AU637720B2 - Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments - Google Patents
Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicamentsInfo
- Publication number
- AU637720B2 AU637720B2 AU84756/91A AU8475691A AU637720B2 AU 637720 B2 AU637720 B2 AU 637720B2 AU 84756/91 A AU84756/91 A AU 84756/91A AU 8475691 A AU8475691 A AU 8475691A AU 637720 B2 AU637720 B2 AU 637720B2
- Authority
- AU
- Australia
- Prior art keywords
- loweralkyl
- chem
- hydrogen
- preparation
- pyridinols
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 Substituted-4-amino-3-pyridinols Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 230000001713 cholinergic effect Effects 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000007074 memory dysfunction Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Surface Treatment Of Glass (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58911390A | 1990-09-27 | 1990-09-27 | |
| US589113 | 1990-09-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8475691A AU8475691A (en) | 1992-04-02 |
| AU637720B2 true AU637720B2 (en) | 1993-06-03 |
Family
ID=24356648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU84756/91A Expired - Fee Related AU637720B2 (en) | 1990-09-27 | 1991-09-26 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US5821239A (OSRAM) |
| EP (1) | EP0477903B1 (OSRAM) |
| JP (1) | JP3090511B2 (OSRAM) |
| KR (1) | KR100215357B1 (OSRAM) |
| AT (1) | ATE136297T1 (OSRAM) |
| AU (1) | AU637720B2 (OSRAM) |
| CA (1) | CA2052433C (OSRAM) |
| CZ (1) | CZ282002B6 (OSRAM) |
| DE (1) | DE69118470T2 (OSRAM) |
| DK (1) | DK0477903T3 (OSRAM) |
| ES (1) | ES2085940T3 (OSRAM) |
| FI (1) | FI914504A7 (OSRAM) |
| GR (1) | GR3019742T3 (OSRAM) |
| HU (1) | HUT60247A (OSRAM) |
| IE (1) | IE73874B1 (OSRAM) |
| IL (1) | IL99581A (OSRAM) |
| NO (1) | NO913778L (OSRAM) |
| NZ (1) | NZ239935A (OSRAM) |
| PT (1) | PT99073B (OSRAM) |
| TW (1) | TW200462B (OSRAM) |
| YU (1) | YU158591A (OSRAM) |
| ZA (1) | ZA917692B (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
| FR2813891B1 (fr) * | 2000-09-14 | 2005-01-14 | Immunotech Sa | Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications |
| DE10102791B4 (de) * | 2001-01-22 | 2004-04-15 | Ifm Electronic Gmbh | Elektrischer Meßumformer |
| KR20040068240A (ko) * | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| KR100443983B1 (ko) | 2002-01-15 | 2004-08-09 | 삼성전자주식회사 | 냉장고 |
| US8007826B2 (en) | 2003-12-11 | 2011-08-30 | Acorda Therapeutics, Inc. | Sustained release aminopyridine composition |
| US8354437B2 (en) | 2004-04-09 | 2013-01-15 | Acorda Therapeutics, Inc. | Method of using sustained release aminopyridine compositions |
| EP2607362B1 (en) | 2005-02-17 | 2014-12-31 | Astellas Pharma Inc. | Piperidine and piperazine carboxylates as FAAH inhibitors |
| AU2009291781A1 (en) * | 2008-09-10 | 2010-03-18 | Acorda Therapeutics, Inc. | Methods of using sustained release aminopyridine compositions |
| EA037187B1 (ru) | 2010-02-09 | 2021-02-17 | Дзе Джонс Хопкинс Юниверсити | Способ и композиция для лечения когнитивного расстройства |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| KR102171152B1 (ko) | 2012-12-13 | 2020-10-29 | 하. 룬드벡 아크티에셀스카브 | 보르티옥세틴 및 도네페질을 포함하는 조성물 |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| JP6433482B2 (ja) | 2013-03-15 | 2018-12-05 | エージンバイオ， インコーポレイテッド | 認知機能を改善するための方法および組成物 |
| AU2016268096B2 (en) | 2015-05-22 | 2021-04-01 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| JP6899120B2 (ja) * | 2016-10-12 | 2021-07-07 | 株式会社ナノエッグ | アセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2562288A (en) * | 1987-11-17 | 1989-05-18 | Ici Americas Inc. | Heterocyclic substituted imino derivatives |
| AU603265B2 (en) * | 1987-10-29 | 1990-11-08 | Ici Americas Inc. | Fungicidal pyridyl cyclopropane carboxamidines |
| AU5784790A (en) * | 1989-06-28 | 1991-01-03 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamio- and naphthyloxy-pyridinamines and related compounds,a process for their preparation and their use as dermatological agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179563A (en) * | 1978-05-19 | 1979-12-18 | Warner-Lambert Company | 3-Aryloxy-substituted-aminopyridines and methods for their production |
| US4734275A (en) * | 1983-08-19 | 1988-03-29 | Research Corporation | Anti-curare agents |
| DE3514073A1 (de) * | 1985-04-18 | 1986-10-23 | Hoechst Ag, 6230 Frankfurt | Mehrfach substituierte pyridin-1-oxide, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| US4735958A (en) * | 1986-12-22 | 1988-04-05 | Warner-Lambert Company | Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis |
| US5019574A (en) * | 1988-09-30 | 1991-05-28 | Chugai Seiyaku Kabushiki Kaisha | 3,4-diaminoquinoline and 3,4-diamino-5,6,7,8-tetrahydroquinoline compounds useful for improving psychoneural function |
| ES2054987T3 (es) * | 1988-11-16 | 1994-08-16 | Hoechst Roussel Pharma | Hidroxi-1,2,3,4-tetrahidroaminoacridinas, un procedimiento para su preparacion y su uso como medicamentos. |
-
1991
- 1991-08-31 TW TW080106907A patent/TW200462B/zh active
- 1991-09-25 AT AT91116336T patent/ATE136297T1/de not_active IP Right Cessation
- 1991-09-25 DE DE69118470T patent/DE69118470T2/de not_active Expired - Fee Related
- 1991-09-25 EP EP91116336A patent/EP0477903B1/en not_active Expired - Lifetime
- 1991-09-25 DK DK91116336.8T patent/DK0477903T3/da active
- 1991-09-25 FI FI914504A patent/FI914504A7/fi not_active Application Discontinuation
- 1991-09-25 ES ES91116336T patent/ES2085940T3/es not_active Expired - Lifetime
- 1991-09-25 CZ CS912936A patent/CZ282002B6/cs not_active IP Right Cessation
- 1991-09-25 NZ NZ239935A patent/NZ239935A/en unknown
- 1991-09-26 IL IL9958191A patent/IL99581A/en not_active IP Right Cessation
- 1991-09-26 YU YU158591A patent/YU158591A/sh unknown
- 1991-09-26 JP JP03273439A patent/JP3090511B2/ja not_active Expired - Fee Related
- 1991-09-26 IE IE338991A patent/IE73874B1/en not_active IP Right Cessation
- 1991-09-26 PT PT99073A patent/PT99073B/pt not_active IP Right Cessation
- 1991-09-26 ZA ZA917692A patent/ZA917692B/xx unknown
- 1991-09-26 AU AU84756/91A patent/AU637720B2/en not_active Expired - Fee Related
- 1991-09-26 HU HU913075A patent/HUT60247A/hu unknown
- 1991-09-26 CA CA002052433A patent/CA2052433C/en not_active Expired - Fee Related
- 1991-09-26 NO NO91913778A patent/NO913778L/no unknown
- 1991-09-27 KR KR1019910016850A patent/KR100215357B1/ko not_active Expired - Fee Related
-
1996
- 1996-02-16 US US08/602,693 patent/US5821239A/en not_active Expired - Fee Related
- 1996-04-24 GR GR960401135T patent/GR3019742T3/el unknown
-
1998
- 1998-06-02 US US09/088,928 patent/US5869480A/en not_active Expired - Fee Related
- 1998-06-02 US US09/088,926 patent/US5866565A/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU603265B2 (en) * | 1987-10-29 | 1990-11-08 | Ici Americas Inc. | Fungicidal pyridyl cyclopropane carboxamidines |
| AU2562288A (en) * | 1987-11-17 | 1989-05-18 | Ici Americas Inc. | Heterocyclic substituted imino derivatives |
| AU5784790A (en) * | 1989-06-28 | 1991-01-03 | Hoechst-Roussel Pharmaceuticals Incorporated | Naphthylamio- and naphthyloxy-pyridinamines and related compounds,a process for their preparation and their use as dermatological agents |
Also Published As
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