AU720381B2 - Modified oligosaccharides - Google Patents

Modified oligosaccharides Download PDF

Info

Publication number
AU720381B2
AU720381B2 AU43788/97A AU4378897A AU720381B2 AU 720381 B2 AU720381 B2 AU 720381B2 AU 43788/97 A AU43788/97 A AU 43788/97A AU 4378897 A AU4378897 A AU 4378897A AU 720381 B2 AU720381 B2 AU 720381B2
Authority
AU
Australia
Prior art keywords
alkyl
cycloalkyl
aralkyl
cycloalkenyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU43788/97A
Other languages
English (en)
Other versions
AU4378897A (en
Inventor
Rolf Banteli
Willy Kinzy
Gebhard Thoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU4378897A publication Critical patent/AU4378897A/en
Application granted granted Critical
Publication of AU720381B2 publication Critical patent/AU720381B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU43788/97A 1996-08-08 1997-08-06 Modified oligosaccharides Ceased AU720381B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP96810527 1996-08-08
EP96810526 1996-08-08
EP96810526 1996-08-08
EP96810527 1996-08-08
EP96810636 1996-09-26
EP96810636 1996-09-26
PCT/EP1997/004279 WO1998006730A1 (en) 1996-08-08 1997-08-06 Modified oligosaccharides

Publications (2)

Publication Number Publication Date
AU4378897A AU4378897A (en) 1998-03-06
AU720381B2 true AU720381B2 (en) 2000-06-01

Family

ID=27237868

Family Applications (1)

Application Number Title Priority Date Filing Date
AU43788/97A Ceased AU720381B2 (en) 1996-08-08 1997-08-06 Modified oligosaccharides

Country Status (19)

Country Link
EP (1) EP0920437A1 (cs)
JP (1) JP2000516224A (cs)
KR (1) KR20000029862A (cs)
CN (1) CN1227563A (cs)
AR (1) AR008283A1 (cs)
AU (1) AU720381B2 (cs)
BR (1) BR9711117A (cs)
CA (1) CA2260854A1 (cs)
CO (1) CO4900075A1 (cs)
CZ (1) CZ39099A3 (cs)
ID (1) ID18010A (cs)
IL (1) IL127908A0 (cs)
NO (1) NO990497L (cs)
NZ (1) NZ334048A (cs)
PE (1) PE99298A1 (cs)
PL (1) PL331286A1 (cs)
SK (1) SK15699A3 (cs)
TR (1) TR199900245T2 (cs)
WO (1) WO1998006730A1 (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
WO2000044367A2 (en) 1999-02-01 2000-08-03 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
WO2004004636A2 (en) * 2002-07-03 2004-01-15 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
DE60329511D1 (de) 2002-10-11 2009-11-12 Astellas Pharma Europ B V Verbindungen auf glukosebasis mit affinitüt für p-selektin
DE602004011272T2 (de) 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
JP2007524658A (ja) * 2003-11-19 2007-08-30 グリコミメティクス， インコーポレイテッド Ｅ−およびｐ−セレクチンの両方のための糖模倣物アンタゴニスト
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
ES2375979T3 (es) 2005-08-09 2012-03-07 Glycomimetics, Inc. Inhibidores glicomiméticos de la lectina pa-il, lectina pa-iil o ambas lectinas de pseudomonas.
DK1934236T3 (da) 2005-09-02 2013-02-25 Glycomimetics Inc Heterobifunktionelle pan-selektininhibitorer
JP5511390B2 (ja) * 2007-02-09 2014-06-04 グリコミメティクス， インコーポレイテッド ヘキソースおよびｎ−アセチルヘキソサミンの置換体を有する糖模倣体の使用方法
WO2009073911A1 (en) 2007-12-10 2009-06-18 Mater Medical Research Institute Treatment and prophylaxis
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
BR112014014547B1 (pt) 2011-12-22 2022-09-27 Glycomimetics, Inc Composto, composição e métodos de uso
WO2014089269A1 (en) 2012-12-07 2014-06-12 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
PL3227310T3 (pl) 2014-12-03 2020-02-28 Glycomimetics, Inc. Heterodwufunkcyjne inhibitory selektyn E i receptorów chemokinowych CXCR4”
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
KR20240046288A (ko) 2016-10-07 2024-04-08 글리코미메틱스, 인크. 매우 강력한 다량체성 e-셀렉틴 길항물질
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
US11548908B2 (en) 2017-12-29 2023-01-10 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
CN108299525B (zh) * 2018-01-05 2021-03-26 佛山科学技术学院 路易斯寡糖-x的合成方法
CA3091454A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
CN109762032A (zh) * 2019-01-16 2019-05-17 天津科技大学 一种磺酸化路易斯x三糖及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023031A1 (en) * 1992-05-08 1993-11-25 The Biomembrane Institute Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
CA2157489A1 (en) * 1993-03-04 1994-09-15 Masaaki Numata Lewis-associated compound, process for producing the same, and anti-inflammatory
SK141695A3 (en) * 1993-05-14 1996-10-02 Cytel Corp Analogous compound sialyl lex, pharmaceutical agent containing this compound and method of preparation of lactoseammoniacal salt
MX9704893A (es) * 1994-12-28 1997-10-31 Sumitomo Pharma Derivados de lewis x y procesos para producir los mismos.

Also Published As

Publication number Publication date
AR008283A1 (es) 1999-12-29
EP0920437A1 (en) 1999-06-09
NO990497L (no) 1999-03-24
CA2260854A1 (en) 1998-02-19
KR20000029862A (ko) 2000-05-25
SK15699A3 (en) 1999-07-12
NZ334048A (en) 2000-05-26
TR199900245T2 (xx) 1999-05-21
AU4378897A (en) 1998-03-06
NO990497D0 (no) 1999-02-03
CO4900075A1 (es) 2000-03-27
WO1998006730A1 (en) 1998-02-19
IL127908A0 (en) 1999-11-30
PE99298A1 (es) 1999-01-21
BR9711117A (pt) 1999-09-08
ID18010A (id) 1998-02-19
CN1227563A (zh) 1999-09-01
JP2000516224A (ja) 2000-12-05
PL331286A1 (en) 1999-07-05
CZ39099A3 (cs) 1999-05-12

Similar Documents

Publication Publication Date Title
AU720381B2 (en) Modified oligosaccharides
AU707474B2 (en) Diglycosylated 1,2-diols as mimetics of sialyl-lewis X and sialyl-lewis A
JPS61148193A (ja) 腫瘍治療剤
JPH07267978A (ja) 接着防止特性を有するマロン酸誘導体
JPH0662663B2 (ja) デスアザプリン―ヌクレオシド―誘導体
JP2004509902A5 (cs)
FR2751334A1 (fr) Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant
EP0801071A1 (en) Lewis x derivative and process for producing the same
US3868360A (en) Process for preparing 2-deroxy-3-desamino-2,3-epimino-aminoglycosides and intermediates useful therein
JPS6345293A (ja) シアロシルセラミド類及びその製造方法
JP7166450B2 (ja) フコシル化コンドロイチン硫酸オリゴ糖、その製造方法、組成物及び用途
CA2442979C (en) Process for the preparation of 2'-halo-.beta.-l-arabinofuranosyl nucleosides
Listkowski et al. Carboxymethylglycoside lactones (CMGLs): structural variations on the carbohydrate moiety
US4691012A (en) Sialic acid derivative and process for preparing the same
CN105418700B (zh) 基于抗肿瘤疫苗gm3关键中间体二糖化合物的制备方法
JPH0717669B2 (ja) ４′−デメチルエピポドフィロトキシングリコシド類
US20150105543A1 (en) Synthesis
KR920001690B1 (ko) 니트로소우레아 유도체의 제조방법
JPS63156798A (ja) アントラサイクリン誘導体およびその製法
MXPA99001287A (en) Modified oligosaccharides
CN116143758B (zh) 一类氮杂黄酮类靶向蛋白嵌合体及其在制备抗肿瘤药物中的应用
Gruza et al. Synthesis of protoescigenin glycoconjugates with O-28 triazole linker
Machado et al. A new approach to the ribosylribitol intermediate for the synthesis of Haemophilus influenzae type B oligosaccharides
GB2071658A (en) Synthesis of daunosamine hydrochloride and intermediates used in its preparation
JP2004518692A (ja) Ｃ−グルコシルエーテル脂質

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired