AU8299901A - Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same - Google Patents
Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using sameInfo
- Publication number
- AU8299901A AU8299901A AU8299901A AU8299901A AU8299901A AU 8299901 A AU8299901 A AU 8299901A AU 8299901 A AU8299901 A AU 8299901A AU 8299901 A AU8299901 A AU 8299901A AU 8299901 A AU8299901 A AU 8299901A
- Authority
- AU
- Australia
- Prior art keywords
- agonists
- antagonists
- methods
- same
- factor receptors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000556 agonist Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 230000004069 differentiation Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/495—Transforming growth factor [TGF]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Biodiversity & Conservation Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Plant Pathology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/626,896 US6656475B1 (en) | 1997-08-01 | 2000-07-27 | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
PCT/US2001/023615 WO2002010214A2 (fr) | 2000-07-27 | 2001-07-26 | Recepteurs du facteur de differenciation de croissance, ses agonistes et antagonistes, et ses procedes d'utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
AU8299901A true AU8299901A (en) | 2002-02-13 |
Family
ID=24512319
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU8299901A Pending AU8299901A (en) | 2000-07-27 | 2001-07-26 | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
AU2001282999A Ceased AU2001282999B2 (en) | 2000-07-27 | 2001-07-26 | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001282999A Ceased AU2001282999B2 (en) | 2000-07-27 | 2001-07-26 | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
Country Status (19)
Country | Link |
---|---|
US (1) | US6656475B1 (fr) |
EP (2) | EP2322199B1 (fr) |
JP (2) | JP5153985B2 (fr) |
CN (2) | CN101402955A (fr) |
AR (1) | AR033384A1 (fr) |
AT (1) | ATE503487T1 (fr) |
AU (2) | AU8299901A (fr) |
BR (1) | BR0112788A (fr) |
CA (1) | CA2417568C (fr) |
DE (1) | DE60144334D1 (fr) |
DK (1) | DK1317485T3 (fr) |
ES (2) | ES2364126T3 (fr) |
IL (2) | IL153975A0 (fr) |
MX (1) | MXPA03000787A (fr) |
NZ (2) | NZ535074A (fr) |
PL (1) | PL365792A1 (fr) |
PT (1) | PT1317485E (fr) |
WO (1) | WO2002010214A2 (fr) |
ZA (1) | ZA200300480B (fr) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2157577C (fr) * | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Facteur-8 de differentiation de croissance |
US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
TW200526779A (en) * | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
US7572763B2 (en) * | 2002-02-21 | 2009-08-11 | Wyeth | Follistatin domain containing proteins |
EP1572909A4 (fr) * | 2002-02-21 | 2007-06-06 | Wyeth Corp | Proteine contenant un domaine de follistatine |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
DE60331778D1 (de) * | 2002-09-16 | 2010-04-29 | Univ Johns Hopkins | Metalloproteaseaktivierung von myostatin und verfahren zur modulation der myostatinaktivität |
AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
KR101304718B1 (ko) | 2002-12-20 | 2013-09-05 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
UA85055C2 (ru) | 2003-06-02 | 2008-12-25 | Уайт | Применение ингибиторов миостатика (gdf8) в сочетании с кортикостероидами для лечения нервно-мышечных заболеваний |
AU2004312411B8 (en) | 2003-12-31 | 2011-11-24 | Schering-Plough Pty. Limited | Neutralizing epitope-based growth enhancing vaccine |
JP4688483B2 (ja) | 2004-04-15 | 2011-05-25 | 株式会社テクノネットワーク四国 | フォリスタチン変異体ポリペプチド |
US9045553B2 (en) | 2004-05-27 | 2015-06-02 | Acceleron Pharma, Inc. | Cerberus/Coco derivatives and uses thereof |
JP2008500373A (ja) | 2004-05-27 | 2008-01-10 | アクセルロン ファーマ インコーポレーテッド | ケルベロス(Cerberus)/ココ(Coco)誘導体およびそれらの使用 |
CA2574777C (fr) | 2004-07-23 | 2015-09-01 | Acceleron Pharma Inc. | Polypeptides du recepteur actrii, procedes et compositions correspondants |
US20060194845A1 (en) * | 2004-07-29 | 2006-08-31 | Schering Corporation | Use of ALK 5 inhibitors to modulate or inhibit myostatin activity leading to increased lean tissue accretion in animals |
BRPI0514253A (pt) * | 2004-08-12 | 2008-06-03 | Wyeth Corp | terapia de combinação para diabetes, obesidade e doenças cardiovasculares usando composições contendo inibidores de gdf-8 |
JP5335239B2 (ja) | 2004-09-30 | 2013-11-06 | マイオスティン・セラピューティクス・プロプライエタリー・リミテッド | ミオスタチンアイソフォーム |
JP2008000003A (ja) * | 2004-10-01 | 2008-01-10 | Oncorex Inc | Pim−1活性/蛋白阻害医薬品 |
TW200634156A (en) * | 2004-12-30 | 2006-10-01 | Schering Plough Ltd | Neutralizing epitope-based growth enhancing vaccine |
MX2007011405A (es) * | 2005-03-23 | 2007-10-11 | Wyeth Corp | Deteccion de una respuesta inmune para agentes moduladores de crecimiento y la diferenciacion del factor 8 (gdf 8). |
GB2441581B (en) * | 2005-06-24 | 2011-01-19 | Roderic M K Dale | Compositions and methods for the treatment of muscle wasting |
CN100393320C (zh) * | 2005-06-24 | 2008-06-11 | 奥林格斯技术有限公司 | 治疗肌肉萎缩的寡核苷酸药物 |
JP5052517B2 (ja) * | 2005-10-06 | 2012-10-17 | イーライ リリー アンド カンパニー | 抗ミオスタチン抗体 |
UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
CN103432568A (zh) | 2005-11-23 | 2013-12-11 | 阿塞勒隆制药公司 | Activin-ActRIIa拮抗剂及其促进骨骼生长的应用 |
US8128933B2 (en) * | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
CA2856436A1 (fr) * | 2005-12-06 | 2007-06-14 | Amgen Inc. | Utilisations d'antagonistes de la myostatine |
JP2007306885A (ja) * | 2006-05-22 | 2007-11-29 | Mitsubishi Chemicals Corp | 新規非ヒト動物 |
US8097596B2 (en) * | 2006-06-30 | 2012-01-17 | Lakewood-Amedex, Inc. | Compositions and methods for the treatment of muscle wasting |
CA2558160C (fr) * | 2006-06-30 | 2017-01-03 | Oligos Etc., Inc. | Oligonucleotide anti-sens ciblant la myostatine ou le fox01 pour le traitement de la perte de masse musculaire |
WO2008005019A1 (fr) * | 2006-07-07 | 2008-01-10 | Dale Roderic M K | Compositions et procédés pour le traitement de l'atrophie musculaire |
CN101522707B (zh) | 2006-08-03 | 2013-08-28 | 莫约斯汀医疗有限公司 | 肌肉生长抑制素拮抗剂 |
EA015916B1 (ru) * | 2006-09-05 | 2011-12-30 | Эли Лилли Энд Компани | Моноклональные антитела к миостатину и их применения |
WO2008073351A2 (fr) | 2006-12-08 | 2008-06-19 | Acceleron Pharma Inc. | Utilisations de cerberus, de coco et de leurs dérivés |
US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
CA2672758C (fr) * | 2006-12-18 | 2019-07-30 | Acceleron Pharma Inc. | Antagonistes de l'activine-actrii et ses utilisations pour accroitre les niveaux de globules rouges |
MX2009008222A (es) * | 2007-02-01 | 2009-10-12 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
TW202021980A (zh) * | 2007-02-02 | 2020-06-16 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
KR20200054317A (ko) | 2007-02-09 | 2020-05-19 | 악셀레론 파마 인코포레이티드 | 액티빈-ActRⅡA 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
US8501678B2 (en) | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
EP2315602A4 (fr) * | 2008-06-26 | 2011-11-02 | Acceleron Pharma Inc | Procédés pour administrer un antagoniste d' actriib et surveiller des patients traités |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
TW201919685A (zh) | 2008-08-14 | 2019-06-01 | 美商艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
BRPI0920962A2 (pt) | 2008-11-26 | 2016-07-12 | Amgen Inc | variantes de polipeptídeos receptores de activina iib e usos dos mesmos |
CA2749544A1 (fr) * | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Procedes permettant d'augmenter l'adiponectine |
MA33279B1 (fr) * | 2009-04-27 | 2012-05-02 | Novartis Ag | Compositions et procédés pour l'augmentation de la croissance des muscles |
CA2764890A1 (fr) * | 2009-06-08 | 2010-12-16 | Acceleron Pharma Inc. | Procede visant a augmenter le nombre d'adipocytes thermogenes |
AU2010263182B2 (en) | 2009-06-12 | 2016-05-12 | Acceleron Pharma Inc. | Truncated ActRIIB-Fc fusion proteins |
EP3260130B1 (fr) * | 2009-11-03 | 2021-03-10 | Acceleron Pharma Inc. | Procédés de traitement de la maladie du foie gras |
US8710016B2 (en) | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
WO2012064771A1 (fr) | 2010-11-08 | 2012-05-18 | Acceleron Pharma, Inc. | Agents de liaison à actriia et leurs utilisations |
EP2793925B1 (fr) | 2011-12-19 | 2019-03-20 | Amgen Inc. | Variants polypeptidiques du récepteur de l'activine, seuls ou en combinaison avec une chimiothérapie, et leurs utilisations |
WO2013158868A1 (fr) | 2012-04-18 | 2013-10-24 | Nogra Pharma Limited | Procédés pour traiter le diabète et/ou favoriser la survie d'îlots pancréatiques après une transplantation |
KR102279522B1 (ko) | 2012-11-02 | 2021-07-19 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
EP2916867A4 (fr) * | 2012-11-06 | 2016-10-05 | Scholar Rock Inc | Compositions et procédés pour la modulation de la signalisation cellulaire |
SG11201505960VA (en) | 2013-02-01 | 2015-08-28 | Santa Maria Biotherapeutics Inc | Administration of an anti-activin-a compound to a subject |
US10092627B2 (en) | 2013-04-08 | 2018-10-09 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating skeletal muscle stem cells |
RS61778B1 (sr) * | 2013-05-06 | 2021-06-30 | Scholar Rock Inc | Kompozicije i postupci za modulaciju faktora rasta |
US20160220640A1 (en) | 2013-06-11 | 2016-08-04 | The Brigham And Women's Hospital, Inc. | Methods and compositions for increasing neurogenesis and angiogenesis |
WO2015070076A2 (fr) * | 2013-11-08 | 2015-05-14 | President And Fellows Of Harvard College | Procédés et compositions permettant de régénérer des jonctions neuromusculaires |
US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
BR112016028520A2 (pt) | 2014-06-04 | 2017-10-24 | Acceleron Pharma Inc | métodos e composições para o tratamento de transtornos com polipeptídeos de folistatina |
TN2016000553A1 (en) | 2014-06-13 | 2018-04-04 | Acceleron Pharma Inc | Methods and compositions for treating ulcers |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
CA3005158A1 (fr) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anticorps anti-pro-myostatine/myostatine latente et leurs utilisations |
RS64214B1 (sr) | 2014-12-03 | 2023-06-30 | Celgene Corp | Antagonisti aktivin-actrii i njihova primena u lečenju mijelodisplastičnog sindroma |
US9975934B2 (en) | 2015-03-26 | 2018-05-22 | Acceleron Pharma Inc. | Follistatin-related fusion proteins |
KR20180006386A (ko) | 2015-04-22 | 2018-01-17 | 얼라이브젠 유에스에이 인코포레이티드 | 신규한 근육 소모 질환 치료용 하이브리드 actriib 리간드 트랩 단백질 |
EP3922645A1 (fr) | 2015-09-15 | 2021-12-15 | Scholar Rock, Inc. | Anticorps anti-pro/myostatine latente et leurs utilisations |
CA3010799A1 (fr) | 2016-01-06 | 2017-07-13 | President And Fellows Of Harvard College | Un traitement par le gdf11 previent la prise de poids, ameliore la tolerance au glucose, et diminue la steatose hepatique |
WO2017120523A2 (fr) | 2016-01-08 | 2017-07-13 | Scholar Rock, Inc. | Anticorps anti-promyostatine et anti-myostatine immature et leurs méthodes d'utilisation |
AU2017230091B2 (en) | 2016-03-10 | 2022-04-07 | Acceleron Pharma Inc. | Activin type 2 receptor binding proteins and uses thereof |
CN105699661A (zh) * | 2016-03-14 | 2016-06-22 | 陈倩 | Smad6在肝癌诊断治疗中的应用 |
SI3368069T1 (sl) | 2016-06-13 | 2021-03-31 | Scholar Rock, Inc. | Uporaba zaviralcev miostatina in kombinirane terapije |
EP4218817A3 (fr) | 2017-01-06 | 2023-09-06 | Scholar Rock, Inc. | Méthodes de traitement de maladies métaboliques par inhibition de l'activation de la myostatine |
CN107267637B (zh) * | 2017-07-25 | 2021-08-24 | 华南农业大学 | 一种鸡肌间脂肪宽度相关的分子标记及其应用 |
CN109540818A (zh) * | 2018-12-21 | 2019-03-29 | 云南农业大学 | 一种基于钙、磷血液生化标记选育武定鸡的方法 |
CN109754858B (zh) * | 2019-01-11 | 2021-09-21 | 余鹏 | 甲氨蝶呤给药方案确定装置、存储介质及设备 |
MX2022002636A (es) | 2019-09-03 | 2022-03-25 | Novartis Ag | Tratamiento de la enfermedad o trastorno hepatico que comprende los antagonistas del receptor de actrii. |
WO2022008976A1 (fr) | 2020-07-10 | 2022-01-13 | Institut Pasteur | Utilisation de gdf11 pour diagnostiquer et traiter l'anxiété et la dépression |
CN113223607B (zh) * | 2021-05-28 | 2023-10-20 | 北京化工大学 | 采用smiles算法随机批量生成肝素类似物结构坐标的方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5314695A (en) | 1990-11-13 | 1994-05-24 | Corvas International, Inc. | Tissue factor based prothrombin time reagent |
US5885794A (en) | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
US6465239B1 (en) * | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
CA2157577C (fr) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Facteur-8 de differentiation de croissance |
US5734039A (en) | 1994-09-15 | 1998-03-31 | Thomas Jefferson University | Antisense oligonucleotides targeting cooperating oncogenes |
AU6274298A (en) | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
IL132922A0 (en) * | 1997-05-16 | 2001-03-19 | Procter & Gamble | The use of a bone morphogenetic protein (bmp) receptor complex for screening |
AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
CA2319703C (fr) * | 1998-02-05 | 2005-09-20 | The Johns Hopkins University School Of Medicine | Facteur-8 de differenciation de la croissance |
US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
WO1999056768A1 (fr) * | 1998-05-06 | 1999-11-11 | Metamorphix, Inc. | Methodes de traitement du diabete par inhibition du gdf-8 |
CA2349869A1 (fr) * | 1998-11-13 | 2000-05-25 | Takeda Chemical Industries, Ltd. | Nouvelle proteine et son utilisation |
DE60027135T2 (de) * | 1999-01-21 | 2007-01-11 | Metamorphix, Inc. | Inhibitoren für wachstumdifferenzierungsfaktor und ihre anwendungen |
EP1250357A4 (fr) * | 2000-01-18 | 2004-06-16 | Ovita Ltd | Myostatine et mimetiques de ces derniers |
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2000
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2001
- 2001-07-26 AT AT01961756T patent/ATE503487T1/de active
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- 2001-07-26 EP EP10183121.2A patent/EP2322199B1/fr not_active Expired - Lifetime
- 2001-07-26 IL IL15397501A patent/IL153975A0/xx unknown
- 2001-07-26 AU AU8299901A patent/AU8299901A/xx active Pending
- 2001-07-26 JP JP2002515943A patent/JP5153985B2/ja not_active Expired - Fee Related
- 2001-07-26 CN CNA2008101449332A patent/CN101402955A/zh active Pending
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- 2001-07-26 PT PT01961756T patent/PT1317485E/pt unknown
- 2001-07-26 AU AU2001282999A patent/AU2001282999B2/en not_active Ceased
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- 2001-07-26 ES ES01961756T patent/ES2364126T3/es not_active Expired - Lifetime
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- 2001-07-26 BR BR0112788-8A patent/BR0112788A/pt not_active IP Right Cessation
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- 2001-07-26 NZ NZ523617A patent/NZ523617A/en not_active IP Right Cessation
- 2001-07-26 DK DK01961756.2T patent/DK1317485T3/da active
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- 2001-07-26 CN CNB018149081A patent/CN100422212C/zh not_active Expired - Lifetime
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CN100422212C (zh) | 2008-10-01 |
US6656475B1 (en) | 2003-12-02 |
CN101402955A (zh) | 2009-04-08 |
CA2417568A1 (fr) | 2002-02-07 |
EP2322199B1 (fr) | 2014-12-10 |
ES2532406T3 (es) | 2015-03-26 |
DK1317485T3 (da) | 2011-07-18 |
CN1449410A (zh) | 2003-10-15 |
AU2001282999C1 (en) | 2002-02-13 |
EP1317485B1 (fr) | 2011-03-30 |
ATE503487T1 (de) | 2011-04-15 |
ES2364126T3 (es) | 2011-08-25 |
AR033384A1 (es) | 2003-12-17 |
ZA200300480B (en) | 2004-01-27 |
AU2001282999B2 (en) | 2006-12-14 |
WO2002010214A2 (fr) | 2002-02-07 |
PT1317485E (pt) | 2011-07-06 |
JP2004504832A (ja) | 2004-02-19 |
CA2417568C (fr) | 2014-07-08 |
MXPA03000787A (es) | 2004-05-21 |
BR0112788A (pt) | 2003-09-09 |
EP1317485A2 (fr) | 2003-06-11 |
IL153975A0 (en) | 2003-07-31 |
NZ523617A (en) | 2005-05-27 |
JP5153985B2 (ja) | 2013-02-27 |
IL198800A0 (en) | 2010-02-17 |
PL365792A1 (en) | 2005-01-10 |
WO2002010214A3 (fr) | 2003-04-03 |
JP2012235781A (ja) | 2012-12-06 |
DE60144334D1 (de) | 2011-05-12 |
JP5785525B2 (ja) | 2015-09-30 |
NZ535074A (en) | 2005-12-23 |
EP2322199A1 (fr) | 2011-05-18 |
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