AU659235B2 - Substituted biphenylpyridones - Google Patents

Substituted biphenylpyridones Download PDF

Info

Publication number
AU659235B2
AU659235B2 AU28232/92A AU2823292A AU659235B2 AU 659235 B2 AU659235 B2 AU 659235B2 AU 28232/92 A AU28232/92 A AU 28232/92A AU 2823292 A AU2823292 A AU 2823292A AU 659235 B2 AU659235 B2 AU 659235B2
Authority
AU
Australia
Prior art keywords
carbon atoms
chain
straight
denotes
branched alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU28232/92A
Other languages
English (en)
Other versions
AU2823292A (en
Inventor
Martin Beuck
Jurgen Dressel
Peter Fey
Rudolf Hanko
Walter Hubsch
Stanislav Kazda
Andreas Knorr
Thomas Kramer
Ulrich Muller
Matthias Muller-Gliemann
Johannes-Peter Stasch
Stefan Wohlfeil
Siegfried Zaiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU2823292A publication Critical patent/AU2823292A/en
Application granted granted Critical
Publication of AU659235B2 publication Critical patent/AU659235B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU28232/92A 1991-11-12 1992-11-09 Substituted biphenylpyridones Ceased AU659235B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4137151 1991-11-12
DE4137151 1991-11-12
DE4221583A DE4221583A1 (de) 1991-11-12 1992-07-01 Substituierte biphenylpyridone
DE4221583 1992-07-01

Publications (2)

Publication Number Publication Date
AU2823292A AU2823292A (en) 1993-05-13
AU659235B2 true AU659235B2 (en) 1995-05-11

Family

ID=25909023

Family Applications (1)

Application Number Title Priority Date Filing Date
AU28232/92A Ceased AU659235B2 (en) 1991-11-12 1992-11-09 Substituted biphenylpyridones

Country Status (23)

Country Link
US (2) US5356911A (enExample)
EP (1) EP0542059B1 (enExample)
JP (1) JPH05255258A (enExample)
KR (1) KR930010030A (enExample)
CN (1) CN1038935C (enExample)
AT (1) ATE135700T1 (enExample)
AU (1) AU659235B2 (enExample)
CA (1) CA2082306A1 (enExample)
CZ (1) CZ281937B6 (enExample)
DE (2) DE4221583A1 (enExample)
DK (1) DK0542059T3 (enExample)
ES (1) ES2086046T3 (enExample)
FI (1) FI925100A7 (enExample)
GR (1) GR3019398T3 (enExample)
HU (1) HUT67018A (enExample)
IL (1) IL103688A (enExample)
MX (1) MX9206305A (enExample)
MY (1) MY109880A (enExample)
NO (1) NO303541B1 (enExample)
NZ (1) NZ245073A (enExample)
RU (1) RU2100350C1 (enExample)
SK (1) SK279433B6 (enExample)
TW (1) TW218874B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU670315B2 (en) * 1992-10-23 1996-07-11 Bayer Aktiengesellschaft Trisubstituted biphenyls

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5674883A (en) * 1992-02-07 1997-10-07 Roussel Uclaf Derivatives of pyridone, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
GB9218449D0 (en) 1992-08-29 1992-10-14 Boots Co Plc Therapeutic agents
DE4319040A1 (de) * 1992-10-23 1994-04-28 Bayer Ag Alkoxymethylsubstituierte Pyridonbiphenyle
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
TW418204B (en) * 1997-03-28 2001-01-11 Dev Center Biotechnology Novel 1,2,4-triazine-5-ketonyl benzene derivatives and the analogs, the preparation, and the pharmaceutical compositions as angiotension II receptor antogonists
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
GB0022483D0 (en) * 2000-09-13 2000-11-01 Eisai Co Ltd 1 2 Dihydropyridine compounds manufacturing method thereof and use thereof
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
AP1822A (en) * 2002-02-14 2008-01-30 Pharmacia Corp Substituted pyridinones as modulators of P38 MAP kinase.
CA2523743A1 (en) * 2003-04-30 2004-11-18 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids as inhibitors of protein tyrosine phosphatase-1b
MY148809A (en) * 2004-07-06 2013-05-31 Eisai R&D Man Co Ltd Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
EP1844043A2 (en) * 2004-11-18 2007-10-17 The Institutes for Pharmaceutical Discovery, LLC Heterocycle substituted carboxylic acids for the treatment of diabetes
MX2007007330A (es) * 2004-12-16 2007-10-04 Vertex Pharma Piridonas de utilidad como inhibidores de quinasas .
DE102005030522A1 (de) * 2005-06-30 2007-01-04 Bayer Healthcare Ag Salz des Embusartans
AU2006285038A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
JP5112317B2 (ja) * 2005-08-29 2013-01-09 バーテックス ファーマシューティカルズ インコーポレイテッド 非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
WO2007027729A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
BRPI0816970A2 (pt) 2007-09-14 2015-03-24 Ortho Mcneil Janssen Pharm 1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
EA017648B1 (ru) 2007-09-14 2013-02-28 Орто-Макнейл-Янссен Фармасьютикалз, Инк. 1',3'-двузамещенные-4-фенил-3,4,5,6-тетрагидро-2н,1'н-[1,4']бипириди-нил-2'-оны
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
CA2704436C (en) * 2007-11-14 2016-01-05 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
WO2010043396A1 (en) 2008-10-16 2010-04-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
JP5690277B2 (ja) 2008-11-28 2015-03-25 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としてのインドールおよびベンゾオキサジン誘導体
HRP20131122T1 (hr) 2009-05-12 2013-12-20 Janssen Pharmaceuticals, Inc. Derivati 1,2,4-triazolo[4,3-a] piridina i njihova uporaba u lijeäśenju ili prevenciji neuroloških i psihijatrijskih poremeä†aja
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439015B (zh) 2009-05-12 2015-05-13 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物和其作为mGluR2受体的正向变构调节剂的用途
CA2774039A1 (en) * 2009-11-06 2011-05-12 Aerpio Therapeutics Inc. Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
JP5852664B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
WO2013093484A1 (en) * 2011-12-21 2013-06-27 Ono Pharmaceutical Co., Ltd. Pyridinone and pyrimidinone derivatives as factor xia inhibitors
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
ME03518B (me) 2014-01-21 2020-04-20 Janssen Pharmaceutica Nv Kombinacije koje obuhvataju pozitivne alosterične modulatore ili ortosterične agoniste metabotropnog glutamatergičnog receptora podtipa 2 i njihova primjena
PL3096790T3 (pl) 2014-01-21 2020-01-31 Janssen Pharmaceutica, N.V. Kombinacje zawierające pozytywne modulatory allosteryczne lub agonistów ortosterycznych metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie
WO2016093285A1 (ja) 2014-12-10 2016-06-16 小野薬品工業株式会社 ジヒドロインドリジノン誘導体
US10322156B2 (en) * 2016-07-07 2019-06-18 Herbalife International Of America, Inc. Methods of treatment using purified (decolorized) aloe vera leaf dry juice
JP2024506858A (ja) 2021-02-02 2024-02-15 リミナル・バイオサイエンシーズ・リミテッド Ｇｐｒ８４アンタゴニストおよびその使用
KR20230153387A (ko) 2021-02-02 2023-11-06 리미널 바이오사이언시스 리미티드 Gpr84 길항제 및 이의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1228792A (en) * 1991-02-16 1992-09-15 Fisons Plc Substituted pyridinones and pyrimidinones as angiotensin ii antagonists
AU2205592A (en) * 1991-09-04 1993-03-11 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridine
AU653734B2 (en) * 1990-06-19 1994-10-13 Meiji Seika Kabushiki Kaisha Substituted 4-biphenylmethoxypyridine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0424317A3 (en) 1989-10-19 1991-09-25 Ciba-Geigy Ag Pyrimidines
EP0435827A3 (en) 1989-12-28 1991-11-13 Ciba-Geigy Ag Diaza compounds
CA2037630C (en) 1990-03-07 2001-07-03 Akira Morimoto Nitrogen-containing heterocylic compounds, their production and use
CN1068109A (zh) * 1991-02-16 1993-01-20 菲索斯有限公司 新的血管紧张肽ii拮抗剂及其制剂的制备和应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653734B2 (en) * 1990-06-19 1994-10-13 Meiji Seika Kabushiki Kaisha Substituted 4-biphenylmethoxypyridine derivatives
AU1228792A (en) * 1991-02-16 1992-09-15 Fisons Plc Substituted pyridinones and pyrimidinones as angiotensin ii antagonists
AU2205592A (en) * 1991-09-04 1993-03-11 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU670315B2 (en) * 1992-10-23 1996-07-11 Bayer Aktiengesellschaft Trisubstituted biphenyls

Also Published As

Publication number Publication date
JPH05255258A (ja) 1993-10-05
ATE135700T1 (de) 1996-04-15
FI925100A0 (fi) 1992-11-10
KR930010030A (ko) 1993-06-21
NO924172L (no) 1993-05-14
EP0542059B1 (de) 1996-03-20
MY109880A (en) 1997-09-30
HUT67018A (en) 1995-01-30
FI925100L (fi) 1993-05-13
IL103688A0 (en) 1993-04-04
DE59205752D1 (de) 1996-04-25
US5356911A (en) 1994-10-18
US5599823A (en) 1997-02-04
GR3019398T3 (en) 1996-06-30
NZ245073A (en) 1996-02-27
AU2823292A (en) 1993-05-13
CN1072180A (zh) 1993-05-19
CA2082306A1 (en) 1993-05-12
DE4221583A1 (de) 1993-05-13
EP0542059A1 (de) 1993-05-19
NO303541B1 (no) 1998-07-27
RU2100350C1 (ru) 1997-12-27
CN1038935C (zh) 1998-07-01
CZ281937B6 (cs) 1997-04-16
ES2086046T3 (es) 1996-06-16
SK338092A3 (en) 1998-11-04
FI925100A7 (fi) 1993-05-13
NO924172D0 (no) 1992-10-29
HU9203552D0 (en) 1993-01-28
IL103688A (en) 1997-02-18
SK279433B6 (sk) 1998-11-04
DK0542059T3 (da) 1996-07-22
TW218874B (enExample) 1994-01-11
CZ338092A3 (en) 1993-09-15
MX9206305A (es) 1993-05-01

Similar Documents

Publication Publication Date Title
US5356911A (en) Substituted biphenylpyridones
ES2325154T3 (es) Derivados de arilsulfonamidas y su utilizacion como antagonistas del receptor b1 de bradiquinina.
HU225052B1 (en) Cycloalkano-indol- and -azaindol derivatives process for producing them and pharmaceutical compositions containing the same
CA2090267A1 (en) Sulphonylbenzyl-substituted pyridones
US5276048A (en) 4-(1H-pyrrol-1-yl)imidazoles with angiotensin II antagonist activity
CZ26396A3 (en) Novel perhydroisoindole derivatives, process of their preparation and pharmaceutical compositions containing thereof
PL177834B1 (pl) Heterocyklicznie podstawiona pochodna kwasu fenylo-cykloheksano-karboksylowego, sposób jej wytwarzania oraz zawierające ją środek leczniczy
CZ16994A3 (en) Heterocyclic compounds and pharmaceutical preparations in which they are comprised
AU725786B2 (en) Novel pyrimido(1,2-a)indoles
US5225428A (en) Cyclic-substituted imidazolyl-propenoic acid derivatives
CZ297692A3 (en) Substituted derivatives of imidazolyl-propenoic acid
AU670487B2 (en) Heterotricyclically substituted phenyl-cyclohexane- carboxylic acid derivatives
NZ247394A (en) Propenoyl-imidazole derivatives, preparation and pharmaceutical compositions thereof
NZ260163A (en) Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives, and pharmaceutical compositions thereof
US5576342A (en) Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives
US5627285A (en) Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives
NZ247974A (en) Imidazole-substituted cyclohexane derivatives; pharmaceutical compositions
SK14293A3 (en) Sulfonylbenzyl substituted imidazopyridines
JPH0753550A (ja) スルホニルベンジル−置換されたベンズイミダゾール類、それらの製造方法および薬品におけるそれらの使用

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired