AU736339B2 - Liquid gonadotropin containing formulations - Google Patents

Liquid gonadotropin containing formulations Download PDF

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Publication number
AU736339B2
AU736339B2 AU52059/98A AU5205998A AU736339B2 AU 736339 B2 AU736339 B2 AU 736339B2 AU 52059/98 A AU52059/98 A AU 52059/98A AU 5205998 A AU5205998 A AU 5205998A AU 736339 B2 AU736339 B2 AU 736339B2
Authority
AU
Australia
Prior art keywords
gonadotropin
formulation
liquid
containing formulation
liquid gonadotropin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU52059/98A
Other languages
English (en)
Other versions
AU5205998A (en
Inventor
Petrus Johannes Maria Oetelaar
Arnold Titus Philip Skrabanja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of AU5205998A publication Critical patent/AU5205998A/en
Application granted granted Critical
Publication of AU736339B2 publication Critical patent/AU736339B2/en
Assigned to N.V. ORGANON reassignment N.V. ORGANON Alteration of Name(s) in Register under S187 Assignors: AKZO NOBEL N.V.
Assigned to MSD OSS B.V. reassignment MSD OSS B.V. Request to Amend Deed and Register Assignors: N.V. ORGANON
Assigned to MERCK SHARP & DOHME B.V. reassignment MERCK SHARP & DOHME B.V. Request to Amend Deed and Register Assignors: MSD OSS B.V.
Assigned to N.V. ORGANON reassignment N.V. ORGANON Request for Assignment Assignors: MERCK SHARP & DOHME B.V.
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU52059/98A 1997-01-15 1998-01-14 Liquid gonadotropin containing formulations Expired AU736339B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97200099 1997-01-15
EP97200099 1997-01-15

Publications (2)

Publication Number Publication Date
AU5205998A AU5205998A (en) 1998-07-23
AU736339B2 true AU736339B2 (en) 2001-07-26

Family

ID=8227932

Family Applications (1)

Application Number Title Priority Date Filing Date
AU52059/98A Expired AU736339B2 (en) 1997-01-15 1998-01-14 Liquid gonadotropin containing formulations

Country Status (29)

Country Link
US (1) US5929028A (enExample)
EP (2) EP1285665A1 (enExample)
JP (1) JP4353549B2 (enExample)
KR (1) KR100498531B1 (enExample)
CN (1) CN1165341C (enExample)
AR (1) AR011410A1 (enExample)
AT (1) ATE237348T1 (enExample)
AU (1) AU736339B2 (enExample)
BR (1) BR9800323B1 (enExample)
CA (1) CA2226803A1 (enExample)
CZ (1) CZ297419B6 (enExample)
DE (2) DE122010000011I1 (enExample)
DK (1) DK0853945T3 (enExample)
ES (1) ES2196474T3 (enExample)
FR (1) FR10C0024I2 (enExample)
HU (1) HU227154B1 (enExample)
ID (1) ID19499A (enExample)
IL (1) IL122732A0 (enExample)
LU (1) LU91655I2 (enExample)
MX (1) MX9800438A (enExample)
NO (3) NO322509B1 (enExample)
NZ (1) NZ329572A (enExample)
PL (1) PL190103B1 (enExample)
PT (1) PT853945E (enExample)
RU (1) RU2203086C2 (enExample)
SA (1) SA98181124B1 (enExample)
TR (1) TR199800062A2 (enExample)
TW (1) TW518235B (enExample)
ZA (1) ZA9883B (enExample)

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JP2000247903A (ja) * 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
JP2007204498A (ja) * 1999-03-01 2007-08-16 Chugai Pharmaceut Co Ltd 長期安定化製剤
CN1360506A (zh) * 1999-07-12 2002-07-24 格兰迪斯生物技术有限公司 生长激素配方
HRP20020651B1 (en) * 2000-02-22 2011-01-31 Laboratoires Serono Sa Purified lh
US7256184B2 (en) * 2000-10-16 2007-08-14 Rodriguez Victorio C Treatment of aging disorders in humans
US20030104996A1 (en) * 2001-08-30 2003-06-05 Tiansheng Li L-methionine as a stabilizer for NESP/EPO in HSA-free formulations
AU2007200662A1 (en) * 2001-08-30 2007-03-08 Kirin-Amgen, Inc. L-methionine as a stabilizer for NESP/EPO in HSA-free formulations
EP1346843A1 (en) * 2002-03-22 2003-09-24 Fuji Photo Film Co., Ltd. Image forming method
DE602004030546D1 (de) 2003-03-04 2011-01-27 Aspenbio Pharma Inc LH zur Verwendung der Erhaltung einer oder mehreren Schwangerschaften durch Induktion der Bildung des sekundären Gelbkörpers.
ES2358330T5 (es) * 2003-04-02 2018-12-03 Ares Trading S.A. Formulaciones farmacéuticas líquidas de FSH y LH junto con un tensioactivo no iónico
WO2004087213A1 (en) * 2003-04-02 2004-10-14 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
US20040248784A1 (en) * 2003-06-03 2004-12-09 Marco Filicori Unitary combinations of FSH and hCG
WO2004112826A1 (en) 2003-06-20 2004-12-29 Ares Trading Sa Freeze-dried fsh / lh formulations
JP4412989B2 (ja) * 2003-12-15 2010-02-10 株式会社日立製作所 複数の記憶システムを有するデータ処理システム
KR100587535B1 (ko) * 2004-02-04 2006-06-08 충남대학교산학협력단 재조합 ｈＦＳＨ 유전자 및 이를 내장하는 발현용 벡터
TWI369401B (en) * 2005-07-05 2012-08-01 Ares Trading Sa Serum-free culture medium for the production of recombinant gonadotropins
KR101105871B1 (ko) * 2005-09-27 2012-01-16 주식회사 엘지생명과학 인 난포자극호르몬의 안정한 용액 제형
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US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
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US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
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CN101517883B (zh) * 2006-09-25 2012-07-04 国立大学法人东京农工大学 超声波操作装置和微细管内检查系统
KR20080106636A (ko) * 2007-06-04 2008-12-09 동아제약주식회사 사람 융모성 성선자극호르몬 함유 즉시 사용형 주사 용액
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CN101720332B (zh) 2007-06-28 2014-08-13 拉蒂奥法姆有限责任公司 生产促卵泡激素的细胞克隆
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TWI488640B (zh) 2008-04-16 2015-06-21 菲瑞茵國際中心股份有限公司 藥學製劑
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CN102309745B (zh) * 2008-09-17 2013-05-08 上海天伟生物制药有限公司 一种卵泡刺激素冻干针剂
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WO2012127500A2 (en) * 2011-03-11 2012-09-27 Sanzyme Limited Composition for spermatogenesis
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AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
KR102662956B1 (ko) 2015-06-19 2024-05-03 옵코 바이오로직스 리미티드 장기-작용성 응고 인자 및 그의 제조 방법
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CN117783545B (zh) * 2023-12-28 2026-03-06 深圳市新产业生物医学工程股份有限公司 经封闭剂封闭的软质材料、容器、液态校准品及检测试剂盒

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WO1993011788A1 (en) * 1991-12-18 1993-06-24 Applied Research Systems Ars Holding N.V. Gonadotropin containing pharmaceutical compositions with sucrose stabilizer
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WO1996029095A1 (en) * 1995-03-21 1996-09-26 Applied Research Systems Ars Holding N.V. Hcg liquid formulations

Also Published As

Publication number Publication date
HK1010150A1 (en) 1999-06-17
CZ13598A3 (cs) 1998-08-12
CZ297419B6 (cs) 2006-12-13
ES2196474T3 (es) 2003-12-16
TR199800062A2 (xx) 1998-08-21
ATE237348T1 (de) 2003-05-15
BR9800323B1 (pt) 2011-04-19
KR19980070493A (ko) 1998-10-26
JP4353549B2 (ja) 2009-10-28
MX9800438A (es) 1998-11-30
CN1165341C (zh) 2004-09-08
EP0853945A1 (en) 1998-07-22
NZ329572A (en) 1999-05-28
US5929028A (en) 1999-07-27
NO2010013I1 (no) 2010-06-07
FR10C0024I1 (enExample) 2010-05-21
NO2010013I2 (no) 2015-05-18
BR9800323A (pt) 1999-06-29
PT853945E (pt) 2003-08-29
LU91655I2 (fr) 2010-04-26
NO980177D0 (no) 1998-01-14
CN1191139A (zh) 1998-08-26
TW518235B (en) 2003-01-21
DK0853945T3 (da) 2003-08-04
PL324279A1 (en) 1998-07-20
NO980177L (no) 1998-07-16
KR100498531B1 (ko) 2005-09-30
ZA9883B (en) 1998-07-08
EP1285665A1 (en) 2003-02-26
AU5205998A (en) 1998-07-23
DE69813322D1 (de) 2003-05-22
DE122010000011I1 (de) 2010-07-08
JPH10203997A (ja) 1998-08-04
FR10C0024I2 (fr) 2011-04-01
CA2226803A1 (en) 1998-07-15
ID19499A (id) 1998-07-16
HU227154B1 (en) 2010-08-30
HUP9800056A2 (hu) 1998-08-28
SA98181124B1 (ar) 2006-07-10
AR011410A1 (es) 2000-08-16
HUP9800056A3 (en) 2001-01-29
HU9800056D0 (en) 1998-03-02
RU2203086C2 (ru) 2003-04-27
DE69813322T2 (de) 2004-02-19
EP0853945B1 (en) 2003-04-16
IL122732A0 (en) 1998-08-16
NO322509B1 (no) 2006-10-16
PL190103B1 (pl) 2005-10-31
NO2021001I1 (no) 2021-01-12

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