AU749792B2 - Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes - Google Patents

Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes Download PDF

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Publication number
AU749792B2
AU749792B2 AU68765/98A AU6876598A AU749792B2 AU 749792 B2 AU749792 B2 AU 749792B2 AU 68765/98 A AU68765/98 A AU 68765/98A AU 6876598 A AU6876598 A AU 6876598A AU 749792 B2 AU749792 B2 AU 749792B2
Authority
AU
Australia
Prior art keywords
diabetes
peptide
seq
insulin
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU68765/98A
Other languages
English (en)
Other versions
AU6876598A (en
Inventor
Satyanarayana Medicherla
Bishwajit Nag
Somesh D. Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theracos Inc
Original Assignee
Calyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calyx Therapeutics Inc filed Critical Calyx Therapeutics Inc
Publication of AU6876598A publication Critical patent/AU6876598A/en
Application granted granted Critical
Publication of AU749792B2 publication Critical patent/AU749792B2/en
Assigned to THERACOS, INC. reassignment THERACOS, INC. Alteration of Name(s) in Register under S187 Assignors: CALYX THERAPEUTICS, INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU68765/98A 1997-04-01 1998-04-01 Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes Ceased AU749792B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US83103997A 1997-04-01 1997-04-01
US08/831039 1997-04-01
US85085597A 1997-05-02 1997-05-02
US08/850855 1997-05-02
PCT/US1998/006450 WO1998043484A1 (en) 1997-04-01 1998-04-01 Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes

Publications (2)

Publication Number Publication Date
AU6876598A AU6876598A (en) 1998-10-22
AU749792B2 true AU749792B2 (en) 2002-07-04

Family

ID=27125412

Family Applications (1)

Application Number Title Priority Date Filing Date
AU68765/98A Ceased AU749792B2 (en) 1997-04-01 1998-04-01 Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes

Country Status (11)

Country Link
US (3) US6127338A (enExample)
EP (1) EP1005274B1 (enExample)
JP (1) JP4156038B2 (enExample)
KR (1) KR100509438B1 (enExample)
CN (1) CN1255044A (enExample)
AT (1) ATE403672T1 (enExample)
AU (1) AU749792B2 (enExample)
CA (1) CA2285452A1 (enExample)
DE (1) DE69839842D1 (enExample)
ES (1) ES2310006T3 (enExample)
WO (1) WO1998043484A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1171455B1 (en) * 1999-04-13 2008-11-19 Pushpa Khanna Polypeptide-k obtained from momordica charantia and a process for the extraction thereof
WO2005063156A1 (en) * 2003-12-22 2005-07-14 Shear/Kershman Laboratories, Inc. Oral peptide delivery system with improved bioavailability
EP1563842A1 (en) * 2004-02-03 2005-08-17 Novartis AG Simarouba amara and/or Momordica charantia extracts for the treatment of coccidiosis in poultry
US20070269898A1 (en) * 2004-09-15 2007-11-22 Yokohama City University Amino Acid Sequences Essential to Neuron Specific Gene Expression
WO2008120240A1 (en) * 2007-03-30 2008-10-09 Aparna Dixit Anti diabetic protein
US20100081860A1 (en) * 2008-04-24 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
TWI342781B (en) * 2008-12-01 2011-06-01 Univ China Medical Blood sugar-modulating polypeptides
WO2011032360A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj2多肽及其应用与微波促进固相合成方法
WO2011032359A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj6多肽及其应用与微波促进固相合成方法
CN101691394B (zh) * 2009-09-17 2012-05-09 中国药科大学 微波促进固相合成苦瓜mc-jj6多肽类似物及其应用
CN101824075A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0101多肽类似物及其应用
CN101824076A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0105多肽类似物及其应用
CN101942010A (zh) * 2010-05-20 2011-01-12 中国药科大学 微波促进固相合成苦瓜mc-jj0106多肽类似物及其应用
CN101824074A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0107多肽类似物及其应用
CN101838309A (zh) * 2010-05-20 2010-09-22 中国药科大学 微波促进固相合成苦瓜mc-jj0102多肽类似物及其应用
CN101824073A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0103多肽类似物及其应用
CN101830969A (zh) * 2010-05-20 2010-09-15 中国药科大学 微波促进固相合成苦瓜降血糖mc-jj0104多肽类似物及其应用
CN101985644B (zh) * 2010-10-25 2013-06-12 邹远东 一种苦瓜多肽及其制备方法与应用
ES2621355T3 (es) 2011-01-28 2017-07-03 Piramal Enterprises Limited Procedimiento para la preparación de un extracto de Momordica Charantia
TWI588153B (zh) 2012-05-18 2017-06-21 中國醫藥大學 多胜肽、編碼該多胜肽之核酸分子、以及該多胜肽之應用
CN104650198B (zh) * 2015-02-09 2018-05-08 武汉华康臣生物科技有限公司 三叉黑顶藻中分离的能治疗糖尿病的活性肽及其用途
CN106729606A (zh) * 2017-01-03 2017-05-31 河北省农林科学院经济作物研究所 苦瓜降糖提取物复合剂及其制备方法
CN107412721B (zh) * 2017-09-15 2020-11-24 李玉保 一种降血糖苦瓜多肽复方胶囊及其制备方法
CN107412720A (zh) * 2017-09-15 2017-12-01 李玉保 一种治疗糖尿病的苦瓜多肽复方植物药及其制备方法
CN108707181B (zh) * 2018-06-14 2021-03-12 苏秀兰 一种抑制肿瘤细胞增殖的苦瓜多肽及其制备方法和应用
CN110755598A (zh) * 2019-10-25 2020-02-07 李玉保 活化胰岛素及治疗糖尿病的复合苦瓜肽口服药及制备方法
CN112675292B (zh) * 2021-01-11 2021-11-02 中食安泓(广东)健康产业有限公司 含有益生菌的制剂在治疗疾病中的应用
CN116813700B (zh) * 2022-11-08 2025-01-24 苏秀兰 一种苦瓜生物活性肽、制备方法及其应用
CN117700489B (zh) * 2023-12-19 2024-08-20 深圳泰华赛尔生物科技有限公司 脂肪干细胞在治疗糖尿病的药物中的应用
CN119320429B (zh) * 2024-10-15 2025-07-29 天津桂芝堂科技有限公司 包含乳铁蛋白的药物组合物及在降血脂中的应用

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NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3853914A (en) * 1971-01-11 1974-12-10 Syva Co Ligand determination of spin labeled compounds by receptor displacement
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3905654A (en) * 1973-11-14 1975-09-16 Kelsey Hayes Co Skid control system for dual brake
US3945988A (en) * 1974-07-16 1976-03-23 Pushpa Khann Process for isolation of insulin from plant source
US4043989A (en) * 1975-09-11 1977-08-23 Syva Company Oxazepam derivatives for immunoassay reagents
US4069105A (en) * 1977-03-03 1978-01-17 Syva Company Lidocaine antigens and antibodies
US4156081A (en) * 1977-04-15 1979-05-22 Syva Company Theophylline antigens and antibodies
JPS57106626A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
US5098710A (en) * 1987-06-18 1992-03-24 Yaguang Liu Production of kuguasu
US5086043A (en) * 1987-06-18 1992-02-04 Yaguang Liu Production of Saponins of Lichi
US4985248A (en) * 1987-06-18 1991-01-15 Yaguang Liu Pharmaceutical composition containing a safe extracts of fruits and vegetables for the treating and preventing of diabetes
ES2128362T3 (es) * 1991-12-03 1999-05-16 Proteus Molecular Design Fragmentos de proteinas de prion.
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes

Also Published As

Publication number Publication date
EP1005274B1 (en) 2008-08-06
US6852695B2 (en) 2005-02-08
DE69839842D1 (de) 2008-09-18
ES2310006T3 (es) 2008-12-16
CA2285452A1 (en) 1998-10-08
US6127338A (en) 2000-10-03
CN1255044A (zh) 2000-05-31
US6391854B1 (en) 2002-05-21
EP1005274A4 (en) 2004-09-08
WO1998043484A1 (en) 1998-10-08
JP2002516608A (ja) 2002-06-04
AU6876598A (en) 1998-10-22
JP4156038B2 (ja) 2008-09-24
EP1005274A1 (en) 2000-06-07
US20020193310A1 (en) 2002-12-19
KR20010005917A (ko) 2001-01-15
KR100509438B1 (ko) 2005-08-23
ATE403672T1 (de) 2008-08-15

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: THERACOS, INC.

Free format text: FORMER OWNER WAS: CALYX THERAPEUTICS, INC.