AU675240B2 - Terfenadine metabolites and their optically pure isomers for treating allergic disorders - Google Patents

Terfenadine metabolites and their optically pure isomers for treating allergic disorders Download PDF

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Publication number
AU675240B2
AU675240B2 AU47986/93A AU4798693A AU675240B2 AU 675240 B2 AU675240 B2 AU 675240B2 AU 47986/93 A AU47986/93 A AU 47986/93A AU 4798693 A AU4798693 A AU 4798693A AU 675240 B2 AU675240 B2 AU 675240B2
Authority
AU
Australia
Prior art keywords
terfenadine
document
compound
vol
pages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU47986/93A
Other languages
English (en)
Other versions
AU4798693A (en
Inventor
Yiwang Chen
Nancy M. Gray
Raymond L. Woosley
James W. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Georgetown University
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27129882&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU675240(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Georgetown University, Sepracor Inc filed Critical Georgetown University
Publication of AU4798693A publication Critical patent/AU4798693A/en
Application granted granted Critical
Publication of AU675240B2 publication Critical patent/AU675240B2/en
Assigned to SEPRACOR, INC. reassignment SEPRACOR, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: GEORGETOWN UNIVERSITY, SEPRACOR, INC.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
AU47986/93A 1992-08-03 1993-08-03 Terfenadine metabolites and their optically pure isomers for treating allergic disorders Expired AU675240B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92415692A 1992-08-03 1992-08-03
US92418292A 1992-08-03 1992-08-03
US924156 1992-08-03
US924182 1992-08-03
PCT/US1993/007260 WO1994003170A1 (en) 1992-08-03 1993-08-03 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU71822/96A Division AU7182296A (en) 1992-08-03 1996-11-19 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Publications (2)

Publication Number Publication Date
AU4798693A AU4798693A (en) 1994-03-03
AU675240B2 true AU675240B2 (en) 1997-01-30

Family

ID=27129882

Family Applications (3)

Application Number Title Priority Date Filing Date
AU47986/93A Expired AU675240B2 (en) 1992-08-03 1993-08-03 Terfenadine metabolites and their optically pure isomers for treating allergic disorders
AU71822/96A Abandoned AU7182296A (en) 1992-08-03 1996-11-19 Terfenadine metabolites and their optically pure isomers for treating allergic disorders
AU18429/99A Abandoned AU1842999A (en) 1992-08-03 1999-02-25 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU71822/96A Abandoned AU7182296A (en) 1992-08-03 1996-11-19 Terfenadine metabolites and their optically pure isomers for treating allergic disorders
AU18429/99A Abandoned AU1842999A (en) 1992-08-03 1999-02-25 Terfenadine metabolites and their optically pure isomers for treating allergic disorders

Country Status (24)

Country Link
US (1) US5375693A (ja)
EP (4) EP1214937B1 (ja)
JP (6) JP3041954B2 (ja)
KR (1) KR950702420A (ja)
AT (3) ATE162399T1 (ja)
AU (3) AU675240B2 (ja)
BR (1) BR9306841A (ja)
CA (1) CA2141572C (ja)
CZ (1) CZ27495A3 (ja)
DE (5) DE69334145T2 (ja)
DK (3) DK0815860T3 (ja)
ES (3) ES2257757T3 (ja)
FI (1) FI950467A (ja)
GB (1) GB2284351B (ja)
GR (3) GR960300024T1 (ja)
HK (1) HK1045806B (ja)
HU (1) HU226242B1 (ja)
NO (1) NO310644B1 (ja)
PL (1) PL174373B1 (ja)
PT (2) PT1214937E (ja)
RO (1) RO116043B1 (ja)
RU (1) RU2167657C2 (ja)
SK (1) SK12495A3 (ja)
WO (1) WO1994003170A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU679910B2 (en) * 1992-05-11 1997-07-17 Merrell Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2257757T3 (es) * 1992-08-03 2006-08-01 Sepracor Inc. Carboxilato de terfenadina y el tratamiento de trastornos alergicos.
JP3034047B2 (ja) * 1993-06-24 2000-04-17 オールバニー・モレキュラー・リサーチ・インコーポレイテッド ピペリジン誘導体及びそれらの製造法
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
JPH10500134A (ja) 1994-05-18 1998-01-06 ヘキスト・マリオン・ルセル・インコーポレイテツド 抗ヒスタミン性ピペリジン誘導体の無水および水和形態、それらの多形態および擬似形態の製造方法
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US5455049A (en) * 1995-01-04 1995-10-03 Ascent Pharmaceuticals, Inc. Terfenadine oral powder
AU701042B2 (en) 1995-02-28 1999-01-21 Aventisub Llc Pharmaceutical composition for piperidinoalkanol compounds
GB9513972D0 (en) * 1995-07-08 1995-09-06 Merck Sharp & Dohme Pharmaceutical compositions
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6486177B2 (en) 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6355656B1 (en) 1995-12-04 2002-03-12 Celgene Corporation Phenidate drug formulations having diminished abuse potential
US5908850A (en) * 1995-12-04 1999-06-01 Celgene Corporation Method of treating attention deficit disorders with d-threo methylphenidate
US5733756A (en) * 1996-01-05 1998-03-31 Celgene Corporation Lactams and processes for stereoselective enrichment of lactams, amides, and esters
US6201124B1 (en) 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
EE04294B1 (et) * 1997-08-26 2004-06-15 Hoechst Marion Roussel, Inc. Farmatseutiline kompositsioon piperidinoalkanooldekongestandi kombineerimiseks
US6194431B1 (en) * 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
DE19913862C2 (de) * 1999-03-26 2003-04-10 Forschungszentrum Juelich Gmbh Verfahren zur biokatalysierten Umsetzung schlecht wasserlöslicher Substanzen
DE10007203A1 (de) * 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
PL366576A1 (en) * 2001-04-09 2005-02-07 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
WO2003020274A1 (en) * 2001-08-30 2003-03-13 Aventis Pharmaceuticals Inc. Treatment of atopic dermatitis
US20040044038A1 (en) * 2002-06-10 2004-03-04 Barnaba Krochmal Polymorphic form XVI of fexofenadine hydrochloride
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
JP4515121B2 (ja) 2004-03-15 2010-07-28 東芝テック株式会社 ワイヤドットプリンタヘッド及びワイヤドットプリンタ
JP4473021B2 (ja) 2004-03-22 2010-06-02 東芝テック株式会社 窒化層形成方法、磁気回路形成部材、アーマチュア、ワイヤドットプリンタヘッド及びワイヤドットプリンタ
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
EP1628959A2 (en) * 2004-04-26 2006-03-01 Teva Pharmaceutical Industries Ltd Crystalline forms of fexofenadine hydrochloride and processes for their preparation
US7498345B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
JP2008514641A (ja) * 2004-09-28 2008-05-08 テバ ファーマシューティカル インダストリーズ リミティド 結晶形フェキソフェナジン、およびその調製方法
AU2005313887B2 (en) * 2004-12-09 2011-10-27 Celgene Corporation Treatment using D-threo methylphenidate
EP1956906A4 (en) 2005-11-09 2009-12-30 Combinatorx Inc METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES
CA2681267C (en) * 2007-04-13 2013-11-19 Southern Research Institute Anti-angiogenic agents and methods of use
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20150238473A1 (en) * 2012-09-27 2015-08-27 University Of Rochester Methods and compositions for treating infection
PL3273952T3 (pl) * 2015-03-26 2022-11-14 SEN-JAM Pharmaceutical LLC Kombinacja naproksenu i feksofenadyny w celu zahamowania objawów związanych z zatruciem alkoholem
DE102017130361A1 (de) 2017-12-18 2019-07-04 Lsp Innovative Automotive Systems Gmbh Statorzahn und Stator mit guter elektrischer Isolierung und gleichzeitig sehr hoher Wärmeleitfähigkeit zur Leistungssteigerung von Elektromotoren

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives

Family Cites Families (13)

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US880801A (en) † 1908-03-03 Harold Larsen Vibrator.
US922890A (en) † 1907-03-26 1909-05-25 Peder Joergen Hansen Stream-motor.
US4552899A (en) † 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4829064A (en) † 1987-06-08 1989-05-09 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4996061A (en) † 1987-10-07 1991-02-26 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol-decongestant combination
MX9302076A (es) * 1992-04-10 1994-03-31 Merrell Dow Pharma Proceso novedoso para preparar derivados de piperidina.
ATE194913T1 (de) * 1992-05-11 2000-08-15 Merrell Pharma Inc Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
ES2257757T3 (es) 1992-08-03 2006-08-01 Sepracor Inc. Carboxilato de terfenadina y el tratamiento de trastornos alergicos.
JP3034047B2 (ja) * 1993-06-24 2000-04-17 オールバニー・モレキュラー・リサーチ・インコーポレイテッド ピペリジン誘導体及びそれらの製造法
HU226037B1 (en) * 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates
CA2128821A1 (en) * 1993-07-27 1995-01-28 Dilip J. Gole Freeze-dried pharmaceutical dosage form and process for separation thereof
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU679910B2 (en) * 1992-05-11 1997-07-17 Merrell Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient

Also Published As

Publication number Publication date
HK1045806B (zh) 2008-03-14
DK0701443T3 (da) 1998-02-09
EP1214937A2 (en) 2002-06-19
EP1688142A1 (en) 2006-08-09
DK1214937T3 (da) 2007-09-17
NO310644B1 (no) 2001-08-06
HK1045806A1 (en) 2002-12-13
DE69334008T2 (de) 2006-10-19
KR950702420A (ko) 1995-07-29
AU7182296A (en) 1997-01-30
CA2141572A1 (en) 1994-02-17
CZ27495A3 (en) 1996-09-11
GB2284351A (en) 1995-06-07
SK12495A3 (en) 1997-01-08
JP2000086512A (ja) 2000-03-28
FI950467A0 (fi) 1995-02-02
EP0815860A3 (en) 1998-01-14
ES2086270T1 (es) 1996-07-01
RO116043B1 (ro) 2000-10-30
DE69316660D1 (de) 1998-02-26
DE69334145D1 (de) 2007-07-12
DK0701443T4 (da) 2000-12-18
EP0815860A2 (en) 1998-01-07
EP0701443A1 (en) 1996-03-20
AU4798693A (en) 1994-03-03
ES2284740T3 (es) 2007-11-16
EP1214937A3 (en) 2002-10-30
BR9306841A (pt) 1998-12-08
DE69316660T3 (de) 2001-04-05
CA2141572C (en) 2001-02-06
JP3288661B2 (ja) 2002-06-04
JP2000086514A (ja) 2000-03-28
DE701443T1 (de) 1997-01-30
DE69316660T2 (de) 1998-05-07
DK0815860T3 (da) 2006-08-14
EP0701443B1 (en) 1998-01-21
US5375693A (en) 1994-12-27
JP2000086515A (ja) 2000-03-28
GR960300024T1 (en) 1996-05-31
GR3026530T3 (en) 1998-07-31
HU9500313D0 (en) 1995-03-28
DE69334008D1 (de) 2006-05-24
JP2000086516A (ja) 2000-03-28
NO950374D0 (no) 1995-02-01
AU1842999A (en) 1999-04-29
JP3037697B2 (ja) 2000-04-24
RU2167657C2 (ru) 2001-05-27
ES2086270T3 (es) 1998-03-01
PL307339A1 (en) 1995-05-15
ES2257757T3 (es) 2006-08-01
JP3041954B2 (ja) 2000-05-15
WO1994003170A1 (en) 1994-02-17
ES2086270T5 (es) 2001-02-01
RU95107881A (ru) 1996-11-27
EP0701443B2 (en) 2000-11-22
EP1214937B1 (en) 2007-05-30
DE69334145T2 (de) 2008-01-24
HUT71889A (en) 1996-02-28
DE9320925U1 (de) 1995-08-31
NO950374L (no) 1995-03-29
GR3035417T3 (en) 2001-05-31
ATE363283T1 (de) 2007-06-15
JPH08500348A (ja) 1996-01-16
HU226242B1 (en) 2008-07-28
PL174373B1 (pl) 1998-07-31
JP3288662B2 (ja) 2002-06-04
ATE322899T1 (de) 2006-04-15
GB9502183D0 (en) 1995-03-22
FI950467A (fi) 1995-03-31
JP2000086513A (ja) 2000-03-28
PT1214937E (pt) 2007-07-25
JP3288660B2 (ja) 2002-06-04
PT815860E (pt) 2006-08-31
ATE162399T1 (de) 1998-02-15
EP0815860B1 (en) 2006-04-12
GB2284351B (en) 1996-11-27

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PC1 Assignment before grant (sect. 113)

Free format text: SEPRACOR INC.

CH Opposition withdrawn

Free format text: HOESCHT MARION ROUSSEL, INC.

FGA Letters patent sealed or granted (standard patent)