AR033384A1 - Un polinucleotido sustancialmente purificado que codifica para receptores del factor de diferenciacion de l crecimiento, una celula huesped recombinante, un receptor del factor de diferenciacion del crecimiento, un anticuerpo, una representacion virtual de un receptor gdf, un metodo para modular un - Google Patents

Un polinucleotido sustancialmente purificado que codifica para receptores del factor de diferenciacion de l crecimiento, una celula huesped recombinante, un receptor del factor de diferenciacion del crecimiento, un anticuerpo, una representacion virtual de un receptor gdf, un metodo para modular un

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Publication number
AR033384A1
AR033384A1 ARP010103595A ARP010103595A AR033384A1 AR 033384 A1 AR033384 A1 AR 033384A1 AR P010103595 A ARP010103595 A AR P010103595A AR P010103595 A ARP010103595 A AR P010103595A AR 033384 A1 AR033384 A1 AR 033384A1
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AR
Argentina
Prior art keywords
differentiation factor
growth differentiation
cell
substantially purified
myostatin
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Application number
ARP010103595A
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English (en)
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Univ Johns Hopkins Med
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Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Publication of AR033384A1 publication Critical patent/AR033384A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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Abstract

Se suministra un polinucleotido que codifica un receptor del factor de diferenciacion del crecimiento (GDF) sustancialmente purificado, que incluye un receptor de GDF-8 (miostatina), como también sus porciones de péptido funcional. Además, se suministra una representacion virtual de un receptor de GDF o su porcion de péptido funcional. Se provee, además, un método para modular el efecto de la miostatina en una célula mediante el contacto de la célula con un agente que afecta la transduccion de la senal de miostatina en la célula. Además, se provee el uso de dicho polinucleotido para la manufactura de un medicamento para aliviar la severidad de una condicion patologica, implicada, por lo menos en parte, por una cantidad anormal, el desarrollo o la actividad metabolica, de un tejido muscular o adiposo en un sujeto, por medio de la modulacion de la transduccion de la senal miostatina en una célula muscular o una célula de tejido adiposo en el sujeto. Se suministra, además, un método para modular el crecimiento del tejido muscular o tejido adiposo en un organismo eucariotico mediante la administracion de un agente que afecta la transduccion de la senal de miostatina en el organismo.
ARP010103595A 2000-07-27 2001-07-27 Un polinucleotido sustancialmente purificado que codifica para receptores del factor de diferenciacion de l crecimiento, una celula huesped recombinante, un receptor del factor de diferenciacion del crecimiento, un anticuerpo, una representacion virtual de un receptor gdf, un metodo para modular un AR033384A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/626,896 US6656475B1 (en) 1997-08-01 2000-07-27 Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same

Publications (1)

Publication Number Publication Date
AR033384A1 true AR033384A1 (es) 2003-12-17

Family

ID=24512319

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103595A AR033384A1 (es) 2000-07-27 2001-07-27 Un polinucleotido sustancialmente purificado que codifica para receptores del factor de diferenciacion de l crecimiento, una celula huesped recombinante, un receptor del factor de diferenciacion del crecimiento, un anticuerpo, una representacion virtual de un receptor gdf, un metodo para modular un

Country Status (19)

Country Link
US (1) US6656475B1 (es)
EP (2) EP2322199B1 (es)
JP (2) JP5153985B2 (es)
CN (2) CN101402955A (es)
AR (1) AR033384A1 (es)
AT (1) ATE503487T1 (es)
AU (2) AU8299901A (es)
BR (1) BR0112788A (es)
CA (1) CA2417568C (es)
DE (1) DE60144334D1 (es)
DK (1) DK1317485T3 (es)
ES (2) ES2532406T3 (es)
IL (2) IL153975A0 (es)
MX (1) MXPA03000787A (es)
NZ (2) NZ535074A (es)
PL (1) PL365792A1 (es)
PT (1) PT1317485E (es)
WO (1) WO2002010214A2 (es)
ZA (1) ZA200300480B (es)

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