AU738494B2 - Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression - Google Patents

Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression Download PDF

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Publication number
AU738494B2
AU738494B2 AU83895/98A AU8389598A AU738494B2 AU 738494 B2 AU738494 B2 AU 738494B2 AU 83895/98 A AU83895/98 A AU 83895/98A AU 8389598 A AU8389598 A AU 8389598A AU 738494 B2 AU738494 B2 AU 738494B2
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AU
Australia
Prior art keywords
nucleic acid
binding domain
ligand
cells
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU83895/98A
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English (en)
Other versions
AU8389598A (en
Inventor
Fred H Gage
Steven T. Suhr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/891,298 external-priority patent/US6300488B1/en
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of AU8389598A publication Critical patent/AU8389598A/en
Application granted granted Critical
Publication of AU738494B2 publication Critical patent/AU738494B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU83895/98A 1997-07-10 1998-07-10 Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression Ceased AU738494B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/891,298 US6300488B1 (en) 1997-07-10 1997-07-10 Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
US08/891298 1997-07-10
US9187498P 1998-07-07 1998-07-07
US60/091874 1998-07-07
PCT/US1998/014215 WO1999002683A1 (en) 1997-07-10 1998-07-10 Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression

Publications (2)

Publication Number Publication Date
AU8389598A AU8389598A (en) 1999-02-08
AU738494B2 true AU738494B2 (en) 2001-09-20

Family

ID=26784430

Family Applications (1)

Application Number Title Priority Date Filing Date
AU83895/98A Ceased AU738494B2 (en) 1997-07-10 1998-07-10 Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression

Country Status (4)

Country Link
EP (1) EP0998560A1 (de)
AU (1) AU738494B2 (de)
CA (1) CA2296093A1 (de)
WO (1) WO1999002683A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1112360A1 (de) 1998-09-10 2001-07-04 Pioneer Hi-Bred International, Inc. Ecdysonrezeptoren und methoden zu deren verwendung
GB9915126D0 (en) 1999-06-30 1999-09-01 Imp College Innovations Ltd Control of gene expression
WO2001036623A2 (en) * 1999-11-05 2001-05-25 Avigen, Inc. Ecdysone-inducible adeno-associated virus expression vectors
AU2001241682A1 (en) * 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
ATE338135T1 (de) * 2000-03-22 2006-09-15 Rheogene Holdings Inc Induziertes genexpressionssystem basierend auf ecdysonrezeptoren
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
AU2002251724B2 (en) * 2000-10-24 2007-06-21 Syngenta Participations Ag Control of gene expression in plants
US20030049689A1 (en) * 2000-12-14 2003-03-13 Cynthia Edwards Multifunctional polypeptides
WO2002066615A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP3470520A2 (de) 2001-02-20 2019-04-17 Intrexon Corporation Neuartige substitution mutanter rezeptoren und deren verwendung in einem auf nuklearen rezeptoren beruhenden induzierbaren genexpressionssystem
DK1572862T3 (da) 2001-02-20 2012-11-26 Intrexon Corp Kimære, retinoide x-receptorer og deres anvendelse i et hidtil ukendt ecdysonrecepttorbaseret inducerbart genekspressionssystem
WO2002066613A2 (en) 2001-02-20 2002-08-29 Rheogene Holdings, Inc Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
EP1436394A4 (de) * 2001-09-26 2004-12-29 Rheo Gene Holdings Inc Zikaden-ecdyson-rezeptor-nukleinsäuren, -polypeptide und ihre verwendungen
CA2930389A1 (en) 2001-09-26 2003-04-03 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US8076517B2 (en) 2007-05-29 2011-12-13 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
MX2010009996A (es) 2008-03-14 2010-10-20 Intrexon Corp Ligandos esteroides y su uso en la modulacion de genes interruptores.
RU2637946C2 (ru) 2013-03-15 2017-12-08 Интрексон Корпорейшн Борсодержащие диацилгидразины
CA2961738A1 (en) 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds
US11692194B2 (en) 2017-01-10 2023-07-04 Precigen, Inc. Modulating expression of polypeptides via new gene switch expression systems
AU2018281316B2 (en) 2017-06-07 2024-05-30 Precigen, Inc. Expression of novel cell tags
US11608362B2 (en) 2018-03-06 2023-03-21 Precigen, Inc. Hepatitis B vaccines and uses of the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037609A1 (en) * 1995-05-26 1996-11-28 Zeneca Limited A gene switch comprising an ecdysone receptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996037609A1 (en) * 1995-05-26 1996-11-28 Zeneca Limited A gene switch comprising an ecdysone receptor

Also Published As

Publication number Publication date
WO1999002683A1 (en) 1999-01-21
EP0998560A1 (de) 2000-05-10
AU8389598A (en) 1999-02-08
CA2296093A1 (en) 1999-01-21

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