EP0998560A1 - Modifizierte lepidoptera-rezeptoren und hybride, multifunktionelle proteine zur regulation der expression von transgenen - Google Patents

Modifizierte lepidoptera-rezeptoren und hybride, multifunktionelle proteine zur regulation der expression von transgenen

Info

Publication number
EP0998560A1
EP0998560A1 EP98934353A EP98934353A EP0998560A1 EP 0998560 A1 EP0998560 A1 EP 0998560A1 EP 98934353 A EP98934353 A EP 98934353A EP 98934353 A EP98934353 A EP 98934353A EP 0998560 A1 EP0998560 A1 EP 0998560A1
Authority
EP
European Patent Office
Prior art keywords
nucleic acid
binding domain
ligand
cells
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98934353A
Other languages
English (en)
French (fr)
Inventor
Fred H. Gage
Steven T. Suhr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salk Institute for Biological Studies
Original Assignee
Salk Institute for Biological Studies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/891,298 external-priority patent/US6300488B1/en
Application filed by Salk Institute for Biological Studies filed Critical Salk Institute for Biological Studies
Publication of EP0998560A1 publication Critical patent/EP0998560A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
EP98934353A 1997-07-10 1998-07-10 Modifizierte lepidoptera-rezeptoren und hybride, multifunktionelle proteine zur regulation der expression von transgenen Withdrawn EP0998560A1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US891298 1997-07-10
US08/891,298 US6300488B1 (en) 1997-07-10 1997-07-10 Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
US9187498P 1998-07-07 1998-07-07
US91874P 1998-07-07
PCT/US1998/014215 WO1999002683A1 (en) 1997-07-10 1998-07-10 Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression

Publications (1)

Publication Number Publication Date
EP0998560A1 true EP0998560A1 (de) 2000-05-10

Family

ID=26784430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98934353A Withdrawn EP0998560A1 (de) 1997-07-10 1998-07-10 Modifizierte lepidoptera-rezeptoren und hybride, multifunktionelle proteine zur regulation der expression von transgenen

Country Status (4)

Country Link
EP (1) EP0998560A1 (de)
AU (1) AU738494B2 (de)
CA (1) CA2296093A1 (de)
WO (1) WO1999002683A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6504082B1 (en) 1998-09-10 2003-01-07 Pioneer Hi-Bred International, Inc. Ecdysone receptors and methods for their use
GB9915126D0 (en) 1999-06-30 1999-09-01 Imp College Innovations Ltd Control of gene expression
AU3642601A (en) * 1999-11-05 2001-05-30 Avigen, Inc. Ecdysone-inducible adeno-associated virus expression vectors
AU2001241682A1 (en) * 2000-02-24 2001-09-03 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
AU2001249315A1 (en) 2000-03-22 2001-10-03 Rheogene, Inc. Ecdysone receptor-based inducible gene expression system
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
AU2002251724B2 (en) 2000-10-24 2007-06-21 Syngenta Participations Ag Control of gene expression in plants
US20030049689A1 (en) * 2000-12-14 2003-03-13 Cynthia Edwards Multifunctional polypeptides
DK1572862T3 (da) 2001-02-20 2012-11-26 Intrexon Corp Kimære, retinoide x-receptorer og deres anvendelse i et hidtil ukendt ecdysonrecepttorbaseret inducerbart genekspressionssystem
WO2002066615A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1373470B1 (de) 2001-02-20 2013-04-24 Intrexon Corporation Neue substitutionsmutantenrezeptoren und ihre verwendung in einem induzierbaren genexpressionssystem auf basis eines nukleären rezeptors
MXPA03007493A (es) 2001-02-20 2004-10-15 Rheogene Holdings Inc Nuevo sistema de expresion genetica inducible a base de receptor de ecdisona/receptor x retinoide de invertebrado.
MXPA04002810A (es) 2001-09-26 2005-06-06 Rheogene Holdings Inc Acidos nucleicos receptores de ecdisona de saltarilla, polipeptidos, y sus usos.
CA2459807C (en) 2001-09-26 2013-09-03 Jianzhong Zhang Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CA2689137C (en) 2007-05-29 2017-05-02 Intrexon Corporation Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
CA2718494C (en) 2008-03-14 2016-05-17 Intrexon Corporation Steroidal ligands and their use in gene switch modulation
NZ712167A (en) 2013-03-15 2018-05-25 Intrexon Corp Boron-containing diacylhydrazines
JP6567657B2 (ja) 2014-09-17 2019-08-28 イントレキソン コーポレーション ホウ素含有ジアシルヒドラジン化合物
EP3568474A1 (de) 2017-01-10 2019-11-20 Intrexon Corporation Modulation der expression von polypeptiden über neue genschalterexpressionssysteme
CN110997920A (zh) 2017-06-07 2020-04-10 英特拉克森公司 新型细胞标签的表达
CA3092935A1 (en) 2018-03-06 2019-09-12 Precigen, Inc. Hepatitis b vaccines and uses of the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11506319A (ja) * 1995-05-26 1999-06-08 ゼネカ・リミテッド エクジソンレセプターを含む遺伝子スイッチ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9902683A1 *

Also Published As

Publication number Publication date
CA2296093A1 (en) 1999-01-21
WO1999002683A1 (en) 1999-01-21
AU738494B2 (en) 2001-09-20
AU8389598A (en) 1999-02-08

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