AU628846B2 - Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof - Google Patents

Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof Download PDF

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Publication number
AU628846B2
AU628846B2 AU40650/89A AU4065089A AU628846B2 AU 628846 B2 AU628846 B2 AU 628846B2 AU 40650/89 A AU40650/89 A AU 40650/89A AU 4065089 A AU4065089 A AU 4065089A AU 628846 B2 AU628846 B2 AU 628846B2
Authority
AU
Australia
Prior art keywords
mitomycin
saccharide
derivative
amino
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU40650/89A
Other languages
English (en)
Other versions
AU4065089A (en
Inventor
Diana Green
Charles Hammer
Philip S. Schein
Abdolhossen Talebian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of AU4065089A publication Critical patent/AU4065089A/en
Application granted granted Critical
Publication of AU628846B2 publication Critical patent/AU628846B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU40650/89A 1988-08-23 1989-07-25 Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof Ceased AU628846B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23
US235224 1988-08-23

Publications (2)

Publication Number Publication Date
AU4065089A AU4065089A (en) 1990-03-23
AU628846B2 true AU628846B2 (en) 1992-09-24

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
AU40650/89A Ceased AU628846B2 (en) 1988-08-23 1989-07-25 Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Country Status (16)

Country Link
EP (1) EP0431008A4 (ja)
JP (1) JPH04500513A (ja)
KR (1) KR900701269A (ja)
CN (1) CN1040593A (ja)
AU (1) AU628846B2 (ja)
CA (1) CA1327037C (ja)
DK (1) DK29691A (ja)
ES (1) ES2018726A6 (ja)
GR (1) GR1000785B (ja)
IE (1) IE63036B1 (ja)
IL (1) IL91332A0 (ja)
NO (1) NO177673C (ja)
NZ (1) NZ230343A (ja)
PT (1) PT91499B (ja)
WO (1) WO1990001931A1 (ja)
ZA (1) ZA896025B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
JP6854759B2 (ja) * 2014-08-22 2021-04-07 ヤフェイ シャンハイ バイオログ メディスン サイエンス アンド テクノロジー カンパニー リミテッド 腫瘍微環境によって特異的活性化する小分子標的結合体およびその使用
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
US4771068A (en) * 1985-04-10 1988-09-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives having anti-tumor and antibacterial utility

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (ja) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
US4771068A (en) * 1985-04-10 1988-09-13 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives having anti-tumor and antibacterial utility

Also Published As

Publication number Publication date
NO910662L (no) 1991-03-21
KR900701269A (ko) 1990-12-01
IE892691L (en) 1990-02-23
DK29691D0 (da) 1991-02-20
CA1327037C (en) 1994-02-15
AU4065089A (en) 1990-03-23
GR1000785B (el) 1992-12-30
CN1040593A (zh) 1990-03-21
PT91499B (pt) 1995-07-06
ZA896025B (en) 1990-05-30
GR890100514A (en) 1991-12-30
PT91499A (pt) 1990-03-08
JPH04500513A (ja) 1992-01-30
NO910662D0 (no) 1991-02-19
WO1990001931A1 (en) 1990-03-08
IE63036B1 (en) 1995-03-22
NZ230343A (en) 1992-01-29
NO177673C (no) 1995-11-01
EP0431008A4 (en) 1992-03-11
IL91332A0 (en) 1990-03-19
EP0431008A1 (en) 1991-06-12
DK29691A (da) 1991-04-23
ES2018726A6 (es) 1991-05-01
NO177673B (no) 1995-07-24

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired