IL88428A0 - Anti-tumor drug-monoclonal antibody conjugates - Google Patents

Anti-tumor drug-monoclonal antibody conjugates

Info

Publication number
IL88428A0
IL88428A0 IL88428A IL8842888A IL88428A0 IL 88428 A0 IL88428 A0 IL 88428A0 IL 88428 A IL88428 A IL 88428A IL 8842888 A IL8842888 A IL 8842888A IL 88428 A0 IL88428 A0 IL 88428A0
Authority
IL
Israel
Prior art keywords
monoclonal antibody
antibody conjugates
drug
tumor drug
conjugate
Prior art date
Application number
IL88428A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IL88428A0 publication Critical patent/IL88428A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
IL88428A 1987-11-23 1988-11-21 Anti-tumor drug-monoclonal antibody conjugates IL88428A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/124,313 US4952394A (en) 1987-11-23 1987-11-23 Drug-monoclonal antibody conjugates

Publications (1)

Publication Number Publication Date
IL88428A0 true IL88428A0 (en) 1989-06-30

Family

ID=22414122

Family Applications (1)

Application Number Title Priority Date Filing Date
IL88428A IL88428A0 (en) 1987-11-23 1988-11-21 Anti-tumor drug-monoclonal antibody conjugates

Country Status (16)

Country Link
US (1) US4952394A (xx)
EP (1) EP0317957B1 (xx)
JP (1) JPH02111731A (xx)
KR (1) KR910005887B1 (xx)
AT (1) ATE81986T1 (xx)
AU (1) AU617380B2 (xx)
CA (1) CA1303524C (xx)
DE (1) DE3875700T2 (xx)
DK (1) DK651088A (xx)
FI (1) FI885361A (xx)
GR (1) GR3006211T3 (xx)
IL (1) IL88428A0 (xx)
NO (1) NO169958C (xx)
NZ (1) NZ226955A (xx)
PT (1) PT89062B (xx)
ZA (1) ZA886811B (xx)

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US7112337B2 (en) 1999-04-23 2006-09-26 Alza Corporation Liposome composition for delivery of nucleic acid
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US7541330B2 (en) * 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
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US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
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CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
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US8956825B2 (en) 2007-05-24 2015-02-17 The United States Of America As Represented By The Department Of Veterans Affairs Intranuclear protein transduction through a nucleoside salvage pathway
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US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
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Also Published As

Publication number Publication date
AU617380B2 (en) 1991-11-28
PT89062B (pt) 1993-07-30
ATE81986T1 (de) 1992-11-15
EP0317957B1 (en) 1992-11-04
FI885361A (fi) 1989-05-24
NO885199D0 (no) 1988-11-22
DK651088D0 (da) 1988-11-22
JPH02111731A (ja) 1990-04-24
PT89062A (pt) 1989-11-30
NZ226955A (en) 1991-11-26
NO885199L (no) 1989-05-24
US4952394A (en) 1990-08-28
ZA886811B (en) 1989-07-26
DK651088A (da) 1989-05-24
EP0317957A3 (en) 1989-07-05
DE3875700T2 (de) 1993-03-18
CA1303524C (en) 1992-06-16
NO169958B (no) 1992-05-18
FI885361A0 (fi) 1988-11-18
GR3006211T3 (xx) 1993-06-21
AU2582488A (en) 1989-05-25
KR910005887B1 (ko) 1991-08-06
EP0317957A2 (en) 1989-05-31
NO169958C (no) 1992-08-26
KR890007724A (ko) 1989-07-05
DE3875700D1 (de) 1992-12-10

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