CA1327037C - Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof - Google Patents

Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Info

Publication number
CA1327037C
CA1327037C CA000608960A CA608960A CA1327037C CA 1327037 C CA1327037 C CA 1327037C CA 000608960 A CA000608960 A CA 000608960A CA 608960 A CA608960 A CA 608960A CA 1327037 C CA1327037 C CA 1327037C
Authority
CA
Canada
Prior art keywords
mitomycin
saccharide
pyranosyl
derivative
morpholinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000608960A
Other languages
English (en)
French (fr)
Inventor
Charles F. Hammer
Abdolhossen Talebian
Dianna Green
Philip S. Schein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Application granted granted Critical
Publication of CA1327037C publication Critical patent/CA1327037C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA000608960A 1988-08-23 1989-08-22 Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof Expired - Fee Related CA1327037C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US235,224 1981-02-17
US23522488A 1988-08-23 1988-08-23

Publications (1)

Publication Number Publication Date
CA1327037C true CA1327037C (en) 1994-02-15

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000608960A Expired - Fee Related CA1327037C (en) 1988-08-23 1989-08-22 Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof

Country Status (16)

Country Link
EP (1) EP0431008A4 (ja)
JP (1) JPH04500513A (ja)
KR (1) KR900701269A (ja)
CN (1) CN1040593A (ja)
AU (1) AU628846B2 (ja)
CA (1) CA1327037C (ja)
DK (1) DK29691A (ja)
ES (1) ES2018726A6 (ja)
GR (1) GR1000785B (ja)
IE (1) IE63036B1 (ja)
IL (1) IL91332A0 (ja)
NO (1) NO177673C (ja)
NZ (1) NZ230343A (ja)
PT (1) PT91499B (ja)
WO (1) WO1990001931A1 (ja)
ZA (1) ZA896025B (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
DE69127345D1 (de) * 1990-11-13 1997-09-25 Kyowa Hakko Kogyo Kk Mitomycinderivate
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
WO2016026458A1 (zh) * 2014-08-22 2016-02-25 亚飞（上海）生物医药科技有限公司 一种肿瘤微环境特异激活的小分子靶向偶联体及其用途
CN104231045B (zh) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 一种靶向激活释放的丝裂霉素衍生物及其用途
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (de) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Mitosanverbindungen
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (ja) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (ja) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
EP0197799B1 (en) * 1985-04-10 1990-09-12 Kyowa Hakko Kogyo Kabushiki Kaisha Pharmacologically active mitomycin derivatives
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPS63246336A (ja) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd マイトマイシン−抗体複合体含有組成物
JPH06335575A (ja) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd 電気かみそり

Also Published As

Publication number Publication date
NZ230343A (en) 1992-01-29
PT91499B (pt) 1995-07-06
PT91499A (pt) 1990-03-08
JPH04500513A (ja) 1992-01-30
AU4065089A (en) 1990-03-23
WO1990001931A1 (en) 1990-03-08
DK29691D0 (da) 1991-02-20
EP0431008A1 (en) 1991-06-12
GR890100514A (en) 1991-12-30
KR900701269A (ko) 1990-12-01
NO910662L (no) 1991-03-21
ES2018726A6 (es) 1991-05-01
IE892691L (en) 1990-02-23
NO177673C (no) 1995-11-01
CN1040593A (zh) 1990-03-21
ZA896025B (en) 1990-05-30
DK29691A (da) 1991-04-23
IE63036B1 (en) 1995-03-22
GR1000785B (el) 1992-12-30
NO910662D0 (no) 1991-02-19
IL91332A0 (en) 1990-03-19
EP0431008A4 (en) 1992-03-11
AU628846B2 (en) 1992-09-24
NO177673B (no) 1995-07-24

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