AU617380B2 - Drug-monoclonal antibody conjugates - Google Patents

Drug-monoclonal antibody conjugates Download PDF

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Publication number
AU617380B2
AU617380B2 AU25824/88A AU2582488A AU617380B2 AU 617380 B2 AU617380 B2 AU 617380B2 AU 25824/88 A AU25824/88 A AU 25824/88A AU 2582488 A AU2582488 A AU 2582488A AU 617380 B2 AU617380 B2 AU 617380B2
Authority
AU
Australia
Prior art keywords
drug
group
substituted
carbon atoms
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU25824/88A
Other languages
English (en)
Other versions
AU2582488A (en
Inventor
Peter D. Senter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AU2582488A publication Critical patent/AU2582488A/en
Application granted granted Critical
Publication of AU617380B2 publication Critical patent/AU617380B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
AU25824/88A 1987-11-23 1988-11-23 Drug-monoclonal antibody conjugates Ceased AU617380B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US124313 1987-11-23
US07/124,313 US4952394A (en) 1987-11-23 1987-11-23 Drug-monoclonal antibody conjugates

Publications (2)

Publication Number Publication Date
AU2582488A AU2582488A (en) 1989-05-25
AU617380B2 true AU617380B2 (en) 1991-11-28

Family

ID=22414122

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25824/88A Ceased AU617380B2 (en) 1987-11-23 1988-11-23 Drug-monoclonal antibody conjugates

Country Status (16)

Country Link
US (1) US4952394A (https=)
EP (1) EP0317957B1 (https=)
JP (1) JPH02111731A (https=)
KR (1) KR910005887B1 (https=)
AT (1) ATE81986T1 (https=)
AU (1) AU617380B2 (https=)
CA (1) CA1303524C (https=)
DE (1) DE3875700T2 (https=)
DK (1) DK651088A (https=)
FI (1) FI885361A7 (https=)
GR (1) GR3006211T3 (https=)
IL (1) IL88428A0 (https=)
NO (1) NO169958C (https=)
NZ (1) NZ226955A (https=)
PT (1) PT89062B (https=)
ZA (1) ZA886811B (https=)

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US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
BRPI0617546A2 (pt) * 2005-09-26 2011-07-26 Medarex Inc conjugado de fÁrmaco-anticorpo, formulaÇço farmacÊutica, mÉtodo para matar uma cÉlula de tumor, mÉtodo para retardar ou interromper o crescimento de um tumor em um sujeito mamÍfero e composto
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TWI412367B (zh) 2006-12-28 2013-10-21 梅達雷克斯有限責任公司 化學鏈接劑與可裂解基質以及其之綴合物
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7027987A (en) * 1986-02-13 1987-09-09 Celltech Limited Conjugate compound

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JPH0651643B2 (ja) * 1983-01-19 1994-07-06 帝人株式会社 殺細胞性修飾免疫グロブリン及びその製造方法
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Also Published As

Publication number Publication date
DK651088D0 (da) 1988-11-22
DE3875700D1 (de) 1992-12-10
EP0317957B1 (en) 1992-11-04
NO885199D0 (no) 1988-11-22
GR3006211T3 (https=) 1993-06-21
CA1303524C (en) 1992-06-16
EP0317957A3 (en) 1989-07-05
EP0317957A2 (en) 1989-05-31
DE3875700T2 (de) 1993-03-18
NO169958B (no) 1992-05-18
KR910005887B1 (ko) 1991-08-06
PT89062B (pt) 1993-07-30
US4952394A (en) 1990-08-28
AU2582488A (en) 1989-05-25
NO169958C (no) 1992-08-26
DK651088A (da) 1989-05-24
FI885361L (fi) 1989-05-24
ATE81986T1 (de) 1992-11-15
NZ226955A (en) 1991-11-26
JPH02111731A (ja) 1990-04-24
KR890007724A (ko) 1989-07-05
NO885199L (no) 1989-05-24
ZA886811B (en) 1989-07-26
FI885361A0 (fi) 1988-11-18
IL88428A0 (en) 1989-06-30
PT89062A (pt) 1989-11-30
FI885361A7 (fi) 1989-05-24

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