CA2319703C - Facteur-8 de differenciation de la croissance - Google Patents
Facteur-8 de differenciation de la croissance Download PDFInfo
- Publication number
- CA2319703C CA2319703C CA002319703A CA2319703A CA2319703C CA 2319703 C CA2319703 C CA 2319703C CA 002319703 A CA002319703 A CA 002319703A CA 2319703 A CA2319703 A CA 2319703A CA 2319703 C CA2319703 C CA 2319703C
- Authority
- CA
- Canada
- Prior art keywords
- gdf
- leu
- pro
- lys
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Cette invention concerne un animal transgénique non humain faisant partie d'une espèce aviaire, bovine, ovine et porcine et présentant un transgène dont l'activité entrave la production et/ou l'activité du facteur-8 de différentiation de la croissance (GDF-8) intégré aux chromosomes des cellules germinales dudit animal. L'invention concerne également des techniques d'obtention et des méthodes de traitement de tels animaux, humains y compris, au moyen d'anticorps dirigés contre le facteur-8 ou de séquences antisens dudit facteur. Les animaux traités de cette manière se caractérisent par une masse tissulaire et osseuse accrue.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1907098A | 1998-02-05 | 1998-02-05 | |
US09/019,070 | 1998-02-05 | ||
US12418098A | 1998-07-28 | 1998-07-28 | |
US09/124,180 | 1998-07-28 | ||
PCT/US1999/002511 WO1999040181A1 (fr) | 1998-02-05 | 1999-02-05 | Facteur-8 de differenciation de la croissance |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2319703A1 CA2319703A1 (fr) | 1999-08-12 |
CA2319703C true CA2319703C (fr) | 2005-09-20 |
Family
ID=26691808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002319703A Expired - Lifetime CA2319703C (fr) | 1998-02-05 | 1999-02-05 | Facteur-8 de differenciation de la croissance |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2586199A (fr) |
CA (1) | CA2319703C (fr) |
WO (1) | WO1999040181A1 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7566768B1 (en) | 1995-10-26 | 2009-07-28 | The Johns Hopkins University School Of Medicine | Promyostatin peptides and methods of using same |
US7393682B1 (en) | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
US6465239B1 (en) * | 1993-03-19 | 2002-10-15 | The John Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptides from aquatic species and non-human transgenic aquatic species |
EP1333035A3 (fr) | 1993-03-19 | 2004-07-07 | The Johns Hopkins University School Of Medicine | Facteur GDF-8 de différentiation de croissance |
US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
US7332575B2 (en) | 1994-03-18 | 2008-02-19 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species |
US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
US6369201B1 (en) | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
WO2001053350A1 (fr) | 2000-01-18 | 2001-07-26 | Agresearch Limited | Myostatine et mimetiques de ces derniers |
TWI329129B (en) * | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
EP1635870A2 (fr) | 2003-06-02 | 2006-03-22 | Wyeth | Utilisation des inhibiteurs du myostatin (gdf8) avec des corticosteroides pour le traitement des desordres neuromusculaires |
US9045553B2 (en) | 2004-05-27 | 2015-06-02 | Acceleron Pharma, Inc. | Cerberus/Coco derivatives and uses thereof |
CA2567810A1 (fr) | 2004-05-27 | 2005-12-08 | Acceleron Pharma Inc. | Derives de cerberus/coco et leurs applications |
CN103450359B (zh) | 2005-08-19 | 2018-07-24 | 惠氏有限责任公司 | 抗gdf-8的拮抗剂抗体以及在als和其他gdf-8-相关病症治疗中的用途 |
EP1951756B1 (fr) | 2005-10-06 | 2015-01-07 | Eli Lilly And Company | Anticorps anti-myostatine |
UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
PT2066695E (pt) | 2006-09-05 | 2013-05-23 | Lilly Co Eli | Anticorpos anti-miostatina |
EP2099471A2 (fr) | 2006-12-08 | 2009-09-16 | Acceleron Pharma, Inc. | Utilisations de cerberus, de coco et de leurs dérivés |
EP2861617A1 (fr) | 2012-06-15 | 2015-04-22 | Pfizer Inc. | Anticorps antagonistes améliorés dirigés contre gdf-8 et leurs utilisations |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1333035A3 (fr) * | 1993-03-19 | 2004-07-07 | The Johns Hopkins University School Of Medicine | Facteur GDF-8 de différentiation de croissance |
ES2251721T3 (es) * | 1994-07-08 | 2006-05-01 | The Johns Hopkins University School Of Medicine | Factor-11 de diferenciacion del crecimiento. |
AU6274298A (en) * | 1997-02-05 | 1998-08-25 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
-
1999
- 1999-02-05 CA CA002319703A patent/CA2319703C/fr not_active Expired - Lifetime
- 1999-02-05 AU AU25861/99A patent/AU2586199A/en not_active Abandoned
- 1999-02-05 WO PCT/US1999/002511 patent/WO1999040181A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO1999040181A1 (fr) | 1999-08-12 |
CA2319703A1 (fr) | 1999-08-12 |
AU2586199A (en) | 1999-08-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20190205 |