KR100509438B1 - 경구적으로 활성인 여주의 분획, 이것의 활성 펩티드 및 당뇨병 치료에 있어서 이들의 사용 - Google Patents

경구적으로 활성인 여주의 분획, 이것의 활성 펩티드 및 당뇨병 치료에 있어서 이들의 사용 Download PDF

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Publication number
KR100509438B1
KR100509438B1 KR10-1999-7008994A KR19997008994A KR100509438B1 KR 100509438 B1 KR100509438 B1 KR 100509438B1 KR 19997008994 A KR19997008994 A KR 19997008994A KR 100509438 B1 KR100509438 B1 KR 100509438B1
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South Korea
Prior art keywords
seq
peptide
diabetes
delete delete
peptides
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Expired - Fee Related
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KR10-1999-7008994A
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English (en)
Korean (ko)
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KR20010005917A (ko
Inventor
낵비쉬와이트
메디셀라사티아나라야나
샤르마소메쉬디.
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테라코스, 인코포레이티드
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Publication of KR20010005917A publication Critical patent/KR20010005917A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR10-1999-7008994A 1997-04-01 1998-04-01 경구적으로 활성인 여주의 분획, 이것의 활성 펩티드 및 당뇨병 치료에 있어서 이들의 사용 Expired - Fee Related KR100509438B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US83103997A 1997-04-01 1997-04-01
US08/831,039 1997-04-01
US8/831,039 1997-04-01
US85085597A 1997-05-02 1997-05-02
US08/850,855 1997-05-02
US8/850,855 1997-05-02
PCT/US1998/006450 WO1998043484A1 (en) 1997-04-01 1998-04-01 Orally active fraction of momordica charantia, active peptides thereof, and their use in the treatment of diabetes

Publications (2)

Publication Number Publication Date
KR20010005917A KR20010005917A (ko) 2001-01-15
KR100509438B1 true KR100509438B1 (ko) 2005-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7008994A Expired - Fee Related KR100509438B1 (ko) 1997-04-01 1998-04-01 경구적으로 활성인 여주의 분획, 이것의 활성 펩티드 및 당뇨병 치료에 있어서 이들의 사용

Country Status (11)

Country Link
US (3) US6127338A (enExample)
EP (1) EP1005274B1 (enExample)
JP (1) JP4156038B2 (enExample)
KR (1) KR100509438B1 (enExample)
CN (1) CN1255044A (enExample)
AT (1) ATE403672T1 (enExample)
AU (1) AU749792B2 (enExample)
CA (1) CA2285452A1 (enExample)
DE (1) DE69839842D1 (enExample)
ES (1) ES2310006T3 (enExample)
WO (1) WO1998043484A1 (enExample)

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ATE414714T1 (de) * 1999-04-13 2008-12-15 Pushpa Khanna Polypeptide-k erhalten vom momordica charantia and eine methode für sein extraktion
US20050136121A1 (en) * 2003-12-22 2005-06-23 Shear/Kershman Laboratories, Inc. Oral peptide delivery system with improved bioavailability
EP1563842A1 (en) * 2004-02-03 2005-08-17 Novartis AG Simarouba amara and/or Momordica charantia extracts for the treatment of coccidiosis in poultry
JPWO2006030722A1 (ja) * 2004-09-15 2008-05-15 公立大学法人横浜市立大学 神経特異的遺伝子発現に必須なアミノ酸配列
WO2008120240A1 (en) * 2007-03-30 2008-10-09 Aparna Dixit Anti diabetic protein
US20100081860A1 (en) * 2008-04-24 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational System and Method for Memory Modification
TWI342781B (en) * 2008-12-01 2011-06-01 Univ China Medical Blood sugar-modulating polypeptides
WO2011032359A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj6多肽及其应用与微波促进固相合成方法
WO2011032360A1 (zh) * 2009-09-17 2011-03-24 中国药科大学 苦瓜mc-jj2多肽及其应用与微波促进固相合成方法
CN101691394B (zh) * 2009-09-17 2012-05-09 中国药科大学 微波促进固相合成苦瓜mc-jj6多肽类似物及其应用
CN101824076A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0105多肽类似物及其应用
CN101824075A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0101多肽类似物及其应用
CN101830969A (zh) * 2010-05-20 2010-09-15 中国药科大学 微波促进固相合成苦瓜降血糖mc-jj0104多肽类似物及其应用
CN101824073A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0103多肽类似物及其应用
CN101824074A (zh) * 2010-05-20 2010-09-08 中国药科大学 微波促进固相合成苦瓜mc-jj0107多肽类似物及其应用
CN101838309A (zh) * 2010-05-20 2010-09-22 中国药科大学 微波促进固相合成苦瓜mc-jj0102多肽类似物及其应用
CN101942010A (zh) * 2010-05-20 2011-01-12 中国药科大学 微波促进固相合成苦瓜mc-jj0106多肽类似物及其应用
CN101985644B (zh) * 2010-10-25 2013-06-12 邹远东 一种苦瓜多肽及其制备方法与应用
CN103458906B (zh) 2011-01-28 2016-05-25 皮拉莫企业有限公司 制备一种草本精的工艺
TWI588153B (zh) 2012-05-18 2017-06-21 中國醫藥大學 多胜肽、編碼該多胜肽之核酸分子、以及該多胜肽之應用
CN104650198B (zh) * 2015-02-09 2018-05-08 武汉华康臣生物科技有限公司 三叉黑顶藻中分离的能治疗糖尿病的活性肽及其用途
CN106729606A (zh) * 2017-01-03 2017-05-31 河北省农林科学院经济作物研究所 苦瓜降糖提取物复合剂及其制备方法
CN107412721B (zh) * 2017-09-15 2020-11-24 李玉保 一种降血糖苦瓜多肽复方胶囊及其制备方法
CN107412720A (zh) * 2017-09-15 2017-12-01 李玉保 一种治疗糖尿病的苦瓜多肽复方植物药及其制备方法
CN108707181B (zh) * 2018-06-14 2021-03-12 苏秀兰 一种抑制肿瘤细胞增殖的苦瓜多肽及其制备方法和应用
CN110755598A (zh) * 2019-10-25 2020-02-07 李玉保 活化胰岛素及治疗糖尿病的复合苦瓜肽口服药及制备方法
CN112675292B (zh) * 2021-01-11 2021-11-02 中食安泓(广东)健康产业有限公司 含有益生菌的制剂在治疗疾病中的应用
CN116813700B (zh) * 2022-11-08 2025-01-24 苏秀兰 一种苦瓜生物活性肽、制备方法及其应用
CN117700489B (zh) * 2023-12-19 2024-08-20 深圳泰华赛尔生物科技有限公司 脂肪干细胞在治疗糖尿病的药物中的应用
CN119320429B (zh) * 2024-10-15 2025-07-29 天津桂芝堂科技有限公司 包含乳铁蛋白的药物组合物及在降血脂中的应用

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JPS57106626A (en) * 1980-12-22 1982-07-02 Teijin Ltd Cytotoxic protein complex and its preparation
US4985248A (en) * 1987-06-18 1991-01-15 Yaguang Liu Pharmaceutical composition containing a safe extracts of fruits and vegetables for the treating and preventing of diabetes
US5098710A (en) * 1987-06-18 1992-03-24 Yaguang Liu Production of kuguasu
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DK0616613T3 (da) * 1991-12-03 1999-09-27 Proteus Molecular Design Fragmenter af prionprotein
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes

Also Published As

Publication number Publication date
EP1005274A4 (en) 2004-09-08
KR20010005917A (ko) 2001-01-15
US6127338A (en) 2000-10-03
US20020193310A1 (en) 2002-12-19
US6391854B1 (en) 2002-05-21
CN1255044A (zh) 2000-05-31
EP1005274A1 (en) 2000-06-07
CA2285452A1 (en) 1998-10-08
JP4156038B2 (ja) 2008-09-24
ES2310006T3 (es) 2008-12-16
US6852695B2 (en) 2005-02-08
DE69839842D1 (de) 2008-09-18
EP1005274B1 (en) 2008-08-06
WO1998043484A1 (en) 1998-10-08
AU749792B2 (en) 2002-07-04
ATE403672T1 (de) 2008-08-15
JP2002516608A (ja) 2002-06-04
AU6876598A (en) 1998-10-22

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