AU1511188A - New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them - Google Patents

New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them

Info

Publication number
AU1511188A
AU1511188A AU15111/88A AU1511188A AU1511188A AU 1511188 A AU1511188 A AU 1511188A AU 15111/88 A AU15111/88 A AU 15111/88A AU 1511188 A AU1511188 A AU 1511188A AU 1511188 A AU1511188 A AU 1511188A
Authority
AU
Australia
Prior art keywords
denotes
tetrahydropyridine
medicaments
preparing
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU15111/88A
Other versions
AU614283B2 (en
Inventor
Fernando Barzaghi
Carla Bonetti
Giulio Galliani
Emilio Toja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of AU1511188A publication Critical patent/AU1511188A/en
Application granted granted Critical
Publication of AU614283B2 publication Critical patent/AU614283B2/en
Assigned to HOECHST MARION ROUSSEL reassignment HOECHST MARION ROUSSEL Alteration of Name(s) in Register under S187 Assignors: ROUSSEL-UCLAF
Assigned to AVENTIS PHARMA S.A. reassignment AVENTIS PHARMA S.A. Alteration of Name(s) in Register under S187 Assignors: HOECHST MARION ROUSSEL
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Abstract

New compounds (I): <IMAGE> in which R denotes a hydrogen, a hydroxyl or an alkyl containing up to 8 C, optionally substituted by a carboxy or R denotes an aralkyl containing up to 10 C or -COOZ, Z being an alkyl containing up to 8 C or an aralkyl containing from 7 to 10 C, R1 denotes an alkyl containing up to 8 C, R2 denotes a hydrogen or an alkyl containing up to 8 C, -COalk1 or (CH2)2N(alk2)2, alk1 and alk2 denoting an alkyl containing up to 8 C, it being understood that if R denotes an alkyl, R2 does not denote a hydrogen, and their addition salts with acids.
AU15111/88A 1987-04-24 1988-04-22 New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them Ceased AU614283B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20260/87 1987-04-24
IT20260/87A IT1203971B (en) 1987-04-24 1987-04-24 1,2,5,6-TETRAHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION AS MEDICATIONS

Publications (2)

Publication Number Publication Date
AU1511188A true AU1511188A (en) 1988-10-27
AU614283B2 AU614283B2 (en) 1991-08-29

Family

ID=11165225

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15111/88A Ceased AU614283B2 (en) 1987-04-24 1988-04-22 New derivatives of 1,2,5,6-tetrahydropyridine, the process for preparing them, their use as medicaments and the compositions containing them

Country Status (22)

Country Link
EP (1) EP0288394B1 (en)
JP (1) JP2727192B2 (en)
KR (1) KR960012365B1 (en)
AT (1) ATE80387T1 (en)
AU (1) AU614283B2 (en)
CA (1) CA1340986C (en)
DE (1) DE3874396T2 (en)
DK (1) DK167758B1 (en)
ES (1) ES2043863T3 (en)
FI (1) FI93211C (en)
GR (1) GR3005647T3 (en)
HU (1) HU199795B (en)
IE (1) IE63172B1 (en)
IL (1) IL86157A (en)
IT (1) IT1203971B (en)
MX (1) MX11201A (en)
NZ (1) NZ224357A (en)
OA (1) OA08835A (en)
PH (1) PH25574A (en)
PT (1) PT87290B (en)
SU (1) SU1678203A3 (en)
ZA (1) ZA882595B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU588972B2 (en) * 1986-02-27 1989-09-28 Aventis Pharma S.A. New derivatives of 1,2,5,6-tetrahydropyridine-3- carboxaldehyde oxime, their preparation process, their use as medicaments, and the compositions containing them
AU607442B2 (en) * 1986-12-08 1991-03-07 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
AU608643B2 (en) * 1987-08-21 1991-04-11 Aventis Pharma S.A. Novel derivatives of the oxime of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338723B1 (en) * 1988-04-15 1993-08-04 Beecham Group Plc Novel compounds
DE69034146T2 (en) * 1989-04-13 2005-07-14 Beecham Group P.L.C., Brentford Chemical compounds
US5278170A (en) * 1989-04-13 1994-01-11 Beecham Group P.L.C. Azabicylo oxime compounds
PT98742A (en) * 1990-08-24 1992-07-31 Beecham Group Plc PROCESS FOR THE PREPARATION OF AZABICYLIC COMPOUNDS
GB9019095D0 (en) * 1990-09-01 1990-10-17 Beecham Group Plc Novel compounds
EP0552213A1 (en) * 1990-10-12 1993-07-28 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
EP0537993A1 (en) * 1991-10-17 1993-04-21 Eli Lilly And Company Nicotinic activity of a series of arecolones and isoarecolones
WO1993011767A1 (en) * 1991-12-18 1993-06-24 Warner-Lambert Company Transdermal delivery of (e)-1,2,5,6-tetrahydro-1-methyl-3-pyridine-carboxaldehyde-o-methyloxine hcl and related compounds in the treatment of cognitive disorders and for analgesia
US5362860A (en) * 1993-02-01 1994-11-08 Warner-Lambert Company Neutral stabilization complex for CI-979 HCl, a cognition activator
US5424301A (en) * 1993-02-01 1995-06-13 Warner-Lambert Company Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
US6250886B1 (en) 1999-09-03 2001-06-26 Chittom International, Inc. Axial flow fan and fan blade

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1258847A (en) * 1960-02-12 1961-04-21 Ciba Geigy Process for the preparation of novel pyridine derivatives, including 1-methyl-3 or 4-acetyl-1, 2, 5, 6-tetrahydropyridine oxime
IL81610A (en) * 1986-02-27 1990-12-23 Roussel Uclaf Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
JPH0641332B2 (en) * 1986-09-17 1994-06-01 株式会社共同精機工作所 Sheet feeding device for cutting machine
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4786648A (en) * 1986-12-08 1988-11-22 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU588972B2 (en) * 1986-02-27 1989-09-28 Aventis Pharma S.A. New derivatives of 1,2,5,6-tetrahydropyridine-3- carboxaldehyde oxime, their preparation process, their use as medicaments, and the compositions containing them
AU607442B2 (en) * 1986-12-08 1991-03-07 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
AU608643B2 (en) * 1987-08-21 1991-04-11 Aventis Pharma S.A. Novel derivatives of the oxime of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde, the process for their preparation, their use as medicaments and the compositions containing them

Also Published As

Publication number Publication date
IL86157A (en) 1994-04-12
MX11201A (en) 1993-10-01
EP0288394A2 (en) 1988-10-26
CA1340986C (en) 2000-05-09
ATE80387T1 (en) 1992-09-15
KR890016009A (en) 1989-11-27
DE3874396D1 (en) 1992-10-15
IT8720260A0 (en) 1987-04-24
HUT47248A (en) 1989-02-28
DE3874396T2 (en) 1993-04-22
AU614283B2 (en) 1991-08-29
IT1203971B (en) 1989-02-23
HU199795B (en) 1990-03-28
PT87290B (en) 1992-08-31
IE881207L (en) 1988-10-24
NZ224357A (en) 1992-01-29
JPS63284160A (en) 1988-11-21
IL86157A0 (en) 1988-11-15
KR960012365B1 (en) 1996-09-20
EP0288394B1 (en) 1992-09-09
JP2727192B2 (en) 1998-03-11
FI881892A (en) 1988-10-25
FI881892A0 (en) 1988-04-22
ES2043863T3 (en) 1994-01-01
PH25574A (en) 1991-08-08
GR3005647T3 (en) 1993-06-07
FI93211C (en) 1995-03-10
PT87290A (en) 1988-05-01
OA08835A (en) 1989-03-31
DK167758B1 (en) 1993-12-13
FI93211B (en) 1994-11-30
SU1678203A3 (en) 1991-09-15
EP0288394A3 (en) 1989-01-25
DK216388A (en) 1988-10-25
ZA882595B (en) 1989-07-26
DK216388D0 (en) 1988-04-21
IE63172B1 (en) 1995-03-22

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired
PC Assignment registered

Owner name: AVENTIS PHARMA S.A.

Free format text: FORMER OWNER WAS: HOECHST MARION ROUSSEL