AU670329B2 - New derivatives of erythromycin, their preparation process, their use as medicaments - Google Patents

New derivatives of erythromycin, their preparation process, their use as medicaments Download PDF

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Publication number
AU670329B2
AU670329B2 AU50477/93A AU5047793A AU670329B2 AU 670329 B2 AU670329 B2 AU 670329B2 AU 50477/93 A AU50477/93 A AU 50477/93A AU 5047793 A AU5047793 A AU 5047793A AU 670329 B2 AU670329 B2 AU 670329B2
Authority
AU
Australia
Prior art keywords
formula
methyl
radical
dideoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU50477/93A
Other languages
English (en)
Other versions
AU5047793A (en
Inventor
Constantin Agouridas
Alain Bonnefoy
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9213320A external-priority patent/FR2697523B1/fr
Priority claimed from FR9308109A external-priority patent/FR2707088B1/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU5047793A publication Critical patent/AU5047793A/en
Application granted granted Critical
Publication of AU670329B2 publication Critical patent/AU670329B2/en
Assigned to HOECHST MARION ROUSSEL reassignment HOECHST MARION ROUSSEL Alteration of Name(s) in Register under S187 Assignors: ROUSSEL-UCLAF
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU50477/93A 1992-11-05 1993-11-05 New derivatives of erythromycin, their preparation process, their use as medicaments Expired AU670329B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9213320A FR2697523B1 (fr) 1992-11-05 1992-11-05 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR9213320 1992-11-05
FR9308109 1993-07-02
FR9308109A FR2707088B1 (fr) 1993-07-02 1993-07-02 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Publications (2)

Publication Number Publication Date
AU5047793A AU5047793A (en) 1994-05-19
AU670329B2 true AU670329B2 (en) 1996-07-11

Family

ID=26229842

Family Applications (1)

Application Number Title Priority Date Filing Date
AU50477/93A Expired AU670329B2 (en) 1992-11-05 1993-11-05 New derivatives of erythromycin, their preparation process, their use as medicaments

Country Status (16)

Country Link
US (2) US5527780A (enExample)
EP (1) EP0596802B1 (enExample)
JP (2) JP3000022B2 (enExample)
KR (1) KR100317149B1 (enExample)
CN (1) CN1040876C (enExample)
AT (1) ATE135706T1 (enExample)
AU (1) AU670329B2 (enExample)
BR (1) BR9304481A (enExample)
CA (1) CA2102457C (enExample)
DE (1) DE69301897T2 (enExample)
DK (1) DK0596802T3 (enExample)
ES (1) ES2085130T3 (enExample)
GR (1) GR3019385T3 (enExample)
HU (3) HU222113B1 (enExample)
MA (1) MA23018A1 (enExample)
RU (1) RU2126416C1 (enExample)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2727969B1 (fr) * 1994-12-09 1997-01-17 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5747466A (en) * 1995-11-08 1998-05-05 Abbott Laboratories 3-deoxy-3-descladinose derivatives of erythromycins A and B
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
DE69733370T2 (de) * 1996-09-04 2006-02-02 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
EP0988308A1 (en) * 1997-06-11 2000-03-29 Pfizer Products Inc. 9-oxime erythromycin derivatives
US5780604A (en) * 1997-09-26 1998-07-14 Abbott Laboratories 11,12-cyclic phosphite or phosphate derivatives of erythromycin and related macrolides
US6034069A (en) * 1997-09-30 2000-03-07 Abbott Laboratories 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives
AU9649698A (en) * 1997-10-29 1999-05-17 Taisho Pharmaceutical Co., Ltd. Erythromycin a 11, 12-carbamate derivatives
ZA989835B (en) * 1997-10-29 1999-05-05 Taisho Pharmaceutical Co Ltd Erythromycin a derivatives
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
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FR2777282B1 (fr) * 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
WO2000017218A1 (en) 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU5995299A (en) * 1998-11-03 2000-05-22 Pfizer Products Inc. Novel macrolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
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US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
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US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
KR100710605B1 (ko) 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
US6939861B2 (en) * 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU640290B2 (en) * 1990-11-21 1993-08-19 Aventis Pharma S.A. New erythromycin derivatives, their preparation process, the new intermediates obtained and their use as medicaments
AU5043893A (en) * 1992-11-05 1994-05-19 Aventis Pharma S.A. New erythromycin derivatives, their preparation process and their use as medicaments
AU5763994A (en) * 1993-03-09 1994-09-15 Aventis Pharma S.A. New derivatives of erythromycin, their preparation process and their use as medicaments

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AT342770B (de) * 1975-04-07 1978-04-25 Thomae Gmbh Dr K Verfahren zur herstellung neuer erythromycinderivate
DE2936865A1 (de) * 1979-09-12 1981-04-02 Bayer Ag, 5090 Leverkusen Verwendung von pikromycin-derivaten als nutritiva
GR77556B (enExample) * 1982-11-15 1984-09-24 Pfizer
JPS6229595A (ja) * 1985-07-31 1987-02-07 Toyo Jozo Co Ltd ５−ｏ−マイカミノシル−ナルボノライド誘導体およびその製法
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US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
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FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU640290B2 (en) * 1990-11-21 1993-08-19 Aventis Pharma S.A. New erythromycin derivatives, their preparation process, the new intermediates obtained and their use as medicaments
AU5043893A (en) * 1992-11-05 1994-05-19 Aventis Pharma S.A. New erythromycin derivatives, their preparation process and their use as medicaments
AU5763994A (en) * 1993-03-09 1994-09-15 Aventis Pharma S.A. New derivatives of erythromycin, their preparation process and their use as medicaments

Also Published As

Publication number Publication date
GR3019385T3 (en) 1996-06-30
JP3000022B2 (ja) 2000-01-17
BR9304481A (pt) 1994-06-21
ATE135706T1 (de) 1996-04-15
AU5047793A (en) 1994-05-19
KR940011474A (ko) 1994-06-21
CA2102457C (fr) 2002-01-22
JP3151188B2 (ja) 2001-04-03
DE69301897T2 (de) 1996-11-07
ES2085130T3 (es) 1996-05-16
HU221978B1 (hu) 2003-03-28
DK0596802T3 (da) 1996-06-03
JPH11180994A (ja) 1999-07-06
JPH06220082A (ja) 1994-08-09
HU220048B (hu) 2001-10-28
EP0596802A1 (fr) 1994-05-11
HU222113B1 (hu) 2003-04-28
DE69301897D1 (de) 1996-04-25
CN1090581A (zh) 1994-08-10
RU2126416C1 (ru) 1999-02-20
EP0596802B1 (fr) 1996-03-20
US5527780A (en) 1996-06-18
CN1040876C (zh) 1998-11-25
HU0003975D0 (enExample) 2000-12-28
KR100317149B1 (ko) 2002-06-20
MA23018A1 (fr) 1994-07-01
HUT66446A (en) 1994-11-28
CA2102457A1 (fr) 1994-05-06
US5614614A (en) 1997-03-25

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Legal Events

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PC Assignment registered

Owner name: AVENTIS PHARMA S.A.

Free format text: FORMER OWNER WAS: HOECHST MARION ROUSSEL