AU614283B2 - New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them - Google Patents
New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them Download PDFInfo
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- AU614283B2 AU614283B2 AU15111/88A AU1511188A AU614283B2 AU 614283 B2 AU614283 B2 AU 614283B2 AU 15111/88 A AU15111/88 A AU 15111/88A AU 1511188 A AU1511188 A AU 1511188A AU 614283 B2 AU614283 B2 AU 614283B2
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- 239000003814 drug Substances 0.000 title description 4
- 238000004519 manufacturing process Methods 0.000 title description 3
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 13
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- 239000001257 hydrogen Substances 0.000 claims abstract description 6
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 claims abstract description 4
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- 238000000034 method Methods 0.000 claims description 22
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- 125000005843 halogen group Chemical group 0.000 claims description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20260/87 | 1987-04-24 | ||
| IT20260/87A IT1203971B (it) | 1987-04-24 | 1987-04-24 | Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1511188A AU1511188A (en) | 1988-10-27 |
| AU614283B2 true AU614283B2 (en) | 1991-08-29 |
Family
ID=11165225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU15111/88A Ceased AU614283B2 (en) | 1987-04-24 | 1988-04-22 | New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them |
Country Status (22)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL81610A (en) * | 1986-02-27 | 1990-12-23 | Roussel Uclaf | Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them |
| US4786648A (en) * | 1986-12-08 | 1988-11-22 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
| IT1222526B (it) * | 1987-08-21 | 1990-09-05 | Roussel Maestretti Spa | Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali |
| EP0338723B1 (en) * | 1988-04-15 | 1993-08-04 | Beecham Group Plc | Novel compounds |
| US5278170A (en) * | 1989-04-13 | 1994-01-11 | Beecham Group P.L.C. | Azabicylo oxime compounds |
| SG48315A1 (en) * | 1989-04-13 | 1998-04-17 | Beecham Group Plc | Novel compounds |
| EP0544773B1 (en) * | 1990-08-24 | 1998-03-18 | Beecham Group Plc | Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them |
| GB9019095D0 (en) * | 1990-09-01 | 1990-10-17 | Beecham Group Plc | Novel compounds |
| CA2093823A1 (en) * | 1990-10-12 | 1992-04-13 | Steven M. Bromidge | 1,2,5,6-tetrahydropyridine oxime derivatives |
| EP0537993A1 (en) * | 1991-10-17 | 1993-04-21 | Eli Lilly And Company | Nicotinic activity of a series of arecolones and isoarecolones |
| AU3142793A (en) * | 1991-12-18 | 1993-07-19 | Warner-Lambert Company | Transdermal delivery of (E)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-O- methyloxine HCL and related compounds in the treatment of cognitive disorders and for analgesia |
| US5362860A (en) * | 1993-02-01 | 1994-11-08 | Warner-Lambert Company | Neutral stabilization complex for CI-979 HCl, a cognition activator |
| US5424301A (en) * | 1993-02-01 | 1995-06-13 | Warner-Lambert Company | Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents |
| GB9502152D0 (en) * | 1995-02-03 | 1995-03-29 | Zeneca Ltd | Proline derivatives |
| DK0915088T3 (da) * | 1997-10-31 | 2003-01-27 | Hoffmann La Roche | D-prolinderivater |
| US6250886B1 (en) | 1999-09-03 | 2001-06-26 | Chittom International, Inc. | Axial flow fan and fan blade |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU588972B2 (en) * | 1986-02-27 | 1989-09-28 | Aventis Pharma S.A. | New derivatives of 1,2,5,6-tetrahydropyridine-3- carboxaldehyde oxime, their preparation process, their use as medicaments, and the compositions containing them |
| AU607442B2 (en) * | 1986-12-08 | 1991-03-07 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1258847A (fr) * | 1960-02-12 | 1961-04-21 | Ciba Geigy | Procédé de préparation de nouveaux dérivés pyridiniques, entre autres de l'oxime de la l-méthyl-3 ou 4-acétyl-1, 2, 5, 6-tétrahydropyridine |
| JPH0641332B2 (ja) * | 1986-09-17 | 1994-06-01 | 株式会社共同精機工作所 | 断裁機へのシ−ト類供給装置 |
| US4710508A (en) * | 1986-12-08 | 1987-12-01 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
| US4798841A (en) * | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
-
1987
- 1987-04-24 IT IT20260/87A patent/IT1203971B/it active
-
1988
- 1988-04-13 ZA ZA882595A patent/ZA882595B/xx unknown
- 1988-04-21 DK DK216388A patent/DK167758B1/da not_active IP Right Cessation
- 1988-04-21 PT PT87290A patent/PT87290B/pt not_active IP Right Cessation
- 1988-04-21 MX MX1120188A patent/MX11201A/es unknown
- 1988-04-22 PH PH36830A patent/PH25574A/en unknown
- 1988-04-22 EP EP88400996A patent/EP0288394B1/fr not_active Expired - Lifetime
- 1988-04-22 AT AT88400996T patent/ATE80387T1/de not_active IP Right Cessation
- 1988-04-22 IL IL8615788A patent/IL86157A/en not_active IP Right Cessation
- 1988-04-22 OA OA59335A patent/OA08835A/xx unknown
- 1988-04-22 FI FI881892A patent/FI93211C/fi not_active IP Right Cessation
- 1988-04-22 JP JP63098476A patent/JP2727192B2/ja not_active Expired - Fee Related
- 1988-04-22 AU AU15111/88A patent/AU614283B2/en not_active Ceased
- 1988-04-22 CA CA000564817A patent/CA1340986C/fr not_active Expired - Fee Related
- 1988-04-22 NZ NZ224357A patent/NZ224357A/en unknown
- 1988-04-22 IE IE120788A patent/IE63172B1/en not_active IP Right Cessation
- 1988-04-22 HU HU882057A patent/HU199795B/hu not_active IP Right Cessation
- 1988-04-22 ES ES88400996T patent/ES2043863T3/es not_active Expired - Lifetime
- 1988-04-22 DE DE8888400996T patent/DE3874396T2/de not_active Expired - Fee Related
- 1988-04-22 SU SU884355793A patent/SU1678203A3/ru active
- 1988-04-23 KR KR1019880004709A patent/KR960012365B1/ko not_active Expired - Fee Related
-
1992
- 1992-09-10 GR GR920401660T patent/GR3005647T3/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU588972B2 (en) * | 1986-02-27 | 1989-09-28 | Aventis Pharma S.A. | New derivatives of 1,2,5,6-tetrahydropyridine-3- carboxaldehyde oxime, their preparation process, their use as medicaments, and the compositions containing them |
| AU607442B2 (en) * | 1986-12-08 | 1991-03-07 | Warner-Lambert Company | O-substituted tetrahydropyridine oxime cholinergic agents |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired | ||
| PC | Assignment registered |
Owner name: AVENTIS PHARMA S.A. Free format text: FORMER OWNER WAS: HOECHST MARION ROUSSEL |