105780T3 (it) |
| IT (1) | IT1270836B (it) |
| WO (1) | WO1995011907A1 (it) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
| JP7502186B2 (ja) | 2018-02-02 | 2024-06-18 | リップル セラピューティクス コーポレーション | ステロイド二量体を含むガラス製剤およびその使用 |
| US12473326B2 (en) | 2019-02-01 | 2025-11-18 | Ripple Therapeutics Corporation | Crystalline forms of dexamethasone dimers and uses thereof |
| CN115956083A (zh) | 2020-05-01 | 2023-04-11 | 波纹疗法公司 | 异二聚体组合物及用于治疗眼部病症的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3517709A1 (de) * | 1985-01-05 | 1986-07-10 | Bayer Ag | Basische zubereitungen von chinoloncarbonsaeuren |
| JPH0228178A (ja) * | 1988-04-23 | 1990-01-30 | Toyama Chem Co Ltd | 新規なピリドンカルボン酸誘導体およびその塩並びにそれらの製造法 |
| IT1248011B (it) * | 1991-06-07 | 1995-01-05 | Mediolanum Farmaceutici Spa | Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. |
-
1993
- 1993-10-27 IT ITMI932286A patent/IT1270836B/it active IP Right Grant
-
1994
- 1994-10-26 DK DK94931550.1T patent/DK0725785T3/da active
- 1994-10-26 EP EP94931550A patent/EP0725785B1/en not_active Expired - Lifetime
- 1994-10-26 DE DE69404476T patent/DE69404476T2/de not_active Expired - Fee Related
- 1994-10-26 WO PCT/EP1994/003512 patent/WO1995011907A1/en not_active Ceased
- 1994-10-26 US US08/632,426 patent/US5731433A/en not_active Expired - Fee Related
- 1994-10-26 JP JP7512408A patent/JPH09504283A/ja active Pending
- 1994-10-26 ES ES94931550T patent/ES2105780T3/es not_active Expired - Lifetime
- 1994-10-26 AT AT94931550T patent/ATE155788T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0725785T3 (da) | 1998-02-23 |
| WO1995011907A1 (en) | 1995-05-04 |
| ATE155788T1 (de) | 1997-08-15 |
| EP0725785B1 (en) | 1997-07-23 |
| US5731433A (en) | 1998-03-24 |
| ITMI932286A0 (it) | 1993-10-27 |
| DE69404476T2 (de) | 1997-12-04 |
| JPH09504283A (ja) | 1997-04-28 |
| EP0725785A1 (en) | 1996-08-14 |
| ES2105780T3 (es) | 1997-10-16 |
| ITMI932286A1 (it) | 1995-04-27 |
| DE69404476D1 (de) | 1997-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971030 |